With the CELEBREX $4 Co-pay Card You May Pay Less for Brand-Name CELEBREX Than the Generic Version*† $4 CO-PAY CARD THE CELEBREX $4 CO-PAY CARD ONLY WORKS Pay as little as * WITH BRAND-NAME CELEBREX. Bin: 610020 Group: 99990873 $ ID: Don’t have a card? Register for one today at Celebrex.com and per4 month Expiration date: 12/31/16 This you may pay as little as $4 per month in out-of-pocket costs. * Eligibility required. Terms and conditions apply. See accompanying letter. card is not health insurance and will Please only seebe accepted accompanying at participating full Prescribing No membership fees. and Medication Guide. pharmacies. BOXED WARNING, Information, including KEEP THESE TIPS IN MIND TO HELP YOU GET BRAND-NAME CELEBREX AT THE PHARMACY. AT THE DOCTOR’S OFFICE • Ask your doctor to write your prescription for brand-name CELEBREX, not the generic • Remind your doctor to note “Dispense As Written” so you can take advantage of the CELEBREX $4 Co-pay Card DROPPING OFF AT THE PHARMACY • Tell your pharmacist that your doctor has prescribed, and that you want, brand-name CELEBREX, and that you would like to use your CELEBREX $4 Co-pay Card • Ask your pharmacist to note your preference for the branded version for future refills PICKING UP AT THE PHARMACY • Check your bag and bottle label at the pharmacy counter to make sure you received brand-name CELEBREX, and check your receipt for savings • If you think you’ve received a generic by mistake, talk to your doctor and pharmacist about your options Important Safety Information All prescription NSAIDs, like CELEBREX, ibuprofen, naproxen, and meloxicam have the same cardiovascular warning. They may all increase the chance of heart attack or stroke that can lead to death. This chance increases if you have heart disease or risk factors for it, such as high blood pressure or when NSAIDs are taken for long periods. CELEBREX should not be used right before or after certain heart surgeries. Serious skin reactions, or stomach and intestine problems such as bleeding and ulcers, can occur without warning and may cause death. Patients taking aspirin and the elderly are at increased risk for stomach bleeding and ulcers. Please see additional Important Safety Information and Indications on reverse and accompanying full Prescribing Information, including BOXED WARNING, and Medication Guide. * Eligibility required. Please see full terms and conditions at Celebrex.com. Card will be accepted only at participating pharmacies. Card is not health insurance. No membership fees. Savings of up to $125 per fill for a maximum savings of up to $1,750 per year. For more information, visit Celebrex.com, call 1-855-612-1956, or write: CELEBREX $4 Co-pay Card, 14001 Weston Parkway, Suite 103, Cary, NC 27513. †Generic prescription celecoxib patients with commercial insurance pay an average co-pay of $23.21 as of January 2015. Important Safety Information (continued) Tell your doctor if you have: • A history of ulcers or bleeding in the stomach or intestines • High blood pressure or heart failure • Kidney or liver problems CELEBREX should not be taken in late pregnancy. Do not take CELEBREX if you have bleeding in the stomach or intestine, or you’ve had an asthma attack, hives, or other allergic reactions to aspirin, any other NSAID medicine or certain drugs called sulfonamides. Life threatening allergic reactions can occur with CELEBREX. Get help right away if you’ve had swelling of the face or throat or trouble breathing. Prescription CELEBREX should be used exactly as prescribed at the lowest dose possible and for the shortest time needed. Indications CELEBREX is indicated for the relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, and for the management of acute pain in adults; the treatment of primary dysmenorrhea; and for relief of the signs and symptoms of juvenile rheumatoid arthritis in patients 2 years and older. Remember to Take Action and Follow the Important Tips So You Can Stay With Brand-Name CELEBREX Get Valuable Offers on Select Pfizer Brands Find out if you are eligible to start saving on your prescriptions today. Terms and conditions apply. Learn more at www.MyPfizerBrands.com. Please see accompanying full Prescribing Information, including BOXED WARNING, and Medication Guide. CSP715602-01 ©2015 Pfizer Inc. All rights reserved. May 2015 HIGHLIGHTS OF PRESCRIBING INFORMATION ------------------------WARNINGS AND PRECAUTIONS------------------------- Serious and potentially fatal cardiovascular (CV) thrombotic events, These highlights do not include all the information needed to use myocardial infarction, and stroke. Patients with known CV CELEBREX safely and effectively. See full prescribing information disease/risk factors may be at greater risk (5.1, 14.6, 17.2). for CELEBREX. Serious gastrointestinal (GI) adverse events, which can be fatal. ® CELEBREX (celecoxib) capsules The risk is greater in patients with a prior history of ulcer disease or Initial U.S. Approval: 1998 GI bleeding, and in patients at high risk for GI events, especially the elderly. CELEBREX should be used with caution in these patients WARNING: CARDIOVASCULAR AND GASTROINTESTINAL RISKS (5.4, 8.5, 14.6, 17.3). See full prescribing information for complete boxed warning Elevated liver enzymes and, rarely, severe hepatic reactions. Cardiovascular Risk Discontinue use of CELEBREX immediately if abnormal liver CELEBREX may cause an increased risk of serious enzymes persist or worsen (5.5, 17.4). cardiovascular thrombotic events, myocardial infarction, and New onset or worsening of hypertension. Blood pressure should stroke, which can be fatal. All NSAIDs may have a similar risk. be monitored closely during treatment with CELEBREX This risk may increase with duration of use. Patients with (5.2, 7.4, 17.2). cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (5.1,14.6) Fluid retention and edema. CELEBREX should be used with caution CELEBREX is contraindicated for the treatment of peri-operative in patients with fluid retention or heart failure (5.3, 17.6). pain in the setting of coronary artery bypass graft (CABG) Renal papillary necrosis and other renal injury with long term use. surgery. (4, 5.1) Use CELEBREX with caution in the elderly, those with impaired renal Gastrointestinal Risk function, heart failure, liver dysfunction, and those taking diuretics, NSAIDs, including CELEBREX, cause an increased risk of ACE-inhibitors, or angiotensin II antagonists (5.6, 7.4, 8.7, 17.6). serious gastrointestinal adverse events including bleeding, Anaphylactoid reactions. Do not use CELEBREX in patients with ulceration, and perforation of the stomach or intestines, which the aspirin triad (5.7, 10, 17.7). can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at Serious skin adverse events such as exfoliative dermatitis, greater risk for serious gastrointestinal (GI) events. (5.4) Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal and can occur without warning even without known prior sulfa allergy. Discontinue CELEBREX at first appearance of rash or skin reactions (5.8, 17.5). -----------------------------INDICATIONS AND USAGE----------------------------- -------------------------ADVERSE REACTIONS-------------------------- CELEBREX is a nonsteroidal anti-inflammatory drug indicated for: Most common adverse reactions in arthritis trials (>2% and Osteoarthritis (OA) (1.1) >placebo): abdominal pain, diarrhea, dyspepsia, flatulence, Rheumatoid Arthritis (RA) (1.2) peripheral edema, accidental injury, dizziness, pharyngitis, rhinitis, Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older (1.3) sinusitis, upper respiratory tract infection, rash (6.1). Ankylosing Spondylitis (AS) (1.4) To report SUSPECTED ADVERSE REACTIONS, contact Acute Pain (AP) (1.5) Pfizer at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch Primary Dysmenorrhea (PD) (1.6) -----------------------DOSAGE AND ADMINISTRATION--------------------------- ---------------------------DRUG INTERACTIONS-------------------------- Use lowest effective dose for the shortest duration consistent Concomitant use of CELEBREX and warfarin may result in with treatment goals for the individual patient. (1, 5.1, 5.4) increased risk of bleeding complications. (7.1) OA: 200 mg once daily or 100 mg twice daily (2.1, 14.1) Concomitant use of CELEBREX increases lithium plasma levels. (7.2) RA: 100 to 200 mg twice daily (2.2, 14.2) JRA: 50 mg twice daily in patients 10-25 kg. 100 mg twice daily in Concomitant use of CELEBREX may reduce the patients more than 25 kg (2.3, 14.3) antihypertensive effect of ACE Inhibitors and angiotensin II antagonists. Concomitant use of CELEBREX with ACE- AS: 200 mg once daily single dose or 100 mg twice daily. If no effect Inhibitors in elderly or volume depleted or renally compromised is observed after 6 weeks, a trial of 400 mg (single or divided doses) patients may result in deterioration of renal function, including may be of benefit (2.4, 14.4) acute renal failure. (7.4) AP and PD: 400 mg initially, followed by 200 mg dose if needed on first Use caution with drugs known to inhibit P450 2C9 or metabolized day. On subsequent days, 200 mg twice daily as needed (2.5, 14.5) by 2D6 due to the potential for increased plasma levels (2.6, 8.4, Reduce daily dose by 50% in patients with moderate hepatic impairment 8.8, 12.3) (Child-Pugh Class