Supplementary Table II. List of the active principles divided according to the target apparatus and pharmacological mechanisms of action, with indication of the type of side effect using a number from 1 to 4 (1: ototoxic drugs; 2: drugs inducing tinnitus; 3: drugs inducing vertigo or dizziness; 4: drugs inducing generic hearing disorders) and the scale of severity according to Adverse Drug Reactions (ADR) - a: very common (≥ 10%); b: common (≥ 1% e < 10%); c: uncommon (≥ 0.1% e <1%); d: rare ( ≥ 0.01% e < 0.1%); e: very rare (< 0.01%); f: unknown). Reference Active principle Commercial name ADR number 1. Abacavir Ziagen 3 2. Abacavir + lamivudine Kivexa 3 3. Abacavir + lamivudine + zidovudine Trizivir 3 4. Abatacept Orencia 3c 5. Acebotulol Prent 3b Sectral 3b 6. Aceclidin + timolol Glautimol 2,3 7. Aceclofenac Airtal 2e,3e Gladio 2e,3e Kafenac 2e,3e 8. Acemetacin Acemix 2,3,4 Solart 2,3,4 9. Acetazolamide Diamox 3,4 10. Acetylcysteine Acetilcisteina (*) 2c Altersol 2c Brunac 2c Dissolvin 2c Expectosol 2c Fluimucil 2c Frobemucil 2c KoKimucil mucol 2c Listemul 2c Hidonac 2c Mucofial 2c Mucomucil 2c Mucofrin 2c Solmucol 2c Tirocular 2c 11. Acetylsalicilic Acid Acido acetilsalicilico (*) 1,2 Aspirina 1,2 Aspirina dolore 1,2 Aspirina rapida 1,2 Aspirinetta 1,2 Aspro 500 1,2 Cardioaspirina 1,2 Cardioral 1,2 Cemirit 1,2 Neaprin febbre e dolore 1,2 Vivin 1,2 12. Acetylsalicilic acid + magnesium Ascriptin 1 13. Acitretine Neotigason 2 14. Acyclovir Aciclin 3 Aciclovir (*) 3 Acy 3 Acyvir 3 Alovir 3 Amodivyr 3 Avirase 3 Avix 3 Avyclor 3 Avyplus 3 Citivir 3 Cycloviran 3 Dravyr 3 Efriviral 3 Esavir 3 Euclivir 3 Fuviron 3 Herpesnil 3 Iliaclor 3 Immunovir 3 Neviran 3 Rexan 3 Riduvir 3 Sanavir 3 Voraclor 3 Zovirax 3 15. Adalimumab Humira 2c,3b 16. Adenosine Adenosina (*) 2d,2e Adenoscan 2d,2e Krenosin 2d,2e 17. Adrenaline Adrenalina (*) 3 FastjeKt 3 18. Adrenaline with articaine hydrochloride Alfacaina sp 1,2,3 Alfacaina 1,2,3 Cartidont 1,2,3 Citocartin 1,2,3 Sarticain 1,2,3 Septanest 1,2,3 Ubistesin 1,2,3 19. Agalsidase alfa - beta Febrazyme 2,3 20. Agomelatine Aldoxan 2c Thymanax 2c 21. Alemtuzumab Lemtrada 3a,3b 22. Alendronic acid Alendronato (*) 3a,3b Adronat 3a,3b Dronal 3a,3b Genalen 3a,3b 23. Alfentanil Fentalim 3 24. Alfuzosin hydrochloride Mittoval 3 Xatral 3 25. AlisKiren Rasilez 3 TeKturna 3 26. Alitritinoin Toctino 2a,2b 27. Alizapride hydrochloride Limican 3 28. Allopurinol Allopurinolo (*) 3 Allurit 3 Zyloric 3 29. Almotriptan Almogran 2c,3b Almotrex 2c,3b 30. Alpha 1 - antitrypsin Prolastina 3 31. Alphacalcidol Alpha D3 3 Dediol 3 Deril 3 Diseon 3 Diserinal 3 Geniad 3 Ostidil D3 3 Sefal 3 32. Alprazolam Alpravecs 3b Alprazig 3b Alprazolam(*) 3b Frontal 3b Mialin 3b Valeans 3b Xanax 3b 33. Amantadine hydrochloride Mantadan 3 34. Ambroxol hydrochloride Ambroxol big 3 Ambroxolo (*) 3 Atus 3 Broxol 3 Secretil 3 Surfactal 3 35. Amifostine Ethyol 3 36. AmiKacin Amicasil 1 AmiKacina teva 1 AmiKan 1 BbK8 1 Chemacin 1 LiKacin 1 Lukadin 1 MediamiK 1 Migracin 1 MiKan 1 MiKavir 1 NeKacin 1 37. AmiKacin sulphate Dramigel 1 LiKacin gel 1 38. Amiloride + hydrochlorothiazide Moduretic 2,3 39. Amiloride hydrochloride + furosemide Co-amilofruse 1,2 40. Aminophylline (intravenous use) Aminofillina (*) 3 Aminomal 3 Tefamin 3 41. Amiodarone hydrochloride Amiodar 1,3 Amiodarone (*) 1,3 Cordarone 1,3 42. Amisulpride Deniban 3 Solian 3 Sulamid 3 43. Amitriptyline + chlordiazepoxide Limbitryl 2,3 Sedans 2,3 44. Amitriptyline hydrochloride Adepril 2,3 Laroxyl 2,3 Triptizol 2,3 45. Amitriptyline hydrochloride + perphenazine Mutabon ansiolitico 2,3 Mutabon antidepressivo 2,3 Mutabon forte 2,3 Mutabon mite 2,3 46. Amlodipine Antacal 2,3 Monopina 2,3 Norvasc 2,3 47. Amoxycillin + clavulanate Abba 3 Amoxicillina + acido clavulanico (*) 3 Anival 3 Augmentin 3 Clavulin 3 Euticlavir 3 Homer 3 Klavox 3 Kruxade 3 Mondex 3 Moxivul 3 Neoduplamox 3 Xinamod 3 48. Amphotericin B Abelcet 1 Ambisome 1 Fungilin 1 Fungizone 1 49. Anagrelide Xagrid 2d,3b 50. Aniracetam Ampamet 3d 51. Aprepitant Emend 2,3 52. Aproclonidin Iopidine 3c 53. Argatroban monohydrate Novastan 1c 54. Aripiprazole Abilify 3b Clozapina (*) 3b Leponex 3b 55. Atazanavir Reyataz 3c 56. Atenolol Atenol 3 Atenololo (*) 3 Atermin 3 Seles beta 3 Tenomax 3 Tenormin 3 57. Atenolol + diuretics Atenigron 3 Atenololo/Clortalidone (*) 3 Atinorm 3 Carnian 3 Clortanol 3 Diube 3 Eupres 3 Eupres mite 3 Igroseles 3 Nor-Pa 3 Normopress 3 Target 3 Tenoretic 3 58. Atomoxetine Strattera 3 59. Atorvastatin Torvast 2,3 Totalip 2,3 60. Atosiban Tractocile 3b 61. Atropine sulphate Atropina solfato 3 Atropina lux 3 Atropina 1% 3 Farmigea 3 62. Axitinib Inlyta 2a 63. Azathioprine Azatioprina (*) 3 64. Azithromycin Azeptin 1,(3d) Aziprome 1,(3d) Azitredil 1,(3d) Azitroerre 1,(3d) Azitromicina(*) 1,(3d) Azitrox 1,(3d) Azylung 1,(3d) Azyter 1,(3d) Batif 1,(3d) Cinetrin 1,(3d) Macrozit 1,(3d) Portex 1,(3d) Rezan 1,(3d) Ribotrex 1,(3d) Tetris 1,(3d) Trozamil 1,(3d) Trozocina 1,(3d) Zimacrol 1,(3d) Zindel 1,(3d) Zitrobiotic 1,(3d) Zitrogram 1,(3d) Zitromax 1,(3d) 65. Aztreonam Azactam 2e,3 Cayston 2e,3 Primbactam 2e,3 66. Bacitracin + neomycin Bimixin 1 Orobicin 1 67. Baclofen Lioresal 3 68. Belatacept Nulojix 3a,3b 69. Benazepril + hydrochlorothiazide Cibadrex 2c,3b Tensadiur 2c,3b Zinadiur 2c,3b 70. Benazepril hydrochloride Cibacen 2,3 Tensanil 2,3 Zinadril 2,3 71. Betamethasone Beben 3 Bentelan 3 Beta 21 3 Betamesol 3 Betametasone dipropionato (*) 3 Betametasone farmacologico milanese 3 Betesil 3 Bettamousse 3 Celestone 3 Cortiflam 3 Diprosone 3 Ecoval 3 72. Betamethasone + bekanamicin + tetryzolin Visumetazone antibiotico 1 73. Betamethasone + clorfenamin Visumetazone antistaminico 2,3 74. Betamethasone + tetryzolin Visumetazone decongestionante 3 75. Bexarotene Targretin 3c 76. Bezafibrate Bezalip 3 77. Bilastine Ayrinal 2c,3c Olisir 2c,3c Robilas 2c,3c 78. Biperiden hydrochloride Akineton 3 79. Bisoprolol fumarate Bisoprololo Eg 3b Cardicor 3b Concor 3b Congescor 3b Pluscor 3b Sequacor 3b 80. Bisoprolol fumarate + diuretics Lodoz 3c 81. Boceprevir Victrelis 2a,2b 82. Bortezomib Velcade 3a,3b 83. Bosutinib Bosulif 2c 84. Botulinum toxin A Azzalure 2c,3b Bocouture 2c,3b Botox 2c,3b Dysport 2c,3b Neurobloc 2c,3b Vistabex 2c,3b Xeomin 2c,3b 85. Brimonidine tartrate Alphagan 3b 86. Brimonidine tartrate + timolole Combigan 3c 87. Brinzolamide Azarga 2c,3c Azopt 2c,3c 88. Brinzolamide + brimonidine Simbrinza 3c 89. Brivaracetam Nubriveo 3a,3b 90. Bromazepam Bromazepam (*) 3 Compendium 3 Lexotam 3 91. Bromocryptina mesylate Bromocriptina dorom 2d,3 Parlodel 2d,3 92. Bromperidol Impromen 3 93. Brotizolam Lendormin 3 Nimbisan 3 94. Buflomedil hydrochloride Buflan 3e Buflocit 3e Buflocit retard 3e Flomed 3e Irrodan 3e Irrodan ritardo 3e Loftil 3e Loftil plus 3e 95. Bupivacaine + adrenaline Bupicain + adrenalina 3 Bupiforan + adrenalina 3 Bupisen + adrenalina 3 Bupisolver + adrenalina 3 Bupixamol + adrenalina 3 96. Bupivacaine hydrochloride Bupibil 1,2,3 Bupicain 1,2,3 Bupiforan 1,2,3 Bupiforan heavy 1,2,3 Bupisen 1,2,3 Bupisolver 1,2,3 Bupivacaina (*) 1,2,3 Bupixamol 1,2,3 Fisiopharma 1,2,3 Marcaina 1,2,3 Marcaina iperbarica 1,2,3 97. Buprenorphine Subutex 2d,3b Temgesic 2d,3b Transtec 2d,3b 98. Bupropion Zyban 2c,3b 99. Buserelin Suprefact 3,4 Suprefact depot 3,4 Suprefact depot 3 mesi 3,4 Suprefact nasale 3,4 100. Buspirone hyrochloride Buspar 2a,2b,3b 101. Butizide + canrenoate potassium Kadiur 3c 102. Buxamina Gamibetal 3 103. Buxamina + diazepam Gamibetal plus 3 104. Buxamina + fenobarbital + fenitoina Gamibetal complex 3 105. Cabazitaxel Jevtana 2,3 106. Cabergoline Actualene 3b Cabaser 3b Cabergolina (*) 3b Dostinex 3b 107. Cabozantinib Cabometyx 2a,2b Cometriq 2a,2b 108. Cadralazina Cadraten 3 109. Calcitriol Calcijex 3 Calcitriolo (*) 3 Difix 3 Rocaltrol 3 TriKal 3 110. Calcium acetate + magnesium carbonate Osvaren 3c 111. Calcium carbonate + cholecalciferol (Vitamin Biocalcium D3 3 D3) Cacit vitamina D3 3 Cadtre 3 Calcicol D3 3 Calcidon 3 Calciocarbonato + Vitamina D3 (*) 3 Calcium D3 Sandoz 3 Calma D3 3 Carbo D3 3 Ditrost 3 Eurocal D3 3 Ideos 3 Kalaz D3 3 Metocal Vit D3 3 Natecal D3 3 Orotre 3 Tonacal D3 3 Urtotre 3 112. CanaKinumab Ilaris 3a,3b 113. Candesartan + diuretics Blopresid 3 Ratacand plus 3 114. Candesartan cilexetil Blopress 3 Ratacand 3 115. Cannabis extract Sativex 3a,3b 116. Capecitabine Capecitabina (*) 3c Xeloda 3c 117. Capreomycin Capastas 2 118. Captopril Acepress 3 Capoten 3 Captopril (*) 3 119. Captopril + diuretics Acediur 3c Aceplus 3c Aceplus mite 3c Captopril id (*) 3c Captopril idroclorotiazide ratiopharm 3c 120. Carbamazepine Carbamazepina (*) 3e Tegretol 3e 121. Carboplatin Carboplatino (*) 1 Paraplatin 1 122. Carboprost Hemabate 2c,3c 123. Carlfizomib Kyprolis 2a,2b 124. Carvedilol Caravel 3e Carvedilolo (*) 3e Carvipress 3e Colver 3e Curcix 3e Dilatrend 3e Dilocar 3e Omeria 3e 125. Catumaxomab Removab 3a,3b 126. Cefaclor Altaclor 3d Bacticef 3d Bactigram 3d Cefaclor (*) 3d Cefacloro sandoz 3d Cefulton 3d Clorad 3d Clorazer 3d Geniclor 3d Kliacef 3d Lafarclor 3d Macovan 3d Necloral 3d Omaspir 3d Oralcef 3d Panacef 3d Panacef Rm 3d Performer 3d Selviclor 3d TaKecef 3d Tibifor 3d Valeclor 3d 127. Cefadroxil Cefadril 3 Oradroxil 3 128. Cefazolin sodium Cefamezin 3 Cefazil 3 Cefazolina (*) 3 Cromezin 3 129. Cefepime Cepim 2d,3d Cepimex 2d,3d Maxipime 2d,3d 130. Cefixime Cefixoral 3 Suprax 3 Unixime 3 131. Cefonicid disodium Cefodie 3 Cefonicid (*) 3 Cefoplus 3 Chefir 3 Davcef 3 Emidoxin 3 Fonicid 3 Krucef 3 Lisa 3 Maxid 3 Modiem 3 Monobiotic 3 Necid 3 NoKid 3 Praticef 3 RaiKocef 3 Sintocef 3 Sofarcid 3 Valecid 3 132. Cefoperazone sodium Bioperazione 3d Dardum 3d 133. Cefotaxime Aximad 3 Batixim 3 Cefomit 3 Cefotaxima (*) 3 Cefotaxime (*) 3 Claforan 3 Lirgosin 3 Refotax 3 Salocef 3 Spectrocef 3 Taxime 3 Zariviz 3 Zimanel 3 134.