PL Detail-Document #290305 −This PL Detail-Document gives subscribers additional insight related to the Recommendations published in− PHARMACIST’S LETTER / PRESCRIBER’S LETTER March 2013 Comparison of Oral Contraceptives and Non-Oral Alternatives —More information about the use of contraceptives is available in our PL Detail-Document, Hormonal Contraception— Productsa Manufacturerb Estrogen Progestin LOW-DOSE MONOPHASIC PILLS Aviane-28 Teva EE 20 mcg Levonorgestrel 0.1 mg Falmina Novast Lessina Teva Lutera Actavis Orsythia Qualitest Sronyx Actavis Gildess Fe 1/20 Qualitest EE 20 mcg Norethindrone acetate Junel 1/20 Teva 1 mg Junel Fe 1/20 Teva Loestrin-21 1/20 Warner Chilcott/Teva Loestrin Fe 1/20 Warner Chilcott/Teva Microgestin 1/20 Actavis Microgestin Fe 1/20 Actavis Generess Fe chewable Actavis EE 25 mcg Norethindrone 0.8 mg Altavera Sandoz EE 30 mcg Levonorgestrel 0.15 mg Kurvelo Lupin Levora Actavis Marlissa Glenmark Nordette-28 Duramed/Teva Portia-28 Teva Cryselle-28 Teva EE 30 mcg Norgestrel 0.3 mg Elinest Novast Low-Ogestrel-21 Actavis Low-Ogestrel-28 Actavis Lo/Ovral-28 Wyeth Gildess Fe 1.5/30 Qualitest EE 30 mcg Norethindrone acetate Junel 1.5/30 Teva 1.5 mg Junel Fe 1.5/30 Teva Loestrin 1.5/30-21 Warner Chilcott/Teva Loestrin Fe 1.5/30 Warner Chilcott/Teva Microgestin 1.5/30 Actavis Microgestin Fe 1.5/30 Actavis More. Copyright © 2013 by Therapeutic Research Center 3120 W. March Lane, Stockton, CA 95219 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 www.PharmacistsLetter.com ~ www.PrescribersLetter.com ~ www.PharmacyTechniciansLetter.com (PL Detail-Document #290305: Page 2 of 7) Productsa Manufacturerb Estrogen Progestin LOW-DOSE MONOPHASIC PILLS (cont.) Apri Teva EE 30 mcg Desogestrel 0.15 mg Desogen Organon Emoquette Qualitest Ortho-Cept Ortho Reclipsen Actavis Solia Prasco levonorgestrel/ethinyl Lupin EE 30 mcg Drospirenone 3 mg estradiol Ocella Teva Safyralc Bayer Syeda Sandoz Zarah Actavis Yasmin Bayer Kelnor 1/35 Teva EE 35 mcg Ethynodiol diacetate Zovia 1/35 Actavis 1 mg Estarylla Sandoz EE 35 mcg Norgestimate 0.25 mg Mono-Linyah Novast MonoNessa Actavis Norgestimate/ethinyl Glenmark estradiol Ortho-Cyclen-28 Ortho Previfem Qualitest Sprintec Teva Necon 1/50 Actavis Mestranol 50 mcg Norethindrone 1 mg Norinyl 1+50 Actavis Balziva Teva EE 35 mcg Norethindrone 0.4 mg; Briellyn Glenmark total of 8.4 mg/cycle.1 Femcon Fe chewable Warner Chilcott Gildagia Qualitest Ovcon-35 Warner Chilcott Philith Novast Vyfemla Lupin Zenchent Actavis Zeosa chewable Teva Brevicon-28 Actavis EE 35 mcg Norethindrone 0.5 mg; Modicon-28 Ortho total of 10.5 mg/cycle. Necon 0.5/35 Actavis Nortrel 0.5/35 Teva Wera Novast Alyacen 1/35 Glenmark EE 35 mcg Norethindrone 1 mg; Cyclafem 1/35 Qualitest total of 21 mg/cycle.1 Dasetta 1/35 Novast Necon 1/35-28 Actavis Norinyl 1+35-28 Actavis Nortrel 1/35-28 Teva Ortho-Novum 1/35-28 Ortho More. Copyright © 2013 by Therapeutic Research Center 3120 W. March Lane, Stockton, CA 95219 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 www.PharmacistsLetter.com ~ www.PrescribersLetter.com ~ www.PharmacyTechniciansLetter.com (PL Detail-Document #290305: Page 3 of 7) Productsa Manufacturerb Estrogen Progestin HIGH-DOSE MONOPHASIC PILLS Ovcon-50 Warner Chilcott EE 50 mcg Norethindrone 1 mg Ogestrel 0.5/50-28 Actavis EE 50 mcg Norgestrel 0.5 mg Zovia 1/50-28 Actavis EE 50 mcg Ethynodiol diacetate 1 mg BIPHASIC PILLS Azurette Actavis EE 20 mcg x 21 days, Desogestrel Kariva Teva placebo x 2 days, 10 mcg 0.15 mg x 21 days Mircette Teva x 5 days. Viorele Glenmark Necon 10/11 Actavis EE 35 mcg Norethindrone 0.5 mg x 10 days, 1 mg x 11 days. TRIPHASIC PILLS Estrostep Fe Warner Chilcott EE 20 mcg x 5 days, Norethindrone acetate Tilia Actavis 30 mcg x 7 days, 35 mcg 1 mg x 21 days Tilia Fe Actavis x 9 days Tri-Legest Fe Teva Norgestimate/ethinyl Lupin EE 25 mcg x 21 days Norgestimate estradiol 0.18 mg x 7 days, Ortho Tri-Cyclen Lo Ortho 0.215 mg x 7 days, Tri Lo Sprintec Actavis 0.25 mg x 7 days. Caziant Actavis EE 25 mcg x 21 days Desogestrel Cesia Prasco 0.1 mg x 7 days, Cyclessa Schering-Plough 0.125 mg x 7 days, Velivet Teva 0.15 mg x 7 days. Enpresse Teva EE 30 mcg x 6 days, Levonorgestrel Levonest Novast 40 mcg x 5 days, 30 mcg 0.05 mg x 6 days, Myzilra Qualitest x 10 days. 0.075 mg x 5 days, Trivora Actavis 0.125 mg x 10 days. Total of 1.925 mg/cycle.1 Ortho Tri-Cyclen Ortho EE 35 mcg x 21 days Norgestimate Tri-Estarylla Sandoz 0.18 mg x 7 days, Tri-Linyah Novast 0.215 mg x 7 days, TriNessa Actavis 0.25 mg x 7 days. Tri-Previfem Qualitest Tri-Sprintec Teva Aranelle Teva EE 35 mcg x 21 days Norethindrone Leena Actavis 0.5 mg x 7 days, Tri-Norinyl Actavis 1 mg x 9 days, 0.5 mg x 5 days. Total of 15 mg/cycle.1 Alyacen 7/7/7 Glenmark EE 35 mcg x 21 days Norethindrone Cyclafem 7/7/7 Qualitest 0.5 mg x 7 days, Dasetta 7/7/7 Novast 0.75 mg x 7 days, Nortrel 7/7/7 Teva 1 mg x 7 days. Necon 7/7/7 Actavis Total of 15.75 mg/cycle.1 Ortho-Novum 7/7/7 Ortho More. Copyright © 2013 by Therapeutic Research Center 3120 W. March Lane, Stockton, CA 95219 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 www.PharmacistsLetter.com ~ www.PrescribersLetter.com ~ www.PharmacyTechniciansLetter.com (PL Detail-Document #290305: Page 4 of 7) Productsa Manufacturerb Estrogen Progestin FOUR-PHASIC Natazia Bayer Estradiol valerate 3 mg x Dienogest 2 days, then 2 mg x 22 none x 2 days, then days, then 1 mg x 2 days, 2 mg x 5 days, then then 2-day pill-free 3 mg x 17 days, then interval. none x 4 days EXTENDED-CYCLE PILLS Lo Loestrin Fe Warner Chilcott EE 10 mcg x 26 days Norethindrone acetate Lo Minastrin Fe chewable Warner Chilcott 1 mg x 24 days Loestrin 24 Fe discontinued Warner Chilcott EE 20 mcg x 24 days Norethindrone acetate Minastrin 24 Fe chewable Warner Chilcott 1 mg x 24 days Amethia Lo Actavis EE 20 mcg x 84 days, Levonorgestrel Ethinyl Lupin 10 mcg x 7 days. 0.1 mg x 84 days estradiol/levonorgestrel LoSeasonique Teva Introvale Sandoz EE 30 mcg x 84 days Levonorgestrel Jolessa Teva 0.15 mg x 84 days Levonorgestrel/ethinyl Lupin estradiol Quasense Actavis Seasonale Teva Amethia Actavis EE 30 mcg x 84 days, Levonorgestrel Seasonique Teva 10 mcg x 7 days. 0.15 mg x 84 days Quartette Teva EE 20 mcg x 42 days, Levonorgestrel 25 mcg x 21 days, 0.15 mg x 84 days 30 mcg x 21 days, then 10 mcg x 7 days Beyazc Bayer EE 20 mcg x 24 days Drospirenone Gianvi Teva 3 mg x 24 days Loryna Sandoz Vestura Actavis Yaz Bayer CONTINUOUS-CYCLE PILLS Amethyst Actavis EE 20 mcg Levonorgestrel 90 mcg (No pill-free interval) PROGESTIN-ONLY PILLSd - “Mini-pill” Camila Teva Not applicable Norethindrone 0.35 mg Errin Teva Heather Glenmark Jolivette Actavis Micronor Ortho Nor-QD Actavis Nora-BE Actavis More. Copyright © 2013 by Therapeutic Research Center 3120 W. March Lane, Stockton, CA 95219 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 www.PharmacistsLetter.com ~ www.PrescribersLetter.com ~ www.PharmacyTechniciansLetter.com (PL Detail-Document #290305: Page 5 of 7) Productsa Manufacturerb Estrogen Progestin EMERGENCY CONTRACEPTION Ella Actavis Not applicable Ulipristal 30 mg tablet (progesterone receptor modulator) Levonorgestrel Perrigo R and D Not applicable Levonorgestrel Next Choice Actavis 0.75 mg tablets x 2 Plan B Teva (separated by 12 hours) Next Choice One Dose Actavis Not applicable Levonorgestrel Plan B One-Step Teva 1.5 mg tablet x 1 Abbreviations: EE = ethinyl estradiol; IUS = intrauterine system HORMONAL ALTERNATIVES TO ORAL CONTRACEPTION Brand Name Manufacturer Estrogen Progestin Dose/Route Depo-Provera CI Pfizer None Medroxyprogesterone Medroxyprogesterone Sicor acetate 150 mg Acetate Injection3,d Intramuscular (IM) injection in the gluteal or deltoid muscle once every 3 months (13 weeks) Depo-subQ Provera 1044,d,e Pfizer None Medroxyprogesterone acetate 104 mg 0.65 mL (104 mg) subcutaneous (SC) injection into the anterior thigh or abdomen, once every 3 months (12-14 weeks) Mirena6,d,g Bayer None Levonorgestrel 20 mcg/day (IUS) for up to 5 years Nexplanon5,d,f Schering-Plough None Etonogestrel (release rate varies over Implanted subdermally just time) for up to 3 years under the skin at the inner side of the non-dominant arm NuvaRing7 Schering-Plough Ethinyl estradiol Etonogestrel (active form 15 mcg/day of desogestrel) Vaginal ring inserted and left 0.12 mg/day in for 3 weeks and removed for 1 week Ortho Evra9,h,i Ortho Ethinyl estradiol Norelgestromin (active 35 mcg/day form of norgestimate) Transdermal patch applied 200 mcg/day weekly (for 3 weeks, then week 4 is patch-free) Skyla8,d Bayer None Levonorgestrel 14 mcg/day (IUS) (after first 24 days of insertion) for up to 3 years More. Copyright © 2013 by Therapeutic Research Center 3120 W. March Lane, Stockton, CA 95219 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 www.PharmacistsLetter.com ~ www.PrescribersLetter.com ~ www.PharmacyTechniciansLetter.com (PL Detail-Document #290305: Page 6 of 7) a. This grouping is not an indication of therapeutic equivalence for purposes of substitution as defined by the FDA’s Orange Book.