springer.com T.C. Northfield, P. Zentler-Munro, R. Jazwari (Eds.) Bile Acids in Health and Disease Update on Cholesterol Gallstones and Bile Acid Diarrhoea Bile acids occupy a central position in in the absorption, excretion and metab• olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage• ment of these diseases is increasingly based on an understanding of the physicochemical and biochemical properties of bile acids, and of their pathophysiological role in disease. Professor Alan Hofmann starts this book with an overview of the enterohepatic circulation of bile acids. The first section then discusses biliary lipid synthesis, transport and secretion by the liver and the solubilisation Softcover reprint of the original 1st ed. of cholesterol in the bile. The next section applies this knowledge to the pathogenesis of 1988, 288 p. cholesterol gallstones. Separate chapters focus on defects in biliary lipid secretion, in cholesterol solubilisation and in gallbladder motility. The succeeding sections then review Printed book posssible approaches to gallstone prevention, and assess recent developments in non-surgical Softcover forms oftreatment. Two exciting new therapies that receive particular attention are contact 64,99 € | £54.99 | $79.99 dissolution therapy with methyl tert-butyl ether and extracorporeal shock wave lithotripsy. [1]69,54 € (D) | 71,49 € (A) | CHF Further sections turn to the absorptive functions of bile acids in health. 77,00 eBook 53,49 € | £43.99 | $59.99 [2]53,49 € (D) | 53,49 € (A) | CHF 61,50 Available from your library or springer.com/shop MyCopy [3] Printed eBook for just € | $ 24.99 springer.com/mycopy Error[en_EN | Export.Bookseller. MediumType | SE] Order online at springer.com / or for the Americas call (toll free) 1-800-SPRINGER / or email us at: [email protected]. / For outside the Americas call +49 (0) 6221-345-4301 / or email us at: [email protected]. The first € price and the £ and $ price are net prices, subject to local VAT. Prices indicated with [1] include VAT for books; the €(D) includes 7% for Germany, the €(A) includes 10% for Austria. Prices indicated with [2] include VAT for electronic products; 19% for Germany, 20% for Austria. All prices exclusive of carriage charges. Prices and other details are subject to change without notice. All errors and omissions excepted. [3] No discount for MyCopy. Part of .