February 13, 2004 MEMORANDUM SUBJECT: Transmittal of Meeting Minutes of the FIFRA Scientific Advisory Panel Meeting Held December 3-5, 2003 TO: James J. Jones, Director Office of Pesticide Programs FROM: Paul I. Lewis, Designated Federal Official FIFRA Scientific Advisory Panel Office of Science Coordination and Policy THRU: Larry C. Dorsey, Executive Secretary FIFRA Scientific Advisory Panel Office of Science Coordination and Policy Joseph J. Merenda, Jr., Director Office of Science Coordination and Policy Please find attached the meeting minutes of the FIFRA Scientific Advisory Panel open meeting held in Arlington, Virginia from December 3-5, 2003. This report addresses a set of scientific issues being considered by the Environmental Protection Agency regarding a draft preliminary probabilistic exposure and risk assessment for children who contact CCA-treated wood on playsets and decks and CCA-containing soil around these structures. Attachment Page 1 of 70 cc: Susan Hazen Adam Sharp Anne Lindsay Janet Andersen Debbie Edwards Steven Bradbury William Diamond Arnold Layne Tina Levine Lois Rossi Frank Sanders Margaret Stasikowski William Jordan Douglas Parsons Daniel Rosenblatt David Deegan Vanessa Vu (SAB) OPP Docket FIFRA Scientific Advisory Panel Members Steven Heeringa, Ph.D. Fumio Matsumura, Ph.D. Mary Anna Thrall, D.V.M. FQPA Science Review Board Members John Adgate, Ph.D. Michael Bates, Ph.D. Chi-Hsin Selene Jen Chou, Ph.D. Natalie Freeman, Ph.D. Marcie Francis, Ph.D. Dale Hattis, Ph.D. John Kissel, Ph.D. Stan Lebow, Ph.D. Peter Macdonald, D. Phil. David MacIntosh, Sc.D. Kenneth Portier, Ph.D. Nu-May Ruby Reed, Ph.D. Jim E. Riviere, DVM, Ph.D. Barry Ryan, Ph.D. Page 2 of 70 Jacob Steinberg, M.D. David Stilwell, Ph.D. Miroslav Styblo, Ph.D. Donald Wauchope, Ph.D. Page 3 of 70 SAP Meeting Minutes No. 2003-04 MEETING MINUTES FIFRA Scientific Advisory Panel Meeting, December 3-5, 2003, held at the Sheraton Crystal City Hotel Arlington, Virginia A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Draft Preliminary Probabilistic Exposure And Risk Assessment For Children Who Contact CCA-Treated Wood On Playsets And Decks And CCA-Containing Soil Around These Structures Page 4 of 70 NOTICE These meeting minutes have been written as part of the activities of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), Scientific Advisory Panel (SAP). This report has not been reviewed for approval by the United States Environmental Protection Agency (Agency) and, hence, the contents of this report do not necessarily represent the views and policies of the Agency, nor of other agencies in the Executive Branch of the Federal government, nor does mention of trade names or commercial products constitute a recommendation for use. The FIFRA SAP was established under the provisions of FIFRA, as amended by the Food Quality Protection Act (FQPA) of 1996, to provide advice, information, and recommendations to the Agency Administrator on pesticides and pesticide-related issues regarding the impact of regulatory actions on health and the environment. The Panel serves as the primary scientific peer review mechanism of the EPA, Office of Pesticide Programs (OPP) and is structured to provide balanced expert assessment of pesticide and pesticide-related matters facing the Agency. Food Quality Protection Act Science Review Board members serve the FIFRA SAP on an ad hoc basis to assist in reviews conducted by the FIFRA SAP. Further information about FIFRA SAP reports and activities can be obtained from its website at http://www.epa.gov/scipoly/sap/ or the OPP Docket at (703) 305-5805. Interested persons are invited to contact Paul Lewis, FIFRA SAP Designated Federal Official, via e-mail at [email protected] Page 5 of 70 TABLE OF CONTENTS PARTICIPANTS ...............................................................................................................8 PUBLIC COMMENTERS.................................................................................................9 INTRODUCTION ...........................................................................................................10 CHARGE .........................................................................................................................11 SUMMARY OF PANEL DISCUSSION AND RECOMMENDATIONS .....................16 PANEL DELIBERATIONS AND RESPONSE TO THE CHARGE .............................20 REFERENCES ................................................................................................................68 Page 6 of 70 SAP Meeting Minutes No. 2003-04 Meeting Minutes: FIFRA Scientific Advisory Panel Meeting, December 3-5, 2003, held at the Sheraton Crystal City Hotel, Arlington, Virginia A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Draft Preliminary Probabilistic Exposure And Risk Assessment For Children Who Contact CCA-Treated Wood On Playsets And Decks And CCA-Containing Soil Around These Structures Mr. Paul Lewis Steven Heeringa, Ph.D. Designated Federal Official FIFRA SAP Session Chair FIFRA Scientific Advisory Panel FIFRA Scientific Advisory Panel Date: February 13, 2004 Date: February 13, 2004 Page 7 of 70 Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel Meeting December 3-5, 2003 Draft Preliminary Probabilistic Exposure And Risk Assessment For Children Who Contact CCA-Treated Wood On Playsets And Decks And CCA-Containing Soil Around These Structures PARTICIPANTS FIFRA SAP Session Chair Steven Heeringa, Ph.D., Research Scientist & Director for Statistical Design, Institute for Social Research, University of Michigan, Ann Arbor, MI FIFRA Scientific Advisory Panel Members Fumio Matsumura, Ph.D., Professor, Environmental Toxicology and Director, Center for Environmental Health Sciences, c/o Dept. Environmental Toxicology, University of California at Davis, Davis Mary Anna Thrall, D.V.M., Professor, Department of Pathology, College of Veterinary & Biomedical Sciences, Colorado State University, Fort Collins, CO FQPA Science Review Board Members John Adgate, Ph.D., Assistant Professor, Division of Environmental and Occupational Health, University of Minnesota School of Public Health, Minneapolis, MN Michael Bates, Ph.D., Adjunct Professor of Epidemiology, School of Public Health, University of California, Berkeley, CA Chi-Hsin Selene Jen Chou, Ph.D., Environmental Health Scientist, Division of Toxicology, Scientific Assessment Section, Agency for Toxic Substance and Disease Registry, Atlanta, GA Natalie Freeman, Ph.D., Adjunct Associate Professor, Environmental/Community Medicine, Robert Wood Johnson School of Medicine, Piscataway, NJ Marcie Francis, Ph.D. CIH, Senior Research Scientist, Battelle Memorial Institute, Kensington, MD Dale Hattis, Ph.D., Research Professor, Center for Technology, Environment and Development, George Perkins Marsh Institute, Clark University, Arlington, MA John Kissel, Ph.D., Associate Professor, Environmental Health, University of Washington, Page 8 of 70 Seattle, WA Stan Lebow, Ph.D., USDA Forest Service, Forest Products Laboratory, Madison, WI Peter Macdonald, D. Phil., Professor of Mathematics and Statistics, Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada David MacIntosh, Sc.D., Senior Associate, Environmental Health and Engineering, Inc. Newton, MA Kenneth Portier, Ph.D., Associate Professor, Statistics, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL Nu-May Ruby Reed, Ph.D., Staff Toxicologist, California EPA, Dept. of Pesticide Regulation, Sacramento, CA Jim E. Riviere, D.V.M., Ph.D., Burroughs Wellcome Fund Distinguished Professor and Director, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC Barry Ryan, Ph.D., Professor, Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA Jacob Steinberg, M.D., Professor of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY David Stilwell, Ph.D., University of Connecticut, Connecticut Agricultural Experiment Station, New Haven, CT Miroslav Styblo, Ph.D., Research Associate Professor, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC Donald Wauchope, Ph.D., Research Chemist, Southwest Watershed Research Lab, USDA, Agricultural Research Service, Tifton, GA PUBLIC COMMENTERS Oral statements were made by: Barbara Beck, Ph.D. (Gradient) on behalf of the Wood Preservative Science Council Chris Chaisson, Ph.D. (Lifeline Group) on behalf of the American Chemistry Council Floyd Frost, Ph.D. (Lovelace Research Institute) on behalf of the Wood Preservative Science Council Mr. John Horton (Osmose) on behalf of the Wood Preservative Science Council Page 9 of 70 Ms. Jane Houlihan (Environmental Working Group) Steven Lamm, M.D. (Consultants in Epidemiology & Occupational Health, Inc; Johns Hopkins University-Bloomberg School of Public Health, Department of Health Policy and Management) Yvette Lowney, Ph.D. (Exponent) on behalf of Georgia Pacific Barbara Petersen, Ph.D. (Exponent) on behalf of Georgia Pacific Mike Ruby, Ph.D. (Exponent) on behalf of Georgia Pacific Raj Sharma, Ph.D. (Arch Chemical Company) on behalf of the Wood Preservative Science Council Leonard Smith, Ph.D. (State University of New York, ESF) on behalf of the