Vol. 55 Number 1 2013 The Pharmacologist March Boston... Here we come! In this issue: • 2013 Award Winners • Election Results • AZT: A Rational Drug Ahead of its Time, by Rebecca J. Anderson, Ph.D. • 2012 P.B. Dews Award Lecture, by James E. Barrett, Ph.D. • International Collaboration article, by John S. Lazo, Ph.D. and Philip Routledge, M.D. Vacancy ASPETAnnouncement Execu ve Offi cer The American Society for Pharmacology and Experimental Therapeutics (ASPET) invites applications from dy- namic and dedicated individuals seeking to ill the position of Executive Oficer with service beginning as soon as August 1, 2013. ASPET is a non-proit scientiic society with more than 5,000 members who are employed in academia, industry, foundations and the government, or are students and postdoctoral fellows. ASPET members are active in a wide array of activities including conducting basic and clinical pharmacological re- search designed to develop new medicines and therapeutic agents that ight existing and emerging diseases, as well as educating the next generation of pharmacologists and other health professionals. ASPET is located in Bethesda, Maryland on the campus of the Federation of American Societies for Experimental Biology (FASEB), of which ASPET is a founding member. The Executive Oficer reports directly to the ASPET Council and is responsible for implementing inancial, scientiic, publication, membership, educational, and other programs and policies approved by the Board. The responsibilities of the individual in this position include but are not limited to the following: • Oversees all operations, programs and initiatives of ASPET including managing an ofice of 14 staff who carry out the day-to-day activities of ASPET • Works closely with the Director of Accounting, Membership and Subscriber Services, senior ASPET staff, the Treasurer and the Finance Committee, which are responsible for the inancial operations of the ASPET to develop and maintain the budget • Interacts with and supervises the Publications Director and staff to ensure eficient publication of ASPET’s journals, the Government and Public Affairs oficer to promote advocacy activities, and the Director of Marketing to promote the society through the use of the website and social media • Develops new programs and initiatives in conjunction with the ASPET Council and directs outreach, fundraising, and educational programs • Is responsible for ASPET's scientiic meetings and coordinates activities of all ASPET Council meetings committees, Divisions and all committees. • Represents ASPET in public and private venues Qualiied candidates should have a record of achievement and leadership in academic, industrial, governmen- tal, association and/or other not-for-proit organizations, prior executive/administrative experience, and a demonstrated ability to conceptualize and implement new projects. An advanced degree in science and knowl- edge of pharmacology are highly preferred. Excellent communication, interpersonal and management skills are required. Please send a letter of application, including a statement of interest and a résumé or curriculum vitae by April 12, 2013 to FASEB/ASPET Human Resources 9650 Rockville Pike, Bethesda, MD 20814 or email materials to [email protected]. Please visit our website at http://www.aspet.org for more information about ASPET. The Pharmacologist 2 Volume 55 Number 1, 2013 President's Corner Comings and Goings Dear ASPET Members, We are fast approaching the 2013 ASPET Annual Mee ng, which will be held in Boston at Experimental Biology 2013 on April 20-24. This year, we are also mee ng with the Bri sh Pharmacological Society, the premier pharmacology society in the U.K. formed in 1931. We have an excit- ing program planned which you will not want to miss: the Sir James Black Lecture features 2012 Nobel Laureate in Chemistry Robert Le owitz, the Julius Axelrod Award Lecture by Gavril W. Pasternak speaking on "No pain, big gain: Truncated mu opioid receptor splice variants as drug targets," and the John J. Abel Award lecture given by Arthur Christopoulos, "Reciprocal rela onships: The yin and yang of GPCR allostery." We have fabulous sessions that should be a rac ve to students, postdoctoral fellows, academic faculty, and scien sts in biotechnology and pharmaceu cal organiza on. For our students and fellows, we have a Graduate Student Colloquium on "Introducing the Individual Devel- opment Plan: A key to success," a symposium on "Transla ng pharmacology into career choices in the pharmaceu cal and biotechnology industry," and a workshop on the "Art of item wri ng (NBME style) and basics of assessment." There are many symposia, including ones on "Cogni ve enhancers for the treatment of neuropsychiatric disorders," "Emerging technologies for delivering neurotherapeu cs across the blood-brain barrier," "Epigene c control of drug metabolism and transport," "Transcrip on factors as therapeu c drug targets," sleep apnea, apolipoprotein E, stem cells, and systems pharmacology. There will be numerous opportuni es for you to meet old friends and make new ones. I hope to see you at our Annual Mee ng at EB 2013. Some of you may know that our Execu ve Offi cer for the last 16 years, Chris e Carrico, has decided to re re later this year. Chris e truly has made an indelible mark on our society, recrui ng and maintaining a remarkable staff in the main offi ce and helping to build it into the pre- mier pharmacological organiza on in the world. She has been the heart and soul of ASPET, overseeing our fi nancial and educa on mission, ensuring members of Council, the Board of Publica on Trustees, divisions, and commi ees fulfi ll their responsibili es in a mely manner. Her outstanding professionalism places ASPET in a fabulous posi on to move forward na onally and interna onally during this exci ng me in pharmacology. We have iden fi ed a search commi ee that will begin the process of iden fying our next Execu ve Offi cer. As we proceed, I hope to provide you with addi onal informa on about our progress. Please feel free to communicate any advice or names of candidates to Rick Neubig ([email protected]) or me ([email protected]). I also hope you will join me in celebra ng Chris e's many accomplishments at our mee ng in Boston. Sincerely, John S. Lazo The Pharmacologist 3 Volume 55 Number 1, 2013 The Pharmacologist is published and distributed by the American Society for Pharmacology and Experimental Contents Therapeu cs. NEWS EDITOR President's Corner 3 Gary Axelrod 2013 Elec on Results 5 EDITORIAL ADVISORY BOARD Stephen M. Lanier, PhD 2013 ASPET Award Winners 6 Charles P. France, PhD ASPET Annual Mee ng at EB 2013 Kenneth E. Thummel, PhD Important Dates and Informa on 10 COUNCIL Proposed Bylaws Change 10 President John S. Lazo, PhD Full Program 12 President-Elect Ac vi es for Students & Postdocs 27 Richard R. Neubig, MD, PhD 4th GPCR Colloquium 28 Past President Lynn Wecker, PhD FEATURES Secretary/Treasurer Interna onal Collabora on 30 Edward T. Morgan, PhD by John S. Lazo, Ph.D. and Philip Routledge, M.D. Secretary/Treasurer-Elect AZT: A Ra onal Drug Ahead of its Time 31 Sandra P. Welch, PhD by Rebecca J. Anderson, Ph.D. Past Secretary/Treasurer Mary E. Vore, PhD 2012 P.B. Dews Lecture 35 Councilors given by James E. BarreƩ , Ph.D. Charles P. France, PhD DEPARTMENTS Stephen M. Lanier, PhD In Sympathy 45 Kenneth E. Thummel, PhD Chair, Board of Publica ons Trustees Obituary: Peter Dews 45 James E. Barre , PhD wriƩ en by W.H. Morse Chair, Program Commi ee Journals 49 Sco Waldman, MD, PhD Science Policy 51 FASEB Board Representa ve Book Review: State of Wonder by Ann Patche , 54 Brian M. Cox, PhD reviewed by ChrisƟ ne K. Carrico, Ph.D. Execu ve Offi cer Chris ne K. Carrico, PhD In the Spotlight: Interviews with ASPET Members 55 The Pharmacologist (ISSN 0031-7004) is published quarterly in Members in the News 58 March, June, September, and December by the American Society Staff News 59for Pharmacology and Experimental Therapeu cs, 9650 Rockville Pike, Bethesda, MD 20814-3995. Annual subscip on rates: New ASPET Members 60 $20.00 for ASPET members; $45.00 for U.S. nonmembers and Division News and Elec on Results ins tu ons; $70.00 for nonmembers and ins tu ons outside the U.S. Single copy: $20.00. Copyright © 2013 by the American Behavioral Pharmacology 62 Society for Pharmacology and Experimental Therapeu cs Inc. All Cardiovascular Pharmacology 63 rights reserved. Periodicals postage paid at Bethesda, MD. GST number for Canadian subscribers: BN:13489 2330 RT. Drug Metabolism 64 ASPET assumes no responsibility for the statements and Integra ve Systems, Transla onal and Clinical Pharmacology 64 opinions advanced by contributors to The Pharmacologist. Molecular Pharmacology 66 Deadlines for submission of material for publica on: Issue 1, Neuropharmacology 66 February 15; Issue 2, May 8; Issue 3, August 6; and Issue 4, November 5. Toxicology 67 Postmaster: Send address changes to: The Pharmacologist, Chapter News ASPET, 9650 Rockville Pike, Bethesda, MD 20814-3995. Upstate New York Pharmacology Society 68 Great Lakes 68 Mid-Atlan c Pharmacology Society 69 2013 Dues Notices Membership Informa on 71 If you haven‛t already done so, please Membership Applica on 72 pay your 2013 dues. You can mail in APPENDIX (ONLINE ONLY) your payment or renew online at: MAPS 2012 Annual Mee ng Abstracts A-1 https://www.aspet.org/login.aspx. The Pharmacologist 4 Volume 55 Number 1, 2013 2013 Election Results ASPET is pleased to announce the following elec on winners: PRESIDENT-ELECT Anne e E. Fleckenstein, Ph.D. Dr. Fleckenstein joined ASPET as a Student Member in 1993 and has been a Regular Member since 1996. As a student mem- ber, she received several travel awards including in 1998 a James A.