Non-invasive cardiovascular risk assessment The AGE Reader provides an immediate prediction for the cardiovascular risk of your patient. The non-invasive and extensively validated AGE Reader is and ideal tool for point of care testing. The measurement result is available in 12 seconds and can be exported directly. Glucose Schiff Bases About AGEs Protein Amadori Products (Advanced Glycation Endproducts) Reactive Intermediates AGEs are the result of a chain of chemical reactions (the Maillard reaction) after an initial glycation. AGEs Advanced Glycation Endproducts normally accumulate slowly over a person’s lifetime in tissues with slow turnover. But this process oc- curs more rapidly in patients with conditions such as diabetes mellitus, renal failure and cardiovascular disease. AGEs also accumulate rapidly under circum- stances of oxidative stress. These accumulated AGEs play a key role in the development of diabetes and its complications. The level of AGEs in tissue reflects the glycometabolic memory and is a valuable predictor of cardiovascular events and (pre)diabetes. Measuring AGEs With any other measurement it has been complicated Many advanced glycation endproducts (AGEs) have a to measure tissue AGEs in patients because they are characteristic fluorescence. Moreover, tissue fluores- expensive, time consuming, lack specificity, are poorly cence in (invasive) biopsies has an established as- reproducible and/or are invasive. The AGE Reader is sociation with chronic complications. The AGE Reader the answer to the need for measuring AGEs without is able to easily, quickly and noninvasively measure the disadvantages of the existing methods. This AGEs by means of fluorescence techniques1. state of the art device provides a simple non-invasive solution, which allows clinicians to determine the AGE level within 12 seconds. AGE Reader The AGE Reader provides an immediate prediction for cardiovascular risk. The measurement is reliable, real time, non-invasive and easy to use. Moreover, the AGE Reader has been validated in clini- cal studies around the world. The AGE Reader has been used in clinical practice and research since 2006 in over 1000 clinics worldwide. Since the introduction of the AGE Reader more than 200 peer reviewed pa- pers have been published. These papers give an over- view of clinical studies in diabetes2, cardiovascular disease3 and renal disease4. Type 2 Diabetes population (n=987) Clinical validation Mean AF with 95% CI Mean AF in the total in healthy subjects T2DM population Type 2 Diabetes Key conclusions of the clinical validation subgroups Microvascular and studies using the AGE Reader: macrovascular complications • Reflects vascular damage in the diabetes Macrovascular 2 complications patients . • Identifies diabetic patients at risk of developing (car- Microvascular 5,6,7 complications diovascular and microvascular) complications . • Predicts the risk of having or developing diabetes No complications and the metabolic syndrome8,9. • Strong predictor of major cardiovascular events in 10 Measurement peripheral artery disease . result 2.0 2.25 2.5 2.75 3.0 3.25 Clinical use Clinical professionals have been successfully using the AGE Reader in their clinics for over 10 years. The AGE Reader is the answer to the need to quickly, reliably and non-invasively measure the cardio- vascular risk of your patient. The AGE Reader assists clinical professionals in This non-invasive and convenient measurement identifying patients with an increased cardiovascular can be performed by any clinical professional risk. This helps clinicians to decide whether a change and is completed within 12 seconds. in treatment is needed. * References can be found on the back The AGE Reader App Export the measurement directly to the AGE Reader App using the Bluetooth connection and add other cardiovascular risk factors to generate a comprehen sive Cardiovascular Risk Report. For each patient all visits can be documented and consulted in the easy - to use App. The Cardiovascular Risk Report can simply be printed , saved and shared. Download the AGE Reader App free of charge on www.diagnoptics.com. Available for: www.diagnoptics.com free of charge on Windows OS X 11-09-2015 Exame date: Diagnoptics Physician: Name: John Doe 01-02-1975 Date of birth: Age: 40 Gender: male 001 Patient ID: Cardiovascular Risk Report Name: Jane Doe Exame date: 11-09-2015 Date of birth: 10-10-1980 Physician: Diagnoptics Age: 34 Gender: female Patient ID: 002 Cardiovascular Risk Report Explain 2.9 Cardiovascular Risk Report & Cardiovascular risk factors are conditions or habits that raise Motivate your risk of cardiovascular disease and events. There are patients traditional and innovative cardiovascular risk factors known. This cardiovascular risk report provides an overview of selected cardiovascular risk factors with special attention for Cardiovascular Risk Report the AGE Reader measurement result. The graphical display allows you to combine the AGE Cardiovascular risk factors are conditions or habits that raise your risk of cardiovascular disease and events. There are traditional and innovative cardiovascular risk factors known. Measurement results This cardiovascular risk report provides an overview of Reader result with desired other cardiovascular risk selected cardiovascular risk factors with special attention for 2.3 Risk Factor Current the AGE Reader measurement result. Previous 11-09-2015 11-09-2015 factors and explain the results to patients. A hardcopy 2.9 2.0 AGE of the report can be handed to the patient, which will Yes Yes Risk Factor Measurement results Measurement results Smoker make it easier to understand the measurement result Previous Yes Current Current - 11-09-2015 11-09-2015 Yes 5 - Diabetes AGE 2.3 4 and the associated cardiovascular risk. 135 3 138 2 LDL cholesterol - 150 43 Systolic blood pressure 1 45 0 20 40 60 80 HDL cholesterol 160 Age (years) 160 Systolic blood pressure Excellent Very Good Fair Poor No Risk group 1: good Risk group 2: Risk group 3: increased Limited increase Increased Definite Current CV risk of CV risk CV risk CV risk Previous results results References Fair Poor AGE Reader result Good Planning Very Excellent good Planning The AGE Reader measurement result is above 1 standard deviation of the age 1. MeerwaldtNext visit R. et relatedal. mean. Diabetologia. This indicates an increased cardiovascular risk. 2004;Depending on 47(7):Previous visit Current1324:1330. visit Next visit overall CV risk, lifestyle or pharmaceutical treatment should be considered. Current visit - 11-09-2015 11-10-2015 Previous visit 11-10-2015 AGE Reader result 11-09-2015 11-09-20152. Lutgers H. et al. Diabetes Care. 2006; 29(12): 2654-2659. The AGE Reader measurement result is 2.9 or above. This indicates a definitely high cardiovascular risk. It is recommended that other cardiovascular risk factors should be assessed and treated, with low EASD threshold and target values for starting or intensifying treatment. 3. HofmannStockholm B. et al. Exp Gerontol. 2012 Epub May 12.EASD - Stockholm - 4. McIntyre N. et al. Clin J Am Soc Nephrol. 2011 Oct;6(10):2356-63. 5. Lutgers H. et al. Diabetolgia, 2009; 52(5): 789-797. 6. Gerrits E. et al. Diabetes care. 2008; 31(3): 517-521. 7. Noordzij M. et. Diabet Med. 2012; 29(12): 1556-1561. 8. Van Waateringe et al. Diabetol Metab Syndr. 2017 May 30;9:42 9. Oral and poster presentations EASD 2017. Submitted for publication 10. De vos L. et al. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):933-8 Please visit www.diagnoptics.com/age-reader for a complete overview of all AGE Reader publications. Diagnoptics Technologies B.V. www.diagnoptics.com Address: www.age-reader.com Aarhusweg 5-9 Contact details: 9723 JJ Groningen P +31 50 589 06 12 The Netherlands F +31 50 589 06 13 E [email protected] AGEs DamAGE Our Bodies. (Advanced glycation end- products) By Brady Hartman in Anti-Aging Science, Healthy Living October 19, 2017 Sharing is caring! Reading Time: 11 minutes. >> Summary: AGEs (advanced glycation end-products) are in the spotlight again as geroscientists implicate this toxic waste of our bodies in a multitude of health conditions, including inflammaging, cancer, and diabetes. Some scientists go as far as to link AGEs to an increase in the chronic inflammation which leads to heart attacks. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ] Executive Summary Are advanced glycation end-products (AGEs) a villain that causes chronic diseases or are they merely an innocent bystander? Anti-aging scientists are coming to the growing conclusion that AGEs play a significant role in inflammation and the chronic diseases of aging, such as diabetes, heart disease, and many others. Furthermore, some geroscientists suspect that AGEs significantly contribute to cancer. In an earlier review that links AGEs with cancer, David P. Turner, a researcher with the Department of Pathology & Laboratory Medicine at the Medical University of South Carolina in Charleston (MUSC) sums it up by saying, “Advanced glycation end-products (AGEs) are reactive metabolites produced as a by-product of sugar metabolism. Failure to remove these highly reactive metabolites can lead to protein damage, aberrant cell signaling, increased stress responses, and decreased genetic fidelity.” Earlier this year, Turner updated his research on the link between advanced glycation end-products and cancer, as you will read later on. Turner and other researchers are adding to the growing body of evidence against AGEs. Geroscientists are sure that the steps we take to reduce AGEs are incredibly good for our health. That is, having low blood sugar, low cholesterol levels and eating less processed foods are sure-fire ways to lengthen our lives and coincidently also reduce advanced glycation end-products. Bottom Line: AGEs are bad for our health. However, scientists don’t know the exact extent. There is hope, however. Scientists have come up with ways to prevent the build-up of advanced glycation end-products. AGEs DamAGE Our Bodies What Scientists Know About AGEs Turner is not the only geroscientist accusing AGEs of misconduct.