Cochrane Library Cochrane Database of Systematic Reviews Central venous access sites for the prevention of venous thrombosis, stenosis and infection (Review) Ge X, Cavallazzi R, Li C, Pan SM, Wang YW, Wang FL Ge X, Cavallazzi R, Li C, Pan SM, Wang YW, Wang FL. Central venous access sites for the prevention of venous thrombosis, stenosis and infection. Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD004084. DOI: 10.1002/14651858.CD004084.pub3. www.cochranelibrary.com Central venous access sites for the prevention of venous thrombosis, stenosis and infection (Review) Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Cochrane Trusted evidence. Informed decisions. Library Better health. Cochrane Database of Systematic Reviews T A B L E O F C O N T E N T S HEADER......................................................................................................................................................................................................... 1 ABSTRACT..................................................................................................................................................................................................... 1 PLAIN LANGUAGE SUMMARY....................................................................................................................................................................... 2 SUMMARY OF FINDINGS.............................................................................................................................................................................. 3 BACKGROUND.............................................................................................................................................................................................. 10 OBJECTIVES.................................................................................................................................................................................................. 10 METHODS..................................................................................................................................................................................................... 11 RESULTS........................................................................................................................................................................................................ 13 Figure 1.................................................................................................................................................................................................. 14 Figure 2.................................................................................................................................................................................................. 16 Figure 3.................................................................................................................................................................................................. 17 DISCUSSION.................................................................................................................................................................................................. 19 AUTHORS' CONCLUSIONS........................................................................................................................................................................... 21 ACKNOWLEDGEMENTS................................................................................................................................................................................ 21 REFERENCES................................................................................................................................................................................................ 22 CHARACTERISTICS OF STUDIES.................................................................................................................................................................. 25 DATA AND ANALYSES.................................................................................................................................................................................... 31 Analysis 1.1. Comparison 1 Internal jugular versus subclavian CVA routes: long-term catheterization, Outcome 1 Catheter 32 related infectious complications.......................................................................................................................................................... Analysis 1.2. Comparison 1 Internal jugular versus subclavian CVA routes: long-term catheterization, Outcome 2 Catheter 32 related thrombotic complications....................................................................................................................................................... Analysis 1.3. Comparison 1 Internal jugular versus subclavian CVA routes: long-term catheterization, Outcome 3 Immediate 33 mechanical complications.................................................................................................................................................................... Analysis 1.4. Comparison 1 Internal jugular versus subclavian CVA routes: long-term catheterization, Outcome 4 Late 33 mechanical complications.................................................................................................................................................................... Analysis 1.5. Comparison 1 Internal jugular versus subclavian CVA routes: long-term catheterization, Outcome 5 Leaving the 34 studies early........................................................................................................................................................................................... ADDITIONAL TABLES.................................................................................................................................................................................... 34 APPENDICES................................................................................................................................................................................................. 36 WHAT'S NEW................................................................................................................................................................................................. 39 HISTORY........................................................................................................................................................................................................ 39 CONTRIBUTIONS OF AUTHORS................................................................................................................................................................... 40 DECLARATIONS OF INTEREST..................................................................................................................................................................... 40 SOURCES OF SUPPORT............................................................................................................................................................................... 40 DIFFERENCES BETWEEN PROTOCOL AND REVIEW.................................................................................................................................... 41 INDEX TERMS............................................................................................................................................................................................... 41 Central venous access sites for the prevention of venous thrombosis, stenosis and infection (Review) i Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Cochrane Trusted evidence. Informed decisions. Library Better health. Cochrane Database of Systematic Reviews [Intervention Review] Central venous access sites for the prevention of venous thrombosis, stenosis and infection Xiaoli Ge1, Rodrigo Cavallazzi2, Chunbo Li3, Shu Ming Pan1, Ying-Wei Wang4, Fei-Long Wang1 1Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Louisville, Louisville, KY, USA. 3Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4Department of Anaesthesiology, Huashan Hospital, Fudan University, Shanghai, China Contact address: Shu Ming Pan, Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. [email protected]. Editorial group: Cochrane Emergency and Critical Care Group Publication status and date: Edited (no change to conclusions), published in Issue 12, 2018. Citation: Ge X, Cavallazzi R, Li C, Pan SM, Wang YW, Wang FL. Central venous access sites for the prevention of venous thrombosis, stenosis and infection. Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD004084. DOI: 10.1002/14651858.CD004084.pub3. Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. A B S T R A C T Background Central venous access (CVA) is widely used. However, its thrombotic, stenotic and infectious complications can be life-threatening and involve high-cost therapy. Research revealed that the risk of catheter-related complications varied according to the site of CVA. It would be helpful to find the