National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES Problems of Drug Dependence, 1993: Proceedings of the 55th Annual Scientific Meeting The College on Problems of Drug Dependence, Inc. Volume II 141 U.S. Department of Health and Human Services • Public Health Service • NATIONAL INSTITUTES OF HEALTH Problems of Drug Dependence, 1993: Proceedings of the 55th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. Volume II: Abstracts Editor: Louis-S. Harris, Ph.D. NIDA Research Monograph 141 1994 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGMENT The Committee on Problems of Drug Dependence, Inc., an independent, nonprofit organization, conducts drug testing and evaluations for academic institutions, government, and industry. This monograph is based on papers or presentations from the 55th Annual Scientific Meeting of the CPDD, held in Toronto, Canada, in June 1993. In the interest of rapid dissemination, it is published by the National Institute on Drug Abuse in its Research Monograph series as reviewed and submitted by the CPDD. Dr. Louis S. Harris, editor of this monograph, is Chairman of the Department of Pharmacology, Medical College of Virginia. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission form the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the Department of Health and Human Services. The U.S. Government does not endorse or favor any specific commercial product or company. Trade, proprietary, or company names appearing in this publication are used only because they are considered essential in the context of the studies reported herein. NIH Publication No. 94-3749 Printed 1994 NIDA Research Monographs are indexed in the Index Medicus. They are selectively included in the coverage of American Statistics Index, Biosciences Information Service, Chemical Abstracts, Current Contents, Psychological Abstracts, and Psychopharmacology Abstracts. ii CPDD BOARD OF DIRECTORS Thomas J. Crowley, M.D., President Jack Henningfield, Ph.D. George E. Bigelow, Ph.D., President-Elect Stephen G. Holtzman, Ph.D. Keith F. Killam, Jr., Ph.D., Past-President Chris-Ellyn Johanson, Ph.D. Joseph V. Brady, Ph.D., Treasurer Thomas R. Kosten, M.D. Robert L. Balster, Ph.D. Mary Jeanne Kreek, M.D. Edgar H. Brenner, JD David F. Musto, M.D. Lawrence S. Brown, Jr.. M.D., MPH Charles P. O’Brien, M.D., Ph.D. Leonard Cook, Ph.D. Craig Reinarman, Ph.D. Linda A. Dykstra, Ph.D. Edward Sellers, M.D., Ph.D. Arthur Falek, Ph.D. James H. Woods, Ph.D. Charles Gorodetzky, M.D., Ph.D. George Woody, M.D. Roland R. Griffiths, Ph.D. EXECUTIVE OFFICER Martin W. Adler, Ph.D. PROGRAM COMMITTEE Mary Jeanne Kreek, M.D., Chairman Martin Adler, Ph.D. Thomas J. Crowley, M.D. William L. Dewey, Ph.D. Loretta P. Finnegan, M.D. Ellen Geller, M.A. Jack Henningfield, Ph.D. Kenner C. Rice, Ph.D. Eric J. Simon, Ph.D. George Woody, M.D. iii The following organizations have generously supported the work of the College on Problems of Drug Dependence during the past year: American Cyanamide (Lederle Laboratories) Anaquest - Boc Group Astra Pharmaceuticals, Inc. Boehringer Ingelheim Pharmaceuticals, Inc. Burroughs Wellcome Company Ciba-Geigy Corporation Hoffman-LaRoche, Inc. ICI Americas, Inc. Janssen Pharmaceuticals, Inc. Marion Merrill Dow, Inc. McNeil (NORAMCO) Merck, Sharp & Dohme National Institute on Drug Abuse Neurobiological Technologies Pfizer, Inc. Research Biochemicals Sandoz, Ltd. (Basle) Schering-Plough, Inc. Sterling Drug, Inc. The Upjohn Company Warner-Lambert Company Wyeth-Ayerst Laboratories iv TABLE OF CONTENTS Oral Communications I Psychological and Social Treatments Dual Recoveries from Smoking and Alcohol Problems Among Naturally Recovered Alcohol Abusers M. B. Sobell and L. C. Sobell 1 Conditioning Factors and Cue Exposure Treatment in Drug Dependence: The Role of Emergent Equivalence Relations R. J. DeGrandpre, W. K. Bickel, A. J. Mortensen and S. T. Higgins 2 Enhanced Continuity of Care and Desipramine in Crack Cocaine Abusers S. M. Hall, S. Tunis, P. Banys, D. Tusel, H. W. Clark, D. Presti and P. Stewart 3 Retention of Cocaine Abusing Women in Residential Treatment P. H. Hughes, S. D. Coletti, R. L. Neri, C. F. Urmann. D. M. Sicilian, S. S. Stahl and J. C. Anthony 4 Incentives Improve Treatment Retention, Cocaine Abstinence and Psychiatric Symptomatology in Ambulatory Cocaine-Dependent Patients S. T. Higgins, A. J. Budney, W. K. Bickel. F. E. Foerg. R. Donham and G. J. Badger 5 Contingency Contracting in Methadone Maintenance D. A. Calsyn, E. A. Wells, A. J. Saxon, A. F. Wrede, R. Jackson and V. Stanton 6 The Effectiveness of Cognitive-Behavioral Treatment for Cocaine-Using Methadone Patients A. Rosenblum, S. Magura, M. Lovejoy. J. Foote, L. Handelsman and B. Stimmel 7 Contingent Reinforcement of Group Participation vs. Drug Free Urines in a Methadone Maintenance Program M. Y. Iguchi. R. J. Lamb and J. J. Platt 8 A Comparison of Functional and Structural Social Support: Role in Relapse Prevention L. Goehl and E. Nunes 9 Oral Communications II Behavioral Pharmacology of Cocaine and Other Stimulants One Trial Conditioned Effect of Amphetamine in Nigral Rats P. B. Silverman 10 Intravenous Self-Injection of Methcathinone in the Baboon B. J. Kaminski and R. R. Griffiths . 11 v The Effects of GBR 12909 on Responding of Rhesus Monkeys Maintained Under Schedules of Cocaine and Food Delivery J. R. Glowa, F. H. Wojnicki, B. de Costa, D. Matecka, K. C. Rice and R. B. Rothman 12 Chronic Haloperidol Enhances Cocaine Conditioned Place Preference T. A. Kosten, M. J. D. Miserendino, D. W. Marby and E. J. Nestler 13 Effects of Adrenalectomy on Intravenous Cocaine Self-Administration in Rats N. E. Goeders and G. F. Guerin 14 Attenuation of Cocaine Self-Administration in Rats by Ibogaine S. Gleeson and S. I. Dworkin 15 Genetic Factors in Acute Cocaine-Induced Locomotor Activity and Context- Specific Conditioned Sensitization A. Brockington, R. B. Rothman. D. A. Gorelick. S. R. Goldberg and G. I. Elmer 16 DNQX in the Nucelus Accumbens Inhibits Conditioned Place Preference Induced by Amphetamine or Cocaine L. J. Wallace, R. T. Layer and F. G. Kaddis 17 Does Accumbens Acetylcholine Play a Role in Addiction G. P. Mark, P. Rada. E. Pothos, K. Taylor, K. Davidson and B. G. Hoebel 18 Oral and IP Caffeine Exposure as Determinants of Locomotor Activity and Tolerance C. E. Lau and J. L. Falk 19 Oral Communications III Behavioral Pharmacology, Human Marijuana Smoking Increases Plasma Cocaine Levels and Subjective Reports of Euphoria in Male Volunteers S. E. Lukas, M. B. Sholar, E. Kouri and J. H. Mendelson 20 Behavioral Effects of Alprazolam in Humans T. H. Kelly, R. W. Foltin and M. W. Fischman 21 Preference for Ethanol and Diazepam in Light and Moderate Drinkers: A Within-Subjects Study H. de Wit and P. Doty 22 Discriminability of Subtherapeutic Doses of Diazepam and Buspirone in Humans C. R. Rush, J. R. Troisi, II, T. S. Critchfield, J. H. Texter and R. R. Griffiths 23 Comparative Abuse Liability of Sertraline, Alprazolam and Dextro- Amphetamine in Drug Non-Abusers L. Zawertailo, H. L. Kaplan, U. Busto and E. M. Sellers 24 vi Independence of Craving Self-Reports and Physiological Reactivity to Cocaine Cues in Cocaine Abuse Patients S. J. Robbins, R. N. Ehrman, A. R. Childress and C. P. O’Brien 25 Naltrexone Interactions with Cocaine, Hydromorphone, and a “Speedball” Combination in Substance Abusers S. L. Walsh, J. T. Sullivan, K. L. Preston and G. R. Bigelow 26 Effects of Agonist/Antagonist Opioids in Human Volunteers Trained to Discriminate Among Hydromorphone 0, 1, and 4 MG G. E. Bigelow and K. L. Preston 27 Differential Cue Reactivity in Heavy and Light Smokers V. W. Rees, J. D. Greeley and R. F. Westbrook 28 A Test of Caffeine Self-Administration in Adolescents K. L. Hale, J. R. Hughes, S. T. Higgins and W. K. Bickel 29 Oral Communications IV Pathophysiological Consequences of Drug Abuse Visual Habituation Performance in Three-Month-Old Infants Exposed Prenatally to Cocaine L. C. Mayes, M. H. Bornstein, K. Chawarska and R. H. Granger 30 The Clinical Neurological Examination in Chronic Cocaine Abusers: Preliminary Findings J. L. Cadet, T. Gendron, W. R. Lange, J. E. Henningfield and R. B. Rothman 31 Differential Regulation of the Dopamine Transporter in Cocaine Overdose Deaths J. Staley, M. Basile, C. V. Wetli, W. L. Hearn, D. D. Flynn, A. J. Ruttenber and D. C. Mash 32 Quantitative EEG Analyses in Cocaine Abstinent Subjects R. A. Roemer, A. Cornwell, D. B. Dewart and P. Jackson 33 Differential Cocaine-Induced Physiological and Pathological Alterations in Rats are Related C. A. Branch, V. W. Fischer, Q. Gan and M. M. Knuepfer 34 Evaluation of the Effects of Nifedipine on Cocaine Intoxication in Mice T. Ansah and D. C. Shockley 35 Nitric Oxide (NO) Synthase Inhibitors Abolish Sensitization to Repeated Cocaine Administration Y. Itzhak and K. M. Kantak 36 Attenuation of Hypothalamic-Pituitary -Adrenocortical Response in Abstinent Alcoholics N. C. Bernardy, A. C. King, W. R. Lovallo and O. A. Parsons 37 vii Oral Communications V Epidemiology and Sociology Genetics and Smoking P.