ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme Friday, 05. July 2019 Registration 15:00 - 19:00 Main Foyer Registration Page 1 / 209 ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme Saturday, 06. July 2019 Registration 06:30 - 19:00 Main Foyer Registration Special Session 08:00 - 10:30 Clarendon A/B Trainee Session The Trainee Session of the ISTH 2019 Congress in Melbourne welcomes all trainees and early career professionals interested in Thrombosis and Hemostasis. This 2.5-hour session developed by the ISTH Early Career Committee will provide career mentoring discussions along with round tables with experts on various career and methodology topics and educational tips. Come and start your ISTH Congress by networking and engaging with peers and experts in your field of interest! Chair: Claire McLintock (New Zealand) Chair: Marc Blondon (Switzerland) Introduction and Lecture: Make the Best of Your ISTH Membership 08:00 Speaker: Claire McLintock (New Zealand) Career Mentoring Sessions: Learning from Each Other 08:15 Speaker: David Rabbolini (Australia) Speaker: Vincent Muczynski (United Kingdom) Speaker: Matthew Harper (United Kingdom) Speaker: Eileen Merriman (New Zealand) Speaker: Alisa S. Wolberg (United States) Speaker: Christopher M. Ward (Australia) Transition to Round Tables 09:00 Round Table Discussion 09:05 - 09:30 09:05 How to Become a Good Journal Reviewer Speaker: Mary Cushman (United States) How to Optimize Papers for Publication Speaker: James H. Morrissey (United States) How to Succeed in Getting Funding: Writing a Grant and the Review Process Speaker: Ross Ian Baker (Australia) How to Combine Research and a Laboratory Career Speaker: Emmanuel Favaloro (Australia) How to Combine Research and Clinical Work: Difficulties in Early Career Stage Speaker: Mandy N. Lauw (the Netherlands) Speaker: David Rabbolini (Australia) Page 2 / 209 ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme How to Transition from a Postdoc Position to a PI: Difficulties for Scientists at an Early Career Level Speaker: Caterina Casari (France) Speaker: Robert Campbell (United States) How to Establish a Career in Thrombosis and Haemostasis in Reach-the- World Countries Speaker: Pedro Henrique Fernandes do Carmo Las Casas (Brazil) Speaker: Pantep Angchaisuksiri (Thailand) Tips for a Good CV / Cover Letter / Recommendation Speaker: Christopher M. Ward (Australia) Tips for a Good Short Oral Presentation Speaker: Peter Lenting (France) How to Improve Your Poster Presentation Speaker: Geoffrey Barnes (United States) How to Be a Good Mentee Speaker: Alisa S. Wolberg (United States) Speaker: Deborah M. Siegal (Canada) How to Maintain a Healthy Work-Life Balance Speaker: Claire McLintock (New Zealand) Speaker: Eileen Merriman (New Zealand) Tips and Pitfalls for Systematic Reviews and Meta-Analyses Speaker: Marc Carrier (Canada) Minimizing Biases in Observational Studies Speaker: Marc Blondon (Switzerland) How to Be a Good Session Moderator Speaker: Walter Ageno (Italy) Break and Networking - 09:30 - 09:50 09:30 Round Table Discussion 09:50 - 10:15 09:50 How to Become a Good Journal Reviewer Speaker: Mary Cushman (United States) How to Optimize Papers for Publication Speaker: James H. Morrissey (United States) How to Succeed in Getting Funding: Writing a Grant and the Review Process Speaker: Ross Ian Baker (Australia) How to Combine Research and a Laboratory Career Speaker: Emmanuel Favaloro (Australia) How to Combine Research and Clinical Work: Difficulties in Early Career Stage Speaker: Mandy N. Lauw (the Netherlands) Speaker: David Rabbolini (Australia) Page 3 / 209 ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme How to Transition from a Postdoc Position to a PI: Difficulties for Scientists at an EC Level Speaker: Caterina Casari (France) Speaker: Robert Campbell (United States) How to Establish a Career in Thrombosis and Haemostasis in Reach-the- World Countries Speaker: Pantep Angchaisuksiri (Thailand) Speaker: Pedro Henrique Fernandes do Carmo Las Casas (Brazil) Tips for a Good CV / Cover Letter / Recommendation Speaker: Christopher M. Ward (Australia) Tips for a Good Short Oral Presentation Speaker: Peter Lenting (France) How to Improve Your Poster Presentation Speaker: Geoffrey Barnes (United States) How to Be a Good Mentee Speaker: Alisa S. Wolberg (United States) Speaker: Deborah M. Siegal (Canada) How to Maintain a Healthy Work-Life Balance Speaker: Claire McLintock (New Zealand) Speaker: Eileen Merriman (New Zealand) Tips and Pitfalls for Systematic Reviews and Meta-Analyses Speaker: Marc Carrier (Canada) Minimizing Biases in Observational Studies Speaker: Marc Blondon (Switzerland) How to Be a Good Session Moderator Speaker: Walter Ageno (Italy) How to Become a Good Educator 10:15 Speaker: Renee Eslick (Australia) Supported Symposia 11:30 - 12:45 Meeting Room 203/204 Supported Symposium Title: Transforming Research Into Clinical Reality: Takeda’s Gene Therapy Program in Hemophilia This session is supported by Takeda Please view the program here Supported Symposia 11:30 - 12:45 Meeting Room 210/211 Supported Symposium Title: The Role of the Protein C System in a Rare Disorder and its Impact in Critical Care This session is supported by Takeda Please view the program here Page 4 / 209 ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme Supported Symposia 11:30 - 12:45 Meeting Room 212/213 Supported Symposium Title: The Evolution of Turning Genes Into Medicine: Leveraging Innovation To Create a Path Forward This session is supported by Spark Therapeutics, Inc. Please view the program here Supported Symposia 11:30 - 12:45 Meeting Room 219/220 Supported Symposium Title: Understanding the Outcomes of Anticoagulation: Insights From the GARFIELD Registries This session is supported by TRI Please visit here Supported Symposia 11:30 - 12:45 Meeting Room 105 Supported Symposium Title: Navigating the New World: Haemophilia in the 21st Century This session is supported by Sanofi Genzyme Please view the program here Supported Symposia 11:30 - 12:45 Meeting Room 106 Supported Symposium Title: Defining a New Paradigm for the Management of Acquired Thrombotic Thrombocytopenic Purpura This session is supported by Sanofi Genzyme Please view the program here Supported Symposia 11:30 - 12:45 Meeting Room 109 Supported Symposium Title: Inhibitors: Prevention and Evolving Treatment Paradigms This session is supported by GRIFOLS Please view the program here Supported Symposia 11:30 - 12:45 Meeting Room 110 Supported Symposium Title: A Decade of Innovation: from DOACs to Reversal Agents This session is supported by Boehringer Ingelheim Please view the program here Page 5 / 209 ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme Oral Communication Session 13:00 - 14:15 Melbourne Room 1 OC 02, New Antithrombotic Targets Chair: Robert Flaumenhaft (United States) Chair: Freda J. Passam (Australia) Thymidine Phosphorylase Is a Novel Anti-atherothrombotic Target 13:00 Speaker: Wei Li (United States) The Cyclooxygenase-1/Microsomal Prostaglandin E 13:15 Synthase-1/Endothelial EP4 Receptor Pathway Constrains Myocardial Ischemia-Reperfusion Injury: New Insight into Microcirculation Speaker: Miao Wang (China) Recombinant Factor VII Activating Protease (FSAP) Decreases Infarct 13:30 Volume and Improves Neurological Outcome in two Different Mouse Models of Ischemic Stroke Speaker: Jeong Yeon Kim (Norway) Patients with Atrial Fibrillation Overexpress Fibrin-binding Platelet 13:45 Receptor GPVI-dimer. A Future Anti-thrombotic Target? Speaker: Isuru Induruwa (United Kingdom) New Peptide-agonist of PAR1 Demonstrates Neuroprotective Effect at the 14:00 Photothrombosis-induced Damage of Mouse Brain Speaker: Liubov Gorbacheva (Russian Federation) Oral Communication Session 13:00 - 14:15 Melbourne Room 2 OC 01, Gene Therapy Clinical Chair: Guy Young (United States) Chair: Julie Curtin (Australia) AMT-061 (AAV5-Padua hFIX variant) an Enhanced Vector for Gene 13:00 Transfer in Adults with Severe or Moderate-Severe Hemophilia B: Follow- up up to 9 Months in a Phase 2b Trial Speaker: Adam Giermasz (United States) Initial Results of the Alta Study, a Phase 1/2, Open Label, Adaptive, Dose- 13:15 Ranging Study to Assess the Safety and Tolerability of SB-525 Gene Therapy in Adult Subjects with Severe Hemophilia A Speaker: Barbara A. Konkle (United States) Health-related Quality of Life Improvements in Adult Haemophilia B 13:30 Patients at One Year Follow-up after Receiving SPK-9001 Gene Transfer Speaker: Sylvia von Mackensen (Germany) Stable Expression of FIX and Maintained Reductions in Bleeding and 13:45 Factor IX Consumption Following AMT-060 Gene Therapy with up to 3.5 Years of Follow Up in Adults with Severe or Moderate-Severe Hemophilia B Speaker: Frank Leebeek (the Netherlands) Page 6 / 209 ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia, July 6 - 10, 2019 Scientific Programme Oral Communication Session 13:00 - 14:15 Meeting