Research Report 2018 A Message from Executive Vice President Gilbert White, II, MD, Chief Scientific Officer 2018 was another strong year for research. Grant and Yan Qing Ma were promoted to Investigator. revenues for the year were $16.1 M, another record Lisa Baumann-Kreuziger, Lynn Malec, and Matt for us and exceeding our 2018 budget by $1 M. Karafin were promoted to Associate Investigator. New NIH R-type grants or competitive renewals Jorge DiPaola of the University of Colorado, David were obtained by Bob Montgomery and by Sandy Lillicrap and Paula James from Queens University in Haberichter. Peter Newman successfully competed Kingston, Canada, James O’Donnell from the Royal for a $6.9 M 7-year R35 Career award from NHLBI. College of Surgeons of Ireland, and Amy Shapiro Karin Hoffmeister received a new $4.8 M K12 award from the Indiana Hemophilia and Thrombosis Center in Glycobiology, one of four in the US together with in Indianapolis were appointed as adjunct Senior Johns Hopkins, Harvard, and UCSD. Gil White is the Investigators at the BRI. PI on a new $1.5 M OT2 consortium grant from NIH that is part of the NIH Precision Medicine Initiative. A Individual accomplishments during the year were new F-type award went to Puja Agrawal in Sid Rao’s numerous. We celebrated Hardy Weiler’s and Pam lab. Altogether, there were 11 new NIH grants in 2018 Christopherson’s 20th year with the organization. that totaled $17.5 M. Nan Zhu received the second Alan Mast chaired the 2018 Hemostasis Gordon R. Douglas Ziegler Innovation Award for her work Conference. Irene Hernandez in Hardy Weiler’s lab related to the pathogenesis of acute myelogenous received Excellence in Action recognition from Versiti. leukemia. Matt Karafin, Josh Field, Peter Newman, Dick Aster received the BizTimes Media Health Care Karin Hoffmeister, and Subra Malarkannan received Heroes Lifetime Achievement Award, recognizing funding for Versiti Moonshot projects. his advancements in transfusion medicine. Karin Hoffmeister chaired the Megakaryocyte and Platelet John Pulikkan joined the faculty as Associate Scientific Committee and the Committee Program Investigator in the stem cell group. John came from the at the annual meeting of the American Society of University of Massachusetts Medical School from the Hematology (ASH). Hervé Falet also serves on the lab of Lucio Castilla, a former scholar of the Leukemia Megakaryocyte and Platelet Scientific Committee. and Lymphoma Society. His research focuses on Peter Newman serves on the Investment and Audit chromatin dynamics and understanding the regulatory Committee of ASH. Alan Mast, Karin Hoffmeister, pathways that are deregulated in hematopoietic stem Magda Chrzanowska, Debra Newman, Roy and progenitor cells in acute myeloid leukemia in order Silverstein and Bob Montgomery continue to serve to better understand the development of leukemia. on NIH review panels. Peter Newman continues His overall goal is to develop novel therapeutic to serve as Associate Editor of Arteriosclerosis, strategies for the treatment of leukemia. Jieqing Zhu Thrombosis, and Vascular Biology (ATVB). Hardy Research Report 2018 1 Continued: A Message from Executive Vice President Gilbert White, II, MD, Chief Scientific Officer Weiler and Roy Silverstein serve on the ATVB Editorial University, on November 8th. His talk was titled “T Zheng in Demin Wang’s lab was the 2018 Doolittle Board. Alan Mast is a new Associate Editor of the Cell Exhaustion and PD-a Immunotherapy”. All four Fellow and Saravanan Subramaniam in Hardy Weiler’s Journal of Thrombosis and Haemostasis. Magda lectures were outstanding and examples of cutting lab was the Gallagher Fellow. Waseem Anani in Karin Chrzanowska is on the Editorial Board of Plos One. edge science and translation. Hoffmeister’s lab was named the first Jaqueline and Bonnie Dittel is Associate Editor of Autoimmunity Arlen Fredrick Scholar. New Directors Fellows were and on the Editorial Boards of the Journal of The 1st Annual Great Lakes Translational Glycomics Heather Ashwood in Karin Hoffmeister’s lab and Neuroimmunology and Brain, Behavior, and Immunity. Symposium was held May 31st at the Blood Amy Siebert-McKenzie in Alan Mast’s lab, bringing Subra Malarkannan is Associate Editor of Frontiers in Research Institute (BRI) and was organized by Karin to 6 the number who have been supported through Immunology. Qizhen Shi is on the Editorial Board of Hoffmeister. Featuring speakers from GlycoMimetics, the contributions of Scott and Genevieve Harkness. Molecular Therapy, Methods and Clinical Development. Inc, Washington University in St. Louis, Virginia Chao Yang in Subra Malarkannan’s lab received the Peter Newman is Co-Editor of the 3rd Edition of Commonwealth University, Roswell Park Cancer inaugural J. Evan Sadler Graduate Scholar Award, as Platelets and Gil White is Co-Editor of the 6th Edition of Center, Brigham and Women’s Hospital, and Medical voted by the BRI graduate students and postdoctoral Thrombosis and Hemostasis. Six students completed College of Wisconsin (MCW), it was attended by more fellows. Moua Yang in Roy Silverstein’s lab received the their PhD degrees in 2018: Michael Reimer from Sid than 60 individuals. The 12th Annual Center for Human Mary Rodes Gibson Memorial Award in Hemostasis Rao’s lab, Aye Myat Myat Thinn from Jieqing Zhu’s Immunology Symposium was held October 25th at and Thrombosis for the highest scoring abstract at lab, David Schauder from Weiguo Cui’s lab, Alex Abel the BRI. The symposium, titled “B Cells and Broadly the American Society of Hematology meeting. Five from Subra Malarkannan’s lab, Erin Wesley from Matt Neutralizing Antibodies,” featured renowned speakers new graduate students selected the BRI as their place Riese’s lab, and Moua Yang from Roy Silverstein’s lab. from Harvard University, Scripps Research Institute, to train: Paytsar Topchyan and Christine Nguyen Vanderbilt University, the Feinstein Institute for Medical in Weiguo Cui’s lab, Yaling Wu in Demin Wang’s lab, The 16th Annual Aster Lecture was delivered on Research, and Sanofi Pharmaceuticals. This year’s Savannah Neu in Bonnie Dittel’s lab, and Yuanhua Cai August 15th by Dr. Olja Finn, Distinguished Professor meeting was hosted by Demin Wang and Renren Wen. in Qizhen Shi’s lab. of Immunology and Surgery at the University of Pittsburgh. Her talk was titled “Vaccines in the The Scientific Advisory Board reviewed part of the Sadly, we lost a long-time and beloved colleague Prevention of Non-Viral Cancers”. The 17th Annual Vascular Biology program in October. Overall, there when Joan Gill passed away on May 9, 2018. Joan Mosesson Lecture was delivered on October 4th was high enthusiasm for this group of investigators. In was internationally renowned in the world of bleeding by Dr. Bjorn Dahlback, Senior Professor in the their summary comments, the Board described the disorders and made a number of lasting contributions Department of Laboratory Medicine at Lund University need for continued succession planning, space for through her work with von Willebrand disease and in Malmo, Sweden. His talk was on “Novel Insights continued expansion, attention to retention, and the hemophilia. One of the first women in the field, Joan into the Regulation of Blood Coagulation by FV success of the mentoring program. They also reported served as an example to countless young women in Isoforms, TFPI alpha and Protein S”. The 2nd Annual some faculty anxiety regarding a perceived emphasis hematology and was the face of bleeding disorders Jacqueline Fredrick Lecture, selected and hosted by on cell therapies and uncertainty regarding changes in care in the State of Wisconsin. the graduate students and postdoctoral fellows at the leadership. BRI, was given on September 20th by Melanie Cobb, At years’ end, there were 38 trainees in the BRI. All of Browning Chair in Medical Science in the Department our T32 Training Grant positions were filled in 2018: of Pharmacology at the UT Southwestern Medical Tyce Kearl in Subra Malarkannan’s lab, Alyssa Moroi Center. The talk was titled “Catching a Few Good in Peter Newman’s lab followed by Lauren Pommert in WNKs”. The 2nd Annual R. Douglas Ziegler Innovation Sid Rao’s lab, Nate Schloemer in Subra Malarkannan’s Lecture was by Dr. Rafi Ahmed, Director of the highly lab followed by Amy Siebert-McKenzie in Alan Mast’s Gilbert C. White, II, MD innovative Harrington Discovery Institute at Emory lab, and Jesse Sundlov in Peter Newman’s lab. Yongwei Chief Scientific Officer 2 Research By The Numbers – 2018 10 $122.4 5 New NIH Million New Diagnostic Grants New Applications Tests Developed $16.1 33 Million 1 Start-Up Company Investigators Research Formed Revenues $614+ 2 13 Thousand Patents Filed Core Labs Average Funding per Investigator Research Report 2018 3 Transfusion Medicine Transfusion Medicine research has a long history at Versiti, reflecting its basic mission to provide a safe and effective supply of blood products for patients who require transfusion. Effective transfusion therapy requires knowledge of the biology and physiology of blood, satisfactory methods for collecting and storing blood cells with maximum preservation of function, and an understanding of the many diseases in which transfusion of blood components can be beneficial. Research conducted by the Transfusion Medicine group addresses each of these areas. Investigators in the Transfusion Medicine Program study basic biology and clinical implications of a range of transfusion-related issues. CEO Emeritus and Senior Investigator, Blood Research Institute Richard H. Aster, MD Professor, Department of Medicine, Medical College of Wisconsin (MCW) MD, University of Michigan 1957 Hematology, Harvard University 1965 Faculty, Harvard 1964-1970 Started at Versiti: 1971 cell destruction and improved understanding of the Funding molecular basis for these conditions. RO1-HL-13629-47 National Heart Lung and Blood Awards, Honors and Service Institute. Renewed June 1, 2017 • Founder: GTI Diagnostics (subsidiary of VBRIF) Publications • Karl Landsteiner Award, American Association of Blood 1.