SCCA_liver SCCA_liver component correlation 14 0.926 5 0.888 1 0.881 19 0.8 2 0.757 3 0.738 8 0.694 18 0.692 11 0.67 16 0.66 10 0.62 6 0.597 4 0.569 9 0.567 7 0.52 17 0.513 20 0.513 12 0.466 15 0.452 13 0.372 Component 14 weight pathology weight Cyp2j3- 0.408 Anisonucleosis 0.5 LOC100911177+ 0.408 Anisonucleosis 0.5 LOC100912996+ 0.408 Anisonucleosis 0.5 Pgcp- 0.408 Anisonucleosis 0.5 Rsad2+ 0.408 Anisonucleosis 0.5 Tspan8+ 0.408 Anisonucleosis 0.5 5 Slco2b1- 0.983 Alteration 0.5 Slc27a5- 0.186 Alteration 0.5 1 Tp53inp1+ 0.998 Anisonucleosis 0.5 Cyp2j3- 0.028 Anisonucleosis 0.5 LOC100911177+ 0.028 Anisonucleosis 0.5 LOC100912996+ 0.028 Anisonucleosis 0.5 Pgcp- 0.028 Anisonucleosis 0.5 Rsad2+ 0.028 Anisonucleosis 0.5 Tspan8+ 0.028 Anisonucleosis 0.5 19 Cgref1+ 0.447 Anisonucleosis 0.5 Gas5+ 0.447 Anisonucleosis 0.5 Id1+ 0.447 Anisonucleosis 0.5 Page 1 SCCA_liver Smox+ 0.447 Anisonucleosis 0.5 Unc5b+ 0.447 Anisonucleosis 0.5 2 Il7+ 0.996 Inflammation 0.5 Ccl21+ 0.045 Inflammation 0.5 Stat3+ 0.045 Inflammation 0.5 Dsc2+ 0.041 Inflammation 0.5 Slc13a5+ 0.041 Inflammation 0.5 3 Tubb2c+ 0.985 Change, acidophilic 0.5 B4galt5+ 0.174 Change, acidophilic 0.5 Rnd1+ 0.009 Change, acidophilic 0.5 8 Stat3+ 0.707 Inflammation 0.5 Ccl21+ 0.707 Inflammation 0.5 18 Pcolce+ 0.707 Hematopoiesis 0.5 Alox15+ 0.707 Hematopoiesis 0.5 11 Neurl3+ 0.983 Proliferation 0.5 Id1+ 0.186 Proliferation 0.5 16 Ltb+ 0.577 Inflammation 0.5 Gpt+ 0.577 Inflammation 0.5 Dcn+ 0.577 Inflammation 0.5 10 Raph1+ 0.408 Cellular foci 0.5 Ppic+ 0.408 Cellular foci 0.5 Phlda3+ 0.408 Cellular foci 0.5 Dynlt1+ 0.408 Cellular foci 0.5 Cd14- 0.408 Cellular foci 0.5 Ccdc68+ 0.408 Cellular foci 0.5 high score compounds for the associated genes Component 14 score ethambutol 12.249 methapyrilene 12.249 nitrosodiethylamine 12.249 acetamidofluorene 3.759 ethionamide 3.759 thioacetamide 3.759 carbon_tetrachloride 1.636 diclofenac 1.636 ethionine 1.636 isoniazid 1.636 Page 2 SCCA_liver naphthyl_isothiocyanate 1.636 puromycin_aminonucleoside 1.636 5 ethambutol 6.444 methapyrilene 6.444 thioacetamide 6.444 ethionine 6.444 WY-14643 0.755 1 ethambutol 6.453 methapyrilene 6.453 nitrosodiethylamine 6.453 ethionamide 5.861 thioacetamide 0.086 acetamidofluorene 0.086 ethionine -0.062 carbon_tetrachloride -0.062 diclofenac -0.062 isoniazid -0.062 naphthyl_isothiocyanate -0.062 puromycin_aminonucleoside -0.062 19 ethambutol 10.167 methapyrilene 10.167 nitrosodiethylamine 10.167 ethionamide 8.036 thioacetamide 5.905 colchicine 5.905 acetamidofluorene 3.774 ethinylestradiol 1.643 etoposide 1.643 fenofibrate 1.643 2 Inflammation meloxicam 5.83 antiinflammation indomethacin 5.571 antiinflammation lornoxicam 5.571 antiinflammation allopurinol 4.947 antiinflammation mefenamic_acid 4.947 antiinflammation naproxen 0.65 antiinflammation diclofenac 0.392 antiinflammation naphthyl_isothiocyanate 0.133 sulindac 0.133 antiinflammation methapyrilene 0.025 3 naphthyl_isothiocyanate 6.294 Page 3 SCCA_liver colchicine 0.593 lomustine 0.593 ethionamide -0.178 puromycin_aminonucleoside -0.178 8 meloxicam 7.938 naproxen 7.938 methapyrilene 3.844 indomethacin 3.844 lornoxicam 3.844 diclofenac 3.844 18 meloxicam 5.187 naproxen 5.187 monocrotaline 5.187 mefenamic_acid 5.187 ibuprofen 5.187 lornoxicam 2.402 colchicine 2.402 allopurinol 2.402 sulindac 2.402 imipramine 2.402 iproniazid 2.402 phenacetin 2.402 vitamin_A 2.402 11 methapyrilene 3.927 nitrosodiethylamine 3.927 thioacetamide 3.927 ethambutol 3.927 acetamidofluorene 3.927 monocrotaline 3.042 colchicine 3.042 indomethacin 3.042 naphthyl_isothiocyanate 3.042 lomustine 3.042 ethionamide 3.042 puromycin_aminonucleoside 3.042 ethinylestradiol 0.533 16 methapyrilene 6.766 meloxicam 6.766 naproxen 6.766 lornoxicam 6.766 indomethacin 4.364 Page 4 SCCA_liver sulindac 4.364 nitrosodiethylamine 1.962 acetamidofluorene 1.962 monocrotaline 1.962 puromycin_aminonucleoside 1.962 mefenamic_acid 1.962 ibuprofen 1.962 diclofenac 1.962 chlorpromazine 1.962 10 nitrosodiethylamine 13.749 acetamidofluorene 13.749 thioacetamide 13.749 methapyrilene 11.386 WY-14643 1.931 high score compounds for the associated pathological records Component 14 ethambutol 13.014 methapyrilene 13.014 nitrosodiethylamine 13.014 5 ethambutol 10.002 methapyrilene 10.002 ethionine 10.002 simvastatin 10.002 thioacetamide 10.002 1 ethambutol 13.014 methapyrilene 13.014 nitrosodiethylamine 13.014 19 ethambutol 13.014 methapyrilene 13.014 nitrosodiethylamine 13.014 2 cimetidine 9.094 indomethacin 9.094 lornoxicam 9.094 mefenamic_acid 9.094 meloxicam 9.094 naproxen 9.094 3 nitrosodiethylamine 11.226 cyclosporine_A 11.226 Page 5 SCCA_liver monocrotaline 11.226 naphthyl_isothiocyanate 11.226 8 cimetidine 9.094 indomethacin 9.094 lornoxicam 9.094 mefenamic_acid 9.094 meloxicam 9.094 naproxen 9.094 18 lornoxicam 6.93 mefenamic_acid 6.93 meloxicam 6.93 naproxen 6.93 bendazac 6.93 cyclophosphamide 6.93 ibuprofen 6.93 iproniazid 6.93 phenacetin 6.93 sulindac 6.93 11 nitrosodiethylamine 5.541 naphthyl_isothiocyanate 5.541 ethambutol 5.541 methapyrilene 5.541 thioacetamide 5.541 acetamidofluorene 5.541 allyl_alcohol 5.541 imipramine 5.541 lomustine 5.541 puromycin_aminonucleoside 5.541 theophylline 5.541 16 lornoxicam 9.094 mefenamic_acid 9.094 meloxicam 9.094 naproxen 9.094 cimetidine 9.094 indomethacin 9.094 10 nitrosodiethylamine 9.094 thioacetamide 9.094 acetamidofluorene 9.094 gemfibrozil 9.094 captopril 9.094 Page 6 SCCA_liver chlormezanone 9.094 Page 7.