Supplemental Table 2: UC vs. NL gene list Gene Name Symbol Entrez UC vs. Gene NL fold ID change solute carrier family 6 (amino acid transporter), member 14 SLC6A14 11254 79.97 dual oxidase 2 DUOX2 50506 73.48 matrix metallopeptidase 1 (interstitial collagenase) MMP1 4312 65.16 matrix metallopeptidase 3 (stromelysin 1, progelatinase) MMP3 4314 60.20 matrix metallopeptidase 10 (stromelysin 2) MMP10 4319 40.71 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein CXCL6 6372 36.11 2) matrix metallopeptidase 12 (macrophage elastase) MMP12 4321 35.94 carboxypeptidase A3 (mast cell) CPA3 1359 33.94 chemokine (C-X-C motif) ligand 5 CXCL5 6374 30.84 cholesterol 25-hydroxylase CH25H 9023 28.08 myeloid cell nuclear differentiation antigen MNDA 4332 24.66 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating CXCL1 2919 22.55 activity, alpha) tryptophan 2,3-dioxygenase TDO2 6999 21.66 chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1 1116 20.78 S100 calcium binding protein A8 S100A8 6279 19.81 cysteine-rich, angiogenic inducer, 61 CYR61 3491 19.71 carboxypeptidase, vitellogenic-like CPVL 54504 18.77 matrix metallopeptidase 7 (matrilysin, uterine) MMP7 4316 16.92 collagen triple helix repeat containing 1 CTHRC1 115908 15.47 proprotein convertase subtilisin/kexin type 1 PCSK1 5122 15.26 hemoglobin, beta HBB 3043 13.55 chemokine (C-C motif) ligand 2 CCL2 6347 13.44 lumican LUM 4060 13.43 tenascin C (hexabrachion) TNC 3371 12.19 dual oxidase maturation factor 2 DUOXA2 405753 12.07 TNFAIP3 interacting protein 3 TNIP3 79931 11.96 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) AGT 183 11.94 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce PDE4B 5142 11.64 homolog, Drosophila) chemokine (C-X-C motif) ligand 9 CXCL9 4283 11.25 chemokine (C-X-C motif) ligand 11 CXCL11 6373 11.12 toll-like receptor 1 TLR1 7096 11.05 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase PTGS2 5743 10.93 and cyclooxygenase) annexin A1 ANXA1 301 10.78 wingless-type MMTV integration site family, member 5A WNT5A 7474 10.69 TIMP metallopeptidase inhibitor 1 TIMP1 7076 10.65 transmembrane protein 158 TMEM15 25907 10.55 8 cadherin 11, type 2, OB-cadherin (osteoblast) CDH11 1009 10.53 serine peptidase inhibitor, Kazal type 4 SPINK4 27290 10.32 interleukin 8 IL8 3576 10.30 tissue factor pathway inhibitor 2 TFPI2 7980 10.24 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide FCER1G 2207 10.14 complement component 4 binding protein, alpha C4BPA 722 10.12 purinergic receptor P2Y, G-protein coupled, 13 P2RY13 53829 10.01 hypothetical protein LOC441168 - 441168 9.99 complement component 4 binding protein, beta C4BPB 725 9.79 similar to omega protein - 91353 9.78 prokineticin 2 PROK2 60675 9.72 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 CHST2 9435 9.65 chemokine (C-C motif) ligand 11 CCL11 6356 9.25 transmembrane protein 45A TMEM45 55076 9.05 A similar to RIKEN cDNA 2310016C16 - 493869 8.84 tumor necrosis factor receptor superfamily, member 17 TNFRSF1 608 8.75 7 ectonucleoside triphosphate diphosphohydrolase 1 ENTPD1 953 8.56 nitric oxide synthase 2A (inducible, hepatocytes) NOS2A 4843 8.55 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) FCGR3B 2215 8.46 KIAA0125 KIAA012 9834 8.34 5 C-type lectin domain family 4, member A CLEC4A 50856 7.97 coagulation factor II (thrombin) receptor F2R 2149 7.89 sulfatase 1 SULF1 23213 7.84 SLAM family member 7 SLAMF7 57823 7.79 likely ortholog of mouse neighbor of Punc E11 - 57722 7.78 chemokine (C-X-C motif) ligand 3 CXCL3 2921 7.67 collagen, type VI, alpha 3 COL6A3 1293 7.63 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KIT 3815 7.61 guanylate binding protein 5 GBP5 115362 7.59 vanin 1 VNN1 8876 7.58 chondroitin sulfate proteoglycan 2 (versican) CSPG2 1462 7.42 pim-2 oncogene PIM2 11040 7.31 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, NCF2 4688 7.27 autosomal 2) plasminogen activator, urokinase PLAU 5328 7.25 complement component 1, s subcomponent C1S 716 7.25 indoleamine-pyrrole 2,3 dioxygenase INDO 3620 7.16 chemokine (C-X3-C motif) receptor 1 CX3CR1 1524 7.12 complement component 4A (Rodgers blood group) C4A 720 7.06 complement component 4B (Childo blood group) C4B 721 7.06 complement component 1, q subcomponent, B chain C1QB 713 7.03 phosphoserine aminotransferase 1 PSAT1 29968 6.97 FK506 binding protein 11, 19 kDa FKBP11 51303 6.97 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte LCP2 3937 6.84 protein of 76kDa) chemokine (C-X-C motif) ligand 2 CXCL2 2920 6.84 protein C receptor, endothelial (EPCR) PROCR 10544 6.83 stress 70 protein chaperone, microsome-associated, 60kDa STCH 6782 6.83 regulator of G-protein signalling 18 RGS18 64407 6.82 IKK interacting protein - 121457 6.80 tumor suppressor candidate 3 TUSC3 7991 6.77 retinoic acid induced 2 RAI2 10742 6.77 major histocompatibility complex, class II, DP alpha 1 HLA- 3113 6.65 DPA1 chromosome 20 open reading frame 100 C20orf10 84969 6.63 0 interleukin 10 receptor, alpha IL10RA 3587 6.56 transforming growth factor, beta-induced, 68kDa TGFBI 7045 6.53 chemokine (C-X-C motif) ligand 10 CXCL10 3627 6.43 lysyl oxidase-like 1 LOXL1 4016 6.31 insulin receptor substrate 1 IRS1 3667 6.31 lymphocyte transmembrane adaptor 1 LAX1 54900 6.24 PDZK1 interacting protein 1 PDZK1IP 10158 6.21 1 hyaluronan synthase 2 HAS2 3037 6.13 immunoglobulin superfamily, member 6 IGSF6 10261 6.05 cat eye syndrome chromosome region, candidate 1 CECR1 51816 6.02 zinc finger protein, multitype 2 ZFPM2 23414 6.01 RAB31, member RAS oncogene family RAB31 11031 5.93 acyl-CoA synthetase long-chain family member 4 ACSL4 2182 5.91 B cell RAG associated protein - 51363 5.91 hemoglobin, alpha 1 HBA1 3039 5.88 adenomatosis polyposis coli down-regulated 1 APCDD1 147495 5.87 proapoptotic caspase adaptor protein - 51237 5.86 cathepsin K (pycnodysostosis) CTSK 1513 5.79 CD38 molecule CD38 952 5.76 latrophilin 2 LPHN2 23266 5.76 major histocompatibility complex, class II, DR alpha HLA- 3122 5.71 DRA apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like APOBEC 60489 5.69 3G 3G complement component 1, r subcomponent C1R 715 5.68 SEC24 related gene family, member D (S. cerevisiae) SEC24D 9871 5.63 ADP-ribosylation factor GTPase activating protein 3 ARFGAP 26286 5.60 3 interleukin 1, beta IL1B 3553 5.55 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) GNA15 2769 5.52 dual specificity phosphatase 4 DUSP4 1846 5.50 mesenchyme homeobox 1 MEOX1 4222 5.50 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) ITGB2 3689 5.50 phospholipase A1 member A PLA1A 51365 5.45 fibrillin 1 FBN1 2200 5.44 lipoma HMGIC fusion partner LHFP 10186 5.40 collagen, type V, alpha 2 COL5A2 1290 5.38 chemokine orphan receptor 1 CMKOR1 57007 5.35 vascular endothelial growth factor C VEGFC 7424 5.35 cathepsin C CTSC 1075 5.34 protein kinase, cAMP-dependent, regulatory, type II, beta PRKAR2 5577 5.34 B calcitonin receptor-like CALCRL 10203 5.32 hemoglobin, alpha 2 HBA2 3040 5.25 G protein-coupled receptor 109B GPR109B 8843 5.24 complement factor I CFI 3426 5.24 elongation factor, RNA polymerase II, 2 ELL2 22936 5.21 epithelial membrane protein 3 EMP3 2014 5.17 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa MMP2 4313 5.13 type IV collagenase) tumor necrosis factor (ligand) superfamily, member 13b TNFSF13 10673 5.09 B guanine nucleotide binding protein (G protein), alpha 14 GNA14 9630 5.02 interleukin 8 receptor, beta IL8RB 3579 5.01 pleckstrin homology-like domain, family A, member 1 PHLDA1 22822 4.95 collagen, type I, alpha 2 COL1A2 1278 4.91 procollagen C-endopeptidase enhancer PCOLCE 5118 4.89 matrix-remodelling associated 5 MXRA5 25878 4.86 RAB38, member RAS oncogene family RAB38 23682 4.86 G protein-coupled receptor 137B GPR137B 7107 4.84 S100 calcium binding protein P S100P 6286 4.82 annexin A3 ANXA3 306 4.79 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, SERPING 710 4.76 (angioedema, hereditary) 1 CD74 molecule, major histocompatibility complex, class II invariant CD74 972 4.76 chain family with sequence similarity 46, member C FAM46C 54855 4.74 damage-regulated autophagy modulator - 55332 4.74 tyrosinase-related protein 1 TYRP1 7306 4.72 CD86 molecule CD86 942 4.71 BCL2-associated athanogene 2 BAG2 9532 4.71 PALM2-AKAP2 protein - 445815 4.70 A kinase (PRKA) anchor protein 2 AKAP2 11217 4.70 transmembrane protein 23 TMEM23 259230 4.68 Rho guanine nucleotide exchange factor (GEF) 3 ARHGEF 50650 4.68 3 caspase recruitment domain family, member 6 CARD6 84674 4.66 bone morphogenetic protein 6 BMP6 654 4.64 interferon, gamma-inducible protein 30 IFI30 10437 4.60 oncostatin M receptor OSMR 9180 4.56 cadherin 13, H-cadherin (heart) CDH13 1012 4.55 toll-like receptor 8 TLR8 51311 4.55 colony stimulating factor 1 receptor, formerly McDonough feline CSF1R 1436 4.51 sarcoma viral (v-fms) oncogene homolog Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog FGR 2268 4.45 interleukin 2 receptor, beta IL2RB 3560 4.44 adrenomedullin ADM 133 4.43 caldesmon 1 CALD1 800 4.37 dedicator of cytokinesis 4 DOCK4 9732 4.32 lipocalin 2 (oncogene 24p3) LCN2 3934 4.31 BH-protocadherin (brain-heart) PCDH7 5099 4.31 NAD(P)H dehydrogenase, quinone 2 NQO2 4835 4.30 degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) DEGS1 8560 4.30 SLAM family member 8 SLAMF8 56833 4.27 ADAM metallopeptidase with thrombospondin type 1 motif, 1 ADAMTS 9510 4.27 1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, COL3A1 1281 4.24 autosomal dominant) major histocompatibility complex, class II, DQ beta 1 HLA- 3119 4.20 DQB1 SEC14 and spectrin domains 1 SESTD1 91404 4.20 caspase recruitment domain family, member 15 CARD15 64127 4.19 thioredoxin domain containing 5 TXNDC5 81567 4.16 ERO1-like beta (S.