New Projects at EMBL Approved in 2007 (for the period 15.11.06-15.11.07) Protein Crystallography PX-06-382 Structure of plasminogen activator inhibitor-I Rabijns Leuven (PAI-I) inhibiting antibody fragments (Fabs) PX-06-383 Structural studies on E. coli Serine Ilari Rome HydroxyMethyl Transferase (SHMT) mutants PX-06-384 UDP-sugar-pyrophosphorylase Ficner Göttingen PX-06-385 Poly-A-specific Ribonuclease PARN Ficner Göttingen PX-06-386 Structure of interferon Lambda and its receptor Nissen Aarhus PX-06-387 Structure of malonate decarboxylase (AMDase) Sträter Leipzig PX-06-388 Finding new trypsin inhibitors Heine Marburg PX-06-389 Structure of Ecto-Nucleosidetriphosphate Sträter Leipzig diphosphohydrolases (ENTPDase) PX-06-390 Structural biology of bacterial disaccharide Savvides Ghent phosphorylases PX-06-391 tehA Schmitt Düsseldorf PX-06-392 Structure of sugar binding hydrolase enzymes DECLERCQ Louvain-la- Neuve PX-06-393 Crystallographic structure analyses of the nuclear Ficner Göttingen import complexes ImpBeta/Imp7/H1 and ImpBeta/SPN1 PX-06-394 Neutral protease from Bacillus polymyxa Wyns Brussel PX-06-395 L-carbamoylase from Sinorhizobium meliloti Wyns Brussel PX-06-396 Structure solution of Early B-Cell Factor (EBF), a Schulz Freiburg transcription factor that contains a novel DNA binding domain bound to DNA PX-06-397 Structure determination of Pex3, a human Schulz Freiburg membrane protein involved in peroxisome biogenesis PX-06-398 Structure of 2,6-Dihydroxypyridine 3- Schulz Freiburg Hydroxylase from arthrobacter nicotinovorans PX-06-399 Structure determination of a complex consisting Schulz Freiburg of PEX19 and the membrane protein PEX3, two human proteins involved in peroxisome biogenesis PX-06-400 Palmitylation of BET3 Heinemann Berlin PX-06-401 Reducion of metal centres by X-rays: Cu,Zn SOD Djinovic- Vienna Carugo PX-06-402 Reducion of metal centres by X-rays: Ni SOD Djinovic- Vienna Carugo PX-06-403 Reducion of metal centres by X-rays: SW Djinovic- Vienna myoglobin Carugo PX-06-404 Carbonic anhydrase:CO2 : does the pH in crystal Djinovic- Vienna change with deposited X-ray dose Carugo 653 PX-06-405 Phytase of klebsiella Heinemann Berlin PX-06-406 Crystal structure of SnogD Schneider Stockholm PX-06-407 Glutaconyl-CoA decarboxylase from Clostridium Essen Marburg symbiosum PX-06-408 Structure of 14-3-3 protein lambda Schomburg Cologne PX-06-409 Structure of Pyrococcus furiosus MoaB Schomburg Cologne PX-06-410 Cofactor Analysis of Arabidopsis thaliana Cnx1 Schomburg Cologne G-Domain PX-06-411 complex of chitinase B with inhibitory peptides Hoehne Berlin PX-06-412 INH data collection PXInternal Hamburg PX-06-413 Putative Heavy atom ATPase chaperone Nissen Aarhus PX-06-414 Complexes of c-terminal tails of vps10 receptors Nissen Aarhus and cytoplasmic factors PX-06-415 Structure determination of the RACK1 protein Nissen Aarhus PX-06-416 Biotin ligase Wyns Brussels PX-06-417 Bacterial ferritin Wyns Brussels PX-06-418 Acyl coA synthase FadD13 Wyns Brussels PX-06-419 Transamidosome Nissen Aarhus PX-06-420 Actin*Riz complex Heinz Braunschweig PX-07-001 Non-receptor tyrosine kinase Fes catalitic domain Rosano Genova PX-07-002 PPI, a new protease inhibitor from papaya Wyns Brussels PX-07-003 Bacterial TA modules Wyns Brussels PX-07-004 Bacterial fimbrial adhesins Wyns Brussels PX-07-005 Crystal structure of IDC epimerase Schneider Stockholm PX-07-006 Crystal structure of AknOx Schneider Stockholm PX-07-007 Dehydropyrimidine dehydrogenase Schneider Stockholm PX-07-008 Crystal structure of RdmE Schneider Stockholm PX-07-009 Phospholipase A2 Schneider Stockholm PX-07-010 Structural studies of plant pathogenesis-related Jaskolski Poznan proteins PX-07-011 Structural biology of plant-bacterium symbiosis Jaskolski Poznan PX-07-012 Protease inhibitors from pathogenic protozoa Jaskolski Poznan PX-07-013 VHH antibody fragments from camels Wyns Brussels PX-07-014 Mechanism of disulphide formation in Wyns Brussels Escherichia coli Ribonuclease 1 PX-07-014 Mechanism of disulphide formation in Wyns Brussels Escherichia coli Ribonuclease 1 PX-07-015 T. cruzi Glucokinase Wyns Brussels PX-07-016 Microbial nucleoside hydrolases Wyns Brussels PX-07-017 IPDC/PPDC from Azospirillum brasilense Wyns Brussels PX-07-018 Structure of enzymatic antioxidants Declerq Louvain-la- Neuve PX-07-019 Complexes and mutants of apoferritin Declerq Louvain-la- 654 Neuve PX-07-020 BAS Schneider Stockholm PX-07-021 MDH Schneider Stockholm PX-07-022 SnogD Schneider Stockholm PX-07-023 Directed evolution of enzymes Declerq Louvain-la- Neuve PX-07-024 Microgravity grown crystals Declerq Louvain-la- Neuve PX-07-025 Structural Genomics Studies of S. mutans Su Beijing proteins PX-07-026 Structural anf functional studies on proteins Su Beijing related to B. subtilis histidine degradation PX-07-027 Structural and functional studies of important Su Beijing human proteins PX-07-028 UDP-sugar-pyrophosphorylase Ficner Göttingen PX-07-029 Class 2 histone deacetylase homologue (HDAH) Ficner Göttingen PX-07-030 Crystal structure of mutants of Salicylate 1,2- Briganti Florence Dioxygenase from Pseudaminobacter salicylatoxidans and of the complex with substrates PX-07-031 Crystallographic study of the substrate specificity Briganti Florence of 4-chlorocatechol 1,2-dioxygenase from Rhodococcus opacus 1CP PX-07-032 Structural Characterization of intermediates in the Briganti Florence catalytic pathway of Laccase from Trametes trogii PX-07-033 Crystallographic structure of Laccase from Briganti Florence Trametes trogii complexed with natural mediator PX-07-034 Alpha-1,3-Galactosyltransferase: Catalytic Acharya Bath Mechanism and Inhibitor Design PX-07-035 Interferon-Inducible Protein 10 (IP-10): Acharya Bath Glycosaminoglycan and Receptor Interactions PX-07-036 Streptococcus suis Dpr Papageorgiou Turku PX-07-037 Glutathione transferase Papageorgiou Turku PX-07-038 tehA Schmitt Düsseldorf PX-07-039 The molecular determinats of OpuAC, the SBP of Schmitt Düsseldorf the osmo-regulated ABC-transporter OpuA from B. subtilis PX-07-040 The nisin exporter complex of L. lactis Schmitt Düsseldorf PX-07-041 An ABC-transporter specific protease domain Schmitt Düsseldorf PX-07-042 ChoX, the SBP of an ectoine specific ABC- Schmitt Düsseldorf importer PX-07-043 Na,K ATPase Nissen Aarhus PX-07-044 Inhibitor complexes of SR Ca2+-ATPase Nissen Aarhus PX-07-045 Structure of interferon Lambda and its receptor Nissen Aarhus 655 PX-07-046 H+-ATPase from A. thaliana Nissen Aarhus PX-07-047 Yeast Rrp6p Nissen Aarhus PX-07-048 Structure of the Vps10p domain of human Nissen Aarhus Sortilin PX-07-049 IgA proteases Nissen Aarhus PX-07-050 Derivatised cyclodextrins and inclusion Mavridis Aghia Paraskevi complexes of cyclodextrins PX-07-051 Complexes of cyclodextrins with DNA and RNA Mavridis Aghia Paraskevi PX-07-052 Structure of Ferredoxins Mavridis Aghia Paraskevi PX-07-053 Depolymerase Papageorgiou Turku PX-07-054 Structural investigation of PACSINs, adaptor Wittmann Göttingen proteins involved in endocytosis and actin rearrangement PX-07-055 AOC I and II - two novel allene oxide cyclases Ficner Göttingen PX-07-056 Novel Uracil-specific DNA repair enzyme Ficner Göttingen PX-07-057 tRNA modifying enzyme ThiI from Thermotoga Ficner Göttingen maritima PX-07-058 Carbonic anhydrase IX Brynda Prague PX-07-059 Archaeal ExoIII homologue Ficner Göttingen PX-07-060 Laccase from Melanocarpus albomyces Rouvinen Joensuu PX-07-061 Tyrosinase from Trichoderma reesei Rouvinen Joensuu PX-07-062 UsnRNA 5'-cap Dimethyltransferase TGS1 Ficner Göttingen PX-07-063 Spliceosomal helicase Prp22 - Truncation H20 Ficner Göttingen PX-07-064 Spliceosomal helicase Prp22 - Truncation H13 Ficner Göttingen PX-07-065 Spliceosomal helicase Prp22 - Truncation H7 Ficner Göttingen PX-07-066 NrfHA complex of W. succinogenes Einsle Göttingen PX-07-067 Diheme cytochrome DHC2 Einsle Göttingen PX-07-068 Acetylene hydratase of P. acetylenicus Einsle Göttingen PX-07-069 Ammonium Transporter Einsle Göttingen PX-07-070 Xanthomonas RoxA Einsle Göttingen PX-07-071 Aquifex aeolicus Ferredoxin Einsle Göttingen PX-07-072 Cytochrome c perxoidases Einsle Göttingen PX-07-073 Aplysia amino acid oxidase Einsle Göttingen PX-07-074 Nitrogenase Einsle Göttingen PX-07-075 Structure-function studies of wild type and Wierenga Oulu mutant bacterial and human thiolases PX-07-076 Structural studies of fatty acyl CoA thioesterases Wierenga Oulu PX-07-077 protein engineering: towards a new substrate Wierenga Oulu specificity of a monomeric variant of TIM PX-07-078 Structural studies of the enzymes involved in Wierenga Oulu protein folding in ER PX-07-079 Novel trypsin from crab Betzel Hamburg PX-07-080 Important RNA's in biotechnology Betzel Hamburg 656 PX-07-081 Glutathione S-transferases from helminths Betzel Hamburg PX-07-082 Student course (Test data collection for different Betzel Hamburg protein crystals) PX-07-083 Different complexes of ML1 with native Betzel Hamburg inhibitors PX-07-084 New plant inhibitors for urease, acetylcholin Betzel Hamburg esterase and glycosidase PX-07-085 Crystallographic structure analyses of the nuclear Ficner Göttingen import complexes ImpBeta/Imp7/H1 and ImpBeta/SPN1 PX-07-086 Myosin-myosin receptor Niessing München PX-07-087 Myosin-myosin receptor co-complex / different Niessing München crystal form PX-07-088 RNA-binding by the novel type of RNA-binding Niessing München protein She2p PX-07-089 Poly-A-specific Ribonuclease PARN Ficner Gttiöngen PX-07-090 Spliceosomal helicase Prp28 Ficner Göttingen PX-07-091 Crystal Structure Determination of Cyclodextrin Hountas Athens Inclusion Compounds with Substanses of Agricultural Interest PX-07-092 Structural studies of a bacterial bifunctional Savvides Ghent glutathione synthetase (gshF) PX-07-093 Structural studies of Old Yellow Enzyme from S. Savvides Ghent Oneidensis at ultra-high resolution PX-07-094 Structural biology of bacterial disaccharide Savvides Ghent phosphorylases PX-07-095 Structural studies of adenylate kinases from the Savvides Ghent malaria parasite PX-07-096 Structural studies of the membrane-associated Savvides Ghent agglutination protein, AggA, from S. Oneidensis PX-07-097 Structural studies of paracoccus C551, a di-heme Savvides Ghent cytochrome.