Official Publication of the National Lipid Association translate LipidSpin verb 1. to explain something in a way that is easier to understand 2. to change words from one language into another language Evaluating Published Clinical Trials and Translating Them into Practice Also in this issue: Translating Clinical Trial Evidence into Practical Medicine Guidelines for the Guidelines — Impact and Controversies This issue sponsored by the Southeast Lipid Association Volume 13 Issue 1 Winter 2015 visit www.lipid.org SPRING CLINICAL LIPID UPDATE REGISTER NOW! 2015 FEBRUARY 27–MARCH 1, 2015 DENVER, CO NATIONAL LIPID ASSOCIATION Hosted by the Pacic and Southwest Chapters ACHIEVING NEW HEIGHTS IN Keynote Address LIPID MANAGEMENT Working Together to Prevent One Million Heart Attacks and Strokes Janet Wright, MD Clinical Lipid Update Friday, February 27 at 4:00 PM February 27–March 1, 2015 Featured Presentations ApoB in Risk Assessment and the Diagnosis Professional Development Courses and Treatment of the Atherogenic Dyslipoproteinemias February 26–27, 2015 Allan D. Sniderman, MD Sunday, March 1 at 9:00 AM Understanding the Molecular Biology of Atherosclerosis: The Future of Prevention and Intervention in Heart Disease Paul N. Hopkins, MD, MSPH Saturday, February 28 at 10:30 AM NATIONAL LIPID ASSOCIATION The ApoC-III Story: Hypertriglyceridemia, Atherogenesis, and Therapeutic Inhibition Frank M. Sacks, MD lipid.org/springclu Saturday, February 28 at 1:45 PM In This Issue: Winter 2015 (Volume 13, Issue 1) Editors 2 From the NLA President JAMES A. UNDERBERG, MD, MS, FACPM, FACP, FNLA* Full Speed Ahead Clinical Assistant Professor of Medicine —Terry A. Jacobson, MD, FACP, FNLA NYU School of Medicine & NYU Center for Prevention of Cardiovascular Disease Director Bellevue Hospital Lipid Clinic 5 From the SELA President Look for the NLA Community logo to discuss New York, NY Researching Progress articles online at www.lipid.org ROBERT A. WILD, MD, PhD, MPH, FNLA* —Lori A. Alexander, MSHS, RD, CCRC, FNLA Clinical Epidemiology and Biostatistics and Clinical Lipidology Professor Oklahoma University Health Sciences Center 6 Letter from the LipidSpin Editors 25 Case Study Oklahoma City, OK Holiday Gifts Applying Clinical Trial Data to Patient —James A. Underberg, MD, MS, FACPM, FACP, Managing Editor Management: A Case Study MELISSA HEYBOER FNLA —Paul Ziajka, MD, PhD, FNLA National Lipid Association Executive Director 7 Clinical Feature 27 Chapter Update CHRISTOPHER R. SEYMOUR, MBA National Lipid Association Translating Clinical Trial Evidence into Contributing to the NLA Mission Practical Medicine —Lori A. Alexander, MSHS, RD, CCRC, FNLA Contributing Editor —Ralph Vicari, MD, FACC, FNLA KEVIN C. MAKI, PhD, CLS, FNLA 29 Member Spotlight Associate Editor for Patient Education 11 Guest Editorial Deborah S. Croy, NP, DNP, RN, VANESSA L. MILNE, MS, NP, CLS Cardiac Vascular Nurse and Family Nurse Practitioner Guidelines for the Guidelines — ANP-BC, AGPCNP-BC, CLS, AACC Bellevue Hospital Lipid Clinic Impact and Controversies New York, NY —Kahlid H. Sheikh, MD, MBA, FACC, FNLA 31 Education, News and Notes LipidSpin is published quarterly by the National Lipid Association 14 EBM Tools for Practice 33 Events Calendar 6816 Southpoint Parkway, Suite 1000 Clinical Trials of Alternative Medicine: Jacksonville, FL 32216 Phone: 904-998-0854 | Fax: 904-998-0855 Testing Whether Magic Works 34 Foundation Update —Gregory S. Pokrywka, MD, FACP, NCMP, FNLA Copyright ©2015 by the NLA. All rights reserved. 35 References Lipid Luminations Visit us on the web at www.lipid.org. 16 HPS2-THRIVE Commentary 37 Patient Tear Sheet The National Lipid Association makes every effort to —Dave Dixon, PharmD, BCPS, CDE, AACC, FNLA provide accurate information in the LipidSpin at the —Evan Sisson, PharmD, MSHA, CDE, FAADE time of publication; however, circumstances may alter certain details, such as dates or locations of events. Any changes will be denoted as soon as possible. 18 Specialty Corner The NLA invites members and guest authors to provide scientific and medical opinion, which do not Physical Activity and Lipid Disorders: necessarily reflect the policy of the Association. Circa 2014 —Ralph LaForge, MSc, CLS, FNLA Clarification: In the Practical Pearls article titled “Lowering Triglycerides with Omega-3 Fatty Acids” from the Fall 2014 issue, the word “supplements” 22 Practical Pearls should have been used rather than “OTC.” Selection of Dyslipidemia Guidelines in Special Populations *indicates ABCL Diplomate status —Pamela Morris, MD, FACC, FACP, FACPM, FAHA, FNLA Official Publication of the National Lipid Association 1 From the NLA President: Full Speed Ahead TERRY A. JACOBSON, MD, FACP, FAHA, FNLA National Lipid Association President Professor of Medicine, Emory University Atlanta, GA Director, Lipid Clinic and Cardiovascular Risk Reduction Program Diplomate, American Board of Clinical Lipidology It also reaffirms the importance of lower Recommendations. Janet S. Wright, MD, cholesterol goals and targets consistent will be presenting the Keynote Address with the 2012 Cholesterol Treatment “Working Together to Prevent One Million Discuss this article at Trialist’s (CTT) meta-analysis of all statin Heart Attacks and Strokes.” She will be www.lipid.org/lipidspin clinical trials. speaking about the Million Hearts initiative and how we can all work together to Greetings, National Lipid Association As a result of requests by many NLA prevent an additional one million heart members! I hope this holiday season members, the NLA leadership has attacks and strokes. The full program, has been a joyous one. As we look back recently posted a slide set comparing including those talks centered on the on 2014, we can reflect on the many the ACC/AHA Guidelines with the NLA Recommendations and the ACC/AHA accomplishments the NLA has put forth. NLA Recommendations. The new slide guidelines, can be viewed online at And, as we look toward the New Year, we presentation — created in large part by lipid.org/springclu. are encouraged for what’s to come — both Carl Orringer, MD, FNLA, and reviewed by for the NLA as a whole and for the field of an NLA Recommendations Review Panel — The Midwest Lipid Association will clinical lipidology. compares and contrasts the perspectives be hosting the 2015 Annual Scientific provided by the ACC/AHA Guidelines and Sessions June 11–14, 2015, in Chicago. Most recently, I had the opportunity to the NLA Recommendations. You can find This is a great opportunity to submit your attend the American Heart Association’s the slide set by visiting, abstracts to be included in the poster hall. Annual Scientific Sessions in Chicago lipid.org/recommendations. All accepted abstracts will be published in November, where the results of the in the Annual Scientific Sessions edition IMPROVE-IT Trial were presented. I was In addition, you will want to make sure of the Journal of Clinical Lipidology (JCL) very excited to hear the results, and as I to attend the NLA Spring Clinical Lipid and up to five abstracts will be selected hoped, the outcome reaffirms the NLA’s Update (CLU) — sponsored by the to be presented during the oral abstract Part 1 Recommendations for the Patient- Pacific Lipid Association and Southwest presentation session during the annual Centered Management of Dyslipidemia. Lipid Association — Feb. 27– March 1, meeting. The study also refocuses the emphasis 2015, in Denver. One of the sessions back to the importance of reducing all will focus on the controversies in clinical I especially urge all Young Investigators (in atherogenic lipoprotein particles, and lipid management, with presentations on training students, residents, and fellows supports our position that lower is better. the ACC/AHA Guidelines and the NLA or members in practice for less than five 2 LipidSpin years) to submit an abstract. As lead their science published in the JCL. Also, author of an accepted abstract, Young lets get to see and acknowledge those Investigators also will have the chance to NLA members who are providing effective compete for the NLA’s enhanced Young mentorship of Young Investigators and Investigator Award. Cash prizes of $1,000 supporting the development of future and $500 along with additional travel lipidologists. The submission deadline for grants will be awarded to the top three all abstracts is Feb. 23, 2015. For more finalists. The award winners will receive information, or to submit your abstract, recognition at a special ceremony during visit lipid.org/abstracts. the Annual Scientific Sessions. In addition, the first place winner will be selected We hope to see you at our upcoming to present his or her abstract during the meetings and appreciate your continued live abstract session and have the poster support of the NLA and the field of clinical published in the LipidSpin following the lipidology. meeting. Also, all Young Investigator lead authors with accepted abstracts will Happy New Year! n receive complimentary registration to the Scientific Sessions. In addition, 4th and 5th place awardees will receive travel grants to get to and from the meeting. Make sure to inform any resident, fellow, or in-practice member of this great opportunity to get A Series of Programs Focused on the Field of Lipidology. TUNE IN TO THE LIPID LUMINATIONS SERIES ON REACHMD.COM • Recent advances in lipid management and heart disease • Scientific and clinical research updates • New treatment options On-air On-the-go • Best practices in patient care Online Mobile Phone Broadcast on Applications