IAEA RADIATION TECHNOLOGY REPORTS No. 5 IAEA Radiation Technology Reports No. 5 Technology IAEA Radiation The availability of a variety of chemical structures and functionality together with precise control of molecular architecture and morphology has enabled new uses of advanced materials. This has brought about a recent explosion of developments in the fi eld of materials science. However, despite their widespread use in health care, many biomaterials lack the desired properties to interface with biological systems. There are thus unmet needs to create biomaterials with enhanced specifi c functionalities, improved biocompatibility and minimal natural rejection. This can be achieved by introduction of proper functionalities at the nanoscale dimension, a task for which radiation techniques are uniquely suited. Under the coordinated research project entitled Nanoscale Radiation Engineering of Advanced Materials for Potential Biomedical Applications, 18 Member State institutions collaborated and developed methodologies for radiation induced synthesis that Nanoscale Radiation enables precise control of the product structure, size and functionality at the nanoscale. This publication showcases these achievements. Engineering of Advanced Materials for Potential Biomedical Applications INTERNATIONAL ATOMIC ENERGY AGENCY VIENNA ISBN 978–92–0–101815–1 @ ISSN 2225–8833 IAEA RADIATION TECHNOLOGY SERIES PUBLICATIONS One of the main objectives of the IAEA Radioisotope Production and Radiation Technology programme is to enhance the expertise and capability of IAEA Member States in utilizing the methodologies for radiation processing, compositional analysis and industrial applications of radioisotope techniques in order to meet national needs as well as to assimilate new developments for improving industrial process efficiency and safety, development and characterization of value- added products, and treatment of pollutants/hazardous materials. Publications in the IAEA Radiation Technology Series provide information in the areas of: radiation processing and characterization of materials using ionizing radiation, and industrial applications of radiotracers, sealed sources and non-destructive testing. The publications have a broad readership and are aimed at meeting the needs of scientists, engineers, researchers, teachers and students, laboratory professionals, and instructors. International experts assist the IAEA Secretariat in drafting and reviewing these publications. Some of the publications in this series may also be endorsed or co-sponsored by international organizations and professional societies active in the relevant fields. There are two categories of publications: the IAEA Radiation Technology Series and the IAEA Radiation Technology Reports. IAEA RADIATION TECHNOLOGY SERIES Publications in this category present guidance information or methodologies and analyses of long term validity, for example protocols, guidelines, codes, standards, quality assurance manuals, best practices and high level technological and educational material. IAEA RADIATION TECHNOLOGY REPORTS In this category, publications complement information published in the IAEA Radiation Technology Series in the areas of: radiation processing of materials using ionizing radiation, and industrial applications of radiotracers, sealed sources and NDT. These publications include reports on current issues and activities such as technical meetings, the results of IAEA coordinated research projects, interim reports on IAEA projects, and educational material compiled for IAEA training courses dealing with radioisotope and radiopharmaceutical related subjects. In some cases, these reports may provide supporting material relating to publications issued in the IAEA Radiation Technology Series. All of these publications can be downloaded cost free from the IAEA web site: http://www.iaea.org/Publications/index.html Further information is available from: Marketing and Sales Unit International Atomic Energy Agency Vienna International Centre PO Box 100 1400 Vienna, Austria Readers are invited to provide feedback to the IAEA on these publications. Information may be provided through the IAEA web site, by mail at the address given above, or by email to: [email protected] NANOSCALE RADIATION ENGINEERING OF ADVANCED MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS The following States are Members of the International Atomic Energy Agency: AFGHANISTAN GERMANY OMAN ALBANIA GHANA PAKISTAN ALGERIA GREECE PALAU ANGOLA GUATEMALA PANAMA ARGENTINA GUYANA PAPUA NEW GUINEA ARMENIA HAITI PARAGUAY AUSTRALIA HOLY SEE PERU AUSTRIA HONDURAS PHILIPPINES AZERBAIJAN HUNGARY POLAND BAHAMAS ICELAND PORTUGAL BAHRAIN INDIA QATAR BANGLADESH INDONESIA REPUBLIC OF MOLDOVA BELARUS IRAN, ISLAMIC REPUBLIC OF ROMANIA BELGIUM IRAQ RUSSIAN FEDERATION BELIZE IRELAND RWANDA BENIN ISRAEL SAN MARINO BOLIVIA, PLURINATIONAL ITALY SAUDI ARABIA STATE OF JAMAICA SENEGAL BOSNIA AND HERZEGOVINA JAPAN SERBIA BOTSWANA JORDAN SEYCHELLES BRAZIL KAZAKHSTAN SIERRA LEONE BRUNEI DARUSSALAM KENYA SINGAPORE BULGARIA KOREA, REPUBLIC OF SLOVAKIA BURKINA FASO KUWAIT SLOVENIA BURUNDI KYRGYZSTAN SOUTH AFRICA CAMBODIA LAO PEOPLE’S DEMOCRATIC SPAIN CAMEROON REPUBLIC SRI LANKA CANADA LATVIA SUDAN CENTRAL AFRICAN LEBANON SWAZILAND REPUBLIC LESOTHO SWEDEN CHAD LIBERIA SWITZERLAND CHILE LIBYA SYRIAN ARAB REPUBLIC CHINA LIECHTENSTEIN TAJIKISTAN COLOMBIA LITHUANIA THAILAND CONGO LUXEMBOURG THE FORMER YUGOSLAV COSTA RICA MADAGASCAR REPUBLIC OF MACEDONIA CÔTE D’IVOIRE MALAWI TOGO CROATIA MALAYSIA TRINIDAD AND TOBAGO CUBA MALI TUNISIA CYPRUS MALTA TURKEY CZECH REPUBLIC MARSHALL ISLANDS UGANDA DEMOCRATIC REPUBLIC MAURITANIA UKRAINE OF THE CONGO MAURITIUS UNITED ARAB EMIRATES DENMARK MEXICO UNITED KINGDOM OF DJIBOUTI MONACO GREAT BRITAIN AND DOMINICA MONGOLIA NORTHERN IRELAND DOMINICAN REPUBLIC MONTENEGRO UNITED REPUBLIC ECUADOR MOROCCO OF TANZANIA EGYPT MOZAMBIQUE UNITED STATES OF AMERICA EL SALVADOR MYANMAR URUGUAY ERITREA NAMIBIA UZBEKISTAN ESTONIA NEPAL VANUATU ETHIOPIA NETHERLANDS VENEZUELA, BOLIVARIAN FIJI NEW ZEALAND REPUBLIC OF FINLAND NICARAGUA VIET NAM FRANCE NIGER YEMEN GABON NIGERIA ZAMBIA GEORGIA NORWAY ZIMBABWE The Agency’s Statute was approved on 23 October 1956 by the Conference on the Statute of the IAEA held at United Nations Headquarters, New York; it entered into force on 29 July 1957. The Headquarters of the Agency are situated in Vienna. Its principal objective is “to accelerate and enlarge the contribution of atomic energy to peace, health and prosperity throughout the world’’. The following States are Members of the International Atomic Energy Agency: IAEA RADIATION TECHNOLOGY REPORTS No. 5 AFGHANISTAN GERMANY OMAN ALBANIA GHANA PAKISTAN ALGERIA GREECE PALAU ANGOLA GUATEMALA PANAMA ARGENTINA GUYANA PAPUA NEW GUINEA ARMENIA HAITI PARAGUAY AUSTRALIA HOLY SEE PERU AUSTRIA HONDURAS PHILIPPINES AZERBAIJAN HUNGARY POLAND BAHAMAS ICELAND PORTUGAL BAHRAIN INDIA QATAR BANGLADESH INDONESIA REPUBLIC OF MOLDOVA BELARUS IRAN, ISLAMIC REPUBLIC OF ROMANIA BELGIUM IRAQ RUSSIAN FEDERATION BELIZE IRELAND RWANDA NANOSCALE RADIATION ENGINEERING BENIN ISRAEL SAN MARINO BOLIVIA, PLURINATIONAL ITALY SAUDI ARABIA OF ADVANCED MATERIALS FOR STATE OF JAMAICA SENEGAL BOSNIA AND HERZEGOVINA JAPAN SERBIA BOTSWANA JORDAN SEYCHELLES POTENTIAL BIOMEDICAL APPLICATIONS BRAZIL KAZAKHSTAN SIERRA LEONE BRUNEI DARUSSALAM KENYA SINGAPORE BULGARIA KOREA, REPUBLIC OF SLOVAKIA BURKINA FASO KUWAIT SLOVENIA BURUNDI KYRGYZSTAN SOUTH AFRICA CAMBODIA LAO PEOPLE’S DEMOCRATIC SPAIN CAMEROON REPUBLIC SRI LANKA CANADA LATVIA SUDAN CENTRAL AFRICAN LEBANON SWAZILAND REPUBLIC LESOTHO SWEDEN CHAD LIBERIA SWITZERLAND CHILE LIBYA SYRIAN ARAB REPUBLIC CHINA LIECHTENSTEIN COLOMBIA LITHUANIA TAJIKISTAN CONGO LUXEMBOURG THAILAND COSTA RICA MADAGASCAR THE FORMER YUGOSLAV CÔTE D’IVOIRE MALAWI REPUBLIC OF MACEDONIA CROATIA MALAYSIA TOGO CUBA MALI TRINIDAD AND TOBAGO CYPRUS MALTA TUNISIA CZECH REPUBLIC MARSHALL ISLANDS TURKEY DEMOCRATIC REPUBLIC MAURITANIA UGANDA OF THE CONGO MAURITIUS UKRAINE DENMARK MEXICO UNITED ARAB EMIRATES DJIBOUTI MONACO UNITED KINGDOM OF DOMINICA MONGOLIA GREAT BRITAIN AND DOMINICAN REPUBLIC MONTENEGRO NORTHERN IRELAND ECUADOR MOROCCO UNITED REPUBLIC EGYPT MOZAMBIQUE OF TANZANIA EL SALVADOR MYANMAR UNITED STATES OF AMERICA ERITREA NAMIBIA URUGUAY ESTONIA NEPAL UZBEKISTAN ETHIOPIA NETHERLANDS VENEZUELA, BOLIVARIAN FIJI NEW ZEALAND REPUBLIC OF FINLAND NICARAGUA VIET NAM FRANCE NIGER YEMEN GABON NIGERIA ZAMBIA GEORGIA NORWAY ZIMBABWE The Agency’s Statute was approved on 23 October 1956 by the Conference on the Statute of the IAEA held at United Nations Headquarters, New York; it entered into force on 29 July 1957. The Headquarters of the Agency are situated in Vienna. Its principal objective is “to accelerate and enlarge the contribution of atomic energy to peace, health and prosperity throughout the world’’. INTERNATIONAL ATOMIC ENERGY AGENCY VIENNA, 2015 COPYRIGHT NOTICE All IAEA scientific and technical publications are protected by the terms of the Universal Copyright Convention as adopted in 1952 (Berne) and as revised in 1972 (Paris). The copyright has since been extended by the World Intellectual Property Organization (Geneva) to include electronic and virtual intellectual property. Permission to use whole or parts of texts contained in IAEA publications in printed or electronic form must be obtained and is usually subject to royalty agreements. Proposals for non-commercial reproductions and translations are welcomed and considered on a case-by-case basis.