Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Atlas Journal Atlas Journal versus Atlas Database: the accumulation of the issues of the Journal constitutes the body of the Database/Text-Book. TABLE OF CONTENTS Volume 3, Number 2, Apr-Jun 1999 Previous Issue / Next Issue Genes NONO (Xq12). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 133-136. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/NONOID168.html PRCC (papillary renal cell carcinoma) (1q21.2). François Desangles, Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 137-140. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/PRCCID69.html PSF (PTB-associated splicing factor) (1p34). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 141-144. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/PSFID167.html PTCH1 (9q22.3) - updated. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 145-153. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/PTCH100.html TFE3 (transcription factor E3) (Xp11.2). Jean-Loup Huret, François Desangles. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 154-160. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/TFE3ID86.html HRAS (Harvey rat sarcoma viral oncogene homolog) (11p15.5). Franz Watzinger, Thomas Lion. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 161-172. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 1999; 2 I URL : http://AtlasGeneticsOncology.org/Genes/HRASID108.html K-RAS (Kirsten rat sarcoma 2 viral oncogene homolog) (12p12). Franz Watzinger, Thomas Lion. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 173-178. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/KRASID91.html N-RAS (neuroblastoma RAS viral oncogene homolog) - (1p13). Franz Watzinger, Thomas Lion. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 179-186. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/NRASID92.html SMARCB1 (SW1/SNF related, matrix associated, actin dependent regulator of chromatin B1) (22q11.2). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 187-191. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/SMARCB1ID169.html FLT3 (FMS-like tyrosine kinase 3) (13q12.2). Olivier Rosnet. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 192-199. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/FLT3ID144.html MEN1 (11q13). Alain Calender. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 200-208. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/MEN1ID148.html Leukaemias t(7;11)(p15;p15). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 209-211. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t0711p15.html Y loss in leukemia. Fran&ccdeil;ois Desangles. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 212-215. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/YlossID1089.html t(2;8)(p12;q24); t(8;14)(q24;q32); t(8;22)(q24;q11). Chrystèle Bilhou-Nabera. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 216-220. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t0814ID1050.html t(5;15)(p15;q11-13). Nyla A. Heerema. Atlas Genet Cytogenet Oncol Haematol 1999; 2 II Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 221-222. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t0515ID1149.html Hodgkin's disease. Niels B Atkin. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 223-225. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/HodgkinID2068.html Congenital leukaemias; Infant leukaemias; Neonatal leukaemias. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 226-233. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/InfantLeukID1084.html t(17;19)(q22;p13). Franck Viguié. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 227-237. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t1719ID1078.html +15 or trisomy 15 (as sole autosomal abnormality). Elizabeth J Sinclair, Anthony M Potter. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 238-239. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/tri15ID1144.html Solid Tumours Breast tumors: an overview. Daniel Birnbaum, Francois Eisinger, Jocelyne Jacquemier, Michel Longy,Hagay Sobol, Charles Theillet. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 240-252. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/breastID5018.html Uterus: Endometrial carcinoma. Jérome Couturier. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 253-255. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/endometrID5045.html Kidney: t(X;1)(p11.2;p34) in renal cell carcinoma. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 256-258. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/tX1ID5056.html Rhabdoid tumor. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 259-261. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/rhabdoidID5037.html Cancer Prone Atlas Genet Cytogenet Oncol Haematol 1999; 2 III Diseases Hereditary papillary renal cell carcinoma. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 262-264. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/papilrenalkpron10053.html Rhabdoid predisposition syndrome. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 265-267. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/rhabdKpronID10051.html Deep Insights An Introduction to Chromosomal Aberrations. John R K Savage. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 268-275. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Deep/Chromaber.html RAS family. Franz Watzinger, Thomas Lion. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (2): 276-285. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Deep/Ras.html Case Reports Educational Items © Atlas of Genetics and Cytogenetics in Oncology and Haematology X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching For comments and suggestions or contributions, please contact us [email protected]. Atlas Genet Cytogenet Oncol Haematol 1999; 2 IV Atlas of Genetics and Cytogenetics in Oncology and Haematology NONO Identity Hugo NONO Location Xq12 DNA/RNA Transcription alternative splicing; 2.4 mRNA complete cds; coding sequence: CDS 129 ... 1550 Protein Description the protein encoded by NONO is called p54nrb (nuclear RNA binbing); 471 amino acids; 54 kDa; N-term glutamine/histidine rich region, tandem RNA binding domains (amino acids 75 to 228), helix-turn-helix implicated in DNA binding, and a proline rich region in C-term; N-term and C-term allow protein-protein interactions. Expression wide Function binds independantly to DNA and RNA; forms a heterodimer with PSF, a protein sharing vast homologies; both form complexes with DNA topoisomerase I, which renders this enzyme much more active; NONO also enhances the binding of several DNA-binding proteins (but not all). Homology with PSF and other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains. Implicated in Entity inv(X)(p11.2q12) in renal cell carcinoma -->NonO/TFE3 Disease only one case of papillary renal cell carcinoma Hybrid/Mutated 5' NONO- 3' TFE3 Gene Abnormal N-term NONO and most of it except the C-term proline rich sequence Protein fused to the DNA binding domains of TFE3 (excluding the acidic transcriptional activation domain, including the C-term helix-loop- Atlas Genet Cytogenet Oncol Haematol 1999; 2 -133- helix, and the leucine zipper); the reciprocal transcript is found External links Nomenclature Hugo NONO GDB NONO Entrez_Gene NONO 4841 non-POU domain containing, octamer-binding Cards Atlas NONOID168 GeneCards NONO Ensembl NONO CancerGene NONO Genatlas NONO GeneLynx NONO eGenome NONO euGene 4841 Genomic and cartography NONO - Xq12 chrX:70286488-70304037 + Xq13.1 (hg17- GoldenPath May_2004) Ensembl NONO - Xq13.1 [CytoView] NCBI Genes Cyto Gene Seq [Map View - NCBI] OMIM Disease map [OMIM] HomoloGene NONO Gene and transcription Genbank Y11289 [ SRS ] Y11289 [ ENTREZ ] Genbank AK055406 [ SRS ] AK055406 [ ENTREZ ] Genbank AU119361 [ SRS ] AU119361 [ ENTREZ ] Genbank BC002364 [ SRS ] BC002364 [ ENTREZ ] Genbank BC003129 [ SRS ] BC003129 [ ENTREZ ] RefSeq NM_007363 [ SRS ] NM_007363 [ ENTREZ ] RefSeq NT_086956 [ SRS ] NT_086956 [ ENTREZ ] AceView NONO AceView - NCBI TRASER NONO Traser - Stanford Unigene Hs.533282 [ SRS ] Hs.533282 [ NCBI ] HS533282 [ spliceNest ] Protein : pattern, domain, 3D structure SwissProt Q15233 [ SRS] Q15233 [ EXPASY ] Q15233 [ INTERPRO ] Prosite PS50102 RRM [ SRS ] PS50102 RRM [ Expasy ] Interpro IPR000504 RNA_rec_mot [ SRS ] IPR000504 RNA_rec_mot [ EBI ] Atlas Genet Cytogenet Oncol Haematol 1999; 2 -134- CluSTr Q15233 Pfam PF00076 RRM_1 [ SRS ] PF00076 RRM_1 [ Sanger ] pfam00076 [ NCBI- CDD ] Blocks Q15233 Polymorphism : SNP, mutations, diseases OMIM 300084 [ map ] GENECLINICS 300084 SNP NONO [dbSNP-NCBI] SNP NM_007363 [SNP-NCI] SNP NONO [GeneSNPs - Utah] NONO [SNP - CSHL] NONO] [HGBASE - SRS] General knowledge Family NONO [UCSC Family Browser] Browser SOURCE NM_007363 SMD Hs.533282 SAGE Hs.533282 Amigo function|DNA binding Amigo function|RNA