WO 2015/200827 Al 30 December 2015 (30.12.2015) P O P C T

WO 2015/200827 Al 30 December 2015 (30.12.2015) P O P C T

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/200827 Al 30 December 2015 (30.12.2015) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A 59/00 (2006.01) A61K 33/20 (2006.01) kind of national protection available): AE, AG, AL, AM, A0 25/00 (2006.01) C25B 1/26 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, AOlP l/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/US2015/038055 KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 26 June 2015 (26.06.2015) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (25) Filing Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/017,940 27 June 2014 (27.06.2014) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/087,872 5 December 2014 (05. 12.2014) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors; and DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicants : BROWN, Solomon [US/US]; 1334 High- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, point Dr., Romeoville, IL 60446 (US). GRADLE, Charles SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [US/US]; 1100 S. Grove Ave., Oak Park, Illinois 60304 GW, KM, ML, MR, NE, SN, TD, TG). (US). RICHARDS, Randall [US/US]; 17226 Nailsworth Way, Dallas, Texas 75252 (US). Published: — with international search report (Art. 21(3)) (74) Agent: SMITH, Jeffry W.; Smith Law Office, 85 17 Ex celsior Drive, Suite 402, Madison, Wisconsin 53717 (US). (54) Title: COMPOSITIONS AND METHODS FOR MIXING AND APPLYING MLXED OXIDANT COMPOSITIONS FOR DAIRY ANIMAL TREATMENT (57) Abstract: A method for mixing dairy animal teat dip from water and additives. The method includes a mixing manifold into which the water and additives are fed and mixed in a controlled manner. Mixed teat dip is automatically quality tested and monitored to provide data for controlling quantities of water and additives being fed to the manifold. COMPOSITIONS AND METHODS FOR MIXING AND APPLYING MIXED OXIDANT COMPOSITIONS FOR DAIRY ANIMAL TREATMENT CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of Provisional Application 62/087,872, filed December 5, 2014, and Provisional Application 62/017,940, filed June 27, 2014, the disclosures of which are incorporated by reference herein. FIELD AND BACKGROUND OF THE INVENTION [0002] The present invention relates to methods and apparatus for mixing dairy animal treatment chemicals and, in particular, for mixing dairy animal teat dip compositions having a mixed oxidant and an additive to enhance the usefulness of the composition. [0003] In dairy harvesting facilities, dairy animals are commonly treated with antimicrobial teat dips ("teat sanitizers") before and/or after milking. Teat sanitizers reduce or eliminate bacteria or other microorganisms that can cause an infection and inflammation of the mammary gland of milk-producing animals such as cows, goats, sheep, and buffalo. This infection, known as mastitis, causes a significant loss in income to dairy farmers worldwide. Some figures in the United States from 1993, for example, state losses in excess of two billion dollars, which includes not only loss in actual milk production, but loss of quality bonuses/premiums, treatment costs, costs related to culling and replacement of animals, and such indirect costs as increased training costs for employees, increased monitoring costs, associated medical costs related to mastitis in addition to animal welfare considerations (Oorsigartikel, A Review of the Factors Affecting the Costs of Bovine Mastitis; K R Petrovskia*, M Trajcevb and G Buneskib 0038-2809 Jl S.Afr.vet.Ass. (2006) 77(2): 52-60; and Jones, G. M.; Bailey, T. L. "Understanding the Basics of Mastitis". Virginia Cooperative Extension). Teat sanitizers have been shown in many field trials on dairy farms to be effective in preventing mastitis, both by killing microorganisms that may be present before milking machine attachment (environmental pathogens) and after the milking of the animal is concluded (contagious pathogens). [0004] Most teat dips are premixed at a chemical mixing plant and shipped to dairies as ready-to-use products. Premixed teat dips often include a large percentage of water that adds bulk and weight to the product and requires substantial shipping and storage costs. Further, some teat dips are unstable and have short shelf lives. Unstable teat dips are sold and shipped with unmixed components that are mixed in batches at a dairy facility or a dairy dealership near the dairy for use while it is still effective. [0005] Stable compositions of mixtures of surfactants and oxidizing materials that produce efficacious teat sanitizers have been described for iodine (U.S. Patent 5,503,838), peracetic acid (U.S. Patent 8,034,759), and peroxide (U.S. Patent 5,139,788). Additionally, stable hypochlorite compositions containing surfactants have been described (U.S. Patent Application Publication No. 2006/0263240). [0006] Another type of oxidizer useful in teat dips is a mixed oxidant. Mixed oxidants can be inexpensively produced with an automated system using an electrolysis process that supplies an electrical current through a salt solution and collects the resulting oxidant mixture. This process has been described in U.S. Patent 7,008,523. The nature of the mixed oxidant solution that is produced by this electrolysis process has been described as containing multiple oxidizing species comprising hypochlorite, peroxide, chlorine dioxide, chlorine radicals, and oxygen radicals. The mixed oxidant solutions have been reported to be more reactive than ordinary oxidants. [0007] Oxidizing materials that include iodine, peroxides, chlorine dioxide, peracetic acid, and hypochlorite have been combined with surfactants to produce stable solutions with good antimicrobial properties, but when a surfactant, colorant, or other additive is added to a mixed oxidant, the mixture can become unstable and have diminished teat sanitizing properties and shelf life. [0008] Some of the advantages of using surfactants in teat sanitizers include better cleaning of the teat skin and better penetration of the germicidal component(s) into the skin surface of the teat, comprising folds and crevices that may be present where harmful microorganisms may be sequestered. [0009] Mixing systems have been described for use in dairy facilities to make cleaning and hygiene products for use on dairy cows. Some of these systems require various scale, meter and pump configurations to accomplish accurate measuring and mixing of chemicals. Flow measurement and gravimetric measurement are two of the primary measuring methods that have been used to combine individual components into a chemical product. Gravimetric means to blend products require precise weighing of chemical components on one or more scales before the components are mixed. [0010] Another mixing system requires a vacuum for moving chemicals to a mixing vessel. Vacuum systems can be unreliable and imprecise because no monitoring of the flow rate is performed and delivery time for the ingredients is used to determine the amount of each component added at a mixing station. [001 1] There are also chemical dilution and dosing systems that use two flow meters, one on a single ingredient entering a mixing manifold and a second meter measuring flow of mixed material exiting the manifold. A disadvantage of this type of system is that it cannot measure more than one ingredient at a time as it enters a mixing manifold. Additionally, such systems typically use air to cause the ingredient to transfer into a mixing manifold, which can be unreliable and difficult to control. [0012] Prior chemical mixing systems suffer from an inherent non-uniform mixing of the finished chemical product and may require an additional mixing step to make a homogenous finished chemical product. [0013] For these reasons, dairy animal treatment chemicals, particularly teat dips, are generally mixed by a manufacturer at a primary chemical mixing facility to ensure complete mixing and teat dip quality. The premixed teat dips are usually shipped to dealers in dairy producing regions, and then sold to dairy harvesting facilities. Teat dips with short shelf lives are not sold this way because they lose efficacy during multiple stages of shipping. Teat dips that are chemically stable are sold and distributed this way, but as stated above, shipping and packaging costs are a substantial portion of a teat dip's volume and price. [0014] Thus, there is a need for stable teat dip compositions that include a mixed oxidant and an additive, such as a surfactant, which can be mixed near a point of use, such as a dairy. SUMMARY OF THE INVENTION [0015] The present invention is directed to mixed oxidant compositions and methods for mixing a mixed oxidant with additives to enhance the effectiveness of the compositions for use on dairy animals. In accordance with the present invention, there is provided a method for sanitizing a dairy animal teat after milking by performing the steps of: mixing a surfactant and a mixed oxidant to produce a composition that is stable and is a teat sanitizer; and applying the composition to the dairy animal teat.

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