Prof. Rumina Hasan Section of Microbiology Department of Pathology and Laboratory Medicine SUMMARY: Publication 182 Book Chapters 06 CONTRIBUTIONS TO REPORTS, GUIDELINES AND POLICY DOCUMENTS: 27 RESEARCH GRANTS As Principal Investigator 18 As Co-Investigator 44 PUBLICATION: Year 2021 01. Antimicrobial resistance and COVID-19: intersections and implications. Gwenan M. Knight, Rebecca E. Glover, C.Finn McQuaid , Ioana D. Olaru, Karin Gallandat, Quentin J. Leclerc, Naomi M. Fuller, Sam J. Willcocks, Rumina Hasan, Esther van Kleef, Clare Chandler. eLife 2021;10:e64139 DOI: https://doi.org/10.7554/eLife.64139 Year 2020 02. Validation of Bedaquiline Phenotypic Drug Susceptibility Testing Methods and Breakpoints: A Multilibrary, Multicounty Study. Kaniga K, Aono A, Borroni E, Cirillo DM, Desmaretz C, Hasan R, Joseph L, Mitarai S, Shakoor S, Torrea G, Ismail NA, Omar SV. J Clin Microbiol. 2020 Jan 22. pii: JCM.01677-19. (Impact Factor: 4.59). https://pubmed.ncbi.nlm.nih.gov/31969421/ 03. Is enhancing the professionalism of healthcare providers critical to tackling antimicrobial resistance in low- and middle-income countries? Mishal Khan; Sothavireak Bory; Sonia Rego; Sovanthida Suy; Anna Durrance-Bagale; Zia Sultana; Sophea Chhorn; Socheata Phou; Chanra Prien; Sotheara Heng; Johanna Hanefeld; Rumina Hasan; Vonthanak Saphonn. Hum Resour Health. 2020 Feb 11;18(1):10. https://pubmed.ncbi.nlm.nih.gov/32046723/ 04. Nontuberculous Mycobacterial Infections - a neglected and emerging problem. Ahmed I, Tiberi S, Farooqi J, Jabeen K, Yeboah-Manu D, Migliori GB, Hasan R. Int J Infect Dis. 2020 Mar; 92S:S46-S50. https://pubmed.ncbi.nlm.nih.gov/32114200/ 05. Post TB treatment infectious complications. Hsu D, Irfan M, Jabeen K, Iqbal N, Hasan R, Migliori GB, Zumla A, Visca D, Centis R, Tiberi S. Int J Infect Dis. 2020 Mar; 92S:S41-S45. https://pubmed.ncbi.nlm.nih.gov/32114203/ 06. Commemorating World TB Day 2020: "IT'S TIME" - It's Time to End the Global TB Epidemic. (Editorial). Tiberi S, Migliori GB, Muhwa Chakaya J, Kaesava T, Al Abri SS, Wejse C, Goletti D, Kapata N, Sotgiu G, Bomanji J, Zellweger JP, Hasan R, Irfan M, Ahmed I, Pshenichnaya N, Vasilieva I, Yeboah- Manu D, Alffenaar JW, Kim HY, Centis R, Cirillo DM, Alagna R, D'Ambrosio L, Cui X, Cao B, Maeurer M, Harries AD, Ippolito G, Raviglione M, Zumla A, Petersen E. Commemorating World TB Day 2020: "IT'S TIME" - It's Time to End the Global TB Epidemic. (Editorial). Int J Infect Dis. 2020 Mar;92S: S1- S4. https://pubmed.ncbi.nlm.nih.gov/32145464/ 07. What are the barriers to implementing national antimicrobial resistance actions plans? A novel mixed-methods policy analysis in Pakistan. Mishal Khan, Ana Durrance-Bagale, Zia Sultana, Rumina Hasan, Johanna Hanefeld. Health Policy and Planning. August 2020 https://doi.org/10.1093/heapol/czaa065 08. Setting a baseline for global urban virome surveillance in sewage. Nieuwenhuijse DF, Oude Munnink BB, Phan MVT, et al. (including Rumina Hasan as part of Global Sewage Surveillance project consortium). Sci Rep. 2020;10(1):13748. Published 2020 Aug 13. https://pubmed.ncbi.nlm.nih.gov/32792677/ 09. Eggerthella lenta bacteraemia in endometrial adenocarcinoma - a case report from Pakistan. Tazeen Fatima, Rumina Hasan, Samia Tariq. J Pak Med Assoc 2020 Jun;70(6):1079-1080. https://pubmed.ncbi.nlm.nih.gov/32810111/ 10. A Multimethod, Multicountry Evaluation of Breakpoints for Bedaquiline Resistance Determination. Nazir Ismail, Akio Aono, Emanuele Borroni, Daniela Cirillo, Christel Desmaretz, Rumina Hasan, Satoshi Mitara, Sadia Shakoor, Gabriela Torrea, Koné Kaniga, and Shaheed Omar. Antimicrob Agents Chemother 2020 Aug 20;64(9):e0047 20. doi: 10.1128/AAC.00479-20. Print 2020 Aug 20. https://pubmed.ncbi.nlm.nih.gov/32660992/ 11. Covid -19, misinformation, and antimicrobial resistance. Mehreen Arshad, Syed Faisal Mahmood, Mishal Khan, Rumina Hasan (Editorial). BMJ 2020; 371:m4501. https://www.bmj.com/content/371/bmj.m4501.full 12. Breakpoint broth microdilution plate’ for susceptibility testing of Gram-negative bacilli against colistin sulfate. Imran Ahmed, Sidra Laiq, Najma Shsheen, Khalid Wahab, Joveria Farooqi, Asima Shahid, Rumina Hasan, Sadia Shakoor. Practical Laboratory Medicine. 2020 Nov. Vol 22 e00192. https://www.sciencedirect.com/science/article/pii/S2352551720301554?via%3Dihub Year 2019 13. Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis. (Review). Akbar Kanji, Rumina Hasan, Zahra Hasan. Indian J Tuberc. 2019 Jan;66(1):20-25. (Impact Factor: 0.38). https://pubmed.ncbi.nlm.nih.gov/30797276/ 14. Ceftriaxone-resistant Salmonella Typhi Outbreak in Hyderabad City of Sindh, Pakistan: High Time for the Introduction of Typhoid Conjugate Vaccine. Yousafzai MT, Qamar FN, Shakoor S, Saleem K, Lohana H, Karim S, Hotwani A, Qureshi S, Masood N, Rauf M, Khanzada JA, Kazi M, Hasan R. Clin Infect Dis. 2019 Feb 15;68 (Supplement_1):S16-S21. (Impact Factor: 9.1) https://pubmed.ncbi.nlm.nih.gov/30767003/ 15. Utility of the microcolony method for evaluation of multidrug-resistant tuberculosis patients in Karachi, Pakistan. Irfan Seema; Rao Nisar Ahmed; Irfan Muhammad; Iftikhar Irim; Azizullah Zahida; Jabeen Kauser; Hasan Rumina. The International Journal of Tuberculosis and Lung Disease 2019, 23 (7), 838-843. (Impact factor: 2.0) https://pubmed.ncbi.nlm.nih.gov/31439116/ 16. Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Hendriksen RS, Munk P, Njage P, van Bunnik B, McNally L, Lukjancenko O, Röder T, Nieuwenhuijse D, Pedersen SK, Kjeldgaard J, Kaas RS, Clausen PTLC, Vogt JK, Leekitcharoenphon P, van de Schans MGM, Zuidema T, de Roda Husman AM, Rasmussen S, Petersen B; Global Sewage Surveillance project consortium, Amid C, Cochrane G, Sicheritz-Ponten T, Schmitt H, Alvarez JRM, Aidara-Kane A, Pamp SJ, Lund O, Hald T, Woolhouse M, Koopmans MP, Vigre H, Petersen TN, Aarestrup FM. Nat Commun. 2019 Mar 8;10(1):1124. (Impact Factor: 11.88). https://pubmed.ncbi.nlm.nih.gov/30850636/ 17. Common Alternative Diagnoses among a Pediatric Hospital‑Based Cohort Evaluated for Tuberculosis in Karachi, Pakistan: The Need for Facilitated Referral in Tuberculosis Clinics. Sadia Shakoor, Fatima Mir, Rumina Hasan. Int J. of Mycobacteriology 2019; 8(1); January-March. (Impact Factor: 0.82).https://pubmed.ncbi.nlm.nih.gov/30860178/ 18. LMICs as reservoirs of AMR': a comparative analysis of policy discourse on antimicrobial resistance with reference to Pakistan. Khan MS, Durrance-Bagale A, Legido-Quigley H, Mateus A, Hasan R, Spencer J, Hanefeld J. Health Policy Plan. 2019 Apr 11. pii: czz022. (Impact Factor: 2.71). https://pubmed.ncbi.nlm.nih.gov/30977804/ 19. Antimicrobial susceptibility against metronidazole and carbapenem in clinical anaerobic isolates from Pakistan. Yusra Shafquat; Kauser Jabeen; Joveria Farooqi; Kiran Mehmood; Seema Irfan; Rumina Hasan; Afia Zafar. Antimicrobial Resistance & Infection Control 2019 Jun 14; 8:99. (Impact Factor: 3.22). https://pubmed.ncbi.nlm.nih.gov/31210928/ 20. Antibiotic-Resistant Enteric Infection. Shakoor S, Platts-Mills JA, Hasan R. In Infectious Diseases Clinics of North America on Emerging and Re-Emerging Infections 2019 Dec;33(4): 1105-1123. (Impact Factor: 4.757) https://pubmed.ncbi.nlm.nih.gov/31668193/ 21. Accuracy of genotype MTBDRplus line probe assay in patients with tuberculous pleural effusion: comparison with clinical and culture-based diagnosis. Irfan M, Idrees F, Jabeen K, Zubairi ABS, Butt S, Hasan R. Infect Dis (Lond). 2019 Dec 4:1-7 (Impact Factor: 2.191). https://pubmed.ncbi.nlm.nih.gov/31797723/ Year 2018 22. Methylation in Mycobacterium tuberculosis is lineage specific with associated mutations present globally. Jody Phelan , Paola Florez de Sessions , Leopold Tientcheu , Joao Perdigao, Diana Machado, Rumina Hasan, Zahra Hasan, Indra Bergval, Richard Anthony, Ruth McNerney, Martin Antonio , Isabel Portugal , Miguel Viveiros, Susana Campino , Martin Hibberd. Scientific Reports. 2018 8:160 (Impact Factor: 4.525) https://pubmed.ncbi.nlm.nih.gov/29317751/. 23. Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Francesc Coll, Jody Phelan, Hill-Cawthorne, Mridul B Nair, Kim Mallard, Shahjahan Ali, Abdallah M Abdallah, Saad Alghamdi, Mona Alsomali, Abdallah O Ahmed, Stephanie Portelli, Yaa Oppong, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Maxine Caws, Anirvan Chatterjee, Amelia C Crampin, Keertan Dheda, Nicholas Furnham, Judith R Glynn, Louis Grandjean, Dang Thi Minh Ha, Rumina Hasan, Zahra Hasan, Martin L Hibberd, Moses Joloba, Edward C. Jones-López, Tomoshige Matsumoto, Anabela Miranda, David J Moore, Nora Mocillo, Stefan Panaiotov, Julian Parkhill, Carlos Penha, João Perdigão, Isabel Portugal, Zineb Rchiad, Jaime Robledo, Patricia Sheen, Nashwa Talaat Shesha, Frik A Sirgel, Christophe Sola, Erivelton de Oliveira Sousa, Elizabeth M Streicher, Paul Van Helden, Miguel Viveiros, Robert M Warren, Ruth McNerney, Arnab Pain, Taane G Clark. Nature Genetics, 22 January 2018 doi:10.1038/s41588-017-0029-0. (Impact Factor: 27.12 ) https://www.nature.com/articles/s41588-017-0029-0. 24. Emergence of an extensively drug-resistant (XDR) Salmonella Typhi harbouring a promiscuous plasmid encoding resistance to fluoroquinolones and third-generation cephalosporins. Elizabeth Klemm, Sadia Shakoor, Andrew Page, Farah Qamar, Kim Judge, Dania Saeed, Vanessa Wong, Timothy Dallman, Satheesh Nair, Stephen Baker, Ghazala Shaheen, Shahida Qureshi, Mohammad Yousafzai, Mohammad Saleem, Zahra Hasan, Gordon Dougan, and Rumina