--~-------------------------- Ahimsa and Alternatives - the Concept of the 4th R. The CPCSEAin India Shiranee Pereira' and Massimo Tettamanii? ICommittee fos the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), IN-Chennai 2International Centre for Alternatives in Research and Education (I-CARE), IN-Chennai Summary Zusammenfassung: Ahimsa und Alternativen - das Konzept The Committee for the Purpose of Control and Supervision of des vierten R. Das CPCSEA in Indien Experiments on Animals (CPCSEA) in India is one of a kind in Das Komitee zur Kontrolle und Aufsicht über Tierversuche the world. It is a statutory body of the government of India (CPCSEA) in Indien ist weltweit einzigartig. Es ist eine Ein- formed by an act of the Indian parliament. This body consists richtung der indischen Regierung, geschaffen durch einen of nominated members and representatives from national Beschluss des indischen Parlaments. Das Gremium besteht aus regulatory agencies, Ministry of Health and Family Welfare, ernannten Mitgliedern und Vertretern von nationalen Aufsichts- Ministry of Environment and Forests, national academic and behörden, des Ministeriums für Gesundheit und Familie und research councils, premier research institutes, eminent seien- des Ministeriums für Umwelt und Wälder. Im Weiteren gehören tists and animal welfare organisations. The CPCSEA draws ihm nationale Berater aus Akademie- und Forschungskreisen, its powers from the Prevention of Cruelty to Animals (PCA) Act bekannte Wissenschaftler sowie Vertreter von führenden of 1960 which states that the duty ofthe committee is "to take Forschungseinrichtungen und Tierschutzorganisationen an. all such measures as may be necessary to ensure that animals Das CPCSEA leitet seine Befugnisse aus dem Gesetz zur are not subject to unnecessary pain or suffering before, during Vermeidung von Grausamkeit gegen Tiere von 1960 ab, in dem or after the performance of experiments on them ". festgelegt ist, dass das Komitee "alle nötigen Massnahmen With the power to promulgate its own laws to ensure the ergreifen muss, um sicherzustellen, dass Tiere vor, während humane and ethical use of animals in research and education, und nach Versuchen keinen unnötigen Schmerzen oder Leiden the CPCSEA in 1998 notified in the gazette of India the ausgesetzt werden ". "Breeding of and Experiments on Animals (Control and Mit der Befugnis eigene Gesetze zu erlassen, um die humane Supervision) Rules 1998". und ethische Nutzung von Tieren in Forschung und Lehre The CPCSEA is unique in that the law in itself has enabled the sicherzustellen, hat das CPCSEA 1998 in der Gazette of India creation of a common platform of discussion for scientists "Richtlinien zur Zucht und Nutzung von Tierenfür Experimente and animal activists for humane and progressive solutions for (Kontrolle und Aufsicht) 1998" publiziert. the use of animals in experimentation. In a country that is Das CPCSEA ist einzigartig, weil hier ein Gesetz unmittelbar caught in a paradox of violence and rich cultural and religious eine Plattform geschaffen hat, auf der Wissenschaftler und Tier- traditions, India still draws a lot of its power from the concept schützet Diskussionen im Sinne humaner und fortschrittlicher of "Ahimsa" (the philosophy of non-violence). This concept is Lösungen bei Tierversuchen führen. In einem Land, das sich also pertinent to the use of animals in laboratories. Unethical, in einem Paradoxon von Gewalt und reicher kultureller und inhumane and unscientific practices, and ignorance of the religiöser Traditionen verfangen hat, schöpft Indien immer use of alternatives were the way of science until 1999 when noch viel seiner Kraft aus dem Konzept der "Ahimsa ", der CPCSEA became functional. For four years CPCSEA has Philosophie der Gewaltlosigkeit. Dieses Prinzip findet nun auch waged a battle, rescued thousands of animals from laborato- in Tierversuchsanlagen Anwendung. Unethische, inhumane ries, fought legal battles to victory, enforced for the first time und unwissenschaftliche Praktiken und Unkenntnis gegenüber in the country good laboratory practice, designed guidelines dem Einsatz von Alternativmethoden waren vor 1999, als das for the use of animals in the production of immunobiologicals, CPCSEA seine Arbeit aufnahm, gängige Methoden in der introduced the credo of 3R principles, trained and taught Wissenschaft. Vier Jahre führte das Komitee einen regelrechten scientific personnel the credibility of humane science and Feldzug, rettete tausende Tiere aus Laboratorien, führte most importantly brought forward the concept of the fourth R, siegreiche Prozesse, setzte erstmals im Land die "gute Labor- "rehabilitation" of used laboratory animals. Today CPCSEA praxis " in Kraft sowie Richtlinien für die Verwendung von has made it anational policy that personnel using experimen- Tieren bei der Herstellung von Immunbiologika, führte das tal animals have amoral responsibility towards these animals Credo der 3R ein, brachte wissenschaftlichem Personal die Received 18 November 2004; received in final form and accepted for publication 3 January 2005 ALTEX 22, 1/05 3 PEREIRA AND TETTAMANTI m.... ----------------------------------------~--- after their use. Costs of after-care/rehabilitation of animals Grundsätze humaner Wissenschaft näher und, am allerwich- post experimentation are to be apart of research costs and tigsten, es verhalf dem Konzept des vierten Rs, der Rehabilitation should be scaled in positive correlation with the level of verwendeter Labortiere, zur Geltung. Das Komitee hat dieses sentience of the animals. Konzept zu einem nationalen Grundsatz erhoben, nach dem This paper is about the Indian law on anima I experimentation Personen, die Tiere verwenden, auch nach dem Experiment eine and the success story of the CPCSEA in India in inculcating moralische Verpflichtung gegenüber diesen Tieren haben. Die the credo of 4Rs - Replacement, Reduction, Refinement, and Kosten der Nachsorge und Rehabilitation der Tiere nach den Rehabilittuion of animals used in experimentation. Experimenten bilden Teil der Forschungskosten; sie sind positiv korreliert mit der Empfindungsfähigkeit der Tiere. In diesem Beitrag geht es um die indische Rechtsprechung zu Tierversuchen und die Erfolgsgeschichte des CPCSEA bei der Festlegung des Bekenntnisses zu den 4Rs - Replacement, Reduction, Refinement und Rehabilitation von Versuchstieren. Keywords: anima I experimentation, rehabilitation, ahimsa, animal welfare in India, control and supervision 1 Introduction Animal Welfare Board of India, by an act the following changes were brought of parliament, with the sole purpose of about: Ahimsa is a Sanskrit word meaning "not controlling and supervising experiments • Over 850 laboratories registered with to kill". In a broader sense it refers to the on animals. The PCA lays down the duty the CPCSEA concept of "non-violence", It is derived of the CPCSEA as "to take all such mea- • IAEC's (Institution al Animal Ethics from the word "himsa" which means "to sures as may be necessary to ensure that Committees) were founded in all regis- kill". Ahimsa is an enduring Indian tradi- animals are not subject to unnecessary tered institutes tion signifying the sacredness of life. pain or suffering before, during or after • Over 300 CPCSEA nominees were ap- Hindus, Buddhists and Jains view all the performance of experiments on pointed in these institutes living things as incarnations of a single them". • An expert committee was appointed to life force. When a creature dies it could With the power to promulgate its own scrutinise and approve large animal be re-incarnated into another form and laws to ensure the humane and ethical use hence be vitalised by a soul of an ances- use of animals in research and education, • Good Laboratory Practice was intro- tor or friend. In a country that is caught the CPCSEA in 1998 notified the duced in a paradox of violence and rich cultur- "Breeding of and Experiments on Ani- • A protocol for the care and use of al and religious traditions, India still mals (Control & Supervision) Rules equines in the production of immuno- draws a lot of its power from the concept 1998" (Anon, 1998) which was amended biologieals was introduced of Ahimsa. Like India's struggle to in 2001. The CPCSEA is unique in that • The 3R credo was introduced freedom from British occupation, the the law itself has enabled the creation • Alternatives validated by ECVAM progress towards laws that govern the of a comrnon platform for recourse and (European Commission for the Valida- care and use of animals in experimenta- discussion between scientists, policy tion of Alternative Methods) and ICC- tion has been guided and propelled by makers and animal activists by way of VAM (Interagency Coordination Com- Ahimsa. which the CPCSEA works for humane mittee for the Validation of Alternative and progressive solutions in the use of Methods) were recommended to regu- animals in experimentation. latory authorities 2 Indian law and animal From 1964 to 1998 little was done to • A national ban on the SempIe vaccine experimentation alleviate the suffering of laboratory ani- was urged mals in India. The CPCSEA committees • Two year phase-out of the ascites The law that governs the use and care of failed to irnpose the laws and lacked ef- method of monoclonal antibody pro- animals in experimentation is the Preven- fective methods for implementation and duction tion of Cruelty to Animals Act (PCA) of a dismal scenario continued in laborato- • Hundreds of laboratory animals