Journal of Biomedical and Clinical Research Vol. 7, No. 1, Suppl. 2, 2014 EDITOR-IN-CHIEF DEPUTY EDITOR-IN-CHIEF Grigor A. Gorchev Mariya Sredkova, Pleven, Bulgaria Pleven, Bulgaria EDITORIAL BOARD ADVISORY BOARD Asparuh Asparuhov, Pleven, Bulgaria Genka Bekyarova, Varna, Bulgaria Chavdar Balabanov, Pleven, Bulgaria Veselin Borisov, Sofia, Bulgaria Petyo Bochev, Pleven, Bulgaria Yvon A. Carpentier, Bruxelles, Belgium Tashko Deliyski, Pleven, Bulgaria Raimund Jakesz, Vienna, Austria Gena Grancharova, Pleven, Bulgaria Jorg Jerosh, Neuss, Germany Dimitar Gospodinov, Pleven, Bulgaria Ivan T. Lambev, Sofia, Bulgaria Emilyan Ivanov, Pleven, Bulgaria Ivan Manchev, Stara Zagora, Bulgaria Yavor Ivanov, Pleven, Bulgaria Pier P. Mariani, Rome, Italy Vaniya Nedkova, Pleven, Bulgaria Evlogi E. Marinov, Pleven, Bulgaria Savelina Popovska, Pleven, Bulgaria Robert P. Mecham, St. Louis, Missouri, USA Jordan Popov, Pleven, Bulgaria Stewart Mennin, New Mexico, USA Dimitar Stoykov, Pleven, Bulgaria Ivan G. Mitov, Sofia, Bulgaria Mariya Simeonova, Pleven, Bulgaria Gilbert Park, Cambridge, UK Vasil Todorov, Pleven, Bulgaria Penka Perenovska, Sofia, Bulgaria Angelika Velkova, Pleven, Bulgaria Peter M. Schlag, Berlin, Deutschland Emil Simeonov, Sofia, Bulgaria Svetla Torbova, Sofia, Bulgaria Nicola Vassilev, Sofia, Bulgaria Carl R. Whitehouse, Weymouth, Dorset, UK Jacques Winand, Bruxelles, Belgium Hans P. Zenner, Tubingen, Germany EDITORIAL OFFICE Assistant Editor Galya Stavreva Manuscript Editor Magdalena Balashkova Statistical Editor Petkana Hristova Translation Editor Yanka Tzvetanova Electronic Publishing Editor Georgi Tzanev Production Editor Silviya Emileva PUBLISHER Publishing center MU - Pleven JBCR (ISSN 1313-6917) is a multidisciplinary peer-reviewed, open access scientific journal of Medical University-Pleven, published two times per year. JBCR Online (ISSN 1313-9053) offers free access to all articles at jbcr.mu-pleven.bg Editorial Office: Journal of Biomedical and Clinical Research, Medical University-Pleven, 1 Kliment Ohridski str., 5800 Pleven, Bulgaria; Phone: +359 64 884 131; e-mail: [email protected] Copyright© 2008 by the Journal of Biomedical and Clinical Research, Medical University-Pleven. All rights reserved. Journal of Biomedical and Clinical Research Vol. 7, No. 1, Suppl. 2, 2014 Free full-text online at jbcr.mu-pleven.bg Abstracts from Jubilee Scientific Conference “40 years Medical University – Pleven”, 30 October - 1 November, 2014, Pleven The Editorial Board and Editorial Office of JBCR gratefully acknowledge the time and efforts of the following colleagues from the organizing committee of the Jubilee Scientific Conference “40 years Medical University – Pleven” who prepared the book of abstracts for publications: Chairmen: Prof. Dr. Mariya Sredkova, MD, PhD Assoc. Prof. Zdravka Radionova, MD, PhD Scientific Committee: Chairman: Assoc. Prof. Anelia Dimitrova, MD, PhD Members: Assoc. Prof. Angelina Stoyanova, PhD Assoc. Prof. Maria Simeonova, MD, PhD Assoc. Prof. Galya Stavreva, MD, PhD Assoc. Prof. Tsvetelina Valentinova, MD, PhD Secretariat: Assoc. Prof. Makreta Draganova, PhD Assoc. Prof. Nadya Veleva, PhD Dr. Diana Pendicheva Dr. Armine Grigoryan Dr. Ivelina Himcheva Dr. Nikolay Kuchukov Dr. Paulina Vladova Tihomir Rashev Journal of Biomedical and Clinical Research Vol. 7, No. 1, Suppl. 2, 2014 Abstracts from Jubilee Scientific Conference “40 years Medical University – Pleven”, 30 October - 1 November, 2014, Pleven Contents Vol. 7, No. 1, Suppl.2, 2014 PLENARY LECTURES 15 Personalized medicine and cochlear implantation Hans-Peter Zenner 15 A career in congenital heart surgery? Tsvetomir Loukanov BIOMEDICAL SCIENCES ORAL PRESENTATION 17 In-vitro evaluation of new chitosan-based materials Maksym V. Pogorielov, O. V. Kalinkevich, Oksana S. Pogorielova, G. F. Tkach 17 Experimental study on the development of tolerance and withdrawal syndrome to pentylenetetrazole- induced sizures in rats treated with retigabine Elisaveta G. Apostolova, Vesela Y. Kokova, Lyudmil P. Peychev 18 Leptin and ghrelin – the new old players in obesity and depression Stanislava M. Mihaylova, Rositsa V. Sandeva, Gergana N. Sandeva 18 Effect of high-fructose solution on body weight, body fat, blood glucose and triglyceride levels in rats Rositsa V. Sandeva, Stanislava M. Mihaylova, Gergana N. Sandeаv, Katya Y. Trifonova, Ruska D. Popova-Katsarov 19 Research on EGFR status in patients with non-small cell lung carcinoma Savelina L. Popovska, Tereza B. Dineva, Iivana Br. Boneva, Ivan N. Ivanov 19 Histological criteria predicting the possibility of mutations in BRCA1 gene in ovarian cancer Savelina L. Popovska, Ivana Br. Boneva, Ivan N. Ivanov, Svetlana Al. Mateva, Angel D. Jordanov, Slavcho T. Tomov, Katia S. Kovacheva, Maria N.Simeonova, Zornitsa B. Kamburova 20 Investigation of triple- negative breast cancers - morphological and immunophenotypic characteristics Savelina L. Popovska, Тereza B. Dineva, Ivan N. Ivanov, Tatiana M. Betova, P. Damyanova, K. Petrov, R. Bonchev 20 Ring study to evaluate the accuracy, relevance and the correlation between immunohistochemistry and in situ hybridization in determining the HER 2 status in women with breast cancer Tereza B. Dineva, Savelina L. Popovska, Ivan N. Ivanov 21 Association of SNPS in C1q gene cluster with some of immunological parameters of lupus nephritis Maria A. Radanova, Vasil V. Vasilev, Boriana P. Deliyska, Valentin C. Ikonomov, Diana G. Ivanova 21 Modulation of insulin secretion and insulin signaling by selenium Boryana K. Ruseva, Ivelina I. Himcheva 22 Evolution of antibiotic resistance and clonal spread of carbapenem resistant Acinetobacter baumannii in Bulgarian university hospitals Rositha Vatcheva-Dobrevska, I. Ivanov, P. Higgins, L. Poirell, M. Lesseva, E. Keuleyan, M. Sredkova, H. Hitkova, E. Dobrev, I. Haydouchka , E. Savov ,V. Dicheva, E. Nedjalkova, M. Citu, T. Kantardjiev, H. Seifert , P. Nordmann , L. Dijkshoorn 3 23 Reproductive problems in women with PSOS, the impact of PAI–1 carriers of 4G PAI-1 polymorphism and BMI Regina Komsa- Penkova, Georgi Golemanov, Galia Georgieva- Alexandrova, Nikolai Slavov, Kalin Popovski, Petar Ivanov, Katia Kovacheva, Milena Atanasova, Alexandar Blajev POSTERS 23 The structural transformation of the immune and endocrine organs under dehydration V. I. Bumeister, O. O. Prykhodko, O. V. Oliinyk 24 Vascular calcification and osteoporosis Genka Ts. Krasteva, Emilia Ts. Lakova 24 Granule cells of the cochlear nucleus in rats: ultrastructural and immunohistochemical study Svetla P. Pencheva, Emilyan A. Ivanov, Nikolai E. Lazarov 25 Antioxidant potential – an ambiguous indicator of oxidative stress Svetoslav D. Alexandrov, Margarita L. Alexandrova 25 Immunofluorescent investigation of dopaminergic neurotransmission in the retina of cold-blooded vertebrates Desislava I. Zhekova, Liliya A. Vitanova 26 Effect of handedness on functional organization of bimanual isometric handgrip Nikolai V. Kolev, Ljudmila I. Halacheva 26 Effects of new MIF-1`s analog on stress-induced analgesia Adriana I. Bocheva, Hristina Hr. Nocheva, Ibtissem Jlalia, Nathalie Lensen, Grégory Chaume, Thierry Brigaud 27 Interactions between the TYR-MIF-1 family of peptides and the endocannabinoid system after hot-stress- induced analgesia Hristina Hr. Nocheva, Dimitar S. Kochev, Adriana I. Bocheva 27 Possible causal links between oxidative and emotional stress Desislava V. Trifonova, Margarita L. Alexandrova 28 Diseases, trace element status, analytical methods Atanaska N. Bozhinova, Maria G. Angelova, Nadia Kolarova-Yaneva, Tsvetelina V. Petkova-Marinova 28 Trace element in iron-deficiency anaemia of children Maria G. Angelova, Tsvetelina V. Petkova-Marinova, Maksym V. Pogorielov, N. Andrii 29 The influence of the maternal smoking, the diet and the level of trace elements in adolescents with primary hypertension Nadia Kolarova-Yaneva, Maria G. Angelova, V. Nedkova, A. Bozhinova, K. Gospodinov 30 Menopause: a source of oxidative stress and a risk factor for disease and mortality Viktoriya R. Varbanova, Margarita L. Alexandrova 30 Intrinsic fluorescence study of human C1q – a target molecule for the autoantibodies in Lupus Nephritis Vishnya S. Stoyanova, Hristo N. Kolev, Georgi S. Georgiev, Svetla D. Petrova, Ivanka G. Tsacheva 31 Saliva – potential biomarkers and diagnostic possibilities Margarita S. Hadjieva, Julia G. Nikolova 31 Magnesium and blood glucose level Ljudmila I. Halacheva, Krasimir Kostov, Nikolai V. Kolev 32 Characterization of pulmonary surfactant composition and properties in patients with lung carcinoma Albena G. Jordanova, Maya P. Bangyozova, Eleonora S. Lontova, Assya S. Tsanova , Sonja I. Ilcheva, Victoria A. Ilieva, Rosen E. Petkov, Yordanka T. Yamakova, Zdravko I. Lalchev 32 Photocatalytic activity of pure and N-modified TIO2 Nina K. Ivanova, Angelina M. Stoyanova, Albena Bachvarova-Nedelcheva, Reni S. Iordanova 33 Mixed adenoneuroendocrine carcinomas of the cecum. Clinical and morphological aspects. A case report 4 Tatyana M. Betova, Polina D. Dimitrova, Yordan D. Yordanov, Krasimir T. Petrov, Temenujka V. Mircheva, Sergey D. Iliev 34 Breast metastasis of a squamous cell carcinoma of the uterine cervix. A case report Tatyana M. Betova, Krasimir T. Petrov, Savelina L. Popovska, Yordan D. Yordanov, Polina D. Dimitrova 34 About vascular female genital tumors with a report of a case: cervical in situ carcinoma during arteriovenous malformation/haemangioma Yordan D. Yordanov, Savelina. L. Popovska, Grigor A. Gortchev, Tatyana M. Betova 35 Intracranial postoperative granuloma