Estrogen --------------------------------------------------------------- Active Ingredient protective neurosteroid i.e. neuromodulators, neuroprotective and regulate neurotransmission. • Estrogen (Estrone, Estradiol, Estriol) Before you take estrogen What is in this leaflet When you must NOT take it: This leaflet contains some information about your • If you are allergic to the active ingredient medication. It does not take the place of talking to • If the medication is expired or has not been stored your doctor or pharmacist. All medicines have risks correctly and benefits. Your doctor has weighed the risks of you • If you have or have history of breast cancer or taking this medication against the positive benefits other estrogen-dependent tumour they expect it will have for you. If you have any • If you have a history of venous thromboembolism concerns about taking this medicine, please contact (blood clots in the vein) us again or speak with your doctor or pharmacist for more information. Keep this leaflet with the medicine Let us know if you are: as you may need to read it again in the future. • Pregnant, planning on becoming pregnant, or breastfeeding What it is used for • Suffer from any other medical conditions such as migraine, diabetes, epilepsy This medication contains one or more active • or take any other medications ingredients of estrogens (estrone, estradiol, estriol). Estrogens play important roles in stimulating growth For a full list of precautions, please contact our of the reproductive tissues, maintaining healthy pharmacy bones, increasing the levels of neurotransmitters in the brain, and helping keep the cardiovascular system How to take estrogen healthy. Estrogens relieve symptoms (e.g. hot flushes, How much to take night sweats and vaginal dryness) caused by reduced Please take this medication as directed by your doctor estrogen production. Therefore, it is used for or pharmacist. Refer to the directions on the product menopausal symptoms and prevention of label if required. postmenopausal osteoporosis when there is high risk of fractures and alternative treatment is Taking tablets with food or at night may reduce inappropriate. nausea. Estradiol (E2): is the most active naturally secreted If you forget to take it estrogen. In women of reproductive age, an E2 peak Take it as soon as you remember, but if it is almost tends to occur in the early morning. In post-menstrual time for your next dose, skip the dose you missed and women, small amounts of E2 continue to be made, take your next dose as normal. Do not take two doses but E1 replaces it as the predominant estrogen. In to make up for a dose you missed. addition to its role in sexual and reproductive functioning, E2 also affects other parts of the body, If you take too much (overdose) including the cardiovascular system, the brain and the Immediately contact your doctor, the Poisons immune system. Information Centre (telephone 13 11 26) or go to the Accident and Emergency at the nearest hospital. Estrone (E1): Of the three major estrogens, E1 is predominant after menopause in women. How to report side effects If you experience any adverse experiences from this Estriol (E3): is largely associated with pregnancy and medication, you should report it via: foetal development. E3 has been examined for its role • Visiting www.tga.gov.au/reporting-problems in bone and lipid metabolism, and its function as a • Call Adverse Medicine Events Line on 1300 134 237 Prepared February 2021 If it is an EMERGENCY call the Poisons Information Centre on 13 11 26 or call 000. Side effects Please let us or your doctor know as soon as possible if you do not feel well while taking this medication. Call your doctor right away if you have any of these side effects: • Abnormal bleeding from the vagina • Lumps in breast (women and men) • Pain in leg (calf), chest or groin • Severe headache • Shortness of breath or trouble breathing • Slurred speech • Sudden vision loss • Yellow eyes or skin If you have problems with these less serious side effects, talk with your doctor: • Appetite loss • Bloating feeling • Fluid retention and weight gain • Nausea • Stomach cramps • Swollen and tender breasts (women and men) Large doses of this medicine taken over long periods of time may increase the risk of some kinds of cancer such as breast cancer, ovarian cancer. Talk to your doctor about this risk. For a full list of possible side effects please contact us. Storage Products expire 6 months after preparation. Keep in the original packaging until you need to take your next dose. Store your medication in a cool, dry place that is below 25°C and away from sunlight. Prepared February 2021 .