Open Journal of Organ Transplant Surgery, 2013, 3, 50-52 http://dx.doi.org/10.4236/ojots.2013.33010 Published Online August 2013 (http://www.scirp.org/journal/ojots) Acute Appendicitis Confined to an Incisional Hernia Following Renal Transplantation Shanel Bhagwandin, Raquel Garcia-Roca, Hoonbae Jeon Department of Transplant Surgery, University of Illinois, Chicago, USA Email: [email protected] Received March 27, 2013; revised April 27, 2013; accepted May 5, 2013 Copyright © 2013 Shanel Bhagwandin et al. This is an open access article distributed under the Creative Commons Attribution Li- cense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT We present a case of a 57 years old moderately obese woman with a known 12 cm incisional hernia, who subsequently developed an incarcerated acute appendicitis. The patient underwent an uneventful orthotopic liver and renal transplant five years prior, and was compliant with ongoing immunosuppression without rejection. She presented with 8 hours of acute onset right lower quadrant pain, associated with anorexia, documented fevers, and nausea. Non-contrast CT dem- onstrated a blind-ending tubular structure with an enhancing and thickened wall within a hernia defect of the right lower quadrant. The patient underwent emergent laparotomy and a non-perforated appendix was completely excised at its base. Discussion: There have been documented reports of an acute appendicitis associated with inguinal hernias, given the eponym Amyand’s hernia. Appendicitis may present within hernias, and there should be a low threshold for ra- diologic assessment of its components when there is clinical doubt about the symptoms associated with the hernia. Our recommendation prompts early use of non-contrast CT scan in transplant patients with known hernias on examination and abdominal tenderness over the renal allograft considering the high risk of perforation of acute appendicitis and strangulation. Keywords: Acute Appendicitis; Renal Transplantation; Renal Allograft; Incisional Hernia; Amyand’s Hernia; Hernial Appendicitis 1. Introduction pression of the base of the appendix within the internal ring of the inguinal canal [1,2]. This particular hernial We present a case report of a 57 years old moderately appendicitis has not been described beyond two other ca- obese woman with a known 12 cm incisional hernia, who ses; however, it proposes complex operative management subsequently developed an incarcerated acute appendici- in consideration of the underlying renal allograft [3,4]. tis. The patient underwent an uneventful orthotopic liver and renal transplant secondary to autoimmune hepatitis 2. Presentation five years prior to presentation. She had developed a re- ducible large incisional hernia in her right lower quadrant, On examination, her temperature was 39.4˚C, heart rate overlying her kidney transplant incision. This was ini- 98 bpm, and blood pressure 94/66 mmHg. The abdomen tially noted six months after the transplant. She was com- was soft, with an obvious firm and irreducible 10 × 10 pliant with her ongoing immunosuppressive regimen of cm mass extending along the length of her right lower prednisone and tacrolimus. This patient presented with 8 quadrant incision. hours of acute onset right lower quadrant pain, associated There was blotchy non-blanching erythema of the with anorexia, documented fevers, and nausea. She de- overlying skin. She was in significant discomfort upon nied any prior episodes of incarceration or obstructive compression of the mass, with associated guarding. symptoms. There were no other suggestions of rebound tenderness There have been documented reports of an acute ap- or Rovsing’s sign upon palpation of the rest of the ab- pendicitis associated with inguinal hernias, given the domen. The remainder of the physical exam was unre- eponym Amyand’s hernia. It remains an uncommon markable. presentation of acute appendicitis with an incidence of Laboratory investigations revealed a leukocytosis of 0.13%, and is believed to occur from extra luminal com- 10,000/mm3 with a neutrophil count of 83%. The re- Copyright © 2013 SciRes. OJOTS S. BHAGWANDIN ET AL. 51 mainder of her serum lab values was not significant; creatinine was baseline at 1.1. Urinalysis was negative for bacteria and blood. A non-contrast CT was performed that demonstrated a blind-ending tubular structure with enhancing and thick- ened wall within a hernia defect of the right lower quad- rant. The structure was closely related to the cecum, with dilated proximal small bowel loops. A fecalith was noted within the sac at the base of the appendix (see Figures 1(a) and (b)). After adequate fluid resuscitation and antibiotic ad- ministration, the patient was taken to the operating room. The previous right lower quadrant “hockey-stick” inci- sion was used to enter the peritoneum given its direct (a) (b) access to the appendix and visualization of cecum and Figure 2. Intraoperative images of the inflamed, dilated ap- small bowel if further resection was warranted. At ex- pendix in situ. ploration, an incarcerated acutely inflamed appendix was found within the hernia sac. The appendix was not was also performed following appendectomy with pri- grossly perforated and did not appear gangrenous; how- mary repair of the defect. There was minimal free fluid ever, upon amputation at the base, the visible mucosa within the abdomen, which was copiously irrigated with was necrotic (see Figures 2(a) and (b)). A hernioplasty 2 liters of warm saline prior to closing the abdomen in a standard fashion. The postoperative course was uncomplicated, and the patient remained afebrile with a progressively declining leukocytosis. Oral intake was resumed on postoperative day 2 with resumption of early bowel activity, and she was discharged home on postoperative day 3 to complete an additional full 1-week course of oral antibiotics. Histopathologic examination of the specimen showed transmural inflammation of the appendix and periappen- dicitis. No fecalith was identifited within the specimen. (a) 3. Discussion Appendicitis may present within hernias, and there should be a low threshold for radiologic assessment of its com- ponents when there is clinical doubt about the symptoms associated with the hernia. Despite the presentation of what appeared to be an incarcerated, possibly strangu- lated hernia, computed tomography (CT) scan was pur- sued on account of the proximity of the patient’s renal allograft and acute presentation with such a large defect. Tenderness and palpable swelling of the graft is usually associated with pyelonephritis or acute rejection in a pa- tient with concomitant azotemia or oliguria [5]. For an acute appendicitis, the initial presentation is highly vari- able and can be dependent on the degree of peritoneal contamination as a result of periappendiceal inflamma- tion. The diagnosis of hernial appendicitis is primarily based on a high index of suspicion; however, the primary differential diagnosis remains as an incarcerated or (b) strangulated hernia. Initially, proximal small bowel may Figure 1. CT images of incarcerated inflamed appendix wi- not be affected and appear functionally normal, but as the thin the hernia sac. periappendiceal inflammation progresses or as the bowel Copyright © 2013 SciRes. OJOTS 52 S. BHAGWANDIN ET AL. becomes invested within the hernia sac, it can ultimately subsequent hernia repair. Utilization of a non-biological become compromised [7-9]. mesh should be avoided given the high incidence of in- Ultrasound is also another alternative of radiological fection, and hernia repair should be delayed if the defect examination, which can also demonstrate a potential in- is too large to close primarily. flammatory mass within the hernia sac and its proximity to other nearby structures, such as the renal allograft in REFERENCES this patient. Although subjective, this is of value to pa- tients who cannot tolerate the oral prep for CT, and [1] C. 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