Laboratory Chemical Hygiene Plan Environmental Health and Safety University of Rhode Island 177 Plains Road Kingston, RI 02881 401-874-7993 https://web.uri.edu/EH&S April 2021, revised University of Rhode Island Laboratory Chemical Hygiene Plan Table of Contents Chapter 1.0 Chemical Hygiene Plan Overview ............................................................................... 1 1.1 Introduction .......................................................................................................................... 1 1.2 Chemical Hygiene Responsibilities ....................................................................................... 2 1.3 Definitions ............................................................................................................................. 4 1.4 Hazard Identification for Substances Synthesized in University Laboratories ..................... 5 1.5 Chemical Safety Fundamentals ............................................................................................. 5 1.5.1 Chemical Safety Training ................................................................................................ 5 1.5.2 Container Labeling ......................................................................................................... 6 1.5.3 Safety Data Sheets (SDS) ................................................................................................ 7 1.5.4 Signs ............................................................................................................................... 8 1.6 Chemical Exposure Assessment ............................................................................................ 8 1.7 Medical Consultation and Examination ................................................................................ 9 1.8 Laboratory Safety Inspection Programs ............................................................................. 10 1.9 Prior Approval ..................................................................................................................... 10 1.10 Standard Operating Procedures (SOPs) ............................................................................ 10 1.11 Respiratory Protection Program for Laboratories ............................................................ 11 1.12 Medical Record Keeping ................................................................................................... 11 1.13 Laboratory Decommissioning ........................................................................................... 11 1.14 Hazmat Security ................................................................................................................ 11 1.15 Shipping Hazardous Materials/Dangerous Goods ............................................................ 12 Chapter 2.0 Standard Operating Procedures for Laboratory Chemicals ...................................... 13 2.1 General Guidelines .............................................................................................................. 13 2.1.1 Generic Standard Operating Procedures for Handling Laboratory Chemicals ............ 13 2.1.2 Personal Hygiene ......................................................................................................... 14 2.1.3 Housekeeping .............................................................................................................. 15 2.1.4 Glassware Safety .......................................................................................................... 15 2.2 Laboratory-Specific Written Standard Operating Procedures Required ............................ 15 2.2.1 When to Review an Existing Standard Operating Procedure ...................................... 17 2.3 Protective Clothing and Laboratory Safety Equipment ...................................................... 17 2.3.1 General Considerations - Personal Protective Clothing/Equipment (PPE) .................. 17 2.3.2 Protection of Skin and Body ........................................................................................ 18 2.3.3 Eye Protection .............................................................................................................. 20 2.3.4 Protection of the Respiratory System .......................................................................... 20 2.3.5 Laboratory Safety Equipment ...................................................................................... 21 2.4 Chemical Procurement, Distribution, and Storage ............................................................. 25 2.4.1 Procurement ................................................................................................................ 25 2.4.2 Moving Chemicals ........................................................................................................ 26 2.4.3 Chemical Storage in the Laboratory ............................................................................ 26 2.5 Chemical Spills and Accidents ............................................................................................. 30 2.5.1 General Information .................................................................................................... 30 2.5.2 Cleaning Up Chemical Spills ......................................................................................... 30 1 2.5.3 Minor Chemical Spill .................................................................................................... 30 2.5.4 Major Chemical Spill .................................................................................................... 31 2.5.5 Mercury Spills and Hydrofluoric Acid Spills ................................................................. 31 2.6 Personal Chemical Contamination and Injury .................................................................... 31 2.6.1 General Information .................................................................................................... 31 2.6.2 Chemicals Spills on the Body ....................................................................................... 32 2.6.3 Chemical Splash in the Eye .......................................................................................... 32 2.6.4 Ingestion of Hazardous Chemicals ............................................................................... 32 2.6.5 Inhalation of Smoke, Vapors and Fumes ..................................................................... 32 2.6.6 Burning Chemicals on Clothing .................................................................................... 33 2.6.7 Actions to be Avoided During Emergencies................................................................. 33 2.7 Fire and Fire Related Emergencies ..................................................................................... 33 2.8 Chemical Hazardous Waste Disposal Program ................................................................... 33 2.9 Chemical Inventory ............................................................................................................. 34 Chapter 3.0 Guidelines for Working with Chemicals of Specific Hazard Classes ......................... 36 3.1 Flammable Liquids .............................................................................................................. 36 3.1.1 Special Handling Procedures ....................................................................................... 36 3.2 Pyrophoric Chemicals.......................................................................................................... 38 3.3 Highly Reactive Chemicals and High Energy Oxidizers ....................................................... 38 3.3.1 Special Handling Procedures ....................................................................................... 39 3.3.2 List of Shock Sensitive Chemicals ................................................................................. 40 3.3.3 List of High Energy Oxidizers ........................................................................................ 41 3.3.4 List of Peroxide Formers .............................................................................................. 42 3.4 Piranha Solutions ................................................................................................................ 42 3.4.1 Special Handling Procedures ....................................................................................... 42 3.5 Compressed Gases .............................................................................................................. 43 3.5.1 Special Handling Procedures ....................................................................................... 43 3.5.2 Special Precautions for Hydrogen ................................................................................ 44 3.5.3 Special Procedures for Toxic Gases ............................................................................. 44 3.6 Cryogenic Liquids ................................................................................................................ 45 3.6.1 Special Handling Procedures ....................................................................................... 46 3.7 Corrosive Chemicals ............................................................................................................ 47 3.7.1 Special Handling Procedures ....................................................................................... 47 3.8 Chemicals of High Acute and Chronic Toxicity ..................................................................