Overview Reserach Programs 2018 _Annual Report Overview Reserach Programs About the Adolphe Merkle Institute The Adolphe Merkle Institute (AMI) is an independent competence center at the University of Fribourg that focuses on research and ed- ucation in the domain of soft nanomaterials. We owe our existence to Dr. Adolphe Merkle, a successful local entrepreneur, who established the Adolphe Merkle Foundation with the goal of strengthening research and teaching at the University of Fribourg. His CHF 100 million endowment constitutes one of the most important private donations in Switzerland in favor of academic research. Founded in 2008, AMI is in many aspects unique in the land- scape of Switzerland’s research institutions. Our focus on soft nano- materials is unmatched in Switzerland and beyond. Our research combines fundamental and application-oriented aspects in a multi- disciplinary setting. Through collaborations with industrial partners, AMI aims to stimulate innovation, foster industrial competitiveness and more generally, improve the quality of life. Our researchers are currently organized in four research groups, which offer complementary expertise and interests in strategically important areas: BioNanomaterials, Polymer Chemistry & Materials, Soft Matter Physics, and BioPhysics. Interdisciplinary collaborations between our researchers are the basis for the successful and effi- cient execution of complex research projects that transcend the boundaries of traditional scientific disciplines. This environment and our world-class research facilities make AMI a desirable destination for Master and PhD students, postdocs, and senior researchers. 2 University of Fribourg Adolphe Merkle Institute Table of contents Table of contents 8 12 A message from the Director 5 Pursuing excellence – Successful national center transitions into second phase 8 – Non-tenure track professors earned their stripes at AMI 12 – Alumni are well prepared for industry 14 – NanoLockin strikes early success 15 – Celebrating a decade of achievements 18 – Up and coming 20 Bio-inspired Launch pad Research at AMI Successful national Non-tenure track pro- – New perspectives for more stable perovskite materials 26 – Creating new membranes to separate liquids 28 center transitions fessors earned – A better understanding of lung tissue repair mechanics 30 into second phase their stripes at AMI – Crystal formation holds clues to fi ghting disease 32 – Developing bigger nanopores 34 – Using light to control nanoreactors 36 – In brief 38 – By the numbers 10 / 17 – Finance 46 – Organization 48 – PhDs & Alumni 52 – Impressum 54 3 University of Fribourg Adolphe Merkle Institute Overview Reserach Programs 4 University of Fribourg Adolphe Merkle Institute Foreword Celebrating a decade of success — A message from the director (Technology Transfer). The Institute also said farewell to Many of our research activities are part of the Prof. Nico Bruns, whose Swiss National Science Foun- National Center of Competence in Research (NCCR) dation Professorship came to an end and who was ap- Bio-Inspired Materials, which was launched in 2014 pointed Full Professor at the University of Strathclyde and has its headquarters at AMI. After four very suc- in Scotland. Both Marc and Nico contributed signifi- cessful years, the Swiss National Science Foundation cantly to AMI’s development and achievements during (SNSF) council not only approved the continuation of their tenures and will be missed. the Center in a second funding phase from 2018 to As every year, selected research stories form the 2022, but also increased the funding level in recogni- core of our annual report. Our Soft Matter Physics tion of the Center’s performance. group published a seminal study in Science that fo- With respect to translating our research into tech- cused on increasing the stability of perovskite solar nologies, we are proud to report the formation of AMI’s Professor Christoph Weder cells, which brings these devices closer to becoming first start-up company NanoLockin, which is develop- a profitable, long-term solution for a sustainable en- ing detection systems for nanoparticles in complex In 2018, AMI celebrated its tenth anniversary with a ergy future. The Polymer Chemistry & Materials team media. We also made significant progress on a range series of events and activities that focused on outreach had a breakthrough in creating artificial membranes of technology platforms and filed a record number of to our stakeholders. We opened our doors to the lo- that mimic the structure and function of leaf cuticles patent applications. cal population, invited children for science afternoons, and that exhibit directional transport characteristics. At AMI, we continue to value our partnerships and and organized a reunion weekend for our alumni. We The BioNanomaterials group has developed a method are once again grateful for all the interest, courtesy, also edited a special issue of the journal Small, which I that should lead to a better grasp of how specific na- and support that continue to receive. We hope that the encourage you to review if you are interested in an in- nomaterials affect cell mechanics during tissue repair. report conveys our passion and enthusiasm for our depth overview of the scientific activities of past and The BioPhysics group has been investigating improve- work and that you enjoy the lecture! current AMI researchers. ments to nanopores used to measure the properties The year brought considerable changes to our of large molecules, relying on a method that is both management team. Dr. Marc Pauchard, AMI’s long-time accessible to more scientists and simpler to apply. Deputy Director and Technology Transfer Manager, left One of the final contributions of the Macromolecular the Institute to join the federal Innovation Agency In- Chemistry team led by Prof. Nico Bruns was the devel- nosuisse. His functions at AMI were assumed by Pro- opment of nanoreactors inspired by the mechanism by Christoph Weder fessor Ulli Steiner (Deputy Director), Dr. Mohammed which light receptors operate in the human eye, which AMI Director and Professor for Polymer Chemistry Benghezal (Managing Director), and Dr. Valeria Mozetti could lead to a new system for drug delivery. & Materials 5 University of Fribourg Adolphe Merkle Institute Overview Reserach Programs 6 University of Fribourg Adolphe Merkle Institute Overview Reserach Programs 7 _Pursuing excellence 7 University of Fribourg Adolphe Merkle Institute Pursuing excellence sponse to external stimulation, such as exposure to Bio-inspired chemicals, heat, light, and mechanical force, or inter- actions with biological molecules or cells. They are of Successful national center transitions fundamental scientific interest and potentially useful in — countless applications. While many intriguing stimuli- responsive materials have already been developed, into second phase their design and function appear crude in compari- son to the sophistication, specificity, and functionality displayed by their counterparts found in living organ- isms. To close this gap, scientists began using design principles found in nature as inspiration to investigate artificial materials with stimuli-responsive properties. Recognizing that the innovation potential in this do- main is enormous, and that a large-scale interdiscipli- nary effort is required to achieve paradigm-changing scientific breakthroughs, the NCCR Bio-Inspired Mate- rials was launched in June 2014 with the vision of be- coming an internationally recognized hub for research, education, and innovation in the domain of stimuli- responsive bio-inspired materials. Led by AMI Director Professor Christoph Weder, and comprising all of the Institute’s research groups, the Center completed in 2018 the first and started the second of three expected four-year periods. During the first phase, the Center’s research activities focused on three major areas: mechanically responsive materials, responsive (optical) materials made by self-assembly, Beetles serve as inspiration for AMI research on structural color and interactions of responsive materials with living cells. Inspired by mechanically responsive biological The National Center of Competence in Research domain. The Center also nucleated many initiatives to materials in nature that translate mechanical forc- (NCCR) Bio-Inspired Materials, headquartered at the promote equal opportunities (EO), as well as educa- es into chemical, electrical, or optical signals, NCCR Adolphe Merkle Institute, provided a substantial boost tional and outreach programs. researchers are mimicking such behavior in synthe- to AMI’s activities during its first four-year phase, tic materials. In the quest to discover new mechano- bringing researchers together to launch interdisci- “Intelligent” materials are materials whose properties phores – mechanically responsive motifs that can be plinary research projects in a strategically important change in a selective and predictable manner in re- integrated into polymers, bestowing them with useful 8 University of Fribourg Adolphe Merkle Institute Pursuing excellence functions – the Polymer Chemistry & Materials group of length scales is a concept commonly used by na- main has been slow, which is attributed to many fac- and colleagues showed that the integration of certain ture to design materials with exceptional properties. tors, including robustness of the materials and the lack metal-ligand complexes can confer polymers with In terms of material properties,