XXII Congress The International Society on Thrombosis and Haemostasis B July 11-16 2009 O 55th Annual Meeting S of the Scientific and Standardization Committee of the ISTH T O Final Program N Boston - July 11-16 2009 XXII Congress of the International Society on Thrombosis and Haemostasis 2009 Table ISTH of Contents Venue and Contacts 2 Wednesday 209 Welcome Messages 3 – Plenary Lectures 210 Committees 7 – State of the Art Lectures 210 Congress Awards and Grants 15 – Abstract Symposia Lectures 212 Other Meetings 19 – Oral Communications 219 – Posters 239 ISTH Information 20 Program Overview 21 Thursday 305 SSC Meetings and – Plenary Lectures 306 Educational Sessions 43 – State of the Art Lectures 306 – Abstract Symposia Lectures 309 Scientific Program 89 – Oral Communications 316 Monday 90 – Posters 331 – Plenary Lectures 90 Nursing Program 383 – State of the Art Lectures 90 Special Symposia 389 – Abstract Symposia Lectures 92 Satellite Symposia 401 – Oral Communications 100 – Posters 118 Technical Symposia Sessions 411 Exhibition and Sponsors 415 Tuesday 185 – Plenary Lectures 186 Exhibitor and Sponsor Profiles 423 – State of the Art Lectures 186 Congress Information 445 – Abstract Symposia Lectures 188 Map of BCEC 446 – Oral Communications 196 Hotel and Transportation Information 447 ISTH 2009 Congress Information 452 Boston Information 458 Social Events 463 Excursions 465 Authors’ Index 477 1 Venue & Contacts Venue Boston Convention & Exhibition Center 415 Summer Street - Boston, Massachusetts 02210 - USA Phone: +1 617 954 2800 - Fax: +1 617 954 3326 The BCEC is only about 10 minutes by taxi from Boston Logan International Airport. The 2009 Exhibition is located in Hall A and B of the Exhibit Level of the BCEC, along with posters and catering. Meeting rooms for oral presentations and symposia are located on the 1st and 2nd floors. For further information about the BCEC, please visit www.massconvention.com/bcec.html Contacts Sponsorship & Exhibit Sales, Industry Relations MCI Suisse is the official Congress Organizer for Requests about sales opportunities or the XXII Congress of the ISTH. questions by industry partners should be directed to: For further information contact: Margo Price, ISTH Director of Corporate Relations ISTH 2009 Congress Organizer Local Number: +1 919 600 4095 MCI Suisse SA Email: [email protected] Rue de Lyon 75 1211 Geneva 13, Switzerland Exhibition & Sponsorship Logistics Local Number: +1 617 954 3360 and Management Phone: +41 22 33 99 587 MCI Suisse SA Local Fax: +1 617 954 3379 Christophe de Rham Fax: +41 22 33 99 601 Email: [email protected] Email: [email protected] Website: www.isth2009.com ISTH Headquarters 610 Jones Ferry Road, Suite 205 Registration and Hotel Accommodation Carrboro, NC 27510, USA MCI Suisse SA Phone: +1 919 929 3807 Local Number: +1 617 954 3368 Fax: +1 919 929 3935 Phone: +41 22 33 99 587 Website: www.isth.org Local Fax: +1 617 954 3379 Email: [email protected] Fax: +41 22 33 99 601 Email: [email protected] General Society Information Requests for information about ISTH and its mission may be directed to: Cathy Cole, ISTH Executive Secretary Email: [email protected] Robert Cary Clark, SSC Coordinator Email: [email protected] Sharon Overcash, ISTH Membership Secretary Email: [email protected] 2 Message from the Congress Presidents Dear Colleagues and Friends, On behalf of the Local Organizing Committee, it is our great pleasure to welcome you to Boston and the XXII Congress of the ISTH. This biennial event is one of the highlights of our professional activities, and we are confident that you will find the meeting enlightening and enjoyable. We have worked to develop an array of topics, lectures and poster presentations that will be of interest to a broad spectrum of physicians and scientists in our field, from students to seasoned practitioners, and covering topics in both basic and clinical science. A new Education Program, special opportunities for trainees, grants to young scientists and attendees from developing countries, and geographic-specific programs, among other initiatives, are all intended to make this an inclusive meeting that embraces the great diversity of our field within the context of an international meeting. We have had the privilege of working with a dedicated Local Organizing Committee and Program Committee, and we can’t thank them enough for their generous commitment of time and energy to this event. This Congress is the result of their efforts, as well as the efforts of countless others, who have shaped the program and tended to the myriad of arrangements that make up a successful meeting. Thank you for joining us. We invite you to take advantage of the full range of program offerings, as well as the exciting social events and opportunities to meet or reconnect with colleagues from around the world. BRUCE FURIE President XXII Congress of the ISTH BARBARA C. FURIE President XXII Congress of the ISTH 3 Message from the Council Chairman Dear Colleagues and Friends, Nearly 150 years ago, Boston was already renowned as a place of learning in the United States, when Mark Twain remarked that in Boston someone was judged on what he knew, rather than on what he was worth or who his parents were. It is therefore most appropriate that in 2009 Boston is our place of learning, as it hosts our XXII Congress. Our biennial Congress is an important event for the advancement of our field, and I am delighted that you are participating. It is here that professional colleagues from all over the world can come together to hear the latest developments in clinical medicine and basic science, as well as have time to meet informally to share ideas and build relationships. The Society is extremely grateful to the Congress Presidents, Barbara and Bruce Furie, and their team, for taking on the task of organizing all aspects of this meeting. Their commitment and efforts are of great benefit to all of us. The ISTH 2009 program is filled with topics important to us all, from basic scientists to clinicians. I look forward to seeing you during the course of the Congress. F. R. ROSENDAAL MD PhD Chairman of Council, ISTH 4 Message from the Executive Director of ISTH Dear Colleagues and Friends, For the first time since the Washington Congress in 1999, the ISTH returns to the United States – to Boston, the site of our 2002 SSC meeting – for our XXII Congress and for the 55th SSC meeting. Congress Presidents Bruce and Barbara Furie and their organizing committee have worked hard and have developed an outstanding and unique program, including for the first time an educational com- ponent aimed at students, trainees, clinicians and basic scientists interested in our field. As always, the scientific program will feature invited speakers and the latest in our science and medicine. The new convention center set on Boston's Inner Harbor provides a beautiful site for the meeting. The social program showcases the remarkable history and culture of the city. It promises to be a memorable Congress. New England is a beautiful place in the summer. From the sand bea- ches of Cape Cod and the maritime islands, Nantucket, Martha's Vineyard, and the Elizabeth Islands, to the Berkshire region in western Massachusetts, to Casco Bay and the dramatic coast of Maine and Acadia National Park, to the Allagash Wilderness in the North Woods, to the White Mountains of New Hampshire, to the crystal waters of Lake Champlain, it is a great place to explore before or after the meeting. Take advantage of the excellent science offered here and become part of the tradition of the International Society on Thrombosis and Haemostasis. GILBERT C. WHITE II Executive Director ISTH 5 Message from the Scientific Program Committee Chairpersons Dear Colleagues and Friends, We are very pleased to present to you the ISTH 2009 Scientific Program - a full array of lectures and programmatic elements that address the varied interests of basic and clinical scientists. Our dedicated committee, with essential input from the distinguished International Scientific Advisory Board, has worked hard to ensure that each of our six core disciplines is well- represented and includes new voices and ground-breaking science. The XXII Congress program includes several innovations. An Education Pro- gram has been developed in conjunction with the SSC meetings on Saturday and Sunday, to provide a basic introduction to key topics. In addition to the traditional Oral Communications, we have organized Abstract Symposia sessions where an invited speaker is paired with the presentation of several abstracts on a related theme, and some of the most outstanding abstracts will be showcased in a special Presidential Plenary Abstract session on Tuesday afternoon. We will of course also hear from some exciting Plenary and State of the Art speakers throughout the Congress as well. The success of each ISTH Congress is measured first and foremost by the quality of the scientific program, and we are confident that you will find the XXII ISTH Congress outstanding in this regard. We are enormously grateful to our wonderful Scientific Program Committee, International Scientific Advisory Board, Abstract Reviewers and Congress Organizers for all the hard work that went into making this program a reality. Welcome. We look forward to your participation in ISTH 2009. KENNETH A. BAUER Congress Vice President and Chair, Education Program Co-Chair Scientific Program Committee (Clinical Sciences) PAULA B. TRACY Co-Chair Scientific Program Committee (Basic Sciences) 6 Committees ୵ Local Organizing Committee From left to right Standing: R. Handin, B. Furie, K. Bauer, K. Mann, R. Flaumenhaft, K. Plazak Seated: D. Wagner, P. Tracy, B. Furie, M. Price Congress Committees Paula B. Tracy PhD Local Organizing Committee Co-Chair, Scientific Program Committee (Basic Sciences) Bruce Furie MD Robert Flaumenhaft MD PhD Barbara C.