OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] AM20794PU-S Monoclonal Antibody to IFNA2 / Interferon alpha-2 - Aff - Purified Alternate names: IFN-alpha 2, Interferon alpha-A, LeIF A Quantity: 0.1 mg Concentration: 1.0 mg/ml Background: A member of the type 1 IFN family of related proteins produced by leucocytes and fibroblasts. IFN alpha 1 has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Uniprot ID: P01563 NCBI: NP_000596.2 GeneID: 3440 Host / Isotype: Mouse / IgG1 Clone: KT5 Immunogen: Recombinant Human IFN-alpha 2a Format: State: Liquid purified Ig fraction Purification: Protein A Chromatography from mouse ascites. Buffer System: PBS containing 0.09% Sodium Azide as a preservative Applications: Indirect ELISA: 1 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody reacts with both Interferon alpha-2a and Interferon alpha-2b. Species: Human. Other species not tested. Add. Information: CHROMOSOMAL LOCATION Genetic locus: IFNA2 (human) mapping to 9p21.3 Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. Adolf, G.R. 1987. Antigenic structure of human interferon-ω1 (interferon-αII1): comparison with other human interferons. J. Gen. Virol. 68: 1669-1676. 2. Lim JK, Xiong J, Carrasco N, Langer JA. Intrinsic ligand binding properties of the human and bovine alpha-interferon receptors. FEBS Lett. 1994 Aug 22;350(2-3):281-6. PubMed PMID: 8070579. 3. Hussain, M., et al. 1996. Identification of interferon-α7, -α14 and -α21. variants in the genome of a large human population. J. Interferon Cytokine. Res. 16: 853-859. 4. Mire-Sluis, A.R., et al. 1996. An anti-cytokine bioactivity assay for interferons-α, -β and -ω. J. Immunol. Methods 195: 55-61. 5. Cutrone EC, Langer JA. Contributions of cloned type I interferon receptor subunits to For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MT/20150605 1 / 2 AM20794PU-S: Monoclonal Antibody to IFNA2 / Interferon alpha-2 - Aff - Purified differential ligand binding. FEBS Lett. 1997 Mar 10;404(2-3):197-202. PubMed PMID: 9119063. 6. Rozera, C., et al. 1999. Interferon (IFN)-β gene transfer into TS/Aadenocarcinoma cells and comparison with IFN-α: differential effectson tumorigenicity and host response. Am. J. Pathol. 154: 1211-1222. 7. Barthe C, Mahon FX, Gharbi MJ, Fabères C, Bilhou-Nabéra C, Hochhaus A, et al. Expression of interferon-alpha (IFN-alpha) receptor 2c at diagnosis is associated with cytogenetic response in IFN-alpha-treated chronic myeloid leukemia. Blood. 2001 Jun 1;97(11):3568-73. PubMed PMID: 11369652. 8. Eriksen, K.W., et al. 2004. Biphasic effect of interferon (IFN)-α: IFN-α up and downregulates interleukin-4 signaling in human T cells. J. Biol. Chem. 279: 169-176. 9. Suyama T, Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ichikawa T, et al. Up- regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma. Cancer. 2005 Jan 15;103(2):258-67. PubMed PMID: 15578685. For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MT/20150605 2 / 2 Powered by TCPDF (www.tcpdf.org).