Quarterly Holdings Report for Fidelity® Select Portfolio® Biotechnology Portfolio May 31, 2021 BIO-QTLY-0721 1.802156.117 Schedule of Investments May 31, 2021 (Unaudited) Showing Percentage of Net Assets Common Stocks – 97.4% Shares Value Shares Value Biotechnology – 89.4% CareDx, Inc. (a) 178,500 $ 14,351,400 Biotechnology – 89.4% Celldex Therapeutics, Inc. (a) 337,900 9,444,305 4D Molecular Therapeutics, Inc. 214,868 $ 5,706,894 Cellectis SA sponsored ADR (a) (b) 157,465 2,467,477 AbbVie, Inc. 9,829,284 1,112,674,949 Cerevel Therapeutics Holdings (a) 201,800 2,647,616 ACADIA Pharmaceuticals, Inc. (a) 199,594 4,458,930 ChemoCentryx, Inc. (a) 2,062,222 20,931,553 Acceleron Pharma, Inc. (a) 924,453 121,001,653 Chinook Therapeutics, Inc. (a) 840,646 13,870,659 ADC Therapeutics SA (a) (b) 755,238 16,350,903 Chinook Therapeutics, Inc. rights (a) (d) 115,821 5,791 Agios Pharmaceuticals, Inc. (a) 1,075,059 59,966,791 Codiak Biosciences, Inc. (b) 436,539 9,874,512 Akouos, Inc. (a) (b) 716,626 9,359,136 Coherus BioSciences, Inc. (a) 58,387 768,373 Albireo Pharma, Inc. (a) (b) 320,350 10,715,708 Connect Biopharma Holdings Ltd. ADR (a) 1,079,600 16,064,448 Aldeyra Therapeutics, Inc. (a) 1,201,911 15,047,926 Constellation Pharmaceuticals, Inc. (a) (b) 90,259 1,788,031 Alector, Inc. (a) (b) 998,482 17,772,980 ContraFect Corp. (a) (b) 456,309 1,843,488 Allakos, Inc. (a) 207,631 21,062,089 Cortexyme, Inc. (a) (b) 1,947 80,547 Allena Pharmaceuticals, Inc. (a) (c) 1,447,443 1,577,713 Crinetics Pharmaceuticals, Inc. (a) (e) 2,123,187 37,261,932 Allena Pharmaceuticals, Inc. (a) (b) 848,640 925,018 CRISPR Therapeutics AG (a) (b) 260,522 30,788,490 Allogene Therapeutics, Inc. (a) 650,470 16,717,079 Cullinan Oncology, Inc. 179,440 5,334,751 Allovir, Inc. (a) 111,300 2,608,872 Cyclerion Therapeutics, Inc. (a) 837,285 2,712,803 Alnylam Pharmaceuticals, Inc. (a) 1,432,939 203,463,009 Cyclerion Therapeutics, Inc. (a) (f) 94,809 307,181 ALX Oncology Holdings, Inc. (a) (b) 643,290 36,384,482 Cytokinetics, Inc. (a) 1,546,871 33,768,194 Amgen, Inc. 401,451 95,521,251 CytomX Therapeutics, Inc. (a) 221,700 1,587,372 Amicus Therapeutics, Inc. (a) 1,229,001 11,380,549 CytomX Therapeutics, Inc. (a) (c) 287,485 2,058,393 Annexon, Inc. (a) 344,736 7,280,824 Day One Biopharmaceuticals, Inc. (a) 310,467 7,354,963 Apellis Pharmaceuticals, Inc. (a) 1,455,747 81,929,441 Decibel Therapeutics, Inc. 213,800 1,913,510 Applied Molecular Transport, Inc. (b) 25,628 1,228,606 Deciphera Pharmaceuticals, Inc. (a) 397,200 13,401,528 Applied Therapeutics, Inc. (a) 569,640 10,954,177 Denali Therapeutics, Inc. (a) (b) 697,951 44,382,704 Aravive, Inc. (a) (b) 456,443 2,341,553 Design Therapeutics, Inc. (a) 1,000,000 26,200,000 Arcturus Therapeutics Holdings, Inc. (a) (b) 730,290 21,339,074 Dicerna Pharmaceuticals, Inc. (a) 618,712 20,170,011 Arcus Biosciences, Inc. (a) 3,091,165 76,722,715 Edgewise Therapeutics, Inc. (a) 713,600 20,601,632 Arcutis Biotherapeutics, Inc. (a) 879,674 23,179,410 Editas Medicine, Inc. (a) (b) 9,789 332,337 Ardelyx, Inc. (a) 97,094 694,222 Eledon Pharmaceuticals, Inc. (a) (e) 1,004,111 9,559,137 Arena Pharmaceuticals, Inc. (a) 281,573 17,206,926 Emergent BioSolutions, Inc. (a) 18,101 1,097,826 Argenx SE ADR (a) 452,386 126,211,170 Epizyme, Inc. (a) (b) 1,799,135 14,806,881 Arrowhead Pharmaceuticals, Inc. (a) 1,052,226 76,391,608 Equillium, Inc. (a) 209,800 1,376,288 Ascendis Pharma A/S sponsored ADR (a) 659,409 88,611,381 Essa Pharma, Inc. (a) 797,203 25,207,559 Atara Biotherapeutics, Inc. (a) 587,995 7,973,212 Evelo Biosciences, Inc. (a) (b) 834,199 11,194,951 aTyr Pharma, Inc. (a) (b) 481,990 2,188,235 Exact Sciences Corp. (a) 526,212 58,162,212 Aurinia Pharmaceuticals, Inc. (a) (b) 1,263,586 18,347,269 Exelixis, Inc. (a) 3,524,744 79,482,977 Autolus Therapeutics Ltd. ADR (a) (b) 1,074,488 7,123,855 Fate Therapeutics, Inc. (a) 970,587 74,346,964 Avidity Biosciences, Inc. (b) 235,484 5,590,390 FibroGen, Inc. (a) 1,071,831 22,776,409 AVROBIO, Inc. (a) 120,951 1,087,349 Foghorn Therapeutics, Inc. 443,055 4,612,203 Axcella Health, Inc. (a) (b) 397,149 1,266,905 Foghorn Therapeutics, Inc. (c) 144,144 1,500,539 Bicycle Therapeutics PLC ADR (a) (b) 211,444 6,237,598 Forma Therapeutics Holdings, Inc. 804,809 22,590,989 BioAtla, Inc. 262,115 11,284,051 Fusion Pharmaceuticals, Inc. (a) 871,443 7,154,547 BioCryst Pharmaceuticals, Inc. (a) (b) 1,123,884 17,723,651 G1 Therapeutics, Inc. (a) (b) 813,600 17,671,392 Biogen, Inc. (a) 1,017,105 272,055,245 Galapagos Genomics NV sponsored ADR (a) (b) 564,459 42,977,908 Biohaven Pharmaceutical Holding Co. Ltd. (a) 1,128,162 98,150,094 Gamida Cell Ltd. (a) 795,067 5,159,985 BioMarin Pharmaceutical, Inc. (a) 8,344 644,991 Gemini Therapeutics, Inc. (f) 1,000,000 12,300,000 Biomea Fusion, Inc. (a) 335,863 5,813,789 Generation Bio Co. 137,100 4,697,046 BioNTech SE ADR (a) 164,628 33,584,112 Genmab A/S ADR (a) 21,490 872,924 BioXcel Therapeutics, Inc. (a) (b) 221,727 7,323,643 Geron Corp. (a) (b) 4,109,206 5,670,704 bluebird bio, Inc. (a) 12,384 385,390 Geron Corp. warrants 12/31/25 (a) 2,100,000 632,908 Blueprint Medicines Corp. (a) 1,304,915 119,203,985 Gilead Sciences, Inc. 448,782 29,668,978 Bolt Biotherapeutics, Inc. 423,000 7,406,730 Global Blood Therapeutics, Inc. (a) 413,716 15,899,106 BridgeBio Pharma, Inc. (a) (b) 696,761 41,248,251 Gritstone Bio, Inc. (a) (b) 780,780 7,183,176 C4 Therapeutics, Inc. (b) 357,691 13,216,682 Halozyme Therapeutics, Inc. (a) 906,308 37,530,214 Cabaletta Bio, Inc. (a) (b) 35,650 404,271 Heron Therapeutics, Inc. (a) (b) 354,625 4,705,874 Homology Medicines, Inc. (a) 1,057,874 7,024,283 Quarterly Report 2 Common Stocks – continued Shares Value Shares Value Biotechnology – continued Nkarta, Inc. (a) (b) 60,200 $ 1,465,870 Biotechnology – continued Novavax, Inc. (a) 368,936 54,462,332 Hookipa Pharma, Inc. (a) (b) (e) 1,405,103 $ 23,451,169 NuCana PLC ADR (a) 369,200 1,129,752 Ideaya Biosciences, Inc. (a) 44,000 886,600 Nurix Therapeutics, Inc. (a) (b) 564,634 15,753,289 Idorsia Ltd. (a) 1,218,641 33,273,844 Olema Pharmaceuticals, Inc. (b) 61,997 1,733,436 IGM Biosciences, Inc. (a) 99,368 7,417,821 Opko Health, Inc. (a) (b) 1,434,911 5,481,360 Immunic, Inc. (a) 602,072 8,133,993 Oragenics, Inc. (a) 155,806 107,008 Immunocore Holdings PLC 400,875 15,614,081 ORIC Pharmaceuticals, Inc. (a) (b) 724,374 16,551,946 ImmunoGen, Inc. (a) 1,176,923 7,273,384 Passage Bio, Inc. (a) 643,962 8,532,497 Immunome, Inc. (b) 226,456 4,737,460 PMV Pharmaceuticals, Inc. (b) 172,300 5,927,120 Incyte Corp. (a) 760,067 63,678,413 Poseida Therapeutics, Inc. (a) 101,700 859,365 Inhibikase Therapeutics, Inc. (b) 100,000 537,000 Poseida Therapeutics, Inc. (c) 513,583 4,339,776 Inozyme Pharma, Inc. (a) (b) 609,380 9,969,457 Praxis Precision Medicines, Inc. 321,261 6,293,503 Insmed, Inc. (a) 742,920 18,275,832 Prelude Therapeutics, Inc. 10,079 350,346 Instil Bio, Inc. (a) 63,200 1,124,960 Prelude Therapeutics, Inc. (c) 550,977 19,151,961 Instil Bio, Inc. 1,431,274 22,929,009 Prometheus Biosciences, Inc. (a) (b) 412,800 9,614,112 Intellia Therapeutics, Inc. (a) 1,150,501 86,218,545 ProQR Therapeutics BV (a) (b) 555,016 3,463,300 Intercept Pharmaceuticals, Inc. (a) (b) 102,794 1,709,464 Protagonist Therapeutics, Inc. (a) 564,855 19,832,059 Invitae Corp. (a) (b) 657,417 18,920,461 Prothena Corp. PLC (a) 1,060,789 30,943,215 Ionis Pharmaceuticals, Inc. (a) (b) 1,722,677 64,169,718 PTC Therapeutics, Inc. (a) 2,268,744 89,093,577 Iovance Biotherapeutics, Inc. (a) 779,179 14,469,354 Radius Health, Inc. (a) 40,249 776,403 iTeos Therapeutics, Inc. (a) 303,681 6,237,608 Rain Therapeutics, Inc. (a) (b) 800,000 15,896,000 Jounce Therapeutics, Inc. (a) 790,934 6,208,832 Recursion Pharmaceuticals, Inc. (a) 220,300 5,807,108 Kalvista Pharmaceuticals, Inc. (a) (b) 218,620 5,902,740 Regeneron Pharmaceuticals, Inc. (a) 14,976 7,524,392 Karuna Therapeutics, Inc. (a) 229,311 25,641,556 REGENXBIO, Inc. (a) 15,108 532,859 Keros Therapeutics, Inc. (a) 310,786 16,956,484 Relay Therapeutics, Inc. (a) (b) 1,319,943 42,396,569 Kezar Life Sciences, Inc. (a) 814,232 4,657,407 Repare Therapeutics, Inc. 540,250 17,460,880 Kiniksa Pharmaceuticals Ltd. (a) (b) 305,540 4,164,510 Replimune Group, Inc. (a) 1,054,117 41,078,939 Kinnate Biopharma, Inc. 639,303 14,860,726 Revolution Medicines, Inc.