TABLE OF CONTENTS Greetings From The Committee ..........................................................................................................................1 The Host Universities ................................................................................................................................................2 The Local Organizing Committee ......................................................................................................................3 Acknowledgments .........................................................................................................................................................4 Sponsors ............................................................................................................................................................................5 Keynote ..............................................................................................................................................................................8 Program ..............................................................................................................................................................................9 Program Podium ........................................................................................................................................................ 12 Program Short Courses......................................................................................................................................... 15 Program Posters ........................................................................................................................................................ 19 Podium Abstracts ...................................................................................................................................................... 25 Short Course Abstracts ......................................................................................................................................... 47 Poster Abstracts......................................................................................................................................................... 55 Practical Info ............................................................................................................................................................. 111 Participants List ....................................................................................................................................................... 113 Transportation In Helsinki ................................................................................................................................. 120 Emergency Information ....................................................................................................................................... 121 Biomedicum ............................................................................................................................................................... 121 GPEN 2014 Conference Personnel Contact Information ............................................................... 121 GPEN 2014 Hotels ................................................................................................................................................. 121 Production of the GPEN 2014 Conference Book sponsored by Allergan Inc. GPEN 2014 - Helsinki GREETINGS FROM THE COMMITTEE Dear Colleagues, It is our great pleasure to welcome you here in Helsinki at GPEN 2014. About one year of organizing and planning lies behind us and finally the 10th biennial meeting of the Globalization of Pharmaceutics Education Network (GPEN) has arrived. It has been both a demanding and rewarding time and we are grateful to all the people involved in organizing GPEN 2014 and supporting the event as session chairs, judges, or by provision of guidance. Over 270 attendees not only means that we repeat to achieve the high attendance of GPEN 2012, but is a clear sign of the quality and importance of GPEN as an institution. Furthermore, this year we are happy to feature 50 podium presentations, 108 poster presentations, and 8 short courses with expert speakers from academia and industry alike. We are very excited to have Professor Jonathan Knowles from the Institute for Molecular Medicine Finland (FIMM, University of Helsinki) give the keynote lecture on curing serious diseases. In our opinion the wish to reach this aim and being able to help and serve humanity is one of strongest motivators when being involved with health sciences. The Organizing Committee wishes great experiences during the scientific sessions, the career center, and the social events as well as new, interesting, and beneficial contacts to all of you. We also wish all the best to the organizers of the upcoming GPEN 2016 meeting in Kansas and encourage the doctoral students to seize these chances to organize, to interact, and to grow beyond the purely day-to-day academic settings whenever possible. Enjoy your time in Finland and have a great time at GPEN 2014! On behalf of the Organizing Committee, Noora Sjöstedt Björn Peters Co-Chair Student Organizing Committee Co-Chair Student Organizing Committee University of Helsinki University of Eastern Finland Prof. Arto Urtti Prof. Paavo Honkakoski Co-Chair Organizing Committee Co-Chair Organizing Committee University of Helsinki University of Eastern Finland 1 The Host Universities THE HOST UNIVERSITIES The School of Pharmacy, University of Eastern Finland The mission of the School of Pharmacy is to teach pharmaceutical subjects at the highest educational level, and to promote scientific drug research and its application for the benefit of society at large. The School of Pharmacy at the University of Eastern Finland started in the present form in 2010, but was originally founded in 1973 in the University of Kuopio. The staff is about 150, and approximately 700 students aspire towards Bachelor and Master Degrees in six disciplines of Social Pharmacy, Pharmaceutical Chemistry, Biopharmacy, Pharmaceutical Technology, Pharmacology and Toxicology. Clinical Pharmacology is taught mainly for students of Medicine and Dentistry. We also run the Master's Degree Programme in General Toxicology and Environmental Health Risk Assessment. The School has about 100 post-graduate students, who conduct their advanced studies towards the Ph. D. degree. The School also houses the Drug Research and Development Centre, which offers a dynamic and flexible model for industrial collaboration. Faculty of Pharmacy, University of Helsinki The history of the Faculty of Pharmacy began in 1897 when the Pharmaceutical Institute was founded in Helsinki. Later the Institute was turned into a Department of Pharmacy. It was first a part of the Faculty of Medicine and then the Faculty of Science. The Faculty of Pharmacy, situated on Viikki Campus, was founded in 2004. The Faculty offers the Bachelor and Master of Science degrees in Pharmacy. The postgraduate degrees are the Doctor of Philosophy in Pharmacy and the Doctor of Philosophy. The Faculty also provides professional postgraduate education in industrial pharmacy and hospital pharmacy and plays an active part in the continuing education in the field. The Faculty is also nationally responsible for the Swedish language Master’s degree programmes in pharmacy. The Faculty of Pharmacy staff is about 183, and approximately 950 students, of which 205 are undergraduate and 127 are postgraduate students. The Faculty complies 3 divisions that are running research in the fields of biopharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmaceutical technology, pharmacology, and social pharmacy. Faculty hosts also Centre for Drug Research (CDR), a multidisciplinary research program that is carrying out research on drug discovery tools and pharmaceutical nanotechnologies, particularly in relation to natural products and biologicals. 2 GPEN 2014 - Helsinki THE LOCAL ORGANIZING COMMITTEE Björn Peters Noora Sjöstedt Hristo Zlatev Astrid Subrizi Laura Pelkonen Eva Ramsay Piia Kokkonen Otto Kari Sofia Sousa Dr. Paul Bromman Prof. Paavo Honkakoski Tatu Lajunen Prof. Arto Urtti Former members: Henna Ylikangas Dr. Pyry Välitälo 3 Acknowledgments ACKNOWLEDGMENTS The GPEN 2014 Local Organizing Committee expresses their upmost gratitude to all who contributed to the successful organization of the GPEN 2014 meeting. In particular a special thanks to: Professor Ron Borchardt and the GPEN Executive Committee and Board of Directors (Professors Kenneth Audus, Teruna Siahaan and Per Artursson) Ms Nancy Helm (University of Kansas) University of Helsinki staff (Professor Marjo Yliperttula, Ms Pia-Tuulia Sonck and Ms Katri Kiiliäinen) Special thanks to Dr. Paul Bromann of the University of Helsinki Faculty of Pharmacy, for valuable assistance in planning and organizing GPEN 2014 University of Eastern Finland, School of Pharmacy staff (Ms Marja Lappalainen) Professor Jonathan K.C. Knowles (Keynote Speaker) All judges of oral and poster presentations All industry observers All short course coordinators All session chairs All faculty and industrial short course invited speakers All faculty and industrial career center participants All GPEN 2014 sponsors GPEN 2012 Organizing Committee (Monash University) 4 GPEN 2014 - Helsinki SPONSORS The GPEN 2014 Local Organizing Committee would like to thank all the meeting sponsors, for their generous contribution and support in all forms. 5 Sponsors