University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln U.S. Department of Agriculture: Agricultural Publications from USDA-ARS / UNL Faculty Research Service, Lincoln, Nebraska 7-31-2001 Chemical Compounds that Attract Arthropods- Patent 2001 Ulrich R. Bernier University of Florida, [email protected] Daniel L. Kline USDA Donald Barnard USDA Kenneth Posey USDA Matthew Booth USDA See next page for additional authors Follow this and additional works at: https://digitalcommons.unl.edu/usdaarsfacpub Part of the Agricultural Science Commons Bernier, Ulrich R.; Kline, Daniel L.; Barnard, Donald; Posey, Kenneth; Booth, Matthew; and Yost, Richard A., "Chemical Compounds that Attract Arthropods- Patent 2001" (2001). Publications from USDA-ARS / UNL Faculty. 973. https://digitalcommons.unl.edu/usdaarsfacpub/973 This Article is brought to you for free and open access by the U.S. Department of Agriculture: Agricultural Research Service, Lincoln, Nebraska at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Publications from USDA-ARS / UNL Faculty by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Authors Ulrich R. Bernier, Daniel L. Kline, Donald Barnard, Kenneth Posey, Matthew Booth, and Richard A. Yost This article is available at DigitalCommons@University of Nebraska - Lincoln: https://digitalcommons.unl.edu/ usdaarsfacpub/973 111111 1111111111111111111111111111111111111111111111111111111111111 US006267953Bl (12) United States Patent (10) Patent No.: US 6,267,953 BI Bernier et ai. (45) Date of Patent: Jui. 31, 2001 (54) CHEMICAL COMPOSITION THAT Carlson, D.A., et aI., "Carbon Dioxide Released from ATTRACT ARTHROPODS Human Skin: Effect of Temperature and Insect Repellents", Journal of Medical Entomology, 29 (2), 165-170, (1992). (75) Inventors: Ulrich R. Bernier; Daniel L. Kline; Carlson, D.A., et aI., "Yellowfever Mosquitoes: Compounds Donald R. Barnard; Kenneth H. Related to Lactic Acid that Attract Females", Journal of Posey; Matthew M. Booth; Richard A. Economic Entomology, 66 (2), 329-331, (Apr. 1973). Yost, all of Gainesville, FL (US) Charlwood, J.D., et aI., "Mosquito-Mediated Attraction of (73) Assignee: The United States of America as Female European but not African Mosquitoes to Hosts", represented by the Secretary of Annals of Tropical Medicine and Parasitology, 89 (3), Agriculture, Washington, DC (US) 327-329, (1995). Davis, E.E., "Development of Lactic Acid-Receptor Sensi­ ( *) Notice: Subject to any disclaimer, the term of this tivity and Host-Seeking Behaviour in Newly Emerged patent is extended or adjusted under 35 Female AedesAegypti Mosquitoes" , Journal ofInsect Physi­ U.S.c. 154(b) by 0 days. ology, 30 (3), 211-215, (1984). Davis, E.E., "Structure-Response Relationship of the Lactic (21) Appi. No.: 09/304,362 Acid-Excited Neurones in the Antennal Grooved-Peg Sen­ silla of the Mosquito Aedes Aegypti ", Journal of Insect (22) Filed: May 4,1999 Physiology, 34 (6), Printed in Great Britain, 443-449, (51) Int. CI? .......................... AOlN 25/00; AOlN 31/00; (1988). A01N 35/00; A01N 37/00; A01N 41/12 de Jong, R., et aI., "Olfactory Responses of Host-Seeking (52) U.S. CI. ............................ 424/84; 514/557; 514/675; Anopheles gambiae s.s. Giles (Diptera: Culicidae)", Acta 514/707; 514/724 Tropica, 59, 333-335, (1995). (58) Field of Search ............................. 424/84, 405, 537; De Jong, R., et aI., "Selection of Biting Sites on Man by Two 514/553,557, 675, 579, 693, 694, 699, Malaria Mosquito Species", Experentia 51, 80-84, (1995). 706,707,708,715,722,724,731,739, Eiras, AE., et aI., "Host Location by Aedes aegypti (Diptera: 743, 762, 763, 764 Culicidae): a Wind Tunnel Study of Chemical Cues", Bul­ letin of Entomological Research, 81, 151-160, (1991). (56) References Cited Eiras, A.E., et aI., "Responses of Female Aedes aegypti U.S. PATENT DOCUMENTS (Diptera: Culicidae) to Host Odours and Convection Cur­ rents Using an Olfactometer Bioassay", Bulletin ofEntomo­ 4,166,112 8/1979 Goldberg ............................... 424/93 logical Research, 84, 207-211, (1994). 4,187,200 2/1980 Jenkin .................................. 252/472 4,818,526 4/1989 Wilson et al. ......................... 424/84 Geier, M., et aI., "A search for components in Human Body 4,907,366 3/1990 Balfour ............................... 43/132.1 Odour that Attract Females of Aedes Aegypti", Ciba Foun­ 5,657,756 8/1997 Vrba et al. ........................ 128/653.1 dation Symposium 200 on Olfaction in Mosquito-Host Inter­ 5,679,364 10/1997 Levy .................................... 424/405 actions, 132-148, (1996). OlliER PUBLICATIONS Gilles, M.T., "The Role of Carbon Dioxide in Host-Finding by Mosquitoes (Diptera: Culicidae) a review", Bulletin of Acree Jr., P., et aI., "L-Lactic Acid: A Mosquito Attractant Entomological Research, 70 (1), 525-532, (Mar. 1980). Isolated from Humans", Science, 161, 1346-1347, (Sep. 27, Guock, H.K., et aI., "Responses of Mosquitoes and Stable 1968). Flies to a Man in a Light-Weight Rubber Diving Suit", Bar-Zeev, M., et aI., "Studies on the Attraction of Aedes Journal of Economic Entomology, 55 (3), 386-392, (1962). Aegypti (Diptera: Culicidae) to Man", Journal of Medical Ikeshoji, T., "Synergistic Effect of Lactic Acid with a Entomology, 14 (1), 113-120, (Aug. 20, 1977). Chemosterilant Metepa to the Sound-Attracted Male Mos­ Bernier, U.R., "Mass Spectrometric Investigation of Mos­ quito", Jpn. J. Sanit. Zool., 38 (4), 333-338, (1987). quito Attraction to Human Skin Emanations", Ph.D. Thesis presented at the University of Florida, Published by UMI (List continued on next page.) Dissertation Services, Ann Arbor, MI, 1-333 p., (1995). Bernier, U.R., et aI., "Analysis of Human Skin Emanations Primary Examiner-Jose' G. Dees by Gas Chromatography/Mass Spectrometry, 1. Thermal Assistant Examiner-Frank Choi Desorption of Attractants for the Yellow Fever Mosquito (74) Attorney, Agent, or Firm-M. Howard Silverstein; (Aedes aegypti) from Handled Glass Beads", Analytical John D. Fado; Gail E. Poulos Chemistry, 71 (1), Accelerated Articles, 1-7 p., (Jan. 1, 1999). (57) ABSTRACT Bowen, M.P., et aI., "Lactic Acid Sensitive Receptors in the Autogenous Mosquito Aedes atropalpus ", Journal of Insect Compositions and methods employing the compositions for Physiology, 40 (7), 611-615, (1994). attracting arthropods. The compositions comprise at least Braks, M.A., et aI., "Incubated Human Sweat But Not Fresh one compound of formula I and at least one compound from Sweat Attracts the Malaria Mosquito Anopheles gambiae group II. Sensu Stricto", Journal of Chemical Ecology, 25 (3), 663-672, (1999). 2 Claims, No Drawings US 6,267,953 BI Page 2 OlliER PUBLICATIONS Takken, W., et aI., "Odor-Mediated Flight Behavior of Anopheles gambiae Giles Sensu Stricto and An. stephensi Kline, D.L., "Olfactory Responses and Field Attraction of Liston in Response to Carbon Dioxide, Acetone, and Mosquitoes to Volatiles from Limburger Cheese and Human 1-Octen-3-01 (Diptera: Culicidae)", Journal of Insect Foot Odor", Journal of Vector Ecology, 23 (2), 186-194, Behavior, 10 (3), 395-407, (May 1997). (Dec. 1998). Kline, D.L., et aI., "Field Studies on the Potential of Vale, G.A., et aI., "The Use of l--{)cten-3--{)1, Acetone, and Butanone, Carbon Dioxide, Honey Extract, 1-octen-3-01, Carbon Dioxide to Improve Baits fot Tsetse Flies, Glossina L-Lactic Acid and Phenols as Attractants for Mosquitoes", spp. (Diptera: Glossinidae)", Bull. ent. Res., 75, 219-231, Medical and Veterinary Entomology, 4, 383-391, (1990). (1985). Knols, B.G., et aI., "Behavioural and Electrophysiological Van Essen, P.H., et aI., "Differential Responses of Aedes and Responses of the Female Malaria Mosquito Anopheles gam­ Culex Mosquitoes to Octenol or Light in Combination with biae (Diptera: Culicidae) to Limburger Cheese Volatiles", Carbon Dioxide in Queensland, Australia", Medical and Bulletin of Entomological Research, 87, 151-159, (1997). Veterinary Entomology, 63-67, (1993). Knols, B.G., et aI., "Limburger Cheese as an Atrractant for Wensler, R.J., "The Effect of Odors on the Behavior of Adult the Malaria Mosquito Anopheles gambiae s.s.", Parasitol­ Aedes aegypti and Some Factors Limiting Responsiveness", ogy Today, 12 (4),159-161, (1996). Can. J. Zool., 50, 415-420, (1972). Mboera, L.E., et aI., "Olfactory Responses of Female Culex Willis, E.R., et aI., "Reactions of Aedes Aegypti (L.) to quinquefasciatus Say (Diptera: Culicidae) in a Dual-Choice carbon Dioxide", J. Exp. Zool., 121, 149-179, (1952). Olfactometer" , Journal of Vector Ecology, 23 (2), 107-113, Saini et al.,' A behavioural bioassay to identify attractive (Dec. 1998). odours for Glossinidae' (Medical and Veterinary Entomol­ McCall, P.J., et aI., "Attraction and Trapping of Aedes ogy, (1987), vol. 1, No.3, pp. 313-318), STN/CAS online, aegypti (Diptera: Culicidae) with Host Odors in the Labo­ file MEDLINE, Abstract.* ratory", Journal of Medical Entomology, 33 (1), 177-179 (1996). Mihok et aI., 'Trials of traps and attractants for Stomoxys Posey, K.H., et aI., "Triple Cage Olfactometer for Evaluating spp. (Diptera: Muscidae' (Journal of Medical Entomology, Mosquito (Diptera: Culicidae) Attraction Responses", J our­ (1995) vol. 32, No.3, pp. 283-289), STN/CAS online, file nal of Medical Entomology, 35 (3), 330-334, (1998). BIOSIS, Abstract. * Price, G.D., et aI., "The Attraction of Female Mosquitoes Voskamp et al.,'Olfactory responses to attractants and repel­ (Anopheles quadrimaculatus SAY) to