Evidence-Based Complementary and Alternative Medicine Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013 Guest Editors: Paul Siu-Po Ip, Karl Wah-Keung Tsim, Kelvin Chan, and Rudolf Bauer Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013 Evidence-Based Complementary and Alternative Medicine Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013 Guest Editors: Paul Siu-Po Ip, Karl Wah-Keung Tsim, Kelvin Chan, and Rudolf Bauer Copyright © 2014 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Evidence-Based Complementary and Alternative Medicine.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board M. A. Abdulla, Malaysia Jen-Hwey Chiu, Taiwan Ching-Liang Hsieh, Taiwan Jon Adams, Australia W. Chi-shing Cho, Hong Kong Jing Hu, China Zuraini Ahmad, Malaysia Jae Youl Cho, Korea Sheng-Teng Huang, Taiwan U. P. Albuquerque, Brazil Seung-Hun Cho, Republic of Korea BennyTanKwongHuat,Singapore Gianni Allais, Italy Chee Yan Choo, Malaysia Roman Huber, Germany Terje Alraek, Norway Li-Fang Chou, Taiwan Angelo Antonio Izzo, Italy Souliman Amrani, Morocco Ryowon Choue, Republic of Korea Suresh Jadhav, India Akshay Anand, India Shuang-En Chuang, Taiwan Kanokwan Jarukamjorn, Thailand Shrikant Anant, USA J.-H. Chung, Republic of Korea Yong Jiang , China Manuel Arroyo-Morales, Spain Edwin L. Cooper, USA Zheng L. Jiang, China Syed B. Asdaq, Saudi Arabia Gregory D. Cramer, USA Stefanie Joos, Germany Seddigheh Asgary, Iran Meng Cui, China Sirajudeen K. N. S., Malaysia Hyunsu Bae, Republic of Korea Roberto N. Cuman, Brazil Z. Kain, USA Lijun Bai, China Vincenzo De Feo, Italy Osamu Kanauchi, Japan Sandip K. Bandyopadhyay, India R. De la Puerta Vazquez,´ Spain Dae Gill Kang, Republic of Korea Sarang Bani, India Martin Descarreaux, USA Wenyi Kang, China Vassya Bankova, Bulgaria Alexandra Deters, Germany Shao-Hsuan Kao, Taiwan Winfried Banzer, Germany Siva S. Durairajan, Hong Kong Krishna Kaphle, Nepal Vernon A. Barnes, USA Mohamed Eddouks, Morocco Kenji Kawakita, Japan Samra Bashir, Pakistan Thomas Efferth, Germany Jong Yeol Kim, Republic of Korea Jairo Kenupp Bastos, Brazil Tobias Esch, USA Youn Chul Kim, Republic of Korea Sujit Basu, USA Saeed Esmaeili-Mahani, Iran Cheorl-Ho Kim, Republic of Korea David Baxter, New Zealand Nianping Feng, China Yoshiyuki Kimura, Japan Andre-Michael Beer, Germany Yibin Feng, Hong Kong Joshua K. Ko, China Alvin J. Beitz, USA Josue Fernandez-Carnero, Spain Toshiaki Kogure, Japan Yong Chool Boo, Republic of Korea Juliano Ferreira, Brazil Jian Kong, USA Francesca Borrelli, Italy Fabio Firenzuoli, Italy Nandakumar Krishnadas, India Gloria Brusotti, Italy Peter Fisher, UK Yiu Wa Kwan, Hong Kong Ishfaq A. Bukhari, Pakistan W. F. Fong, Hong Kong Kuang Chi Lai, Taiwan Arndt Bussing,¨ Germany Joel J. Gagnier, Canada Ching Lan, Taiwan Rainer W. Bussmann, USA Siew Hua Gan, Malaysia Alfred Langler,¨ Germany Raffaele Capasso, Italy Jian-Li Gao, China Lixing Lao, Hong Kong Opher Caspi, Israel Gabino Garrido, Chile Clara Bik-San Lau, Hong Kong Han Chae, Korea M. N. Ghayur, Pakistan Jang-Hern Lee, Republic of Korea Shun-Wan Chan, Hong Kong Anwarul Hassan Gilani, Pakistan Myeong Soo Lee, Republic of Korea Il-Moo Chang, Republic of Korea Michael Goldstein, USA Tat leang Lee, Singapore Rajnish Chaturvedi, India Mahabir P. Gupta, Panama Christian Lehmann, Canada Chun Tao Che, USA Svein Haavik, Norway Marco Leonti, Italy Tzeng-Ji Chen, Taiwan Abid Hamid, India Lawrence Leung, Canada Kevin Chen, USA N. Hanazaki, Brazil Kwok Nam Leung, Hong Kong Jian-Guo Chen, China K. B. Harikumar, India Ping-Chung Leung, Hong Kong Hubiao Chen, Hong Kong Cory S. Harris, Canada ChunGuang Li, Australia Yunfei Chen, China Thierry Hennebelle, France Xiu-Min Li, USA Juei-Tang Cheng, Taiwan Seung-Heon Hong, Korea Ping Li, China Evan Paul Cherniack, USA Markus Horneber, Germany Shao Li, China Man Li, China Berit Smestad Paulsen, Norway Mayank Thakur, Germany Min Li, China Andrea Pieroni, Italy Menaka C. Thounaojam, India Yong Hong Liao, China Richard Pietras, USA Mei Tian, China Sabina Lim, Korea Waris Qidwai, Pakistan Evelin Tiralongo, Australia Bi-Fong Lin, Taiwan Xianqin Qu, Australia Stephanie Tjen-A-Looi, USA Wen Chuan Lin, China CassandraL.Quave,USA MichaThl Tomczyk, Poland Christopher G. Lis, USA Roja Rahimi, Iran Yao Tong, Hong Kong Gerhard Litscher, Austria Khalid Rahman, UK Karl Wah-Keung Tsim, Hong Kong I-Min Liu, Taiwan Cheppail Ramachandran, USA Volkan Tugcu, Turkey Ke Liu, China Gamal Ramadan, Egypt Yew-Min Tzeng, Taiwan Yijun Liu, USA Ke Ren, USA Dawn M. Upchurch, USA Cun-Zhi Liu, China Man Hee Rhee, Republic of Korea MarynaVandeVenter,SouthAfrica Gaofeng Liu, China Mee-Ra Rhyu, Republic of Korea Sandy van Vuuren, South Africa Gail B. Mahady, USA JoseLuisR´ ´ıos, Spain Alfredo Vannacci, Italy Juraj Majtan, Slovakia Paolo Roberti di Sarsina, Italy Mani Vasudevan, Malaysia Subhash C. Mandal, India Bashar Saad, Palestinian Authority Carlo Ventura, Italy Jeanine L. Marnewick, South Africa Sumaira Sahreen, Pakistan Wagner Vilegas, Brazil Virginia S. Martino, Argentina Omar Said, Israel Pradeep Visen, Canada James H. McAuley, Australia Luis A. Salazar-Olivo, Mexico Aristo Vojdani, USA Karin Meissner, Germany Mohd. Zaki Salleh, Malaysia Shu-Ming Wang, USA Andreas Michalsen, Germany Andreas Sandner-Kiesling, Austria Chong-Zhi Wang, USA David Mischoulon, USA Adair Santos, Brazil Chenchen Wang, USA Syam Mohan, Saudi Arabia G. Schmeda-Hirschmann, Chile Y. Wang, USA J. Molnar, Hungary Andrew Scholey, Australia Kenji Watanabe, Japan Valerio´ Monteiro-Neto, Brazil Veronique Seidel, UK Jintanaporn Wattanathorn, Thailand Hyung-In Moon, Republic of Korea Senthamil R. Selvan, USA Jenny M. Wilkinson, Australia Albert Moraska, USA Tuhinadri Sen, India Darren R. Williams, Republic of Korea Mark Moss, UK Hongcai Shang, China Haruki Yamada, Japan Yoshiharu Motoo, Japan Ronald Sherman, USA Nobuo Yamaguchi, Japan Frauke Musial, Germany Karen J. Sherman, USA Junqing Yang, China MinKyun Na, Republic of Korea Kuniyoshi Shimizu, Japan Yong-Qing Yang, China Richard L. Nahin, USA Kan Shimpo, Japan Eun Jin Yang, Republic of Korea Vitaly Napadow, USA Byung-Cheul Shin, Korea Ling Yang, China F. R. F. Nascimento, Brazil Yukihiro Shoyama, Japan Xiufen Yang, China S. Nayak, Trinidad And Tobago Chang-Gue Son, Korea Ken Yasukawa, Japan Roland Ndip Ndip, South Africa Rachid Soulimani, France Min Ye, China Isabella Neri, Italy Didier Stien, France M. Yoon, Republic of Korea T. B. Nguelefack, Cameroon Shan-Yu Su, Taiwan Jie Yu, China Martin Offenbaecher, Germany Mohd Roslan Sulaiman, Malaysia Zunjian Zhang, China Ki-Wan Oh, Republic of Korea Venil N. Sumantran, India Hong Q. Zhang, Hong Kong Yoshiji Ohta, Japan John R. S. Tabuti, Uganda Wei-Bo Zhang, China Olumayokun A. Olajide, UK Toku Takahashi, USA Jin-Lan Zhang, China Thomas Ostermann, Germany Rabih Talhouk, Lebanon Boli Zhang, China Stacey A. Page, Canada Wen-Fu Tang, China Ruixin Zhang, USA Tai-Long Pan, Taiwan Yuping Tang, China Hong Zhang, China Bhushan Patwardhan, India Lay Kek Teh, Malaysia Haibo Zhu, China Contents Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013, Paul Siu-Po Ip, Karl Wah-Keung Tsim, Kelvin Chan, and Rudolf Bauer Volume 2013, Article ID 463929, 2 pages Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway, Yan-Fang Xian, Zhi-Xiu Lin, Qing-Qiu Mao, Jian-Nan Chen, Zi-Ren Su, Xiao-Ping Lai, and Paul Siu-Po Ip Volume 2013, Article ID 163057, 8 pages Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells, Yan Wang, Wen-Liang Pan, Wei-Cheng Liang, Wai-Kit Law, Denis Tsz-Ming Ip, Tzi-Bun Ng, Mary Miu-Yee Waye, and David Chi-Cheong Wan Volume 2013, Article ID 937370, 11 pages Kai-Xin-San, a Chinese Herbal Decoction Containing Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria, Stimulates the Expression and Secretion of Neurotrophic Factors in Cultured Astrocytes, Kevin Yue Zhu, Sherry Li Xu, Roy Chi-Yan Choi, Artemis Lu Yan, Tina Ting-Xia Dong, and Karl Wah-Keung Tsim Volume 2013, Article ID 731385, 9 pages Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells, Maitinuer Maiwulanjiang, Kevin Y. Zhu, Jianping Chen, AbudureyimuMiernisha,SherryL.Xu,CrystalY.Q.Du,KittyK.M.Lau,RoyC.Y.Choi,TinaT.X.Dong, Haji A. Aisa, and Karl W. K. Tsim Volume 2013, Article ID 687958, 11 pages The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity, Chun-Fai Ng, Chun-Hay Ko, Chi-Man Koon, Jia-Wen Xian, Ping-Chung Leung, Kwok-Pui Fung, Ho Yin Edwin Chan, and Clara Bik-San Lau Volume 2013, Article ID 516741, 12 pages P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells, Xiang-Bao Meng, Gui-Bo Sun, Min Wang, Jing Sun, Meng Qin, and Xiao-Bo Sun Volume 2013, Article ID 971712, 15 pages Open Randomized Clinical Trial on JWSJZ Decoction for the Treatment of ALS Patients, Weidong Pan, Xiaojing Su, Jie Bao, Jun Wang, Jin Zhu, Dingfang Cai, Li Yu, and Hua