8/21/20 CURRICULUM VITAE Sean J. Morrison PERSONAL DATA Address: Children’s Research Institute University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard Dallas, Texas, 75390-8502 Telephone: 214-648-2352 Fax: 214-648-5517 E-mail: [email protected] EDUCATION September 1986 - May 1991: B.Sc. with First Class Honors in Biology and Chemistry, Dalhousie University (Halifax, Canada) September 1991- June 1996: Ph.D. in Immunology, Stanford University (Stanford, CA) Supervisor, Dr. Irving L. Weissman POSTDOCTORAL TRAINING July 1996 - August 1999: Postdoctoral Scholar in the laboratory of Dr. David J. Anderson, California Institute of Technology (Pasadena, CA) EMPLOYMENT AND ACADEMIC APPOINTMENTS September 1987 - September 1990 President, Endogro Systems Inc., a company that developed technology for the agricultural use of plant growth-promoting fungi. August 1999 – August 2004 Assistant Professor, Departments of Internal Medicine (Division of Molecular Medicine and Genetics) and Cell and Developmental Biology, University of Michigan. June 2000 – Present Investigator, Howard Hughes Medical Institute September 2004 – September 2008 Associate Professor, Departments of Internal Medicine (Division of Molecular Medicine and Genetics) and Cell and Developmental Biology; Research Associate Professor, Life Sciences Institute, University of Michigan. September 2005 – August 2011 Director, University of Michigan Center for Stem Cell Biology and Henry Sewall Professor in Medicine, University of Michigan Page 1 8/21/20 September 2008 – August 2011 Professor, Departments of Internal Medicine (Division of Molecular Medicine and Genetics) and Cell and Developmental Biology; Research Professor, Life Sciences Institute, University of Michigan. September 2011 – present Director, Children’s Research Institute; Professor, Department of Pediatrics; Mary McDermott Cook Chair in Pediatric Genetics, Kathryne and Gene Bishop Distinguished Chair in Pediatric Research; University of Texas Southwestern Medical Center SCIENTIFIC ACTIVITIES Editorial Boards: 10/03 – 05/09 Stem Cells 01/06 – 04/15 Faculty of 1000, Section Head “Stem cells & Regeneration” 12/06 – present Cell Stem Cell 01/10 – present Journal of Experimental Medicine 03/11 – present EMBO Journal 09/11 – 05/17 Current Opinion in Cell Biology 04/12 – 05/20 Cancer Cell 04/12 – present eLife, Senior Editor 09/12 – present EMBO Reports 12/12 – present Stem Cell Reports 08/14 – present Cancer Discovery Grant Reviewer: 02/04 National Institutes of Health: Neurogenesis and Cell Fate (NCF) Study Section 10/06 California Institute for Regenerative Medicine: periodic ad hoc reviewer 01/07 – 02/11 Italian Association for Cancer Research (AIRC) 02/08 National Institutes of Health: Ad Hoc, Hematopoiesis (HP) Study Section 05/09 Damon Runyon Cancer Research Foundation Postdoctoral Fellowship Review Committee 10/09 – 04/11 Cancer Prevention and Research Institute of Texas, Basic Science Review Panel 11/10 National Inst. of Health: Chair, Special Emphasis Panel ZAG1 ZIJ-2 05/11 – 01/13 Chair, Howard Hughes Medical Institute International Predoctoral Fellowship selection committee 09/13 National Institutes of Health: Center for Regenerative Medicine Therapeutic Challenge Program 01/15 California Institute for Regenerative Medicine: Center for Excellence in Stem Cell Genomics 04/17 National Institutes of Health: Study section to review applications in response to the Pro/Anti-Geronic Factor RFA 07/17 National Institutes of Health: ZRG1 EMNR-P (02) M Nutrient and Lipid Regulation Study Section 07/19 National Cancer Institute: Biological Comparisons in Patient-Derived Models of Cancer (U01) Page 2 8/21/20 Meeting Organizer: 07/06 American Society for Cell Biology Summer Meeting, Stem Cell Niches; Boston, MA 02/08 Keystone Symposium Tumor Suppressors and Stem Cell Biology, Vancouver 08/09 – 07/10 International Society for Stem Cell Research Annual Meeting Chair, Program Committee 02/11 Abcam Symposium Therapeutic approaches to neurodegeneration: age modifiers, proteostasis, and stem cells 02/13 Keystone Symposium Stem Cell Regulation in Homeostasis and Disease Banff, Alberta, Canada 10/18 American Society for Cell Biology Doorstep Meeting (associated with the Annual Meeting), San Diego, CA Scientific Advisory Boards: 02/07 - present Scientific Advisory Board, University of California, Los Angeles Broad Stem Cell Research Center 12/10 – 07/11 External Advisory Committee, National Heart Lung and Blood Institute Progenitor Cell Biology Consortium 01/11 – 09/11 National Academy of Sciences panel to consider whether there should be a new taxonomy for disease 05/11 – present Chair, Scientific Advisory Board, University of Washington Institute for Stem Cells and Regenerative Medicine 07/11 – 01/13 Morgridge Institute, University of Wisconsin 10/12 – 10/13 Common Fund External Consultant for the NIH Center for Regenerative Medicine 08/13 – 08/15 Scientific Advisory Board, California Institute for Regenerative Medicine 10/14 – 03/15 Chair, New York State Stem Cell Program (NYSTEM) External Review Panel 06/18 – present FDA Cellular Tissue and Gene Therapies Advisory Committee 11/19 – present AACR Princess Takamatsu Memorial Lectureship Committee GRANT SUPPORT ONGOING 001823 (PI, Morrison) 09/01/00 – 10/31/21 Howard Hughes Medical Institute Funding is not associated with a specific project RP180778 (PI, Morrison) 08/31/18 – 8/30/22 Cancer Prevention and Research Institute of Texas “Metabolic enablers of melanoma progression – MIRA” This is a program project grant in which three laboratories (Morrison, DeBerardinis, and Mishra) will collaborate to study metabolic mechanisms that enable melanoma metastasis. The Morrison laboratory will study whether differences in oxidative stress, lactate metabolism, or mitochondrial function among melanomas from different patients confer intrinsic differences in metastatic potential. Page 3 8/21/20 R01 DK11875-02A1 (Morrison) 04/01/19 – 03/31/24 NIH – National Institutes of Health “The Metabolic Regulation of Hematopoietic Stem Cell Function” To determine whether ascorbate (vitamin C) depletion, which is common among people in Western countries, promotes hematopoietic regeneration or clonal hematopoiesis and to identify the mechanisms by which ascorbate regulates hematopoiesis. U01 CA228608-01A1 (PI, Morrison) 09/05/19 – 09/04/24 NCI – National Cancer Institute “The Metabolic Regulation of Melanoma Metastasis” The goal of this project is to compare patient-derived xenograft and patient-derived organoid assays to study the regulation of oxidative stress in melanoma cells. RECENT R37 AG02494514 (PI, Morrison) 08/01/04 – 5/31/20 NIH/NIA (MERIT Award) “The Regulation of Stem Cell Aging” To test whether the Bmi-1 polycomb protein is required to maintain adult neural stem cells and neurogenesis by opposing the age-related increases in p16Ink4a and p19Arf expression such that Bmi-1 deficiency leads to stem cell depletion and behavioral deficits that worsen with age. RP170114 (PI, Morrison) 12/1/16 - 11/30/19 Cancer Prevention and Research Institute of Texas “Mechanisms of melanoma metastasis” To test whether metastasizing melanoma cells exhibit increased dependence on pentose phosphate and malic enzyme pathways relative to primary cutaneous melanomas and whether RUNX3 promotes metastasis by regulating oxidative stress. RP170633 Morrison (PI, Morrison) 09/01/17 – 08/31/19 Cancer Prevention and Research Institute of Texas “The Role of the CACNA1D Calcium Channel in Melanoma” To test whether human melanoma cells are sensitive to therapeutic inhibition of L-type Ca2+ channel function. 1R56DK118745-01 (PI, Morrison) 07/15/18 – 06/30/19 NIH-NIDDK “The metabolic regulation of hematopoietic stem cell function” To test whether ascorbate negatively regulates hematopoietic stem cell clonal expansion or hematopoietic regeneration by promoting Tet2 function. 1 R01 DK100848 (PI, Morrison) 02/01/14 – 01/31/17 NIH/NIDDK “The regulation of protein synthesis in stem cells” HONORS AND AWARDS 1986 Young Canadians Award for Excellence in Science 1986 Waverly Award, Dalhousie University 1987 Dalhousie University McKenzie Trust Scholarship Page 4 8/21/20 1988 Dalhousie University Ross S. Smith and Alan Pollok Scholarships 1990 Dalhousie University Ross S. Smith Scholarship 1991 Natural Sciences and Engineering Research Council of Canada Research Award 1991 Dalhousie University Medal in Biology 1991 United Kingdom Commonwealth Scholarship, Oxford University (declined) 1991 Natural Sciences and Engineering Research Council 1967 Scholarship (declined) 1991-96 Howard Hughes Medical Institute Predoctoral Fellowship in Biological Sciences 1996 Guenther Foundation Postdoctoral Fellowship 1996-98 Natural Sciences and Engineering Research Council Postdoctoral Fellowship 1997-99 American Cancer Society, California Division Junior Postdoctoral Fellowship 1999 American Cancer Society, California Division Senior Postdoctoral Fellowship 2000-03 Searle Scholar 2000 Mental Illness Research Association Milestone Award 2002 Named to TR100 list: MIT Technology Review Magazine’s list of 100 young innovators 2003 Wired Magazine Rave Award for Science 2003 Presidential Early Career Award for Scientists and Engineers, White House Office of Science and Technology Policy 2004 Dean’s Award for Basic Science, University of Michigan Medical School 2006 Detroit News Michiganian of the Year 2007 Pfizer Young Michigan Biomedical Investigator of the Year Award 2007 McCulloch and Till Award, International Society for Hematology