List of genes de-regulated between treatment (QD) and vehicle at 1h 4080_vs_untreat Fold-change q.value Gene Acc Description 1,9 2,48E-02 Ogt AK076418 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1,66 2,48E-02 AK036420 AK036420 #N/D 1,64 2,48E-02 Rbm25 AK169022 RNA binding motif protein 25 1,48 2,48E-02 EG639396 NM_001039251 #N/D 2,27 3,04E-02 D830012I16Rik AK031521 RIKEN cDNA D830012I16 gene 1,83 3,04E-02 4833414E09Rik BC023710 RIKEN cDNA 4833414E09 gene 1,78 3,04E-02 Wnk1 AK044849 WNK lysine deficient protein kinase 1 1,78 3,04E-02 D530037H12Rik AK052577 RIKEN cDNA D530037H12 gene 1,58 3,04E-02 Mast2 AK048193 microtubule associated serine/threonine kinase 2 1,49 3,04E-02 Sfpq BC033603 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 2,46 3,12E-02 BM114715 BM114715 #N/D 2,4 3,12E-02 Luc7l2 AK166155 LUC7-like 2 (S. cerevisiae) 2,33 3,12E-02 2310067E19Rik NM_172427 RIKEN cDNA 2310067E19 gene 2,09 3,12E-02 AK076574 AK076574 #N/D 2,02 3,12E-02 Tlk2 AK048492 tousled-like kinase 2 (Arabidopsis) 2 3,12E-02 Ccnt2 AK156621 cyclin T2 1,96 3,12E-02 AK037824 AK037824 #N/D 1,94 3,12E-02 D17Ertd165e BG066166 DNA segment, Chr 17, ERATO Doi 165, expressed 1,92 3,12E-02 BE995972 BE995972 #N/D 1,88 3,12E-02 Tead1 AK035595 TEA domain family member 1 1,83 3,12E-02 Thrap3 BC026580 thyroid hormone receptor associated protein 3 1,81 3,12E-02 2810017D21Rik AK012752 RIKEN cDNA 2810017D21 gene 1,8 3,12E-02 Rad23b AK084917 RAD23b homolog (S. cerevisiae) 1,78 3,12E-02 2610001A08Rik AK011250 RIKEN cDNA 2610001A08 gene 1,74 3,12E-02 A430081F14Rik AK084623 RIKEN cDNA A430081F14 gene 1,74 3,12E-02 2610319H10Rik AK012053 RIKEN cDNA 2610319H10 gene 1,73 3,12E-02 Phf21a AK083682 PHD finger protein 21A 1,73 3,12E-02 AI317158 BY732663 expressed sequence AI317158 1,71 3,12E-02 D5Ertd798e AK041660 DNA segment, Chr 5, ERATO Doi 798, expressed 1,71 3,12E-02 C76450 BG065672 expressed sequence C76450 1,69 3,12E-02 9930017N22Rik AK036847 RIKEN cDNA 9930017N22 gene 1,68 3,12E-02 Mll3 AK087368 myeloid/lymphoid or mixed-lineage leukemia 3 1,67 3,12E-02 Cltc AK049578 clathrin, heavy polypeptide (Hc) 1,66 3,12E-02 AK034548 AK034548 #N/D 1,65 3,12E-02 5830411K21Rik AY039009 #N/D 1,64 3,12E-02 AK156581 AK156581 #N/D 1,6 3,12E-02 D18Ertd693e BG083290 DNA segment, Chr 18, ERATO Doi 693, expressed 1,6 3,12E-02 2610011E03Rik AK011375 RIKEN cDNA 2610011E03 gene 1,54 3,12E-02 6330417A16Rik AK018186 RIKEN cDNA 6330417A16 gene 1,54 3,12E-02 AK041923 AK041923 #N/D 1,53 3,12E-02 C230096C10Rik BB591623 RIKEN cDNA C230096C10 gene 1,5 3,12E-02 C530036F05Rik AK083039 RIKEN cDNA C530036F05 gene 1,49 3,12E-02 AK164390 AK164390 #N/D 1,43 3,12E-02 Ubap2l AK014274 ubiquitin associated protein 2-like 1,38 3,12E-02 Slc26a11 NM_178743 solute carrier family 26, member 11 1,35 3,12E-02 Tagap NM_145968 T-cell activation Rho GTPase-activating protein 1,35 3,12E-02 Pten AK164302 phosphatase and tensin homolog 1,34 3,12E-02 Fcho2 BC053718 FCH domain only 2 1,23 3,12E-02 Slc4a3 NM_009208 solute carrier family 4 (anion exchanger), member 3 2,11 3,17E-02 Rbm26 NM_134077 RNA binding motif protein 26 2,07 3,17E-02 AK141643 AK141643 #N/D 1,96 3,17E-02 AI790442 AK039096 expressed sequence AI790442 1,92 3,17E-02 B430203M17Rik CA882616 #N/D 1,89 3,17E-02 Tcf4 AK033220 transcription factor 4 1,84 3,17E-02 E230020A03Rik AK084995 RIKEN cDNA E230020A03 gene 1,82 3,17E-02 Trpc2 ENSMUST00000094130 transient receptor potential cation channel, subfamily C, member 2 1,81 3,17E-02 2900018N21Rik AK013552 RIKEN cDNA 2900018N21 gene 1,79 3,17E-02 AK143436 AK143436 #N/D 1,75 3,17E-02 Man2b1 AK169830 mannosidase 2, alpha B1 1,75 3,17E-02 AK038224 AK038224 #N/D 1,7 3,17E-02 AI843755 AK132333 #N/D 1,68 3,17E-02 Rnf130 AK220529 ring finger protein 130 1,64 3,17E-02 AK134193 AK134193 #N/D 1,61 3,17E-02 AA589532 AK079655 expressed sequence AA589532 1,61 3,17E-02 AI324963 CA526845 expressed sequence AI324963 1,58 3,17E-02 Fbxw11 AK135210 F-box and WD-40 domain protein 11 1,54 3,17E-02 Ddef1 DV047853 #N/D 1,51 3,17E-02 B930096F20Rik AK081173 RIKEN cDNA B930096F20 gene 1,5 3,17E-02 1500012F01Rik LIT1141 RIKEN cDNA 1500012F01 gene 1,49 3,17E-02 Hrbl NM_145566 #N/D 1,47 3,17E-02 5930405F01Rik AK037374 RIKEN cDNA 5930405F01 gene 1,43 3,17E-02 5830443J22Rik AK017987 RIKEN cDNA 5830443J22 gene 1,38 3,17E-02 B3gnt3 BC047217 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 1,37 3,17E-02 Mta3 BC050134 metastasis associated 3 1,34 3,17E-02 2610202C22Rik AK011859 RIKEN cDNA 2610202C22 gene 1,34 3,17E-02 Tspyl2 NM_029836 TSPY-like 2 1,32 3,17E-02 Acrbp BC011079 proacrosin binding protein 1,31 3,17E-02 CD544507 CD544507 #N/D 1,29 3,17E-02 D14Ertd581e NM_029454 #N/D 1,24 3,17E-02 Zdhhc2 NM_178395 zinc finger, DHHC domain containing 2 1,87 3,18E-02 5930436O19Rik AK020044 RIKEN cDNA 5930436O19 gene List of genes de-regulated between treatment (QD) and vehicle at 6h Fold-change q.value Fold-change q.value Fold-change q.value 4080_vs_untreat 40_vs_untreat 80_vs_untreat Gene Acc Description -11,39 8,55E-03 -9,35 0,02 -15,97 0,02 Gli1 NM_010296 GLI-Kruppel family member GLI1 -3,73 8,55E-03 -3,51 0,02 -4,15 0,02 Sox18 NM_009236 SRY-box containing gene 18 -3,62 8,55E-03 -3,26 0,02 -4,29 0,02 Pdgfa NM_008808 platelet derived growth factor, alpha -3,14 8,55E-03 -2,71 0,02 -4,02 0,02 Clic6 NM_172469 chloride intracellular channel 6 -3,14 8,55E-03 -3,12 0,02 -3,18 0,02 Rgma NM_177740 RGM domain family, member A -3,08 8,55E-03 -2,94 0,02 -3,33 0,02 Bcl11b NM_021399 B-cell leukemia/lymphoma 11B -2,63 8,55E-03 -2,51 0,02 -2,85 0,02 9430069J07Rik NM_213727 #N/D -2,49 8,55E-03 -2,39 0,02 -2,65 0,02 Hk2 NM_013820 hexokinase 2 -4,94 8,55E-03 -5,18 0,02 -4,57 0,02 Gdf10 NM_145741 growth differentiation factor 10 -3,18 8,55E-03 -3,03 0,02 -3,45 0,02 4631405J19Rik NM_001002794 RIKEN cDNA 4631405J19 gene -2,29 8,55E-03 -2,15 0,02 -2,54 0,02 Ptch1 AK147626 patched homolog 1 -3,26 8,55E-03 -2,93 0,02 -3,90 0,02 Wif1 NM_011915 Wnt inhibitory factor 1 -2,91 8,55E-03 -2,79 0,02 -3,11 0,02 Tmem28 NM_173446 transmembrane protein 28 -2,89 8,55E-03 -2,65 0,02 -3,33 0,02 Bcl11b AK020296 B-cell leukemia/lymphoma 11B -2,72 8,55E-03 -2,65 0,02 -2,85 0,02 Tmem28 AK162130 transmembrane protein 28 -2,51 8,55E-03 -2,51 0,02 -2,51 0,02 AU022229 AK046833 expressed sequence AU022229 -1,97 8,55E-03 -1,81 0,02 -2,25 0,02 Col27a1 NM_025685 collagen, type XXVII, alpha 1 -2,07 8,55E-03 -1,87 0,02 -2,45 0,02 Hs3st3b1 AK171996 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 -2,42 8,55E-03 -2,19 0,02 -2,85 0,02 9130211I03Rik NM_030060 #N/D -2,17 8,55E-03 -2,57 0,02 Pgf NM_008827 placental growth factor -3,18 8,55E-03 -2,99 0,02 -3,50 0,02 Bcl11b ENSMUST00000066060 B-cell leukemia/lymphoma 11B -2,11 8,55E-03 -2,00 0,02 -2,32 0,02 Phldb1 NM_153537 pleckstrin homology-like domain, family B, member 1 2,26 8,55E-03 2,25 0,02 2,30 0,02 Igfbp5 NM_010518 insulin-like growth factor binding protein 5 -2,15 8,55E-03 -2,07 0,02 -2,31 0,02 Sez6l ENSMUST00000075387 seizure related 6 homolog like -2,77 8,55E-03 -2,47 0,02 -3,38 0,02 Angptl2 NM_011923 angiopoietin-like 2 -2,49 8,55E-03 -2,48 0,02 -2,52 0,02 Wnt4 NM_009523 wingless-related MMTV integration site 4 -2,40 8,55E-03 -2,33 0,02 -2,54 0,02 Hk2 AK009328 hexokinase 2 -2,30 8,55E-03 -2,27 0,02 -2,37 0,02 Ngfr NM_033217 nerve growth factor receptor (TNFR superfamily, member 16) -2,42 8,55E-03 -2,43 0,02 -2,40 0,02 Cfc1 NM_007685 cripto, FRL-1, cryptic family 1 -2,38 8,55E-03 -2,27 0,02 -2,60 0,02 Angptl2 AK155464 angiopoietin-like 2 -2,32 8,55E-03 -2,26 0,02 -2,41 0,02 Tiam1 NM_009384 T-cell lymphoma invasion and metastasis 1 -2,23 8,55E-03 -2,10 0,02 -2,47 0,02 Col27a1 AK003879 collagen, type XXVII, alpha 1 -2,17 8,55E-03 -2,18 0,02 -2,16 0,02 Wnt4 AK135561 wingless-related MMTV integration site 4 -2,15 8,55E-03 -2,26 0,02 -1,99 0,02 Ptch1 NM_008957 patched homolog 1 -2,12 8,55E-03 -2,21 0,02 -1,99 0,02 Smad3 NM_016769 MAD homolog 3 (Drosophila) -1,87 8,55E-03 -1,75 0,02 -2,09 0,02 Gpr153 NM_178406 G protein-coupled receptor 153 1,85 8,55E-03 1,87 0,02 1,81 0,02 Barhl1 AF264026 BarH-like 1 (Drosophila) -2,42 8,55E-03 -2,28 0,02 -2,68 0,02 Tiam1 AK161477 T-cell lymphoma invasion and metastasis 1 1,99 8,55E-03 1,98 0,02 2,01 0,02 Barhl1 NM_019446 BarH-like 1 (Drosophila) 2,20 8,55E-03 2,30 0,02 2,05 0,02 Dmrta1 NM_175647 doublesex and mab-3 related transcription factor like family A1 -2,02 8,55E-03 -2,01 0,02 -2,04 0,02 Lhx3 NM_001039653 LIM homeobox protein 3 -1,89 8,55E-03 -1,89 0,02 -1,88 0,02 1700021K02Rik NM_001017433 #N/D -1,83 8,55E-03 -1,76 0,02 -1,96 0,02 Lrig3 NM_177152 leucine-rich repeats and immunoglobulin-like domains 3 -2,11 8,55E-03 -1,98 0,02 -2,33 0,02 Hes3 NM_008237 hairy and enhancer of split 3 (Drosophila) -1,91 8,55E-03 -1,90 0,02 -1,94 0,02 Ung NM_001040691 uracil DNA glycosylase -1,88 8,55E-03 -1,81 0,02 -2,02 0,02 Gli2 AK078489 GLI-Kruppel family member GLI2 -1,68 8,55E-03 -1,66 0,02 -1,71 0,02 Gpsm1 NM_153410 G-protein signalling modulator 1 (AGS3-like, C.