Gene regulatory mechanisms in neural fate decisions San Juan de Alicante, Spain 07 – 10 September 2017 Gene regulatory mechanisms in neural fate decisions Organizers Vijay Tiwari Magdalena Götz Yukiko Gotoh Institute of Molecular Helmholtz Zentrum University of Tokyo, Biology (IMB), Mainz, Munich and LMU, Tokyo, JAPAN GERMANY Munich, GERMANY Federico Calegari Jovica Ninkovic Victor Borrell CRTD, Helmholtz Zentrum Instituto de Neurociencias, Dresden, GERMANY München (HMGU) and LMU, CSIC & Universidad Munich, GERMANY Miguel Hernández, Alicante, SPAIN 2 · Gene regulatory mechanisms in neural fate decisions. 7 - 10 September 2017 | San Juan de Alicante, Spain Sponsors The Company of Biologists www.biologists.com 7 - 10 September 2017 | San Juan de Alicante, Spain. Gene regulatory mechanisms in neural fate decisions · 3 4 · Gene regulatory mechanisms in neural fate decisions. 7 - 10 September 2017 | San Juan de Alicante, Spain Programme Programme Day 1 – 7 September 2017 11:00 - 13:45 Registration 13:45 - 14:00 Welcome and Opening remarks Session 1. Histone Modifications Chair: Victor Borrell 14:00 - 14:30 Epigenetic priming contributes to lineage-appropriate binding of transcription factors Gunnar Schotta, Biomedical Center, Munich, Germany 14:30 - 15:00 Mechanisms regulating synapse-specific gene expression by HDAC2 in neurons Li-Huei Tsai, Massachusetts Institute of Technology, Cambridge, USA 15:00 - 15:30 Regulation of embryonic and adult neural stem cell fate Yukiko Gotoh, University of Tokyo, Tokyo, Japan 15:30 - 16:00 Epigenetic regulation of neuronal development and function Vijay Tiwari, Institute of Molecular Biology (IMB), Mainz, Germany 16:00 - 16:30 Short Talks: Kdm5c prevents spurious transcription, silences germ line genes and modulates transcription of regulatory ncRNAs Marilyn Scandaglia, Universidad Miguel Hernández-CSIC, Alicante, Spain DOT1L and H3K79 methylation establish transmittable layer identity in progenitors of the cerebral cortex Tanja Vogel, Institute for Anatomy and Cell Biology, Department of Molecular Embryology, Albert-Ludwigs-University Freiburg, Germany 16:30 - 17:00 Coffe break (Venue’s Science Lounge) and informal discussion 6 · Gene regulatory mechanisms in neural fate decisions. 7 - 10 September 2017 | San Juan de Alicante, Spain Session 2. Modifications of DNA Chair: Magdalena Götz 17:30 - 18:00 Epitranscriptomic mechanism regulating mammalian cortical neurogenesis Hongjun Song, University of Pennsylvania, USA 18:00 - 18:30 A role for endogenous retroviruses in human brain evolution Johan Jakobson, Wallenberg Neuroscience Center, Lund University, Lund, Sweden 18:30 - 19:00 Gene regulation in chromatin Dirk Schübeler, FMI, Basel, Switzerland 19:00 - 19:30 The Chromatin deacetylase SIRT6 drives early cell-fate decisions in embryonic development Raul Mostoslawsky, The Massachusetts General Hospital Cancer Cen- ter, Harvard Medical School, Boston, MA USA 19:30 - 20:00 Transposable elements, their polydactyl controllers and the uniqueness of the human brain Didier Trono, EPFL, Geneva, Switzerland 20:00 - 20:30 Epigenetic control of neural stem cells during corticogenesis Federico Calegari, CRTD, Dresden, Germany 20:30 - 22:00 Dinner and informal discussions Day 2 – 8 September 2017 Session 3. Non-coding Genome Chair: Francois Guillemot 09:00 - 09:30 Long non-coding RNAs (lncRNAs) in neural development Dan Lim, UCSF, San Francisco, USA 09:30 - 10:00 Molecular basis of synaptic plasticity Michael Kiebler, Ludwig-Maximilians-University, Munich, Germany 7 - 10 September 2017 | San Juan de Alicante, Spain. Gene regulatory mechanisms in neural fate decisions · 7 10:00 - 10:30 Systematic identification of regulators of an alternative splicing regulatory network underlying nervous system development and autism spectrum disorders Benjamin J. Blencowe, University of Toronto, Toronto, Canada 10:30 - 11:00 Bimodal gene regulation of neural progenitors by Nup153 in cooperation with Sox2 Rusty Gage, Salk Institute for Biological Studies, La Jolla, USA 11:00 - 11:30 Short Talks: miRNA-independent functions of Dgcr8 control mouse corticogene- sis: implications for neocortex expansion Davide De Pietri Tonelli, Neurobiology of microRNA lab, Istituto Italiano di Tecnologia, Genoa, Italy Transcriptional and chromatin accessibility dynamics during status epilepticus J. Fernàndez-Albert, Instituto de Neurociencias de Alicante (Univer- sidad Miguel Hernández-CSIC), Alicante, Spain 11:30 - 12:00 Coffe break (Venue’s Science Lounge) and informal discussion Non-coding Genome Continues 12:00 - 12:30 L1 retrotransposition in the mammalian brain Geoffrey J. Faulkner, University of Queensland, Brisbane, Australia 12:30 - 13:00 Quantitative and dynamic analysis of neurogenesis with single cell resolution at the tissue level Nancy Papalopulu, The University of Manchester, Manchester, UK 13:00 - 13:30 Chromatin regulation of cerebellar granule neuron maturation Anne West, Duke University, Durham, USA 13:30 - 14:00 Choroid Plexus releases miR-204 regulating the number of neural stem cells in the subependymal zone Jovica Ninkovic, Helmholtz Zentrum München and LMU, Munich, Germany 14:00 - 15:00 Lunch (Venue’s Social Lounge) and informal discussion 15:00 - 17:30 Poster Session I – Presenting odd numbers 16:30 - 17:30 Coffee in parallel to poster sessions 8 · Gene regulatory mechanisms in neural fate decisions. 7 - 10 September 2017 | San Juan de Alicante, Spain Session 4. Chromatin remodeling Chair: Vijay Tiwari 17:30 - 18:00 Shaping the Neuronal Epigenetic Landscape in development and disease by neuron-specific nBAF Complexes Jerry Crabtree, Stanford University, San Francisco, USA 18:00 - 18:30 Chromatin as a hub integrating environmental signals and fate decisions in adult neural stem cells Ana Martin Villalba, DKFZ Heildeberg, Germany 18:30 - 19:00 Role of the chromatin remodeller CHD7 in neurogenesis and brain diseases Haikun Liu, DKFZ Heidelberg, Germany EMBO Young Investigator Lecture 19:00 - 19:30 Proliferation control, temporal identity and cell immortalization in Dro- sophila neural stem cell lineages Jurgen Knoblich, IMBA, Vienna, Austria 19:30 - 20:00 Short Talks: Epigenetic and genetic programming of growth by modulating Zdbf2 dosage in the brain Juliane Glaser, Institut Curie, PSL Research University, INSERM, CNRS, Paris, France The POU homeobox gene BRN3A maintains the identity of multiple neu- ron types throughout the CNS Esther Serrano-Saiz, Columbia University of New York 20:00 - 22:00 Dinner (Venue’s Social Lounge) and informal discussion Day 3 – 9 September 2017 Session 5. Transcription Factors Chair: Federico Calegari 09:00 - 09:30 Post-translational regulation of stem cell quiescence and activity in the adult brain Francois Guillemot, The Francis Crick Institute, London, UK 7 - 10 September 2017 | San Juan de Alicante, Spain. Gene regulatory mechanisms in neural fate decisions · 9 09:30 - 10:00 What does the FOX say: Gene regulatory networks in the developing neocortex Soo-Kyung Lee, Oregon Health & Science University, Portland, USA 10:00 - 10:30 Transcriptional dynamics in cortical development Verdon Taylor, University of Basel, Basel, Switzerland 10:30 - 11:00 Uncovering spatiotemporal windows in cortical development Shubha Tole, Tata Institute of Fundamental Research, India 11:00 - 11:30 Short Talks: Sox2 is required for global functional chromatin connectivity in brain-derived neural stem cells Silvia Nicolis, Department of Biotechnology and Biosciences, University Milano-Bicocca, Milano, Italy Identifying Novel Transcriptional Regulators of Neurogenesis Angela Garding, Institute of Molecular Biology (IMB), Mainz, Germany 11:30 - 12:00 Coffe break (Venue’s Science Lounge) and informal discussion Transcription Factors continues 12:00 - 12:30 Decoding the gene regulatory logic of neuronal cell type specification in C. elegans Oliver Hobert, Columbia University, New York, USA 12:30 - 13:00 Dynamic transcriptional control of neural stem cells Ryoichiro Kageyama, Kyoto University, Kyoto, Japan 13:00 - 13:30 Epigenetic regulation of aging neural stem cells Anne Brunet, Standford University, San Francisco, USA 13:30 - 14:30 Lunch (Venue’s Social Lounge) and informal discussion 14:30 - 17:30 Poster Session II – Presenting even numbers 16:30 - 17:30 Coffee in parallel to poster sessions 10 · Gene regulatory mechanisms in neural fate decisions. 7 - 10 September 2017 | San Juan de Alicante, Spain Session 6. Distal gene regulation and nuclear organization Chair: Li-Huei Tsai 17:30 - 18:00 Chromosomal enhancer nuclear syntax: ligand-dependent 3D redistribu- tion of “First Tier” enhancers generate mega-enhancers that associate with subnuclear phase-separated structures to dictate enhancer robustness Michael Rosenfeld, University of California, San Francisco, USA 18:00 - 18:30 Gene regulation in development and evolution of the human cerebral cortex Christopher A. Walsh, Boston Children’s Hospital, Boston, USA 18:30 - 19:00 Genome Architecture Mapping: discovering chromatin contacts in rare cell types Ana Pombo, MDC, Berlin, Germany 19:00 - 19:30 Short Talks: Gene network governing the commitment of radial glial cells to ependymal lineage Stavros Taraviras, Department of Physiology, Medical School, University of Patras, Greece Mechanisms of epigenetic priming that underpin changes in neuronal identity Philipp Mews, Icahn School of Medicine at Mount Sinai, New York, USA 20:00 - 22:00 Dinner (Venue’s Social Lounge) and informal discussion Day 4 – 10 September 2017 Session 7. Single cell transcriptome and epigenome