COMPLETE ENERGY (Lipoic Acid – 50% R form and 50% S form) COMPLETE ENERGY Complete Energy provides critical redox agents for the energy‐ producing Krebs cycle (Co‐Q 10 and PQQ) with synergy and additional Formulated by Dr. Dan Murphy ingredients high in PQQ levels that support energy levels and healthy Article by Dr. Lynn Toohey aging. Support for energy production, mitochondrial health, healthy aging/cognition, nerve, brain & heart health, muscular strength/coordination, antioxidant function, Each Tablet Contains: Vitamin E (as succinate) 5 mg. Proprietary blend 125 mg* of: Coenzyme Q- nociceptive pathways. 10, Lecithin (as sunflower), Pyrroloquinoline Announcing outperforming super nutrient Pyrroloquinoline Quinone, Quercetin, Alpha Lipoic Acid, Quinone (PQQ) along with energy giant Coenzyme Q-10 (Co-Q Lycopene, Rhodiola Rosea (root), Cordyceps, Broccoli Powder (tops), Parsley (leaf). 10) and synergistic superstars like Lycopene, Quercetin, Alpha Lipoic Acid, Rhodiola Rosea, Cordyceps, Broccoli, Vitamin E (as succinate), and Parsley. 90 - Tablets Per Bottle 1572*** - Product Order Number Co-Q-10, PQQ, lycopene, quercetin, alpha lipoic acid, broccoli and parsley – the synergy of it all: Energy is made in the mitochondria by generating ATP in the Krebs cycle, and several factors are necessary to run that cycle. One of those factors is Coenzyme Q-10 (Co-Q 10), and if it is not ***No Frees with this product around to pick up the electrons in the cycle, the cycle would stop. We need ATP not just for physical exercise, but for every biochemical reaction that takes place in the body. In fact, we need ATP for maintaining our health and longevity. Dr. Bruce Ames discusses the triage theory, proposing that if even one important nutrient or cofactor is modestly deficient, then it triggers a built-in rationing mechanism that favors the proteins needed for immediate survival, while sacrificing those needed to guard against future damage (longevity proteins) (Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10836-10844. Prolonging healthy aging: Longevity vitamins and proteins. Ames BN). Impairment of these longevity proteins results in an insidious acceleration of the milieus associated with unhealthy aging. Compliments of NUTRI-WEST FOR YOUR NEAREST DISTRIBUTOR CALL 1-800-443-3333; FAX 1-307-358-9208 ANY QUESTIONS? EMAIL: [email protected] www.NutriWest.com The statements contained herein have not been evaluated by the FDA. The nutritional information, suggestions, and research provided are not intended to diagnose, treat, cure, or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health. Co-Q 10, PQQ, lycopene, quercetin, alpha lipoic acid, broccoli and Healthy aging involves maintaining optimal biochemical pathways parsley–the synergy of it all (cont’d): throughout the body. “Recent evidence has strongly indicated that the rate of Dr. Ames also notes that the elements required for the function of longevity aging is controlled, at least to some extent, by evolutionarily conserved proteins constitute a class of longevity nutrients that play a dual support role nutrient sensing pathways (e.g. the insulin/IGF-1-signaling, mTOR, AMPK, for both survival and longevity. Included in this category of longevity and sirtuins”, and that rhodiola rosea can help in that homeostatic nutrients is pyrroloquinoline quinone (PQQ) and lycopene, which help Co- maintenance of those pathways (Curr Pharmacol Rep. 2015 Dec 1;1(6):420-433 When Q 10 in its energy function and are included in this formula as supportive Anti-Aging Studies Meet… Yokoyama NN et al.) ingredients. PQQ, described in further detail below, is a kick starting super support nutrient for the mitochondria and mitochondrial biogenesis, a quality shared by synergistic quercetin (Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC- 1α Expression. J Biol Chem. October 27, 2009. Chowanadisai, W et al.) Broccoli and parsley are food sources that are particularly high in PQQ. Mitochondrial metabolism links energy production to other essential cellular processes such as signaling, cellular differentiation, apoptosis, and synaptic functioning of the nerves; in fact, dysfunctional mitochondria interfere with nerve synapse connections, which affect conduction and release of neurotransmitters. Synaptic connections are associated with cognitive function, impacting central nervous system communication and the neural units that control voluntary muscular contraction - meaning that strength and Rhodiola Rosea (cont’d): In a double blinded, crossover study in 10 males, coordination are also supported. ingestion of rhodiola rosea “favorably influenced RPE (rated perceived exertion) and exercise affect without changes in energy expenditure or All of these processes are necessary for energy, for healthy aging and for substrate utilization during 30-minute submaximal cycling performance” nervous system health. In addition to producing ATP as an energy source, (J Sports Med (Hindawi Publ Corp). 2014;2014:563043. The Effect of Acute Rhodiola mitochondria are responsible for the synthesis of a myriad of important rosea Ingestion on Exercise Heart Rate, Substrate Utilization, Mood State, and Perceptions of energy metabolites and cofactors such as tetrahydrofolate, biotin, lipoic acid, Exertion, Arousal, and Pleasure/Displeasure in Active Men. Duncan MJ & Clarke ND.) acetyl-CoA and Co-Q 10, amongst others. Cordyceps is an adaptogenic herb with high antioxidant potential that is “Therefore, there is great known to support cellular respiration and cardiac energy metabolism and interest in understanding upregulate the cAMP and AMPK signaling pathways (Mol Med Rep. 2018 mitochondrial metabolism Sep;18(3):3229-3241. Effect of fermented Cordyceps sinensis.. .Wu R et al.) “Cordyceps and the complex supports mitochondrial ATP generation and preserves mitochondrial relationship it has with structural and functional integrity, thus aiding the aging process.”(Ko KM, Leung other cellular processes” HY. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities (Wiley Interdiscip Rev Syst Biol by Chinese Yang and Yin tonifying herbs. Chinese Medicine. 2007;2:3.) Med. 2017 Mar;9(2). Traditional and novel tools to probe the The ability of cordyceps to contribute to metabolic homeostasis and blood mitochondrial metabolism in sugar was reported and believed to be due to regulation of energy health... Zhang Y, Avalos JL). metabolism, amino acids, and intestinal microbes (Nat Prod Res. 2018 Nov 23:1-7. Shang XL et al.) Cordyceps was able to support the integrity of pancreatic beta Vitamin E is a respected, cells when exposed to the toxic assault from endoplasmic reticulum stress lipid soluble antioxidant, and in the succinate form, dramatically supports (Can J Diabetes. 2016 Aug;40(4):329-35. The Herbal Medicine Cordyceps sinensis… Streptozotocin- the whole Krebs cycle and resulting ATP generation. Induced Endoplasmic Reticulum Stress. Liu H et al.) Co-Q-10 (cont’d) The succinate dehydrogenase complex is also known as complex II of the electron transport system. There is evidence to suggest that vitamin E Normal Biological Processes: Another beneficial effect of Co-Q 10 besides succinate is a lipophilic carrier for the succinate, thereby promoting optimal antioxidant and energy restoration properties is that it has the ability to cellular energy production support. Lipoic Acid is necessary at the very reduce several markers when they were increased because of the beginning of the cycle, as a substrate, to reduce NAD to NADH. inflammatory process (MDA, TNF-α, IL-1β, PGE2 etc.) Evidence that Co- Q 10 was able to elevate ATP and make a difference in maintaining colon cell Pyrroloquinoline Quinone (PQQ), like Co-Q 10, is known as a redox agent, structure was because it is active in the reduction-oxidation reactions of the Krebs cycle. seen upon PQQ activates CREB, a gene that facilitates mitochondria development and histological function. PQQ and coenzyme-Q 10 both function to optimize the Krebs examination in a cycle and the body’s production of energy. PQQ and Co-Q 10 are both pre-clinical trial (Immunopharmacol quinones. PQQ has actually been noted to regulate the energy-producing Immunotoxicol. 2015 mitochondria and support and aid nerve cells, especially when they have been Jun;37(3):244-51. exposed to toxic assault. (Neurosci Lett. 2018 Nov 20;687:104-110… Lu J. et al) Attenuating effects of coenzyme Q10 and amlodipine…. El The mechanism of action by which PQQ influences energy-related metabolism Morsy EM1, Kamel and neurologic functions involves interactions with the previously mentioned R, Ahmed MA.) cell signaling pathways of mitochondrial function. It has been discovered that Additionally, Co-Q 10 is believed to play a role in thermogenesis when toxic injury to the nerve cells occurs, and mitochondrial biogenesis (homeostatic fat-burning cycle). (Cell Rep. 2015 Feb 3;10(4):505-15. Dependence of genes are downregulated, the downregulation does not happen if pre-clinical brown adipose tissue function on CD36-mediated coenzyme Q uptake. Anderson CM et models were supplemented with PQQ. The research findings indicate al.) that PQQ can regulate mitochondrial function by promoting mitochondrial biogenesis and supporting mitochondrial fission and fusion. Rhodiola Rosea is an interesting plant that