(19) TZZ Z_T (11) EP 2 588 067 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 8/19 (2006.01) A61K 8/21 (2006.01) 26.10.2016 Bulletin 2016/43 A61K 8/27 (2006.01) A61K 8/44 (2006.01) A61K 8/66 (2006.01) A61K 8/67 (2006.01) (2006.01) (2006.01) (21) Application number: 11711963.6 A61K 8/97 A61Q 11/00 A61K 8/34 (2006.01) (22) Date of filing: 22.03.2011 (86) International application number: PCT/GB2011/000399 (87) International publication number: WO 2012/001337 (05.01.2012 Gazette 2012/01) (54) COMPOSITION FOR DENTAL HEALTH ZUSAMMENSETZUNG FÜR MUNDGESUNDHEIT COMPOSITION POUR SOIN BUCCAL (84) Designated Contracting States: WO-A2-2009/043588 US-A1- 2005 079 140 AL AT BE BG CH CY CZ DE DK EE ES FI FR GB US-A1- 2007 053 849 US-A1- 2007 122 362 GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO US-A1- 2007 231 277 US-B1- 6 372 198 PL PT RO RS SE SI SK SM TR • DATABASE WPI Week 200164 Thomson (30) Priority: 01.07.2010 GB 201011074 Scientific, London, GB; AN 2001-569531 XP002661799, & KR 2001 0028609 A (OH S G) 6 (43) Date of publication of application: April 2001 (2001-04-06) 08.05.2013 Bulletin 2013/19 • DATABASE WPI Week 200961 Thomson Scientific, London, GB; AN 2009-M94126 (73) Proprietors: XP002661800, &CN 101 502 482 A (YUXI JIANKUN • Taylor, Robert Peter BIOLOGICAL PHARM CO LTD) 12 August 2009 Little Venice (2009-08-12) London W9 1AH (GB) • MATIVANDLELA S P N ET AL: "ANTIMICROBIAL • LALVANI, Tej ACTIVITY OF PELARGONIUM SIDOIDES", London W1G 9YA (GB) SOUTH AFRICAN JOURNAL OF BOTANY - • SHELATKAR, Rohit SUID-AFRIKAANS TYDSKRIFT Maida Vale VIRPLANTKUNDE, FOUNDATION FOR London W9 3SP (GB) EDUCATION, SCIENCE AND TECHNOLOGY, PRETORIA, SA, vol. 70, no. 2, 1 May 2004 (72) Inventors: (2004-05-01), page 344, XP009074186, ISSN: • Taylor, Robert Peter 0254-6299 Little Venice • DATABASE GNPD MINTEL 10231717, 01 London W9 1AH (GB) September 2005 ’Antibacterial mouthwash’ • LALVANI, Tej • DATABASE GNPD [Online] MINTEL 03 March London W1G 9YA (GB) 2008 ’Toothpaste’ Database accession no. • SHELATKAR, Rohit 874992 Maida Vale • DATABASE GNPD [Online] MINTEL 01 London W9 3SP (GB) September 2008 ’Nano-whitening toothpaste’ Database accession no. 976003 (56) References cited: WO-A2-02/02128 WO-A2-2006/109344 Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 2 588 067 B1 Printed by Jouve, 75001 PARIS (FR) (Cont. next page) EP 2 588 067 B1 • DATABASE GNPD [Online] MINTEL 03 December 2007 ’All Natural Ester CoQ10 Tooth Gel’ Database accession no. 826739 2 1 EP 2 588 067 B1 2 Description flavoured toothpaste does exist, however, most are fla- voured and sweetened. Because sugar promotes growth TECHNICAL FIELD of bacteria that cause tooth decay, artificial sweeteners such as sorbitol or saccharin are generally used instead. [0001] This invention concerns a composition, com- 5 bined with standard constituents of toothpastes and Mouthwash mouthwashes for use in dental and oral hygiene, infec- tions and inflammations. [0007] Mouthwash (or mouth rinse) is a product used to enhance oral hygiene. Antiseptic and anti-plaque BACKGROUND ART 10 mouth rinse claims to kill the dental plaque causing dental caries, gingivitis, and bad breath. Anti-cavity mouth rinse Toothpaste uses fluoride to protect against tooth decay. However, the use of mouthwash does not eliminate the need for [0002] Toothpaste is a paste or gel dentifrice used with both brushing and flossing. a toothbrush as an accessory to clean and maintain the 15 [0008] Active ingredients in commercial brands of aesthetics and health of teeth. It aids in removing dental mouthwash can include thymol, eucalyptol, methylpa- plaque and food from the teeth, helps to eliminate or mask raben, hydrogen peroxide, domiphen bromide, fluoride, halitosis, and delivers active ingredients such as fluoride enzymes and calcium. Ingredients also include water, or xylitol in order to prevent tooth and gum disease (gin- sweeteners such as sorbitol, sucralose, sodium saccha- givitis). Most of the cleaning is done by the mechanical 20 rine, and xylitol, which doubles as a bacterial inhibitor. use of the toothbrush. Sometimes a significant amount of ethanol is added. [0003] Fluoride in various forms is the most popular Commercial mouthwashes usually contain a preserva- active ingredient in toothpaste. It is included in tooth- tive such as sodium benzoate and methylparaben to pre- pastes in order to prevent cavities. It occurs naturally in serve freshness once the container has been opened. small amounts in plants and animals. Sodium fluoride is 25 Many newer brands are alcohol free and contain odour the most common form of flouride used in toothpastes. elimination agents such as oxidizers to keep future bad Some brands of toothpaste use sodium monofluorophos- breath from developing. phate. Other ingredients are less commonly used, includ- ing Hydroxyapatite nanocrystals and calcium phosphate Oral hygiene products for remineralisation of teeth, and potassium nitrate to re- 30 duce sensitivity. Triclosan, which is an antibacterial [0009] The following are the formulations of commonly agent, is an active ingredient in some toothpastes, that used oral and dental hygiene products : is used to prevent gingivitis. [0004] In addition to fluoride, the other fundamental in- Sensodyne Multiaction with iso-active® technology gredient in most toothpastes is an abrasive. Abrasives 35 (general cleansing) - Active ingredients : Potassium in toothpaste reduce the time needed to remove plaque Nitrate 5% (for antihypersensitivity), Sodium fluoride from the teeth by half. Abrasives, like the dental polishing 0.15% w/v fluoride ion (for anticavity); Inactive agents used in dental surgeries, also cause a small ingredients : Water, sorbitol, glycerin, hydrated sili- amount of enamel erosion which is termed "polishing" ca, PEG-8, sodium methyl cocoyl taurate, isopen- action. Some brands contain powdered white mica,40 tane, flavor, cocamidopropyl betaine, xanthan gum, which acts as a mild abrasive, and adds a cosmetically carrageenan, sodium saccharin, sucralose, sodium pleasing glittery shimmer to the paste. Removal of plaque hydroxide, FD&C blue #1. and calculus prevents caries and periodontal disease. The polishing of teeth removes stains from tooth surfac- Sensodyne Multiaction with iso-active® technology es, but has not been shown to improve dental health be- 45 (general cleansing & whitening) - Active ingredients : yond the effects of the removal of plaque and calculus. Potassium Nitrate 5% (for anti -hypersensitivity), So- [0005] Many, though not all, toothpastes contain sodi- dium fluoride 0.15% w/v fluoride ion (for anticavity); um lauryl sulfate. It is largely a foaming agent although Inactive ingredients : Water, glycerin, sorbitol, hy- it also acts as a powerful antimicrobial. However, sodium drated silica, pentasodium triphosphate, PEG-8, iso- lauryl sulfate may cause a greater frequency of mouth 50 pentane, flavor, sodium methyl cocoyl taurate, co- ulcers in some people as it can dry out the protective camidopropyl betaine, xanthan gum carrageenan, layer of oral tissues causing the underlying tissues to sodium hydroxide, sodium saccharin, sucralose, FD become damaged. & C Blue, # 1. [0006] Toothpaste comes in a variety of colours and flavours. The more usual flavorings are some variation 55 Sensodyne Pronamel - Active ingredients : Potassi- on mint, spearmint, peppermint, and regular mint. More um nitrate 5% w/w, Sodium Fluoride (1450 ppm flu- exotic flavours include : anise, apricot, cinnamon, fennel, oride); Inactive ingredients : Water, glycerin, sorbi- lavender, neem, ginger, vanilla, lemon, orange, pine. Un- tol, hydrated silica, PEG-6, cocamidopropyl betaine, 3 3 EP 2 588 067 B1 4 xanthan gum carrageenan, sodium hydroxide, sodi- [0017] Arm and Hammer- advanced whitening - um saccharin, aroma, titanium dioxide, limonene, Ingredients : Sorbitol, Sodium Bicarbonate, Aqua, Hy- anise alcohol. drated Silica, Glycerin, Tetrasodium Pyrophosphate, Aroma, Sodium Lauroyl Sarcosinate, Sodium Saccharin, Sensodyne TOTAL CARE (gentle whitening) - Active 5 Cellulose Gum, Sodium Lauryl Sulfate, Limonene, CI ingredients : Potassium nitrate, Sodium Fluoride 77891. (1400 ppm fluoride); Inactive Ingredients : Water, [0018] Colgate- sensitive pro-relief - Ingredients : ar- glycerin, sorbitol, hydrated silica, pentasodium tri- ginine-8%, Hydrated silica, calcium carbonate, glycerin, phosphate, PEG-6, cocamidopropyl betaine, xan- water, bicarbonate, flavour, cellulose gum, sodium sac- than gum carrageenan, sodium hydroxide, sodium 10 charin, FD&C blue no. 1 (CI 42090). saccharin, aroma, titanium dioxide, sodium methyl [0019] Colgate -enamel protect - Ingredients : Aqua, cocoyl taurate. Sorbitol, Glycerin, Hydrated Silica, Potassium Nitrate, PEG-12, Sodium Lauryl Sulfate, Aroma, Cellulose Gum, [0010] Pearl Drops-replenishing white - Ingredients : Tetrasodium Pyrophosphate, Sodium Fluoride, Sodium Sodium Bicarbonate (Baking Soda), Glycerin, PEG-8, 15 Saccharin, Xanthan Gum, Eugenol, Limonene, CI 77891. Hydrated Silica, Silica, PEG/PPG-116/66 Copolymer, [0020] Colgate-cavity protection - Ingredients : Dical- Calcium Sulphate, Sodium Lauryl