(12) United States Patent (10) Patent No.: US 9.241,773 B2 Bolan Et Al

(12) United States Patent (10) Patent No.: US 9.241,773 B2 Bolan Et Al

US009241773B2 (12) United States Patent (10) Patent No.: US 9.241,773 B2 Bolan et al. (45) Date of Patent: *Jan. 26, 2016 (54) MAGING FIDUCALMARKERS AND A61B 2019/547; A61B 2019/5408: A61B METHODS 2019/5425; A61B 2019/5454: A61B 2019/5495; A61B 2019/5458: A61B (71) Applicant: Breast-Med, Inc., Golden Valley, MN 2019/5466; G01R 33/4814; G01 R33/5601; (US) A61M31/005; A61K 49/0002: A61 K (72) Inventors: Patrick Bolan, Minneapolis, MN (US); 49/0447; A61K 49/18: A61K 49/226; Y1OT Michael G. Garwood, Medina, MN 29/4998; Y10T 29/49982; Y10T 29/49888 (US); Michael T. Nelson, Golden Valley, See application file for complete search history. MN (US); Daniel A. Halpern, St. Louis Park, MN (US) (56) References Cited (73) Assignee: Breast-Med, Inc., Golden Valley, MN U.S. PATENT DOCUMENTS (US) (*) Notice: Subject to any disclaimer, the term of this 2,678,195 A * 5/1954 Hunter et al. ..................... 74/87 patent is extended or adjusted under 35 5,016,639 A 5, 1991 Allen U.S.C. 154(b) by 0 days. (Continued) This patent is Subject to a terminal dis FOREIGN PATENT DOCUMENTS claimer. CA 2579914 A1 11/2006 (21) Appl. No.: 14/634,965 EP 1491147 A1 12/2004 (22) Filed: Mar. 2, 2015 (Continued) (65) Prior Publication Data OTHER PUBLICATIONS US 2015/O1 73848A1 Jun. 25, 2015 “U.S. Appl. No. 1 1/281,801. Examiner Interview Summary mailed Related U.S. Application Data Sep. 2, 2009, 4pgs. (63) Continuation of application No. 14/022.539, filed on (Continued) Sep. 10, 2013, now Pat. No. 8,966,735, which is a continuation of application No. 12/762,837, filed on Primary Examiner — Christopher M Koehler Apr. 19, 2010, now Pat. No. 8,544,162, which is a (74) Attorney, Agent, or Firm — Schwegman Lundberg & continuation-in-part of application No. 1 1/281,801, Woessner, P.A. filed on Nov. 17, 2005, now Pat. No. 7,702,378. (51) Int. C. (57) ABSTRACT A6B 9/00 (2006.01) An implantable tissue marker incorporates a contrast agent A6 IK 49/00 (2006.01) sealed within a chamber in a container formed from a solid (Continued) material. The contrast agent is selected to produce a change, (52) U.S. C. Such as an increase, in signal intensity under magnetic reso CPC ................. A61B 19/54 (2013.01); A61B 8/481 nance imaging (MRI). An additional contrast agent may also (2013.01); A61B 17/3468 (2013.01); be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (Continued) (CT) imaging or ultrasound imaging. (58) Field of Classification Search CPC ... A61B 8/481; A61 B 17/3468; A61B 19/54; 37 Claims, 6 Drawing Sheets v A. 6 A. US 9.241,773 B2 Page 2 (51) Int. Cl. 6,761,679 B2 7/2004 Sajo et al. A6 IK 49/04 (2006.01) 6,773,408 B1 8, 2004 Acker et al. 6,778,850 B1 8/2004 Adler et al. A6 IK 49/8 (2006.01) 6,862,470 B2 3/2005 Burbank et al. A6 IB 8/08 (2006.01) 6,927.406 B2 8/2005 Zyromski A6 IB 7/34 (2006.01) SS E3 2.58: RE:urbank et al. A6 IK 49/22 (2006.01) 7,010,340 B2 3/2006 Scarantino et al. A6M 3L/00 (2006.01) 7,044,957 B2 5/2006 Foerster et al. GOIR 33/48 (2006.01) 7,047,063 B2 5, 2006 Burbank et al. GOIR 33/56 (2006.01) 76.53.s sy 358 SARE".ag. Cal. ............ 600.414 HOIF 41/02 (2006.01) 7,702.378 B2 * 4/2010 Bolan et al. ................... 600,414 (52) U.S. Cl. 7,792,568 B2 * 9/2010 Zhong et al. .................. 600,431 CPC ........ A61K 49/0002 (2013.01); A61K 49/0447 2: 3: 833, Nissal 69; (2013.01); A61K 49/18 (2013.01); A61 K 88: 5. '58 E. N. O. 29,460 49/223 (2013.01); A61M31/002 (2013.01); 2002/0035324 A1 3/2002 Sirimanne et al. ............ 600,431 A61M31/005 (2013.01); G0IR 33/4812 2002, 0083591 A1 7/2002 GeertSma et al. (2013.01); G0IR 33/4814 (2013.01); G0IR 29:29:395). A 2992 Stegmaier et al. ... 128,899 33/5601 (2013.01); A61B 2019/547 (2013.01); 38885 A. 858 Satyal. 600/407 A61B 2019/5408 (2013.01); A61B 2019/5425 2002/0188196 A1 12/2002 Burbank et al. (2013.01); A61B 2019/5454 (2013.01); A61B 2004/003O262 A1* 2, 2004 Fisher et al. 600/S64 2019/5458 (2013.01); A61B 2019/5466 2004/0176684 A1* 9, 2004 Tabuchi et al. ... 600,424 (2013.01); A61B 2019/5495 (2013.01); HOIF 338E. A. 239: fA, (ao 600,431 41/02 (2013.01); HOIF 41/0253 (2013.01); 200402363.11. A 11/2004 Burbanket al. Y10T 29/49075 (2015.01); Y10T 29/4998 2004/0236212 A1 11/2004 Jones et al. (2015.01); Y10T 29/49888 (2015.01); Y10T 2004/0236213 A1 11/2004 Jones et al. 29/49982 (2015.01) 2005, 000445.6 A1 1/2005 Thomas et al. 2005/002091.6 A1 1/2005 MacFarlane et al. 2005, OO33157 A1 2/2005 Klein et al. 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