The Enzyme List Class 2 — Transferases Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB) LATEX version prepared by Andrew McDonald, School of Biochemistry and Immunology, Trinity College Dublin, Ireland Generated from the ExplorEnz database, March 2019 © 2019 IUBMB Contents EC 2.1 Transferring one-carbon groups 2 EC 2.1.1 Methyltransferases................................................2 EC 2.1.2 Hydroxymethyl-, formyl- and related transferases................................ 87 EC 2.1.3 Carboxy- and carbamoyltransferases....................................... 90 EC 2.1.4 Amidinotransferases............................................... 93 EC 2.1.5 Methylenetransferases.............................................. 93 EC 2.2 Transferring aldehyde or ketonic groups 94 EC 2.2.1 Transketolases and transaldolases......................................... 94 EC 2.3 Acyltransferases 97 EC 2.3.1 Transferring groups other than aminoacyl groups................................ 97 EC 2.3.2 Aminoacyltransferases.............................................. 164 EC 2.3.3 Acyl groups converted into alkyl groups on transfer............................... 174 EC 2.4 Glycosyltransferases 178 EC 2.4.1 Hexosyltransferases................................................ 179 EC 2.4.2 Pentosyltransferases................................................ 273 EC 2.4.99 Transferring other glycosyl groups....................................... 288 EC 2.5 Transferring alkyl or aryl groups, other than methyl groups 294 EC 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)....... 294 EC 2.6 Transferring nitrogenous groups 333 EC 2.6.1 Transaminases................................................... 333 EC 2.6.3 Oximinotransferases............................................... 360 EC 2.6.99 Transferring other nitrogenous groups...................................... 360 EC 2.7 Transferring phosphorus-containing groups 361 EC 2.7.1 Phosphotransferases with an alcohol group as acceptor............................. 361 EC 2.7.2 Phosphotransferases with a carboxy group as acceptor.............................. 408 EC 2.7.3 Phosphotransferases with a nitrogenous group as acceptor............................ 411 EC 2.7.4 Phosphotransferases with a phosphate group as acceptor............................ 413 1 EC 2.7.6 Diphosphotransferases.............................................. 420 EC 2.7.7 Nucleotidyltransferases.............................................. 422 EC 2.7.8 Transferases for other substituted phosphate groups............................... 445 EC 2.7.9 Phosphotransferases with paired acceptors.................................... 457 EC 2.7.10 Protein-tyrosine kinases............................................. 459 EC 2.7.11 Protein-serine/threonine kinases......................................... 460 EC 2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)...................... 469 EC 2.7.13 Protein-histidine kinases............................................. 470 EC 2.7.14 Protein-arginine kinases............................................. 471 EC 2.7.99 Other protein kinases.............................................. 471 EC 2.8 Transferring sulfur-containing groups 471 EC 2.8.1 Sulfurtransferases................................................. 472 EC 2.8.2 Sulfotransferases................................................. 476 EC 2.8.3 CoA-transferases................................................. 486 EC 2.8.4 Transferring alkylthio groups........................................... 492 EC 2.8.5 Thiosulfotransferases............................................... 493 EC 2.9 Transferring selenium-containing groups 494 EC 2.9.1 Selenotransferases................................................. 494 EC 2.10 Transferring molybdenum- or tungsten-containing groups 495 EC 2.10.1 Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors.............. 495 References 496 Index 705 EC 2.1 Transferring one-carbon groups This subclass contains the methyltransferases (EC 2.1.1), the hydroxymethyl-, formyl- and related transferases (EC 2.1.2), the carboxy- and carbamoyltransferases (EC 2.1.3) and the amidinotransferases (EC 2.1.4). EC 2.1.1 Methyltransferases EC 2.1.1.1 Accepted name: nicotinamide N-methyltransferase Reaction: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide Other name(s): nicotinamide methyltransferase Systematic name: S-adenosyl-L-methionine:nicotinamide N-methyltransferase References: [469] [EC 2.1.1.1 created 1961] EC 2.1.1.2 Accepted name: guanidinoacetate N-methyltransferase Reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine Other name(s): GA methylpherase; guanidinoacetate methyltransferase; guanidinoacetate transmethylase; methionine-guanidinoacetic transmethylase; guanidoacetate methyltransferase Systematic name: S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase References: [472, 473] [EC 2.1.1.2 created 1961] 2 EC 2.1.1.3 Accepted name: thetin—homocysteine S-methyltransferase Reaction: dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine Other name(s): dimethylthetin-homocysteine methyltransferase; thetin-homocysteine methylpherase Systematic name: dimethylsulfonioacetate:L-homocysteine S-methyltransferase References: [1703, 2177, 2178] [EC 2.1.1.3 created 1961] EC 2.1.1.4 Accepted name: acetylserotonin O-methyltransferase Reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin Other name(s): hydroxyindole methyltransferase; hydroxyindole O-methyltransferase; N-acetylserotonin O- methyltransferase; acetylserotonin methyltransferase Systematic name: S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase Comments: Some other hydroxyindoles also act as acceptor, but more slowly. References: [140] [EC 2.1.1.4 created 1961] EC 2.1.1.5 Accepted name: betaine—homocysteine S-methyltransferase Reaction: betaine + L-homocysteine = dimethylglycine + L-methionine Other name(s): betaine-homocysteine methyltransferase; betaine-homocysteine transmethylase Systematic name: trimethylammonioacetate:L-homocysteine S-methyltransferase References: [1703] [EC 2.1.1.5 created 1961] EC 2.1.1.6 Accepted name: catechol O-methyltransferase Reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol Other name(s): COMT I ; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase Systematic name: S-adenosyl-L-methionine:catechol O-methyltransferase Comments: The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. References: [139, 1175, 1405] [EC 2.1.1.6 created 1965] EC 2.1.1.7 Accepted name: nicotinate N-methyltransferase Reaction: S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate Other name(s): furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyltransferase Systematic name: S-adenosyl-L-methionine:nicotinate N-methyltransferase References: [1540] [EC 2.1.1.7 created 1965] EC 2.1.1.8 3 Accepted name: histamine N-methyltransferase Reaction: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Nt-methylhistamine Other name(s): histamine 1-methyltransferase; histamine methyltransferase; histamine-methylating enzyme; imida- zolemethyltransferase; S-adenosylmethionine-histamine N-methyltransferase Systematic name: S-adenosyl-L-methionine:histamine N-tele-methyltransferase References: [404] [EC 2.1.1.8 created 1965] EC 2.1.1.9 Accepted name: thiol S-methyltransferase Reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether Other name(s): S-methyltransferase; thiol methyltransferase; TMT Systematic name: S-adenosyl-L-methionine:thiol S-methyltransferase Comments: H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors. References: [355, 387, 3809] [EC 2.1.1.9 created 1965] EC 2.1.1.10 Accepted name: homocysteine S-methyltransferase Reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine Other name(s): S-adenosylmethionine homocysteine transmethylase; S-methylmethionine homocysteine transmethy- lase; adenosylmethionine transmethylase; methylmethionine:homocysteine methyltransferase; adeno- sylmethionine:homocysteine methyltransferase; homocysteine methylase; homocysteine methyl- transferase; homocysteine transmethylase; L-homocysteine S-methyltransferase; S-adenosyl-L- methionine:L-homocysteine methyltransferase; S-adenosylmethionine-homocysteine transmethylase; S-adenosylmethionine:homocysteine methyltransferase Systematic name: S-methyl-L-methionine:L-homocysteine S-methyltransferase Comments: The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. References: [172, 3152, 3153, 2339, 2812, 2811, 1156] [EC 2.1.1.10 created 1965, modified 2010] EC 2.1.1.11 Accepted name: magnesium protoporphyrin IX methyltransferase Reaction: S-adenosyl-L-methionine + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + magne- sium protoporphyrin IX 13-methyl ester Systematic name: S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase References: [1053, 3173, 345, 1054, 801] [EC 2.1.1.11 created 1965, modified 2003] EC 2.1.1.12 Accepted name: