Wine and Vine Components and Health Edited by Norbert Latruffe and Jean-Pierre Rifler Printed Edition of the Special Issue Published in Diseases www.mdpi.com/journal/diseases Wine and Vine Components and Health Wine and Vine Components and Health Special Issue Editors Norbert Latruffe Jean-Pierre Rifler MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editors Norbert Latruffe Jean-Pierre Rifler Universite´ de Bourgogne Haute Coteˆ d’Or hospital center France France Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Diseases (ISSN 2079-9721) from 2018 to 2019 (available at: https://www.mdpi.com/journal/diseases/special issues/wine vine health) For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03921-138-8 (Pbk) ISBN 978-3-03921-139-5 (PDF) Cover image courtesy of Norbert Latruffe and Jean-Pierre Rifler. c 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Special Issue Editors ..................................... vii Preface to ”Wine and Vine Components and Health” ......................... ix Norbert Latruffe and Jean-Pierre Rifler Special Issue: Wine and Vine Components and Health Reprinted from: Diseases 2019, , 30, doi:10.3390/diseases7010030 ................... 1 Pincemail Jo¨el,Kaci Mouna-Messaouda, Kevers Claire, Tabart Jessica, Ebabe Elle Raymond and Meziane Smail PAOT-Liquid R Technology: An Easy Electrochemical Method for Evaluating Antioxidant Capacity of Wines Reprinted from: Diseases 2019, 7, 10, doi:10.3390/diseases7010010 .................. 4 Anna Boronat, Miriam Mart´ınez-Hu´elamo,Ariadna Cobos and Rafael de la Torre Wine and Olive Oil Phenolic Compounds Interaction in Humans Reprinted from: Diseases 2018, 6, 76, doi:10.3390/diseases6030076 .................. 14 Amira Namsi, Thomas Nury, Haithem Hamdouni, Aline Yammine, Anne Vejux, Dominique Vervandier-Fasseur, Norbert Latruffe, Olfa Masmoudi-Kouki and G´erard Lizard Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin Reprinted from: Diseases 2018, 6, 67, doi:10.3390/diseases6030067 .................. 27 Zuri ˜neRasines-Perea, Isabelle Ky, G´erardCros, Alan Crozier and Pierre-Louis Teissedre Grape Pomace: Antioxidant Activity, Potential Effect Against Hypertension and Metabolites Characterization after Intake Reprinted from: Diseases 2018, 6, 60, doi:10.3390/diseases6030060 .................. 47 Toshio Tanaka, Atsuhiko Iuchi, Hiroshi Harada and Shoji Hashimoto Potential Beneficial Effects of Wine Flavonoids on Allergic Diseases Reprinted from: Diseases 2019, 7, 8, doi:10.3390/diseases7010008 ................... 62 Norbert Latruffe and Dominique Vervandier-Fasseur Strategic Syntheses of Vine and Wine Resveratrol Derivatives to Explore Their Effects on Cell Functions and Dysfunctions Reprinted from: Diseases 2018, 6, 110, doi:10.3390/diseases6040110 ................. 73 Souheila Amor, Pauline Chˆalons,Virginie Aires and Dominique Delmas Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers Reprinted from: Diseases 2018, 6, 106, doi:10.3390/diseases6040106 ................. 88 Jean-Pierre Rifler Is a Meal without Wine Good for Health? Reprinted from: Diseases 2018, 6, 105, doi:10.3390/diseases6040105 .................100 Eleni Pavlidou, Maria Mantzorou, Aristeidis Fasoulas, Christina Tryfonos, Dimitris Petridis and Constantinos Giaginis Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases Reprinted from: Diseases 2018, 6, 73, doi:10.3390/diseases6030073 ..................121 v About the Special Issue Editors Norbert Latruff (http://bioperoxil.u-bourgogne.fr/) obtained his Ph.D. in 1977, and in 1989, was appointed full Professor in Biochemistry at the University of Burgundy-Dijon, France, where he was head of the Laboratory of Molecular and Cellular Biology until 2006. Following that, he was in charge of the team of Biochemistry of Metabolism and Nutrition in the INSERM research center, UMR 866 of Dijon until the end of 2011. Since 2013, Latruffe has been senior Professor at the Laboratory of Biochemistry at the Faculty of Life Science. In 1998, he has been addressing new challenges regarding the preventative role of vine polyphenols, especially resveratrol, against age-related pathologies such as cancer and inflammatory cardiovascular disease. He was one of the first to explore resveratrol transport and metabolism (2004) and its pro-apoptotic properties (2004), and discovered a new resveratrol signaling pathway through microRNA modulation (2010). In 2014, he demonstrated the preventive effect of wine polyphenols towards colon cancer in mice models. Latruffe has organized several and workshops on wine and health. Latruffe has recently served as Editor and Co-editor of two Special Issues of Molecules: Natural Products and Inflammation (2016) and Improvement of Resveratrol Efficacy (2017). To date, Latruffe has published nearly 170 international papers and presented over 140 invited lectures. In 2017, he managed the a book deal on an edition covering wine and the Mediterranean diet (EUD editor, Dijon). Latruffe is an expert or past expert of several evaluation councils, and is a member of the orientation council of the prestigious UNESCO Chair “heritage and traditions of wine”. He has also been awarded several distinctions. Jean-Pierre Rifler is emergency physician at the Haute Coteˆ d’Or hospital center, F-21350, France (https://etablissements.fhf.fr/annuaire/hopital-fiche.php?id struct=473) and is passionate about wine. After his obtained a diploma of Oenolog technician in 1988, he prepared his medical doctoral thesis in 1994 on wine and health, especially on the cardiovascular protection of red wine polyphenols. Since this date and in parallel to his professional activities, he has collaborated with scientists in Burgundy with the aim of promoting knowledge regarding the beneficial effects of a regular and moderate consumption of wine. He has managed the theses of medical doctors and set up clinical protocols to validate secondary prevention for post-infarcted patients by wine in 2012. This important work has been published in collaboration with Prof. Norbert Latruffe, co-Guest Editor of this Special Issue “A Moderate Red Wine Intake Improves Blood Lipid Parameters and Erythrocyte Membrane Fluidity in Post-myocardial Infarct Patients” by Rifler JP., et al., Molecular Nutrition and Food Research 2011. vol. 55 pp. 1–7. Dr. Jean-Pierre Rifler has also published numerous specialized papers and is periodically invited in congresses and organizations such as in WAC (Wine Active Compounds), Beaune 2011; or 5e` ICPH (International Conference on Polyphenols and Health), Sitges (Barcelona), 2011. He is co-founder of the Mediterranean Nutrition and Health Association which organized a colloquium in Hyeres` (Provence) in 2016 on Wine, Mediterranean Nutrition, and Health. Dr. Jean-Pierre Rifler is also well known for having initiated the French program on heart defibrillators in public spaces to save lives. vii Preface to ”Wine and Vine Components and Health” In terms of biochemical mechanisms, vine, like other plants, produces numerous non-energy compounds called secondary metabolites (e.g., flavonoids, polyphenols), in order to adapt their defenses against often unfavorable environments (biotic and non-biotic stresses). Interestingly, in humans and in the animals kingdom, these microconstituents provide similar valuable bioactive properties for essential cell and physiological functions (signaling, gene regulation, prevention of acquired or infectious disease, etc.). These compounds have been selected through evolution and are generally preserved in all living organisms. For instance, resveratrol, that plays an essential role in vine plants as an elicitor of natural defenses, has been shown to be a protector of health in humans. It can delay, or even block, the appearance of predominant diseases, such as atherosclerosis, by protecting low-density lipoproteins from the oxidation, in addition to positive effects on diabetes and cancer. Grape, both fresh or dried, is a widely consumed fruit by large human populations, as are its byproducts, including grape juice and wine and even extracts of vine leaves and shoots. Grape products contain vast and highly varied quantities of polyphenols as a protective micronutrient. Wine provides unique polyphenols, for instance, resveratrol, procyanidins, and monophenols such as hydroxytyrosol and tyrosol. Research supports the idea that wine—a natural biological product—if consumed regularly and not in excess, can act preventively. In addition to eliciting its more well-known activities against vascular diseases (illustrated by the so-called French paradox), the moderation consumption of wine may also prevent infections, decrease inflammation, and delay neurodegenerative