BOARD OF DIRECTORS Linda J. Porrino, PhD, President David A. Fiellin, MD Sharon Walsh, PhD, Past-President Leonard L. Howell, PhD Anna Rose Childress, PhD, President-Elect Scott E. Lukas, PhD Stephen G. Holtzman, PhD, Treasurer Geoffrey K. Mumford, PhD Patrick M. Beardsley, PhD Michael A. Nader, PhD Lawrence S. Brown, MD, MPH Edward V. Nunes, MD Steven R. Childers, PhD Richard A. Rawson, PhD Theodore J. Cicero, PhD Maxine L. Stitzer, PhD Sandra D. Comer, PhD Eric C. Strain, MD Richard De La Garza, II, PhD Dace S. Svikis, PhD EXECUTIVE OFFICER Martin W. Adler, PhD SCIENTIFIC PROGRAM COMMITTEE Sari Izenwasser, PhD, Chair Martin W. Adler, PhD, ex officio Ellen B. Geller, MA, ex officio Alan J. Budney, PhD Howard D. Chilcoat, ScD Sandra D. Comer, PhD Patrick M. Flynn, PhD Cindy Kuhn, PhD Michelle R. Lofwall, MD Lance R. McMahon, PhD Janet L. Neisewander, PhD Jennifer W. Tidey, PhD Ellen M. Unterwald, PhD Elise M. Weerts, PhD PRE-MEETING SATELLITES NIDA: Application of Genetic Approaches to Understand Sonoran Drug Abuse and Addiction June 11 Chaired by Minda R. Lynch and David Shurtleff Third Meeting of the International Women’s and Children’s Salon BC Health and Gender Group June 11 Chaired by Frances E. Ashe-Goins and Wendee Wechsberg The 14th Annual NIDA International Forum on Sonoran Drug Abuse Research, Policy and the Public Good June 11 - 12 Chaired by Steven Gust Addiction Studies Program for Journalists (ASPJ) McDowell (By Invitation Only) June 11 - 12 The International Study Group Investigating Salon D Drugs as Reinforcers (ISGIDAR) June 12 Chaired by S. Barak Caine 10 th Annual Meeting Center for Substance Abuse Salon BC Treatment (CSAT) June 12 Chaired by Peter Edwards 2010 AAAP Addiction Board Review Course at CPDD: Salon F A Clinical Review of Substance Use Disorders June 12 CPDD REGISTRATION Conference Center – East Foyer Saturday, June 12 1:30 PM - 5:30 PM Sunday, June 13 8:00 AM - 12:00 PM 1:30 PM - 5:00 PM Monday, June 14 9:00 AM - 12:30 PM 1:30 PM - 5:00 PM Tuesday, June 15 11:00 AM - 5:00 PM Wednesday, June 16 9:00 AM - 11:00 PM 2:00 PM - 5:00 PM Thursday, June 17 8:00 AM - 1:00 PM OPENING RECEPTION (Cash Bar) Hacienda Plaza Saturday, June 12 7:00 PM - 9:00 PM (Pre-registrants can pick up badges only) Sunday, June 13, 2010 CSAT Travel Awards Breakfast Princesa (By Invitation Only) 7:00 - 8:00 AM Plenary Session Salons DEFG 8:45 - 11:30 AM 8:45 Welcome, CPDD President Linda Porrino 8:55 Report from the National Institute on Drug Abuse Nora D. Volkow, NIDA, Bethesda, MD 9:25 Drug Strategies and Potential for Research Opportunities A. Thomas McLellan, Deputy Director for Demand Reduction, ONDCP, Bethesda, MD 9:55 Presentation of the Distinguished Service Award to Jack Henningfield Introduction by Sharon Walsh 10:00 Presentation of the Media Award to Allan Brandt Introduction by Marc Kaufman 10:05 Presentation of the J. Michael Morrison Award to Cora Lee Wetherington Introduction by Marilyn Carroll 10:10 Presentation of the Joseph Cochin Young Investigator Award to David Jentsch Introduction by Edythe London 10:15 Presentation of the Mentorship Award to Charles O’Brien Introduction by Anna Rose Childress 10:20 Presentation of the Nathan B. Eddy Award to Theodore Cicero Introduction by Linda Cottler 10:30 Nathan B. Eddy Award Lecture by Theodore Cicero Early Career Investigator Awards Luncheon La Hacienda (By Invitation Only) 12:00 - 1:30 PM President’s Lecture Salons DEFG 1:30 - 2:30 PM GENE X ENVIRONMENT INTERACTIONS IN PRIMATES Stephen J. Suomi, National Institutes of Health, DHHS Symposium I Salons HI 3:00 - 5:00 PM TRANSLATING THE GENETICS AND NEUROCHEMISTRY OF NICOTINE DEPENDENCE TO DRUG DEVELOPMENT Chairs: Linda Porrino and Joni L. Rutter 3:00 Genetic variation in nicotine metabolism and implications for targeted therapy for nicotine addiction Caryn Lerman, Psychiatry, University of Pennsylvania, Philadelphia, PA 3:25 Genetics of nicotine dependence and the convergence with lung cancer and chronic obstructive pulmonary disease Laura Bierut, Washington University at St. Louis, St. Louis, MO 1 Sunday, June 13, 2010 3:50 Alpha-5-containing nicotinic acetylcholine receptors transmit a negative reward signal that controls nicotine intake Paul Kenny, Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 4:15 The influence of the Alpha-5 subunit on the regulation of brain nicotinic cholinergic receptors by nicotine Ken Kellar, Pharmacology, Georgetown University School of Medicine, Washington, DC 4:40 Discussant Nora Volkow, National Institute on Drug Abuse, Bethesda, MD Symposium II Salons ABC 3:00 - 5:00 PM CPDD INTERNATIONAL COMMITTEE SYMPOSIUM: A COMPREHENSIVE APPROACH TO EXAMINE THE USE AND IMPACT OF CANNABIS: FROM BRAIN EFFECTS TO EPIDEMIOLOGICAL IMPACT ACROSS THE WORLD Chairs: Flavio Pechansky and Alison Ritter 3:00 Cognitive effects of cannabinoids: Lessons from animal models Marco Bortolato, Neurological Science, University of Cagliari, Monserrato, Italy 3:25 Is cannabis smoking harmful? Epidemiological perspectives and evidence on this question James C. Anthony, Epidemiology, Michigan State University, East Lansing, MI 3:50 Periadolescent cannabinoid exposure effects on self-administration behavior and several neurotransmitter systems in the adulthood Emilio Ambrosio Flores, Psychobiology, UNED-Ciudad Universitaria Madrid, Madrid, Spain 4:15 Imaging trials of cannabis users in South Africa Paul Carey, Psychiatry, University of Stellenbosch, Stellenbosch, South Africa 4:40 Discussant Jan Copeland, National Cannabis Prevention and Information Centre, University of New South Wales, Sydney, NSW, Australia Oral Communications 1 Salon DE 3:00 - 5:00 PM WHAT’S NEW WITH MU? HUMAN LABORATORY RESEARCH WITH OPIOIDS Chairs: Mark Greenwald and Bethea A. Kleykamp 3:00 Yohimbine increases opioid-seeking behavior in buprenorphine-stabilized, heroin-dependent volunteers M. Greenwald, C. L. Steinmiller, Psychiatry, Wayne State University, Detroit, MI 3:15 Pharmacodynamic and pharmacokinetic profile of crushed intranasal Suboxone® and Subutex® in sporadic opioid abusers L. S. Middleton1, P.A. Nuzzo1, M. R. Lofwall1,2, D. E. Moody3, M. J. Wunsch1,2, S. L. Walsh1,2, 1Behavioral Science/Center on Drug & Alcohol Research, and 2Psychiatry, University of Kentucky, Lexington, KY, 3Center for Human Toxicology, University of Utah, Salt Lake City, UT 2 Sunday, June 13, 2010 3:30 Oral intact extended-release oxymorphone has fewer subjective and cognitive effects than equianalgesic controlled-release oxycodone S. O. McMorn1, K. A. Schoedel2, B. Chakraborty2, E. M. Sellers2, 1Endo Pharmaceuticals Inc., Chadds Ford, PA, 2Kendle Early Stage, Toronto, ON, Canada 3:45 The effect of methadone on emotional reactivity S. Savvas, A. A. Somogyi, J. M. White, Adelaide University, Adelaide, SA, Australia 4:00 Effects of methadone alone and in combination with alcohol on cognitive performance in methadone-maintained volunteers B. A. Kleykamp, R. G. Vandrey, G. E. Bigelow, E. C. Strain, M. Z. Mintzer, Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 4:15 The effects of the opiate neutral antagonist 6β-naltrexol in opiate-dependent subjects J. Mendelson1, K. Flower1, M. Jang1, C. W. Harris1, W. Sadee2, W. Snape1, G. P. Galloway1, 1Addiction Pharmacology, California Pacific Medical Center Research Institute, San Francisco, CA, 2Pharmacology, Ohio State University, Columbus, OH 4:30 Effects of cycloserine and gabapentin in methadone-maintained humans under a naloxone novel-response discrimination procedure A. Oliveto1, W. B. Gentry1, J. B. Guise1, C. Cargile2, W. K. Bickel1, M. J. Mancino1, 1Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, 2Psychiatry, Texas A & M Health Science Center, College Station, TX 4:45 Assessing temptations to use heroin and cocaine during drug detoxification using ecological momentary assessment A. J. Waters1, I. Franken2, R. Marhe2, 1Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, 2Psychology, Erasmus University, Rotterdam, Netherlands Oral Communications 2 Salon FG 3:00 - 5:00 PM UP FRONT WITH DRUG ADDICTION: ROLE OF FRONTAL CORTEX Chairs: Anna R. Childress and Hedy Kober 3:00 Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates cue-elicited reinstatement of cocaine-seeking behavior in rats L. A. Pockros, N. S. Pentkowski, S. E. Swinford, L. M. Robertson, M. Ostos, J. L. Neisewander, Arizona State University, Tempe, AZ 3:15 BDNF in the prefrontal cortex: Involvement in psychostimulant- and social defeat stress-induced behavioral sensitization E. Nikulina1,2, M. Lacagnina1, J. Wang2, S. Fanous1, R. Hammer, Jr1,2, 1Basic Medical Sciences, University of Arizona, College of Medicine -Phoenix, Phoenix, AZ, 2Neuroscience, Arizona State University, Tempe, AZ 3:30 Psychostimulant drug effects on spike train coding of sensory and decision-related signals in rodent thalamic and cortical circuits during quiet resting and sustained attention B. Waterhouse, K. L. Agster, B. D. Clark, J. S. Shumsky, Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA BADGES MUST BE WORN FOR ALL SESSIONS AND SOCIAL EVENTS 3 Sunday, June 13, 2010 3:45 Impaired fronto-amygdalar connectivity: A marker of poor behavioral control in cocaine dependence? J. J. Suh1,2, R. Ehrman1,2, Y. Li1, Z. Wang1, D. Willard1, R. Fabianski1, R. Carson1, R. Hazan1, A. Fornash1, M. Goldman1, T. Franklin1, A. V.Hole1,2, R. Szucs1,2, C. P. O’Brien1,2, A. R. Childress1,2, 1University of Pennsylvania School of Medicine, and 2VA VISN4 MIRECC, Philadelphia, PA 4:00 Changes in brain activation pattern during cue reactivity after one month abstinence in heroin dependents H. Ganjgahi1, P. Hasani Abharian1,2, J. Mc Clernon4, Z. Alam Mehrjerdi1, H. Tabatabaei1, M. Oghabian3, H. Ekhtiari1, 1Neurocognitive, Iranian National Center for Addiction Studies, 2Institute for Cognitive Sciences Studies, and 3Neuroimaging, Research Center for Science and Technologies, Tehran, Islamic Republic of Iran, 4Center for Nicotine and Smoking Cessation Research, Duke University Medical Center, Durham, NC 4:15 Relationship of impulsive personality traits and orbitofrontal rCBF in cocaine-addicted and healthy subjects J.