1 Table of Contents I. Table of Contents ......................................................................................... 2 II. Thanks to our Sponsors ................................................................................ 3 III. Welcome Message...................................................................................... 5 IV. AOPT Membership Information .................................................................. 6 V. AOPT Past Meetings ..................................................................................... 7 VI. Your AOPT Board .......................................................................................... 8 VII. Your Local Organizing Committee .......................................................... 10 VIII. Travel Award Winners ................................................................................ 11 IX. General Information .................................................................................. 14 X. Information for Presenters ......................................................................... 15 XI. Hotel Amenities .......................................................................................... 16 XII. Hotel Floor Plan .......................................................................................... 19 XIII. Your Local Program Committee .............................................................. 22 XIV. Program At-A-Glance ............................................................................... 23 XV. Keynote Speaker ....................................................................................... 24 XVI. Platform Sessions ........................................................................................ 25 XVII. Platform Abstracts ...................................................................................... 38 XVIII. Poster Session ........................................................................................... 109 XIX. Poster Abstract ......................................................................................... 110 XX. Poster Abstract Index .............................................................................. 154 2 Thanks to our Sponsors Platinum Level 3 Gold Level Bronze Level YOUNG INVESTIGATOR TRAVEL AWARDS 4 Welcome Message Welcome to New Orleans to take part in the 14th Scientific Meeting of the Association for Ocular Pharmacology and Therapeutics (AOPT). The topic of this year’s conference is “Next Generation Ocular Therapeutics”. Our Keynote Speaker is Casey Kopczynski, PhD, Chief Scientific Officer and Co-founder of Aerie Pharmaceuticals, Inc. who will present: "Between a ROCK and a Hardened Meshwork: The Discovery and Development of Rhopressa”. We are thankful to our hosts, who have helped put together an exciting meeting at a great venue, the Hotel Moteleone, in the heart of New Orleans. The meeting agenda is packed with exciting new information set in thirteen sessions including a session with young investigators presenting. The Association for Ocular Pharmacology and Therapeutics is a global not-for-profit organization for scientists and individuals from all disciplines related to ocular pharmacology and its therapeutic applications. AOPT- has a diverse, multi-national membership composed of preclinical and clinical scientists, students, and healthcare professionals. Members are from academic institutions, pharma and biotech industries, device companies, clinics and private practice. AOPT’s mission is to serve as a global forum and network for the publication, dissemination and exchange of information and knowledge on treatments of eye diseases, from basic and clinical ocular pharmacology and therapeutics to related disciplines such as pharmacokinetics and dynamics, metabolism, translational research, safety, drug delivery, and pharmaceutics. The conference brings together those individuals at the forefront of scientific advancement related to ocular pharmacology and therapeutics. The program is rich in provocative presentations that we hope stimulate productive discussions and opportunities for networking and establishing potential collaborators. What better place to come together to discuss science than in “The Big Easy”. Tom Yorio, PhD, FARVO President, AOPT 5 AOPT Membership Information There are four classes of membership in AOPT: Regular Members, Associate Members, Contributing Members, and Emeritus Members. • REGULAR MEMBERS. The Regular Membership represent individuals demonstrating a genuine interest in or making significant contribution to ocular pharmacology and therapeutics. This may be evidenced by a) scientific publications; b) attendance at pharmacological, ophthalmological, optometric, or visual science meetings; c) direct involvement in research. A candidate for membership completes the online membership form and pays the appropriate membership dues. Membership is for two years. A subscription to the Journal of Ocular Pharmacology and Therapeutics is optional. • ASSOCIATE MEMBERS. Associate Membership is for pre-doctoral and postdoctoral students. A candidate for this membership must have a pre-doctoral, or postdoctoral student status, and must complete the online membership form and pay the appropriate membership dues. • CONTRIBUTING MEMBERS. Contributing Membership is restricted to corporations, associations, and individuals who support the objectives of AOPT but do not satisfy the requirements of Regular Membership or individuals elected to membership in any class who voluntarily choose to become Contributing Members. A candidate for contributing membership completes the online membership form and pays the appropriate membership dues. • EMERITUS MEMBERS. Any Regular Member may make a written request to the Treasurer that his/her membership be transferred to that of an Emeritus Member. The request is subject to approval of the membership committee. Emeritus Members have all the rights and privileges of Regular Members, except those of voting and holding elective office. AOPT Official Journal: The Journal of Ocular Pharmacology and Therapeutics (JOPT), published by Mary Ann Liebert, Inc., publishers (140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801), is the official Journal of AOPT. A substantially reduced subscription rate for this journal (electronic format) is an optional membership benefit, as indicated above. 6 AOPT Past Meetings Meeting Date Location Organizer THIRTEENTH MEETING FEB 16-19, 2017 FLORENCE, ITALY Filippo Drago TWELFTH MEETING FEB 26 - MAR 1, 2015 CHARLESTON, SC DAN STAMER ELEVENTH MEETING FEBRUARY 7-10, 2013 ALICANTE, SPAIN JUANA GALLAR MARTINEZ TENTH MEETING FEBRUARY 17-20, 2011 FT. WORTH, TX TOM YORIO / ABBOT CLARK NINTH MEETING FEBRUARY 18-21, 2009 SALZBURG, AUSTRIA HERBERT REITSAMER EIGHTH MEETING FEBRUARY 9-11, 2007 SAN DIEGO, CA JOHN LIU / ACHIM KRAUSS SEVENTH MEETING FEBRUARY 3-5, 2005 CATANIA, SICILY, ITALY FILIPPO DRAGO SIXTH MEETING FEBRUARY 1-4, 2003 KONA, HI PETER KADOR FIFTH MEETING NOVEMBER 2-5, 2000 BIRMINGHAM, AL JIMMY BARTLETT FOURTH MEETING JANUARY 28-31, 1999 IRVINE, CA ACHIM KRAUSS THIRD MEETING OCTOBER 22-24, 1997 BETHESDA, MD PETER KADOR SECOND MEETING AUGUST 15-17, 1996 LOS ANGELES, CA DAVID LEE FIRST MEETING JANUARY 26-29, 1995 NEW ORLEANS, LA HERB KAUFMAN OCULAR PHARMACOLOGY AUGUST 8-10, 1993 NOVI, MI HITOSHI SHICHI SYMPOSIUM 7 Your AOPT Board President Vice-President Immediate-Past- /President-Elect President Dr. Thomas Yorio Dr. Filippo Drago Dr. Achim H. Krauss Treasurer Secretary Dr. Peter Kador Dr. Carol Toris 8 Trustee Trustee Trustee Trustee Dr. Catherine Bowes Dr. Claudio Bucolo Dr. Ash Jayagopal Dr. Iok-Hou Pang Rickman Trustee Trustee Trustee Trustee Dr. Ganesh Prasanna Dr. Cheryl Rowe- Dr. Christine Wildsoet Dr. Heping Xu Rendleman 9 Your Local Organizing Committee Dr. Shusheng Wang Dr. Nicolas G. Bazan Organizer Co-organizer Tulane University Louisiana State University Dr. Delmar R. Caldwell Dr. Jayne S. Weiss Dr. Haydee E.P. Bazan Tulane University Louisiana State Louisiana State University University Dr. Maria Reinoso Dr. Partha Dr. Ash Jayagopal Bhattacharjee Louisiana State Roche University Xavier University 10 Travel Award Winners National Eye Institute (NEI) Travel Awardees (21 in total) Junior Faculty (4): Dorota Stankowska, PhD, Research Assistant Professor, University of North Texas Health Science Center Manas Biswal, PhD, Assistant Professor, University of South Florida Shaoqing He, PhD, Research Assistant Professor, University of North Texas Health Science Center Zhongjie (Kira) Fu, PhD, Instructor, Boston Children’s Hospital, Harvard Medical School Post-doctoral Fellows and Students (17): Bo Yu, PhD, Postdoctoral Fellow, Tulane University Fiona McDonnell, PhD, Postdoctoral Fellow, Duke University Heather Schmitt, PhD, Postdoctoral Fellow, Duke University Leona Ho, PhD, Postdoctoral Fellow, Duke University Lin Cheng, PhD, Postdoctoral Fellow, University of Iowa Hospitals and Clinics Mohamed M Ibrahim, PhD, Postdoctoral Fellow, University of Tennessee Health Science Center Monika Lakk, PhD, Postdoctoral Fellow, University of Utah Prabhavathi Maddineni, PhD, Postdoctoral Fellow, University of Tennessee Health Science Center Sri Konda, B. M., Postdoctoral Fellow, University of Wisconsin Madhoosudan Patil, PhD, Postdoctoral Fellow, University of Colorado Anschutz Medical Campus Yanfei Wang, PhD, Postdoctoral Fellow, Harvard Medical School Amanda Roberts, M.A., graduate student, University of North Texas Health Science Center Daniel Grigsby, B.S.,