ANNUAL .2003REPCOLD SPRING HARBOR LABORATORY .1; ANNUAL REPORT 2003 © 2004 by Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory One Bungtown Road Cold Spring Harbor, New York 11724 Web Site: www.cshl.edu Managing Editors Jeff Picarello, Lisa Becker Production Editor Rena Steuer Copy Editor Dorothy Brown Development Manager Jan Argentine Project Coordinators Maria Falasca, Nora Rice Production Manager Denise Weiss Desktop Editor Susan Schaefer Nonscientific Photography Miriam Chua, Bill Geddes Cover Designer Denise Weiss Book Designer Emily Harste Front cover: McClintock Laboratory (right) and Carnegie Library (left) (photos by Miriam Chua) Back cover: Magnolia Kobus on grounds of Cold Spring Harbor Laboratory (photo by Bruce Stillman) Section title pages: Miriam Chua Contents Officers of the Corporation/Board of Trusteesiv-v Governancevi Committees vii Edwin Marks (1926-2003) viii PRESIDENT'S REPORT Highlights5 CHIEF OPERATING OFFICER'S REPORT 25 50TH ANNIVERSARY OF THE DOUBLE HELIX 29 RESEARCH 47 Cancer: Gene Expression 49 Cancer: Genetics 74 Cancer: Cell Biology 106 Bioinformatics and Genomics 134 Neuroscience152 Plant Development and Genetics 199 CSHL Fellows 212 Author Index 217 WATSON SCHOOL OF BIOLOGICAL SCIENCES 219 Dean's Report 221 Courses 238 Undergraduate Research Program245 Partners for the Future 248 Nature Study 249 COLD SPRING HARBOR LABORATORY MEETINGS AND COURSES 251 Academic Affairs253 Symposium on Quantitative Biology 255 Meetings 258 Postgraduate Courses295 Seminars 353 BANBURY CENTER 355 Director's Report357 Meetings 365 DOLAN DNA LEARNING CENTER 403 Director's Report 405 Workshops, Meetings, and Collaborations 418 COLD SPRING HARBOR LABORATORY PRESS 425 Publications 426 Executive Director's Report 427 FINANCE 431 History of the CSHL Endowment 433 Financial Statements 444 Financial Support448 Grants448 Institutional Advancement 457 Capital and Program Contributions 458 Watson School of Biological Sciences Capital Campaign 459 Annual Contributions 460 LABORATORY STAFF 474 III Officers of the Corporation William R. Miller, Chairman Bruce Stillman, Ph.D., President and Chief Executive Officer Edwin S. Marks, Vice Chairman James D. Watson, Ph.D., Chancellor Lola N. Grace, Secretary/Treasurer W. Dillaway Ayres, Jr., Chief Operating Officer G. Morgan Browne, Chief Financial Officer Board of Trustees Scientific Trustees David Botstein, Ph.D. Titia de Lange, Ph.D. Edward E. Harlow, Ph.D. Jeff Hawkins pSuosavosnt,Hockfuoltd; Ph.D. Director and Mthony B. Eunin Leon Hess Pro fessor,The Chairman for the Dept of Biological Chief Technology Offlcer, palmOne, Inc. Professor of Genomics, Lewis-Siger RockefellerUniversity Chemistry and Molecular Pharmacology, Institute, Princeton University Harvard Medical School Susan Lee Lindquist, Ph.D. Lorne Mendell, Ph.D. Charles J. Sherr, M.D., Ph.D. Bruce Stillman, Ph.D. Director Whitehead Institute for Distinguished Professor/Chairman, Chairman, Dept. of Tumor Cell President and CEO, Biomedical Research, Massachusetts Dept of Neurobiology & Behavior, Biology, HHMI/St. Jude Children's Co, Spring Harbor Laboratory Institute of Technology Stony Brook University Research Hospital Individual Trustees Trudy H. Calabrese Kristina Perkin Davison Jacob Goldfield Amy Goldman, Ph.D. Lola N. Grace Lloyd Harbor, New York Partner, Europe Capital, LLC New York, New York Rhinebeck New York Managing Director, Stedng Grace Capita/ Management Charles E. Harris Robert D. Lindsay Edwin S. Marks Eduardo G. Mestre William R. Miller Chairman and CEO, Co-Managing Partner, President, Chairman,Investment Banking, New York, New York Harris & Harris Group, Inc. Goldberg Lindsay & Co. Carl Marks & Co, Inc Citigroups Global Markets, Inc. iv Douglas P. Morris Thomas C. Quick William S. Robertson Howard Solomon Arthur M. Spiro Chairman and CEO, Palm Beach, Florida Naples, Florida Charman of the Board and Kings Point, New York Universal Music Group CEO, Forest Laboratories Alan C. Stephenson James M. Stone Edward Travagilanti James D. Watson, Ph.D. Roy J. Zuckerberg Partner, Cravath Swaine & CEO, The Plymouth Rock Lloyd Harbor, New York Chancellor, Senior Director, Goldman Moore, LLP Company Cold Spring Harbor Laboratory Sachs and Company Honorary Trustees Bayard Clarkson, M.D. John P. Cleary, Esq. Charles F. Dolan Helen Ann Dolan Martha Fadsh Gerry Memorial Sloan-Kettering Locust ValleY, New Y.. Oyster Bay, New York Oyster Bay, New York Mill Neck, New York Cancer Center, New York H. Bentley Glass Evelyn H. Lauder Maly D. Lindsay David L. Luke Ill New York, New Yo. New York, New York Boulder, Colorado New York, New Y. Es. Lauder Companies, Inc. William E. Murray Wendy Vander Pool Russell New York, New York Oyster Bay, New York Governance The Laboratory is governed by a Board of Trustees of up to 35 members which meets three or four times a year. Authority to act for the Board of Trustees between meetings is vested in the Executive Committee of the Board of Trustees. The Executive Committee is composed of the Officers of the Board and any other members who may be elected to the Executive Committee by the Board of Trustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specific areas of the Laboratory's operations. Representation on the Board of Trustees itself is divided between business and community leaders and scientists from major educational and research institutions. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York. It is authorized to operate a graduate program under the name "Cold Spring Harbor Laboratory, Watson School of Biological Sciences" and thereat to confer the degrees of Doctor of Philosophy (Ph.D.), Master of Science (M.S.), and Doctor of Science (Sc.D.), Honorary. It is designated as a "public charity" under Section 501(0(3) of the Internal Revenue Code. Grace Auditorium vi Committees Audit Lawrence Scherr, M.D. W. Dillaway Ayres, Jr. Bruce Stillman, Ph.D. Eduardo G. Mestre Charles E. Harris, Chair William R. Miller William R. Miller Bruce Stillman, Ph.D. Arthur M. Spiro Executive Committee William R. Miller, Chair Building W. Dillaway Ayres, Jr. Banbury Center, G. Morgan Browne Helen A. Dolan, Chair Robertson/Meier Houses Trudy Calabrese Arthur Brings Lola N. Grace William S. Robertson, Chair John P. Cleary Esq. Edwin S. Marks W. Dillaway Ayres, Jr. Mary D. Lindsay Eduardo G. Mestre Jan Witkowski, Ph.D. Nancy Marks Arthur M. Spiro James D. Watson, Ph.D. Wendy Vander Poel Russell Bruce Stillman, Ph.D. Elizabeth Watson Robertson Research Fund Finance Commercial Relations Carl Schafer, Chair Lola N. Grace, Chair W. Dillaway Ayres, Jr. William R. Miller, Chair W. Dillaway Ayres, Jr. Hollis Cline, Ph.D. W. Dillaway Ayres, Jr. G. Morgan Browne Lola N. Grace G. Morgan Browne Jacob Goldfield William R. Miller John P Cleary, Esq. Charles E. Harris Bruce Stillman, Ph.D. John P. Maroney Robert D. Lindsay Bruce Stillman, Ph.D. Edwin S. Marks William R. Miller Family Representatives Compensation William S. Robertson Katherine Ernst Lari Russo Walter Meier, M.D. William R. Miller, Chair Howard Solomon William S. Robertson Lola N. Grace Charles E. Harris Investment Tenure and Appointments Lola N. Grace, Chair Dolan DNA Learning Center Titia de Lange, Ph.D. W. Dillaway Ayres, Jr. Edward Harlow, Ph.D. Arthur M. Spiro, Chair Jacob Goldfield Susan Hockfield, Ph.D. Marion Wood Ahmed Edwin S. Marks Susan Lindquist, Ph.D. W. Dillaway Ayres, Jr. William S. Robertson Edward Chernoff Lorne Mendell, Ph.D. Edward M. Scolnick, M.D. Lola N. Grace Nominating Suzanne Kleinknecht Charles J. Sherr, M.D., Ph.D. David Mick los Robert D. Lindsay, Chair Bruce Stillman, Ph.D. Committees as of November, 2003, VII Edwin S. Marks (1926-2003) First and foremost a family man, Edwin Marks gave to others as he did to those nearest to him. Successful in business, a generous philanthropist, provider of sound advice, and a man with broad interests and intellect, Edwin Marks died on April 24, 2003. At the time of his death, he was Vice Chairman of our Board of Trustees and a most devoted and valued advi- sor. Born and raised in Brooklyn on the same block as his future wife, Nancy, Edwin's forma- tive years occurred as his father founded and developed a successful banking business. Established in the year before Edwin was born, Carl Marks & Co. initially traded foreign secu- rities but later, under Edwin's skilled leadership, expanded into a diverse banking enterprise including venture capital, private equities, corporate development, real estate, and financial advise and planning. Despite-or perhaps because of-his father's success, upon entering college, Edwin did not intend to pursue a career in banking. After schooling at Brooklyn's Poly Prep Country Day School, Edwin initially studied at Princeton, but a yearning to enter into the diplomatic core caused a change in direction that greatly influenced his future. Following the advice of a fam- ily friend, he transferred to the United States Military Academy at West Point. This surprising turn of events uprooted a potentially comfortable academic life at Princeton, but due to influ- ences from both West Point and General Maxwell Taylor, Edwin stretched himself beyond his upbringing. It was clear from discussions and e-mail correspondence with him that West Point was a special place never to leave Edwin's universe. Upon graduating, he married Nancy, and together, they set off on an adventure that lasted 54 years. Initially stationed in El Paso, Texas and Anchorage, Alaska, environs far from the neigh- borhood in Brooklyn, Edwin began to use his considerable skills in an eight-year military career. His capabilities as an entrepreneur, leader, and diplomat emerged. He enjoyed serv- ing his country. viii In 1953, when his father's health began to fail, Edwin's life took what must have been an unexpected turn when he joined his father's Wall Street firm, working his way up from the bottom to learn the business and eventually head the company.