Abstracts of papers presented at the 2004 meeting on COMPUTATIONAL & SYSTEMS NEUROSCIENCE March 24–March 28, 2004 Arranged by Carlos Brody, Cold Spring Harbor Laboratory Alexandre Pouget, University of Rochester Michael Shadlen, University of Washington Anthony Zador, Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory Cold Spring Harbor, New York Major funding for this meeting is provided by the Swartz Foundation and the Redwood Neuroscience Institute. Funding also provided in part by the National Science Foundation; and the National Institute of Mental Health, a branch of the National Institutes of Health; with additional support provided by Advanced Acoustic Concepts, Inc. Contributions from the following companies provide core support for the Cold Spring Harbor meetings program. Corporate Benefactors Amgen Inc. Eli Lilly and Company Aventis Pharma AG GlaxoSmithKline Bristol-Myers Squibb Company Pfizer Inc. Corporate Sponsors Applied Biosystems Lexicon Genetics Inc. BioVentures, Inc. Merck Research Laboratories Cogene BioTech Ventures, Ltd. New England BioLabs, Inc. Diagnostic Products Corporation OSI Pharmaceuticals, Inc. Genentech, Inc. Pall Corporation Hoffmann-La Roche Inc. Wyeth Genetics Institute Kyowa Hakko Kogyo Co., Ltd Plant Corporate Associates Monsanto Company Corporate Affiliates Affymetrix, Inc. Corporate Contributors Axxora, LLC Integrated DNA Technologies Biogen IRx Therapeutics, Inc. Epicentre Technologies KeyGene Illumina Foundations Albert B. Sabin Vaccine Institute, Inc. Cover: Illustrated by Marjorie Domenowske. COMPUTATIONAL & SYSTEMS NEUROSCIENCE Wednesday, March 24 – Sunday, March 28, 2004 Wednesday 7:30 pm Opening Lecture Thursday 9:00 am Session 1 Thursday 2:00 pm Poster Session I Thursday 4:30 pm Wine and Cheese Party * Thursday 7:30 pm Session 3 Friday 9:00 am Session 4 Friday 2:00 pm Poster Session II Friday 7:30 pm Session 6 Saturday 9:00 am Session 7 Saturday 2:00 pm Session 8 Saturday 6:00 pm Banquet Sunday 9:00 am Session 9 Poster sessions are located in Bush Lecture Hall * Airslie Lawn, weather permitting Mealtimes at Blackford Hall are as follows: Breakfast 7:30 am-9:00 am Lunch 11:30 am-1:30 pm Dinner 5:30 pm-7:00 pm Bar is open from 5:00 pm until late These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with consent of the author. Please note that recording of oral sessions by audio, video or still photography is strictly prohibited except with the advance permission of the author(s), the organizers, and Cold Spring Harbor Laboratory. PROGRAM WEDNESDAY, March 24—7:30 PM OPENING LECTURE Abbott, L.F., Volen Center for Complex Systems and Dept. of Biology, Brandeis University, Waltham, Massachusetts: Cascades and multi- timescale plasticity. 1 THURSDAY, March 25—9:00 AM SESSION 1 Meister, M., Harvard University, Cambridge, Massachusetts: Adaptation in the neural code of the retina. 2 Brainard, D.H.,1 Longère, P.,2 Kraft, J.M.,3 Delahunt, P.B.,4 Freeman, W.T.,5 Xiao, B.,1 1University of Pennsylvania, Philadelphia; 224 Chemin de la Cavalerie, Grasse, France; 3Institute of Science and Technology, University of Manchester, United Kingdom; 4University 5 of California, Davis; Massachusetts Institute of Technology, 3 Cambridge: Computational models of human color constancy. Deneve, S., Gatsby Computational Neuroscience Unit, University College London, United Kingdom: Bayesian inference with recurrent spiking networks. 4 Newsome, W.T., Sugrue, L.P., Corrado, G.S., Howard Hughes Medical Institute and Dept. of Neurobiology, Stanford University School of Medicine, California: Decision-making and the neural representation of "experienced value". 5 Niv, Y.,1 Duff, M.,2 Dayan, P.,2 1Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem, Israel; 2Gatsby Computational Neuroscience Unit, University College London, United Kingdom: The effects of uncertainty TD learning. 6 v THURSDAY, March 25—2:00 PM SESSION 2 POSTER SESSION I Aaron, G.,1 Ikegaya, Y.,1 Lampl, I.,2,3 Ferster, D.,2 Yuste, R.,1 1Dept. of Biological Sciences, Columbia University, New York, New York; 2Dept. of Neurobiology and Physiology, Northwestern University, Evanston, Illinois; 3Dept. of Neurobiology, Weizmann Institute of Science, Rehovot, Israel: Precisely repeating motifs of synaptic activity in neocortex. 7 Acker, C.D.,1,2 Sen, K.,1,2,3 White, J.A.,1,2,4 1Dept. of Biomedical Engineering,2Center for BioDynamics,3Hearing Research Center,4Center for Memory and Brain, Boston University, Massachusetts: Backpropagating action potentials—Role in synaptic plasticity. 8 Andermann, M.L., Ritt, J., Neimark, M.A., Moore, C.I., Program in Biophysics, Harvard University, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge: Neural correlates of vibrissa resonance—Band-pass and somatotopic representation of high-frequency stimuli. 9 Anemüller, J., Sejnowski, T.J., Makeig, S., Swartz Center for Computational Neuroscience, University of California, San Diego, Computational Neurobiology Laboratory, Salk Institute, La Jolla: Mapping spatio-temporal dynamics. 10 Archie, K.A., Mel, B.W., Neuroscience Graduate Program and Dept. of Biomedical Engineering, University of Southern California, Los Angeles: Stimulus competition and attentional modulation in V2/V4 could be computed by nonlinear dendritic sub-units. 11 Archie, K.A., Mel, B.W., Neuroscience Graduate Program and Dept. of Biomedical Engineering, University of Southern California, Los Angeles: Interactions between excitation and inhibition in bio- physically detailed and simplified models of neocortical pyramidal cells. 12 Aronov, D., Cossart, R., Yuste, R., Columbia University, New York, New York: Circuit attractors in the neocortex—Dynamics and mechanisms of network UP states. 13 vi Atwal, G., Dept. of Physics, Princeton University, New Jersey: Topographic plasticity in barn owls. 14 Averbeck, B.B.,1 Romanski, L.M.,2 1Center for Visual Science, Depts. of Brain and Cognitive Sciences2Neurobiology and Anatomy, Center for Navigation and Communication Sciences, University of Rochester, New York: Principal and independent components of macaque vocalizations. 15 Baccus, S.A., Ölveczky, B.P., Meister, M., Dept. of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts: Circuit mechanisms of differential motion selectivity in the retina. 16 Baker, J.L., Yen, S.C., Gray, C.M., Center for Computational Biology, Montana State University, Bozeman: Multineuron response dynamics in cat visual cortex during the presentation of time-varying natural scenes. 17 Bartlett, E.L., Wang, X., Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland: Persistent modulation by temporal context in auditory cortex of awake primates. 18 Bell, A.J., Redwood Neuroscience Institute, Menlo Park, California: A self-organizing sensorimotor spiking network. 19 Benda, J., Longtin, A., Maler, L., Depts. of Physics, Cellular and Molecular Medicine, University of Ottawa, Canada: Encoding communication signals with timescale separation by spike frequency adaptation. 20 Bennett, T.J., Gutkin, B., Dayan, P., Gatsby Computational Neuroscience Unit, University College London, United Kingdom: Temporal cognition and working memory. 21 Bethge, M., Redwood Neuroscience Institute, Menlo Park, California: How to "reset" a neural network? 22 Bohte, S.M., Mozer, M.C., University of Colorado, Boulder: Reducing spike train variance—A computational theory of spike-timing dependent plasticity. 23 Boloori, A.S., Stanley, G.B., Div. of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts: Implications of nonlinear center-surround interactions in the rat cortex for texture discrimination. 24 vii Bonin, V., Mante, V., Durand, S., Carandini, M., Smith-Kettlewell Eye Research Institute, San Francisco, California: Integration of stimulus contrast in the early visual system. 25 Boucher, L., Logan, G.D., Palmeri, T.J., Schall, J.D., Vanderbilt University, Nashville, Tennessee: An interactive race model of countermanding saccades. 26 Bressler, S.L.,1 Ding, M.,1 Ledberg, A.,1 Brovelli, A.,1 Chen, Y.,1 Nakamura, R.,2 1Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton; 2Laboratory of Neuropsychology, NIMH, National Institutes of Health, Bethesda, Maryland: Granger causality analysis of sensorimotor cortex in motor maintenance behavior. 27 Briggman, K.L.,1 Abarbanel, H.,2 Kristan, W.B.,1 Depts. of 1Neurobiology,2Physics, University of California, San Diego: Identification of decision making neurons in the leech CNS. 28 Britten, K.H., Zhang, T., Maciokas, J.B., Center for Neuroscience, University of California, Davis: The perception of heading depends on multiple cortical areas. 29 Broome, B., Laurent, G., Div. of Biology, California Institute of Technology, Pasadena: Aggregation pheromone processing in the locust antennal lobe. 30 Brown, E.,1 Moehlis, J.,1 Holmes, P.,1,2 Clayton, E.,3 Rajkowski, J.,3 Aston-Jones, G.,3 1Program in Applied and Computational Mathematics,2Dept. of Mechanical and Aerospace Engineering, Princeton University, New Jersey; 3Dept. of Psychiatry and Laboratory of Neuromodulation and Behavior, University of Pennsylvania, Philadelphia: From spikes to speed—Accuracy via 31 the locus coeruleus. Brozovic, M.,1 Abbott, L.,2 Andersen, R.,1 1Div. of Biology, California Institute of Technology, Pasadena; 2Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts: