The Ebola Research Database www.ukcds.org.uk/resources/ebola-research-database Hosted by in collaboration with the Country/ Regional Funding Organisation/s Funding Start date and Value Title Type of study Type of Recipient Organisation Lay abstract Study sites Timelines (e.g. time to next phase) Link funder scheme* duration intervention Study the safety and efficacy of Favipiravir, an Institut National de la Sante et antiviral already licensed for influenza, first in an http://europa.eu/rapid/press- Europe European Commission Horizon 2020 € 2,575,810 REACTION Pre-clinical / Clinical Therapeutics de la Recherche Medicale 6 months until initial results expected animal model of the disease and then on patients release_IP-14-1194_en.htm (INSERM) (France) with Ebola virus disease. Research on interactions between the Ebola virus and the host. This will provide urgently needed answers regarding the pathophysiology and Bernhard-Nocht-Institut fuer http://europa.eu/rapid/press- Europe European Commission Horizon 2020 € 1,759,326 EVIDENT Clinical Trial transmissibility of the disease, and will help better Tropenmedizin (Germany) release_IP-14-1194_en.htm guide the planned clinical trials on vaccines and potential treatments, as well as the management of patients with Ebola virus disease. Study the safety and efficacy of using antibodies Institut de Recherche pour le produced in horses against Ebola, as a passive http://europa.eu/rapid/press- Europe European Commission Horizon 2020 € 1,992,770 IF-EBOla Basic science/ Pre-clinical Therapeutics Developpement (France) immunity treatment for patients with Ebola virus release_IP-14-1194_en.htm disease. NIAID is supporting Crucell’s development of a J&J (Crucell), New Brunswick, multivalent Ebola/Marburg vaccine using Multivalent Ebola/Marburg NJ in collaboration with recombinant adenovirus vector platforms and US NIH/NIAID Pre-clinical/ Clinical Trial Vaccine Phase I site TBD A Phase I clinical trial is planned for late 2015. vaccine Bavarian Nordic - Kvistgaard, Bavarian Nordic’s MVA (modified vaccinia Ankara) DK vectored Ebola vaccine which will be used in a prime-boost strategy NIAID's Laboratory of Infectious Diseases Thomas Jefferson University and intramural NIAID, in collaboration with DoD, is supporting http://www.niaid.nih.gov/topics/ebola US NIH/NIAID Rabies/Ebola vaccine Pre-clinical Vaccine (Bethesda, MD) and Thomas investigators are developing a vaccine candidate on TBD development and GMP manufacture of the Marburg/Pages/rabiesVaccEbola.asp Jefferson University, the licensed rabies virus vaccine backbone. vaccine. Results sometime in 2015. x. (Philadelphia, PA) In vitro - More than 30 different therapeutic Therapeutics – selected candidates with different formulations/regimens are Various academic and for US NIH/NIAID preclinical in vitro studies Pre-clinical Therapeutics being evaluated, including cysteine-protease Candidates still in development or preclinical. profit entities (various candidates) inhibitors, polymerase inhibitors, kinase inhibitors, and monoclonal antibody cocktails In vivo - A novel drug (nucleoside analogue) that NHP studies ongoing - Results expected end US NIH/NIAID BCX4430 Therapeutic Pre-clinical Therapeutics BioCryst Pharmaceutical TBD interferes with the reproductive process of the virus of 2014. Limited in vitro data against Ebola. Recently administered under emergency IND in the In vivo - A broad-spectrum antiviral derivative of US NIH/NIAID CMX-001, Brincidofovir Pre-clinical Therapeutics Chimerix, Inc. TBD U.S. NIAID supporting in vivo testing against cidofovir. Limited in vitro data against Ebola. Ebola. In clinical development for other viral diseases. Phase I already completed. The aim of this project is the preclinical development and characterisation new vaccines against Ebola virus infections, based on recombinant vaccinia viruses MVA. There are currently two promising candidate vaccines against the Ebola virus available, which are yet to be tested in humans. Clinical trial preparations are underway Developing MVA and an implementation is expected at the beginning http://www.dzif.de/en/news_press/ne Federal Ministry of Education (Combined budget vector vaccines to of 2015. These vaccines are either effective against ws_press_releases/view/detail/artikel/ Germany EBOKON Pre-clinical Vaccine Institute for Infection Medicine and Zoonoses, LMU Munich Clinical trials anticipated for early 2015. and Research (BMBF) of €2.3million) prevent Ebola virus two subtypes of the Ebola virus (adenovirus-based ebokon_strengthening_ebola_researc infections vaccine), or monovalently effective against the h/ Zaire Ebola virus only (VSV-based vaccine). However, there are currently three independent virus outbreaks in Africa, highlighting the need for multivalent Ebola vaccines. The project will contribute to developing broad and specific Ebola virus vaccines which can quickly be drawn upon for testing in clinical settings. The antibody cocktail (ZMAPP) seems to cause significant improvement in some people with Ebola infections. However, the cocktail is globally no longer available and the production of a few new http://www.dzif.de/en/news_press/ne Developing and Federal Ministry of Education (Combined budget doses takes months. There is currently a lack of ws_press_releases/view/detail/artikel/ Germany EBOKON validating pan-Ebola Pre-clinical Therapeutics Paul-Ehrlich Institut, Langen and Research (BMBF) of €2.3million) concepts for rapidly developing and producing ebokon_strengthening_ebola_researc vaccination strategies passive immune therapies. This project compares h/ different vaccination strategies and validates the most promising ones with further experiments in Marburg. Basic and Pre-clinical Country/ Regional Funding Organisation/s Funding Start date and Value Title Type of study Type of Recipient Organisation Lay abstract Study sites Timelines (e.g. time to next phase) Link funder scheme* duration intervention There are currently no antiviral drugs available against Ebola viruses. One potential mechanism of anti-Ebola virus therapy could be to inhibit its entry http://www.dzif.de/en/news_press/ne Analysing and inhibiting into target cells. Ebola viruses contain glycoprotein Federal Ministry of Education (Combined budget ws_press_releases/view/detail/artikel/ Germany EBOKON Ebola virus entry into host Basic science/ Pre-clinical Therapeutics German Primate Centre, GöttingenGP, a substance which mediates their entry into and Research (BMBF) of €2.3million) ebokon_strengthening_ebola_researc cells host cells. In order to identify potentially highly h/ effective antiviral drugs, this project will investigate the interaction between the virus and host cells and how it can be inhibited. Immune responses to Ebola viruses are not well understood because insufficient numbers of patient samples have been available up to now. For Using chimeric mouse example, it is not known how the T cell response of http://www.dzif.de/en/news_press/ne Federal Ministry of Education (Combined budget models to investigate patients who survive Ebola infections differs to ws_press_releases/view/detail/artikel/ Germany EBOKON Basic science Bernhard Nocht Institute for Tropical Medicine, Hamburg and Research (BMBF) of €2.3million) Ebola virus immunity and immune responses in cases where infection was ebokon_strengthening_ebola_researc pathogenesis fatal. Mouse models in which the virus can replicate h/ will be used to help investigate these questions. This project is in collaboration with the Heinrich Pette Institute in Hamburg. ebola viruses (EBOVs) are NIAID category A priority pathogens that cause severe viral hemorrhagic fever. A critical research task is to define how the molecular interactions between A novel inhibitor of http://projectreporter.nih.gov/project_i 01/12/2014, 12 ICAHN School of Medicine at filoviruses and the human host trigger life- US NIH/NIAID $432,835 interferon and oxidative Basic science nfo_description.cfm?aid=8769134&ic month duration Mount Sinai threatening infections. Defining such interactions will stress signalling shed light on the triggers of viral hemorrhagic fever de=23418087 and will facilitate prophylactic and therapeutic interventions for this frequently lethal syndrome. We hypothesize that evasion of host innate defenses, ebolaparticularly viruses interferon are among (IFN)-??? the most responses, lethal human is critical pathogens with mortality rates approaching 90% for the Zaire subtype. They are also a potential bioterrorism agent. ebola virus infection causes a Interactions of Ebola virus http://projectreporter.nih.gov/project_i 1/05/2010, 5 year severe hemorrhagic disease in humans for which US NIH/NIAID $410,485 glycoproteins with host Basic science University of Pennsylvania nfo_description.cfm?aid=8653523&ic duration there are no therapeutic treatments nor protective cells vaccines currently available. For these de=23418087 reasons, ebola virus is classified as a "category A priority pathogen" by NIH. Expressed on the virus and infected cell surface, the ebolaglycoproteins Wefacilitate reviewed entry availableof the virus epidemiologic, into host cells clinical, and also and laboratory records of patients in whom EVD was diagnosed between May 25 and June 18, 2014. The incubation period and case fatality rate among Protective and Pathogenic patients with EVD in Sierra Leone are similar to B Cell Epitope August 2009; 6 http://www.nejm.org/doi/full/10.1056/N US NIH/NIAID B Cell Epitopes in human Pre-clinical Tulane University those