New Psychoactive Substances (NPS) reference materials 2015 phenethylamines • amphetamines • cathinon es • try pt am i ne s • p ip e r a z i n e s • s y n t h e t i c c a n n a b i n o i d s • d i s s o c i a t i v e s • d e s i g n e r b e n z o d i a z e p i n e s • a r y l c y c l o h e x a m i n e s LGC Quality - ISO Guide 34 • GMP/GLP • ISO 9001 • ISO/IEC 17025 • ISO/IEC 17043 reference materials Solutions and powders for all your analytical needs: • Drugs of abuse • Therapeutic drug monitoring • Derivatizing reagents • Steroids • Ethanol • Stable isotope labeled • Metabolites compounds • New psychoactive • Custom synthesis substances (NPS) and many more • Prescription drugs www.lgcstandards.com • Science for a safer world LGC Quality - ISO Guide 34 • GMP/GLP • ISO 9001 • ISO/IEC 17025 • ISO/IEC 17043 © LGC Limited, 2014. All rights reserved. LGC Standards is part of the LGC Group. LoGiCal is a registered trademark of LGC Standards GmbH 4063/CB/0714 4063_LoGiCal_advert_A4_v3.indd 1 8/12/2014 11:35:36 AM Welcome to our latest catalogue of reference standards for New Psychoactive Substances (NPS) We have expanded the format slightly to include sequential reference numbers for the many materials listed in the various sections. These reference numbers will help you to easily identify and order the reference materials you need. This listing can be divided into three broad groups. Sections 1-7 are compounds that are generally considered to be stimulants and hallucinogens and are comprised of phenethylamines, tryptamines, cathinones, piperazines, and amphetamines. Sections 8-9 list the synthetic cannabinoids and their metabolites. Sections 10-11 detail other NPS chemicals, including designer variants of pharmaceuticals such as benzodiazepines and opioids, plant chemicals, and the dissociative drugs. At the beginning of each Section, a generic chemical structure has been given to aid with identification of the numerous NPS that are available. In addition, there is an explanation of the trivial nomenclature used with the synthetic cannabinoids at the beginning of Section 8. Many of these products are produced under the rigorous quality assurance standards set out in ISO Guide 34. If you don’t see what you are looking for, please contact your local sales office as the range of these products is continuously evolving. We look forward to hearing from you. The LGC Team Contents 1. Phenethylamines 8. Synthetic cannabinoids 1.1 Simple phenethylamines ............................................. 5 Organisation of our listing of available reference standards ... 20 1.2. “2C-X” compounds ..................................................... 5 (1) Pyrrole core (2,5-Dimethoxyphenethylamines) 8.1 Naphthoyl pyrroles .............................................. 22 1.3 “2C-X-NBOMe” and related derivatives ...................... 6 (2) Indene core 1.4 Methylenedioxyphenethylamines ................................ 6 8.2 Naphthyl indenes ................................................ 22 1.5 Trialkoxyphenethylamines ........................................... 7 (3) Indole core 1.6 “Fly” and “Dragonfly” compounds ................................ 7 8.3 Naphthoyl indoles ............................................... 22 1.7 “Benzofuries” (APBs and APDBs) ............................... 7 8.4 Naphthyl methyl indoles ..................................... 24 1.8 Other phenethylamine-related compounds ................. 8 8.5 Phenylacetyl indoles ........................................... 25 8.6 Benzoyl indoles ................................................... 25 2. Metabolites of ‘ecstasy’ chems ......................................... 8 8.7 Pyridinoyl indoles ................................................ 25 3. Amphetamines 8.8 Adamantoyl indoles ............................................ 26 3.1 Amphetamines ................................................................ 9 8.9 Tetramethylcyclopropoyl indoles ........................ 26 3.2 Dimethoxyamphetamines ............................................... 9 8.10 3,4,4-Trimethyl-pent-2-en-1-one indoles .......... 26 3.3 Trialkoxyamphetamines ............................................... 10 8.11 Indole carboxamides ......................................... 26 3.4 N-Methyl amphetamines ............................................. 10 8.12 Indole carboxylates ........................................... 27 3.5 N-Ethyl amphetamines ................................................. 11 8.13 Quinolinyl indole carboxylates .......................... 27 3.6 Other amphetamines .................................................... 11 8.14 Pyridinoyl indoles .............................................. 28 8.15 Piperidinyl indole carboxamides ....................... 28 4. Cathinones 8.16 Thiazole indoles ................................................ 28 4.1 Beta-keto “2C-X” compounds .................................... 11 (4) Indazole core 4.2 Simple cathinones ..................................................... 11 8.17 Naphthoyl indazoles ......................................... 29 4.3 N-Methyl cathinone and derivatives ......................... 12 8.18 Tetramethylcyclopropoyl indazoles ................... 29 4.4 N-Ethyl cathinone and derivatives ............................ 12 8.19 Indazole carboxamides .................................... 29 4.5 Simple butanones ..................................................... 13 8.27 Indazole carboxylates ....................................... 30 4.6 Simple pentanones ................................................... 13 8.20 Naphthyl indazole carboxylates ........................ 30 4.7 Simple hexanones .................................................... 13 8.21 Quinolinyl indazole carboxamides .................... 30 4.8 Other simple cathinones ........................................... 14 8.22 Quinolinyl indazole carboxylates ...................... 30 4.9 Methylenedioxycathinones (C3 to C5 sidechains) ... 14 (5) Benzimidazole core 4.10 Ethylenedioxycathinones .......................................... 15 8.23 Naphthoyl benzimidazoles ............................... 30 4.11 Pyrrolidinocathinones (C3 to C9 sidechains) ........... 15 (6) Carbazole core 4.12 Methylenedioxypyrrolidinocathinones ...................... 15 8.24 Naphthoyl carbazoles ....................................... 31 (C3 to C6 side chain) (7) Azaindole core 4.13 Naphthyl cathinones and pyrrolidinocathinones ...... 16 8.28 Azaindole carboxamides .................................. 31 4.14 Related materials ...................................................... 16 (8) Other synthetic cannabinoids ....................................... 31 5. Metabolites of Cathinones .............................................. 16 8.25 Single components ........................................... 31 8.26 Mixed standards ............................................... 31 6. Tryptamines 6.1 Tryptamine ................................................................ 17 9. Synthetic cannabinoid metabolites ............................... 32 6.2 Alpha-Alkyl tryptamines ............................................ 17 10. Other NPS chemicals 6.3 N-Alkyl tryptamines .................................................... 17 10.1 Cocaine-like materials .............................................. 36 6.4 Ring-Methoxy N-Alkyl tryptamines ........................... 18 10.2 Benzodiazepine-like materials .................................. 37 6.5 Ring-Hydroxy N-Alkyl tryptamines ............................ 18 10.3 Other pharmaceuticals ............................................. 37 6.6 Ring-Acetoxy N-Alkyl tryptamines ............................ 18 10.4 ‘Designer’ forms of pharmaceuticals ......................... 37 6.7 Other mushroom hallucinogens ............................... 18 10.5 Pipradrol-related materials ....................................... 37 6.8 Related compounds .................................................. 19 10.6 Plant chemicals ......................................................... 38 7. Piperazines 10.7 Materials with alcohol-like effects ............................. 38 7.1 Benzylpiperazines ..................................................... 19 10.8 Indanes ..................................................................... 38 7.2 Phenylpiperazines .................................................... 19 10.9 Synthetic opioids ....................................................... 38 10.10 Dissociatives ............................................................ 38 10.11 Thiophene analogues of amphetamines ................. 38 10.12 Other materials ....................................................... 39 11. Aryl Cyclohexylamines .................................................. 40 Ref. no. Substance Other names 1. Phenethylamines 1.1 Simple phenethylamines 2 β 3 NH2 α 4 6 5 1.1.1 PEA 2-Phenethylamine 1.1.2 N-Me-PEA N-Methyl-2-phenylethylamine 1.1.3 α,α-Dimethyl-PEA Phentermine 1.1.4 α,α-Dimethyl-PEA-D5 1.1.5 β-Methyl-PEA 2-Phenylpropan-1-amine 1.1.6 N,β-Dimethyl-PEA Phenylpropylmethylamine 1.1.7 N,N-Diethyl-PEA 1.1.8 β-Methoxy-PEA 2-MeO-2-phenylethylamine 1.1.9 α-Ethyl-PEA 2-Amino-1-phenylbutane 1.1.10 N-Methyl-α-ethyl-PEA 2-Methylamino-1-phenylbutane 1.1.11 N-Ethyl-α-ethyl-PEA 2-Ethylamino-1-phenylbutane 1.1.12 4-Chloro-α-ethyl-PEA 4-CAB 1.2. “2C-X” compounds (2,5-Dimethoxyphenethylamines) O R 2 NH2 3 6 4 R'/X 5 O 1.2.1 2C-B ('Nexus') 2,5-DiMeO-4-Br-PEA 1.2.2 2C-B-D6 1.2.3 2C-C 2,5-DiMeO-4-Cl-PEA 1.2.4 2C-C-D6 1.2.5 2C-D 2,5-DiMeO-4-Me-PEA 1.2.6 2C-D-D6 1.2.7