ligand P-gp inhibition (11-Me-Leu)-Cyclosporin A 1 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol 0 1,2,3,4-Tetrahydro-6,7-dimethoxy-isoquinoline 0 1,2,3,4-Tetrahydro-isoquinoline 0 1,3,5-Triazacycloheptane 4b 1 1,3,5-Triazacycloheptane 4c 1 1,3,5-Triazacycloheptane 5b 1 1,3,5-Triazacycloheptane 5c 1 1,3,5-Triazacycloheptane 5d 1 1,3,5-Triazacycloheptane 6b 1 1,3,5-Triazacycloheptane 6c 1 1-(3-methoxyphenyl)-N,N-dimethylmethanamine 0 1-(4-chlorbenzhydryl)piperazine 0 1-Benzyl-3-pyrroline 0 1-Benzylimidazole 0 1-Phenethylpiperidine 0 1-Phenylpiperazine 0 11-Deoxycortisol 1 14-Benzoylyohimbine 1 16-Dehydroprogesterone 1 16-Methylprogesterone 1 17-Hydroxypregnenolone 0 17-Hydroxyprogesterone 1 2,2'-Diphenylethylamine 0 2,4,6,8-Tetradiethano 0 2,4,6,8-Tetramopholin 0 2,4,6,8-Tetrapiperidy 0 2,4,6-Trimorpholinepy 0 2,4,8-Trimorpholinepy 0 2-Benzylpyridine 0 2-Chloro-10-[2-(dimethylamino)ethyl] phenothiazine 1 2-Chloro-10-[4-(dimethylamino)butyl] phenothiazine 1 2-Chloroimipramine 1 2-Oxazolidinone 0 3'-4'-Dichlorobenzamil 0 3,8-Dihydroxychlorpromazine 0 3-Methyl choroquine 1 4,8-Dipiperidyl-2,6-D 0 4,8-Dipiperidyl-2,6-M 0 4,8-Dipiperidyl-Dimet 0 4-(2-Dimethylamino)ethyl)morpholine 0 4-Androstene-3,17-dione 1 4-Hydroxytamoxifen 1 4-Hydroxytoremifene 1 4-Iodotamoxifen 1 4-beta-Phorbol 12,13-dibutyrate 1 4-beta-Phorbol 13-acetate 0 4-beta-Phorbol 13-butyrate 0 5-(N,N-hexamethylene)amiloride 0 5-(N-Methyl-N-isobutyl)amiloride 0 5-N-acetyl-8-demethylardeemin 1 5-N-acetylardeemin 1 5-[N-Methyl-N-(tert-butyl)]-amiloride 0 6-Phenyl-2,4,7-pterid 0 7,8-Dihydroxychlorpromazine 0 7-Hydroxychlorpromazine 0 AF-1393 1 AG-1112 0 AG-213 0 AG-690 1 AHC-52 1 AHR 06601 1 AHR 16462 1 AHR-16303 1 AN-989 1 AY 9944 1 Acapriazine 0 Acebutolol 0 Acecainide 0 Acepromazine 1 Aceprometazine 1 Acetophenazine 1 Acridine 0 Acridone-4-carboxamide 22 1 Acridone-4-carboxamide 23 1 Acridone-4-carboxamide 24 1 Acridone-4-carboxamide 28 1 Acridone-4-carboxamide 29 1 Acridone-4-carboxamide 30 1 Acridone-4-carboxamide 31 1 Acridone-4-carboxamide 32 1 Acridone-4-carboxamide 36 1 Acridone-4-carboxamide 39 1 Acridone-4-carboxamide 43 1 Acridone-4-carboxamide 44 1 Acridone-4-carboxamide 47 1 Acridone-4-carboxamide 48 1 Acridone-4-carboxamide 49 1 Acridone-4-carboxamide 50 1 Acridone-4-carboxamide 51 1 Acridone-4-carboxamide 52 1 Acridone-4-carboxamide 53 1 Acridone-4-carboxamide 54 1 Acridone-4-carboxamide 55 1 Acridone-4-carboxamide 59 1 Acridone-4-carboxamide 60 1 Acridone-4-carboxamide 61 1 Acridone-4-carboxamide 64 1 Acridone-4-carboxamide 65 1 Acridone-4-carboxamide 66 1 Acridone-4-carboxamide 67 1 Acridone-4-carboxamide 68 1 Acridone-4-carboxamide 69 1 Acridone-4-carboxamide 70 1 Acridone-4-carboxamide 71 1 Acridone-4-carboxamide 72 1 Acridone-4-carboxamide 73 1 Acridone-4-carboxamide 74 1 Acridone-4-carboxamide 75 1 Acridone-4-carboxamide 76 1 Acridone-4-carboxamide 77 1 Acridone-4-carboxamide 78 1 Acridone-4-carboxamide 79 1 Acridone-4-carboxamide 80 1 Acridone-4-carboxamide 81 1 Acridone-4-carboxamide 82 1 Acridone-4-carboxamide 83 1 Acridone-4-carboxamide 85 1 Acrivastine 0 Actinomycin D 0 Adiphenine 0 Aldicarb 0 Aldoxycarb 0 Aldrich 21430-2 1 Almitrine 1 Alpertine 1 Alpha-Tocopherol 0 Alprenolol 1 Alverine Amantadine 0 Ambodryl 0 Amiloride 0 Aminocarb 0 Aminopentamide 0 Amiodarone 1 Amitriptyline 1 Amlodipine 1 Amodiaquin 0 Amotriphene 1 Amoxapine 1 Amoxecaine 0 Amperozide 1 Amphotericin B 0 Amprenavir 1 Androstenedione 1 Androsterone 1 Antazoline 0 Antenolol 0 Antipyrine 0 Apomorphine 0 Aprindine 1 Ascorbic acid 0 Asocainol 1 Astemizole 1 Atorvastatin (methyl ester) 1 Atorvastatin lactone 1 Atrazine 0 Atropine 0 Aureobasidin A (ABA) 1 Azaclorazine 1 Azaconazole 0 Azaperone 0 Azelastine 1 Azidopine 1 Azidoprocainamide methoiodide 0 Azipramine 1 B3-243 1 B669 1 B9109-012 1 BIBW 22 1 BW 1019W91 1 BW 1136U89 1 BW 1288U89 1 BW 1351W91 1 BW 1379W91 1 BW 565C81 1 Bamipine 0 Barnidipine 1 Befuraline 0 Benactyzine 0 Bencyclane 0 Benidipine 1 Benzathine 1 Benzmalecene 0 Benzofuran derivative 2a 0 Benzofuran derivative 2c 1 Benzofuran derivative 2d 1 Benzofuran derivative 2e 1 Benzofuran derivative 2f 1 Benzquinamide 0 Benztropine 1 Bepridil 1 Berberine 0 Bevantolol 1 Bifonazole 1 Biperiden 0 Biphenamine 0 Biricodar 1 Bisobrin 0 Bleomycin A2 0 Boldine 0 Boxidine 0 Bromocriptine 1 Brompheniramine 0 Bryostatin 0 Bucainide 1 Buclizine 1 Budipine Buflomedil 0 Bufuralol 1 Bunaftine 1 Buspirone 1 Butalamine 0 Butaperazine 1 Buterizine 1 Butethamate 0 CP-100356 1 CP-101556 1 CP-114416 1 CP-114769 1 CP-117227 1 CP-12379 1 CP-141938 1 CP-147478 1 CP-69042 1 Calcimycin 0 Calphostin C 1 Captodiame Carbamazepine 0 Carbaryl 0 Carbinoxamine 1 Carbiphene 1 Carnitine 0 Caroverine 1 Carphenazine 1 Carvedilol 1 Carvedilol metabolite M2 0 Carvedilol metabolite M4 0 Carvedilol metabolite M5 0 Catharanthine 1 Cefoperazone 0 Cefotetan 0 Ceftazidime 0 Celiprolol 0 Cepharanthine 1 Cephradine 0 Cetiedil 1 Cetrizine 0 Chelerythrine 0 Chlophedianol 0 Chloracyzine 1 Chlorbenzoxamine 1 Chlorcyclizine 0 Chlorogenic acid 0 Chloropyramine 0 Chloroquine 0 Chlorpheniramine 0 Chlorphenoxamine Chlorproethazine 1 Chlorpromazine 1 Chlorprothixene 1 Chlorzoxazone 0 Chromonar Cimetidine 0 Cinchonidine 1 Cinepaxadil 1 Cinepazet 0 Cinepazic acid 0 Cinepazide 0 Cinnarizine 1 Cinprazole 1 Cinpropazide 0 Cintriamide 0 Cinuperone 1 Ciprofloxacin 0 Citalopram 0 Citatepine 1 Citenamide 0 Clamoxyquin 0 Clanobutin 0 Clebopride 0 Clemastine 1 Clemizole 1 Cletoquine 0 Clobutinol 0 Clocinizine 1 Clomestrone 0 Clomiphene 0 Clomipramine 1 Clonidine 0 Clopenthixol 1 Cloperastine 1 Clopimozide 1 Clopipazan 1 Clothiapine 1 Clothixamide 1 Clotrimazole 1 Colchicine 0 Colforsin 1 Coralyne 0 Corticosterone 0 Cortisone 0 Corynanthine 1 Coumaphos 1 Cryptophycin 1 Cyclobenzaprine 1 Cyclofenazine 1 Cyclopeptolide(1) 0 Cyclopeptolide(11) 0 Cyclopeptolide(12a) 1 Cyclopeptolide(12b) 1 Cyclopeptolide(15a) 1 Cyclopeptolide(15b) 1 Cyclopeptolide(16a) 1 Cyclopeptolide(16c) 1 Cyclopeptolide(16h) 1 Cyclopeptolide(18) 1 Cyclopeptolide(19) 0 Cyclopeptolide(2a) 1 Cyclopeptolide(2c) 1 Cyclopeptolide(2f) 1 Cyclopeptolide(3a) 1 Cyclopeptolide(3c) 1 Cyclopeptolide(3f) 1 Cyclopeptolide(3g) 1 Cyclopeptolide(3h) 1 Cyclopeptolide(3i) 1 Cyclopeptolide(3j) 1 Cyclopeptolide(3l) 1 Cyclopeptolide(3n) 1 Cyclopeptolide(4) 1 Cyclopeptolide(7) 1 Cyclopeptolide(8) 1 Cyclopeptolide(9) 1 Cyclophenazine 1 Cyclosporin A 1 Cyclosporin C 1 Cyclosporin G 1 Cypermethrin 1 Cyproheptadine 1 Cytochalasin A 0 Cytochalasin C 0 Cytochalasin D 0 Cytochalasin E 1 Cytochalasin H 0 Cytochalasin J 0 D490 1 D525 1 D528 0 D557 1 D559 1 D595 1 D784 1 D894 1 DDE 0 DDT 0 DHP-014 1 DMDP 1 DPDPE 0 Dagapamil 1 Danitracen 0 Dapiprazole 0 Darodipine 1 Debrisoquin 0 Dehydroemetine 0 Delavirdine 1 Delfantrine 0 Deltorphin II 0 Denzimol 0 Deoxycorticosterone 1 Desethylamiodarone 1 Desipramine 1 Desmethoxyyangonin 1 Desmethylazelastine 1 Desmethylchlorpromazine 0 Desmethylcitalopram 0 Desmethylsertraline 1 Devapamil 1 Dexamethasone 0 Dexniguldipine 1 Dialifos 0 Dibenzylamine 0 Dibozan 0 Dibucaine 1 Dicapthon 1 Diclofensine 0 Didesmethylchlorpromzine 0 Diethylaniline 0 Diethylstilbestrol 1 Difloxacin 0 Difluanine 1 Digoxin 0 Dihydroergotamine 0 Dihydromethysticin 1 Dihydropyridine DP11 1 Dihydropyridine DP5 1 Dihydropyridine DP6 1 Dihydropyridine DP7 1 Dihydropyridine DP9 1 Dihydropyrroloquinoline series 14 0 Dihydropyrroloquinoline series 27 1 Diisopromine Dilazep 1 Diltiazem 1 Dimethindene 1 Diosmetin 0 Diosmin 0 Diphenamid 0 Diphenazoline 0 Diphenidol 1 Diphenylpyraline 1 Disopyramide 0 Dixyrazine 1 Dobutamine 0 Doconazole 1 Domperidone 0 Doxapram 1 Doxazosin Doxepine 1 Doxorubicin 0 Doxylamine 0 Drobuline 1 Drofenine 0 Droloxifen 0 Droprenilamine 1 Droproizine 0 Duoperone 1 EKI-785 1 Ebastine 1 Econazole 0 Efonidipine 1 Eletriptan 0 Eltoprazine 0 Emepronium 0 Emetine 0 Emopamil 1 Enciprazine 1 Endosulfan 1 Enilconazole 0 Enoxacin 0 Epinephrine 0 Eprazinone 1 Eprozinol 1 Equilenine 0 Equilin 0 Ergocristine 1 Ergocryptine 1 Ergonovine 0 Ergotamine 1 Erythromycin 1 Estradiol 0 Estriol 0 Estrone 0 Etafenone 1 Ethylbenztropine 1 Ethylbenzylaniline 0 Etifelmin 0 Etodroxizine Etolotifene 1 Etomidoline 1 Etoposide 0 Euphodendroidin A 1 Euphodendroidin B 1 Euphodendroidin C 1 Euphodendroidin D 1 Euphodendroidin E 1 Euphodendroidin G 1 Euphodendroidin H 1 Euphodendroidin I 1 Euprocin 1 Falipamil 0 Famciclovir 0 Farnesyl analog AFCA 1 Farnesyl analog AFCMA 1 Farnesyl analog AFCME 1 Febuverine 1 Felodipine 1 Fenbutrazate 1 Fendiline 1 Fenoctimine 0 Fenoterol 0 Fenoxedil 1 Fenpipramide 0 Fenpiverinium 0 Fenticonazole 1 Fenvalerate 0 Fexofenadine 0 Filipin 0 Fisetin 0 Flavonoid ID 13 1 Flavonoid ID 21 0 Flavonoid ID 22 0 Flavonoid ID 23 0 Flavonoid ID 24 0 Flavonoid ID 37 1 Flavonoid ID 38 0 Fleroxacin 0 Flesinoxan 0 Flezelastine 1 Flordipine 1 Fluanisone 1 Fluazifop-butyl 0 Fluconazole 0 Flumazenil 0 Flunarizine 1 Fluoxetine 1 Fluperamide 1 Fluperlapine 1 Fluphenazine 1 Flurazepam 1 Fluspirilene 1 Fluvoxamine 1 GF120918 1 GGCME 1 GW 420867 1 Gallopamil 1 Gamfexine 0 Geldanamycin 1 Geldanamycin 17-AAG 1 Gepirone 0 Ginsenoside Rg3 1 Ginsenoside Rh2 1 Glaucine 1 Gramine 0 Guanabenz 0 Guanfacine 0 H-7 0 H-89 1 HA-1004 0 HDL-2722 0 Halopemide 1 Haloperidol 1 Hepzidine 1 Hexadiline 0 Hexobendine 1 Hexoprenaline 0 Histapyrrodine 0 Hoechst 33342 0 Homochlorocyclizine 0 Homofenazine Homoveratrylamine 0 Hoquizil 0 Hydramethylnon 1 Hydrastine 0 Hydrocotarnine 0 Hydromorphone 0 Hydroxyzine 1 Hyperforin 0 Idarubicin 1 Imatinib 1 Imiclopazine 0 Imipramine 1 Imolamine 0 Imoxiterol 0 Indinavir 0 Indomethacin 0 Isoconazole