European Medicines Agency Evaluation of Medicines for Human Use London, 5 July 2007 Doc. Ref: EMEA/249428/2007 COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC) DRAFT LIST OF REFERENCES FOR ASSESSMENT OF: Eleutherococci radix Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. (eleutherococcus root) The EMEA acknowledges that copies of the underlying works used to produce this monograph were provided for research only with exclusion of any commercial purpose. 1. Abascal K, Yarnel E, 2003. Increasing vitality with adaptogens. Multifaceted herbs for treating physical and mental stress. Altern Complement Therapies, 9, 2:54-60. 2. Abramova JI, Chorny ZH, NatalenkoVP et al, 1972a. Pharmacological analysis for the adaptogenic action mechanism of Eleutherococcus and dibazole. Medicines of the Soviet Far East. Vladivostok. 11:102-5. [Article in Russian] 3. Abramova JI, Chorny ZH, NatalenkoVP et al, 1972b. Stimulation of catecholamine and serotine circulation caused by Eleutherococcus and dibazole. Medicines of the Soviet Far East. Vladivostok. 11:106-8. [Article in Russian] 4. Afanasiev BG, Zhestovsky VA, Mazurov KV et al, 1973. Comparative assessment of the effect produced by Eleutherococcus and the acid-saline beverage on the development of adaptation to intermittent exposure to heat. Vopr Pitan, 32, 1:3-9. [Article in Russian] 5. Afanasyeva TN, 1981. Effect of Eleutherococcus on dynamics of electrocardiographs disturbances at experimental myocardial infarction. In: New Data on Eleutherococcus and other adaptogens. Vladivostok. 34-8. [Article in Russian] 6. Afanasyeva TN, Krivchik AA, Kurtasova TP, 1986. Some mechanisms of positive effect of Eleutherococcus upon the course and outcome of experimental myocardial infarction. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 81-9. [Article in Russian] 7. Afanasyeva TN, Lebkova NP, 1987. The effect of Eleutherococcus on subcellular heart structures in experimental myocardial infarct. Biull Eksp Biol Med, 103, 2:212-5. [Article in Russian] 8. Aicher B, Wozniewski T, 1998. Eleutherococcus. In: Blaschek W, Hansel R, Keller K et al, eds. Hagers Handbuch der Pharmazeutischen Praxis, 5th ed. Folgeband 2. Berlin-Heidelberg-New York: Springer. 556-97. [Article in German] 9. Akimov AA, 1966. Influence of Eleuterococcus on the therapeutic action of cortisone in rats with the interwoven lymphosarcoma. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:117-20. [Article in Russian] 7 Westferry Circus, Canary Wharf, London, E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 75 23 70 51 E-mail: [email protected] http://www.emea.europa.eu ©EMEA 2007 Reproduction and/or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged 10. Alekseeva LV, Bykhovtseva TL, Bezlepkin VG et al, 1975. Influence of liquid extracts of Ginseng and Eleutherococcus roots on some systems of the metabolism. Proceedings USSR Akad Sciences, Biological series, 4:609-12. [Article in Russian] 11. Amaryan G, Astvatsatryan V, Gabrielyan E et al, 2003. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytomedicine, May, 10 (4):271-85. 12. Andreev IF, 1976. Effect of Eleutherococcus extract on some functions of the digestive organs. Vrach Delo, (8):40-1. [Article in Russian] 13. Anetai M, Jamagishi T, Kaneshima H, 1987. Quantitative determination of pharmacologically active constituents in the stems of Acanthopanax senticosus collected in Hokkaido. Hokkaidoritsu Eisei Kenkyushoho 37:85-7. 14. Anisimov MM, Suprunov NI, Prokofeva NG, 1972. Effect of compounds isolated from Araliaceae family plants on the biosynthesis of protein in vitro. Rast Resur, 8:378-80. [Article in Russian] 15. Anisimov MM, Fronert EB, Frolova GM et al, 1973. Influence of Eleutherococcus senticosus glycosides on early embryogenesis in the sea urchin. Proceedings USSR Akad Sciences, Biological series, 4:590-3. [Article in Russian] 16. Anton R, 1987. Reflexions sur quelques nouvelles acquisitions en phytotherapie. J Pharm Belg, 42:138-51. [Article in French] 17. Antonova AI, 1979. Extract of Eleuterococcus in the treatment of the atrophies of optical nerve. Oftalmolog J, 34, 3(227):183-4. [Article in Russian] 18. Arushanyan EB, Baida OA, Mastyagin SS et al, 2003. The effect of Eleutherococcus on short- term memory and visual perception in healthy humans. Eksper Clin Pharmacol, 66, 5:10-3. [Article in Russian] 19. Asano K, Takakhashi T, Kugo Kh et al, 1986a. Effects of Eleutherococcus senticosus on physical performance and resources in maximal and submaximal work. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 166-70. [Article in Russian] 20. Asano K, Takakhashi T, Miyashita M et al, 1986b. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med, Jun, (3):175-7. 21. Asanova NA, Teslov SV, Burnasheva LA et al, 1977. On the possibility of the complex use of rhizomes and roots of Eleuterococcus in medicine and the cosmetic. In: Search of pharmacological and chemotheraputic means from the products of synthesis and natural substances. (Transactions of scientific papers). Perm. 58-61. [Article in Russian] 22. Awang DVC, 1991a. Maternal use of Ginseng and neonatal androgenization. JAMA, April 10, 264-5, (14):1828. 23. Awang DVC, 1991b. Maternal use of Ginseng and neonatal androgenization. JAMA, July 17, 266, 3:363. 24. Awang DVC, 1996a. Eleuthero. Canad Pharm J, 129:52-4. 25. Awang DVC, 1996b. Siberian ginseng toxicity may be a case of mistaken identity. CMAJ, Nov 1, 155(9):1237. 26. Awang DVC, 2003. What in the name of Panax are those other "Ginsengs"? HerbalGram, 57:35-40. 27. Azizov AP, 1997. The effect of Eleutherococcus, elton, Leuzea, and levton on the blood coagulation system in physical exertion of athletes. Eksp Klin Farmakol, 60, 5:58-60. [Article in Russian] ©EMEA 2007 2/38 28. Azizov AP, Seifulla RD, 1998. The effect of elton, leveton, phytoton and adapton on the work capacity of experimental animals. Eksp Klin Farmakol, 61, 3:61-3. [Article in Russian] 29. Baburin EF, 1966a. The influence of Eleutherococcus on work results and hearing sensitivity in radio telegraphers. In: Brekhman, II ed. Eleutherococcus and other adaptogens among the Far Eastern Plants. Vladivostok. 7:179-84. [Article in Russian] 30. Baburin EF, 1966b. The influence of Eleutherococcus on the Hearing organ. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants.Vladivostok. 7:173-8. [Article in Russian] 31. Baburin EF, Porkalov PV, Polonsky VV, 1970a. Influence of Eleutherococcus on some parameters of functional condition in organism of divers at chamber tests. Medicines of the Soviet Far East. Khabarovsk.10: 67-71. [Article in Russian] 32. Baburin EF, Polonsky VV, 1970b. The first results of the use of Eleutherococcus for preservation of working capacity in divers on actual diving. Medicines of the Soviet Far East. Khabarovsk. 10:72-3. [Article in Russian] 33. Baburin EF, Tarasov IK, Alexejev VN, 1972. On the prophylaxis of motion sickness. Medicines of the Soviet Far East. Vladivostok. 11:120-5. [Article in Russian] 34. Baburin EF, 1976. In: Brekhman II, ed. Adaptation processes and biologically active substances. Vladivostok. 91. [Article in Russian] 35. Badalyan M, Panosyan V, Gabrielyan E, 2005. Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. 12(8): 539-47. 36. Baldwin CA, Anderson LA, Phillipson JD, 1986. What pharmacists should know about Ginseng. Pharm J, 583-6. 37. Baranov AI, 1979. On a Technical English Name for Eleutherococcus. Taxon, 28(5/6):586-7. 38. Baranov AI, 1982. Medicinal uses of Ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol Nov, 6(3):339-53. 39. Baranov AI, 1986. On the problem of the Russian technical name for Eleutherococcus. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 221-2. [Article in Russian] 40. Barchas JD, Mefford IN, Roth K et al, 1981. Neuroregulators and stress. Naval Res Rev, 23(4):2-12. 41. Barenboim GM, Sterlina AG, Fisenko AP et al, 1984. Studies of Natural Killers Activators with Eleutherococcus extract. In: 2nd International Symposium on Eleutherococcus. All-Union Cancer research center. Moskow. [Article in Russian] 42. Barenboim GM, Sterlina AG, Bebyakova NV et al, 1986. Investigation of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VIII. Investigation of natural killer activation by the Eleutherococcus extract. Khim Farm Zh, 20, 7:914-7. [Article in Russian] 43. Barenboim GM, 2005. Eleutherococcus: Application and the mechanism of action. http://www.oxyfreshww.com/nutrition/articles/part5.asp 44. Barkan AI, Gaiduchenya LI, Makarenko IA, 1980. Effect of Eleutherococcus on respiratory viral infectious morbidity in children in organized collectives. Pediatriya, 4:65-6. [Article in Russian] 45. Barna P, 1985. The case of Ginseng. Lancet, Sept, 7, 2(8454):548. 46. Batin