JOINT CLINICAL RESEARCH CENTRE (JCRC) 2016 Annual Report For Quality Health Care Services Table of Contents List of Acronymns……………………………………………………………………………..iii JCRC Patron ……………………………………………………………………………………iv JCRC Board Management structure……………………………………………………………v JCRC Senior Management structure……………………………………………………………vi Message from the JCRC Executive Director……………………………………………………ix Brief about JCRC………………………………………………………………………………..x JCRC Silver Jubilee Celebrations …………………………………………..………………1 Clinical Care services……………………………………………………………..……………5 Nursing……….…………………………………………………………..……………..6 Paediatric Clinic …………………………………………………………...…………...9 Private Clinic……………………………………………………………..…………….10 Laboratory Services……………………………………………………….…….…………….13 CWRU Collaborative Laboratory…………………………………………………...…14 Tuberculosis Laboratory………………………………………………….……………15 Research Services…………………………………………………………………………...…16 ACTG…………………………………………………………………………….…….22 Finance and Administration………….………………………………………………….........24 ICT…………………………………………………………….…………………….….24 Finance….………………………………………………………..…………….……….25 Human Resources………………………………………………………………………26 Stores………………………………………………………………..…..………………27 Projects…………………………………………………………………………….……………28 THALAS………………………………………………………………………………..28 ESP……………………………………………………………………………………..31 RCE ……..…………………………………………………………………………………......35 Pictorial representation of the JCRC Silver Jubilee………………………………..……….37 Staff Accomplishments of the year…………………………………………………………....43 RCE Contacts…………………………………………………………………………..………55 ii List of Acronyms EMTCT Elimination of Mother to Child Transmission RCE Regional Centre of Excellence ANC Anti natal care PLHIV People Living with HIV/AIDS TB Tuberculosis UNCHE Uganda National Council of Higher Education WHO World Health Organisation ICEA Integrated Clinical Enterprises Application LIMS Laboratory Information Management System SCIPHA Strengthening Civil Society for Improved HIV/AIDS and OVC service delivery PEP Post Exposure Prophylaxis FP Family Planning USAID United States Agency for International Development THALAS Targeted HIV/AIDS and Laboratory Sevices MOH Ministry of Health CWRU Case Western Reserve University CAP College of American Pathology IPs Implementing Partners OVC Orphans and Vulnerable Children IDI Infectious Disease Institute MUJHU Makerere University Johns Hopkins University DSDM Disseminated Service Delivery Model GCLP Good Clinical & Laboratory Practice CAB Community Advisory Board iii JCRC PATRON H.E. Yoweri Kaguta Museveni iv JCRC Board Management Structure Board Chairman: Prof. J. Epelu Opio Prof. Peter .N. Mugyenyi Mr. Ben Okello Prof. Nelson Dr. Jesse Kagimba (Executive Director –JCRC) Luwum Ssewankambo Hon. Ruth Jane Dr. James Makumbi Dr. Jessica Jita Mr. Richard Masereje Aceng (Board Secretary) v Prof. Manfred Dietrich Dr. Cissy Kityo (External Advisor) (ex-official) JCRC Senior Management Team Prof. Peter N. Mugyenyi FRCP ScD Executive Director JCRC Dr. Cissy Kityo Deputy Executive Director Dr. Francis Ssali Dr. Victor Musiime. Benson Ouma Director Clinical Incharge Directorate of Research Director Laboratory vi Dr. Henry Mugerwa Dr. William Tamale Dr. Iva Natukunda Sr. Deborah Masiira Head of Research Clinic Manager Head Pediatrics Head Nursing & Deputy Incharge Research Directorate Rose Byaruhanga Paul Ocitti Head Counseling Head Pharmacy Ameria Natukunda Collins Makanga Fred Byaruhanga Godfrey Kuboi Head HRM Finance Manager Business Dev’t Manager Chief Programmer Nsumba Lameck Annet Namara Nelson Kakande Boaz Wakabi Internal Auditor Head Stores Training Quality Head Procurement Assurance Specialist vii JCRC Regional Heads Dr. Abbas Lugemwa Dr.James Abach Dr. Allan Musinguzi Dr. Keith Baleta Faith Balmoi Head Mbarara Head Gulu Head F/Portal RCE Head Mbale Head Kakira Project Heads Michael Kabugo Denis Akakimpa THALAS C.O.P ESP Project Manager James Rusoke Alfred Tumwesigye Incharge Estates Head Transport viii Message from the Executive Director I start by paying tribute to our patron H.E. Yoweri K. Museveni, the JCRC Board of trustees, our partners and all staff upon attaining 25 years of quality medical research, training and health care which was commemorated on 11th November, 2016. Collaborative networks continue to enhance research activities at JCRC with 14 studies successfully concluded in 2016, 15 presentations made at international conferences such as CROI and IAS, and 33 peer reviewed publications made in 2016. The laboratory capacity has been advanced with the completion of the Bio-safety Level III(BSL-3) facility at JCRC Lubowa. In addition, the centre is in the final stages of CAP accreditation expected to be completed in 2017. The center continues to maintain the highest quality standards in HIV/AIDS care and treatment services in the country with total of 15,643 patients receiving at least a clinical assessment (WHO staging) OR CD4 count OR viral load, By the end of the year, 15,402 patients were active on antiretroviral treatment, and 7.1% of these were children. The reduction in number of children newly enrolled in care is evidence to the successful implementation of Option B+ for elimination of mother to child transmission of HIV program at the clinic. As evidence of quality service delivery, one of JCRC clinic staff Ms. Florence Kintu was among the 5 candidates in the country that were recognized by USAID Uganda for her exceptional contribution towards patient care and treatment. As a way of JCRC staying afloat, the centre strengthened sustainability strategies that include strengthening provision of private clinical services at Lubowa with capacity to provide services such as; Consultations, Ultra sound, X-rays, Dental services, Non-communicable diseases, Rheumatic heart diseases, Diabetic services, admission services and pharmaceutical services strengthened. Once again, I congratulate the JCRC staff, the management team, the board of trustees and above all our patron H.E Yoweri K.Museveni for a successful year of implementation. Yours Sincerely, ……………………………. Prof. Peter .N. Mugyenyi Executive Director – JCRC ix Brief about JCRC The Joint Clinical Research Centre (JCRC) is an autonomous Organization established in 1991 as a limited liability not-for-profit company. It is a joint-venture between the Uganda Ministries of Health (MoH), Ministry of Defense and Makerere College of Health Sciences. The Centre was established in 1991 to respond and provide a scientific approach to the national HIV&AIDS crisis. Over the years, various institutions and organizations such as USAID, WHO, Case Western Reserve University (CWRU), FHI, NIH, European and Developing Countries Clinical Trials Partnership (EDCTP), Medical Research Council (MRC), have partnered with JCRC for medical Research Grants to study HIV, tuberculosis (TB), malaria and other tropical diseases. JCRC also competitively wins and implements HIV/AIDS projects and was the first recipient of PEPFAR funding in December 2013 for ART scale up across Uganda under the TREAT program. Between the period December 2003 to June 2010, JCRC established 52 ART sites and 25 outreaches across the country and became the largest provider of ART in Africa before transitioning these sites to MOH for mainstreaming into the national HIV/care network. A follow on 5 year project (THALAS) which has had 2 year extension was awarded. JCRC also implemented a community project across 19 districts of Uganda (SCIPHA) increasing the mobilization towards increased HIV/AIDS treatment in the country. Current JCRC Network Coverage: JCRC headquarters are located at Lubowa Complex, off Entebbe Road, Wakiso district, with a regional network of 6 Regional Centres of Excellence (RCEs) strategically located at Kakira, Mbale, Gulu, Fort Portal, Mbarara, and Kabale. Vision A vibrant self sustaining centre of excellence in medical research, training and health care services Mission To conduct quality medical research and training, provide equitable and sustainable HIV/AIDS care and other health care services in Uganda and other parts of Africa Core Values: Integrity, Confidentiality, Compassion, Mutual Respect, Teamwork, Accountability, Continuous Learning and Excellence x JCRC JUBILEE YEAR, 2016 The Joint Clinical Research Centre (JCRC) celebrated Silver Jubilee on 11th November, 2016 marking 25 years of existence since her inception in 1991. A remarkable achievement that saw JCRC take a lead in the fight against HIV/AIDS in Uganda and sub Saharan Africa, participating in ground breaking studies which have over the years informed national and international HIV/AIDS treatment guidelines and policies. The function was held at the new JCRC Lubowa campus on plot 101 off Entebbe Road and was graced by Rt.Hon. Ruhakana Rugunda who represented the JCRC Patron and President of Uganda H.E Yoweri K. Museveni. The Chief Guest Rt. Hon. Dr. Ruhakana Rugunda (second right) being ushered in by the JCRC Chairman Prof. Peter Epelu (extreme right) Prof. Peter Mugyenyi (Second left) and Prof. Dr. Mbonye (left) Rt. Hon. Dr. Ruhakana Rugunda plants a tree during the celebrations. Rt. Hon. Dr. Ruhakana Rugunda plants a tree during the celebrations. 2 The JCRC Board Chairman Prof. Opio Epelu (second left) Introduces some of the board members present. The JCRC Executive Director (Prof. Peter Mugyenyi) gives his speech during the Jubilee celebrations 3 Rt. Hon. Dr. Ruhakana Rugunda reads the President’s speech at the function 4 SELECTED ACHIEVEMENTS FOR THE YEAR 2016 1. CLINICAL SERVICES The directorate is well resourced under the leadership of the Director of Clinical