Suppementary Table 9. Predicted targets of hsa-miR-181a by TargetScan 6.2. Total Aggregate Cancer Target Gene ID Gene name context+ P gene score CT ABL2 NM_001136000 V-abl Abelson murine leukemia viral oncogene homolog 2 > -0.03 0.31 √ ACAN NM_001135 Aggrecan -0.09 0.12 ACCN2 NM_001095 Amiloride-sensitive cation channel 2, neuronal > -0.01 0.26 ACER3 NM_018367 Alkaline ceramidase 3 -0.04 <0.1 ACVR2A NM_001616 Activin A receptor, type IIA -0.16 0.64 ADAM metallopeptidase with thrombospondin type 1 ADAMTS1 NM_006988 > -0.02 0.42 motif, 1 ADAM metallopeptidase with thrombospondin type 1 ADAMTS18 NM_199355 -0.17 0.64 motif, 18 ADAM metallopeptidase with thrombospondin type 1 ADAMTS5 NM_007038 -0.24 0.59 motif, 5 ADAMTSL1 NM_001040272 ADAMTS-like 1 -0.26 0.72 ADARB1 NM_001112 Adenosine deaminase, RNA-specific, B1 -0.28 0.62 AFAP1 NM_001134647 Actin filament associated protein 1 -0.09 0.61 AFTPH NM_001002243 Aftiphilin -0.16 0.49 AK3 NM_001199852 Adenylate kinase 3 > -0.02 0.6 AKAP7 NM_004842 A kinase (PRKA) anchor protein 7 -0.16 0.37 ANAPC16 NM_001242546 Anaphase promoting complex subunit 16 -0.1 0.66 ANK1 NM_000037 Ankyrin 1, erythrocytic > -0.03 0.46 ANKRD12 NM_001083625 Ankyrin repeat domain 12 > -0.03 0.31 ANKRD33B NM_001164440 Ankyrin repeat domain 33B -0.17 0.35 ANKRD43 NM_175873 Ankyrin repeat domain 43 -0.16 0.65 ANKRD44 NM_001195144 Ankyrin repeat domain 44 -0.17 0.49 ANKRD52 NM_173595 Ankyrin repeat domain 52 > -0.05 0.7 AP1S3 NM_001039569 Adaptor-related protein complex 1, sigma 3 subunit -0.26 0.76 Amyloid beta (A4) precursor protein-binding, family A, APBA1 NM_001163 -0.13 0.81 member 1 APLP2 NM_001142276 Amyloid beta (A4) precursor-like protein 2 -0.05 0.55 APOO NM_024122 Apolipoprotein O -0.32 0.41 ARID2 NM_152641 AT rich interactive domain 2 (ARID, RFX-like) -0.07 0.55 √ ARL3 NM_004311 ADP-ribosylation factor-like 3 > -0.03 0.51 ARRDC3 NM_020801 Arrestin domain containing 3 > -0.02 0.47 ATF7 NM_001130059 Activating transcription factor 7 > -0.01 0.26 ATG2B NM_018036 ATG2 autophagy related 2 homolog B (S. Cerevisiae) > -0.02 0.61 ATG7 NM_001136031 ATG7 autophagy related 7 homolog (S. Cerevisiae) -0.03 0.61 ATP11A NM_015205 ATPase, class VI, type 11A > -0.04 0.79 ATP2B3 NM_001001344 ATPase, Ca++ transporting, plasma membrane 3 -0.11 0.25 √ ATP8B2 NM_020452 ATPase, class I, type 8B, member 2 > -0.01 0.53 ATXN1 NM_000332 Ataxin 1 > -0.06 0.88 √ ATXN7 NM_000333 Ataxin 7 -0.19 0.77 UDP-Gal:betaglcnac beta 1,4- galactosyltransferase, B4GALT1 NM_001497 -0.12 0.69 polypeptide 1 BAG4 NM_001204878 BCL2-associated athanogene 4 -0.27 0.64 BAI3 NM_001704 Brain-specific angiogenesis inhibitor 3 -0.19 0.68 BCL2 NM_000633 B-cell CLL/lymphoma 2 > -0.04 0.83 √ BCL9 NM_004326 B-cell CLL/lymphoma 9 -0.03 0.32 √ BCR NM_004327 Breakpoint cluster region > -0.01 0.34 BHLHE40 NM_003670 Basic helix-loop-helix family, member e40 -0.3 0.77 BMF NM_001003940 Bcl2 modifying factor -0.01 0.53 BNC2 NM_017637 Basonuclin 2 > -0.03 0.39 BRD1 NM_014577 Bromodomain containing 1 -0.22 0.47 BRWD1 NM_033656 Bromodomain and WD repeat domain containing 1 -0.32 0.9 BTBD3 NM_014962 BTB (POZ) domain containing 3 -0.39 0.95 C10orf46 NM_153810 Chromosome 10 open reading frame 46 N/A 0.73 C11orf30 NM_020193 Chromosome 11 open reading frame 30 -0.15 0.42 C11orf75 NM_020179 Chromosome 11 open reading frame 75 -0.04 0.61 C12orf68 NM_001013635 Chromosome 12 open reading frame 68 > -0.02 0.36 C13orf23 NM_025138 Chromosome 13 open reading frame 23 -0.17 0.61 C13orf30 NM_182508 Chromosome 13 open reading frame 30 > -0.02 0.63 C14orf43 NM_001043318 Chromosome 14 open reading frame 43 -0.23 0.76 C17orf63 NM_001077498 Chromosome 17 open reading frame 63 > -0.03 0.65 Core 1 synthase, glycoprotein-N-acetylgalactosamine 3- C1GALT1 NM_020156 -0.12 0.76 beta-galactosyltransferase, 1 C3orf43 NM_001077657 Chromosome 3 open reading frame 43 -0.16 0.22 C3orf62 NM_198562 Chromosome 3 open reading frame 62 -0.18 0.38 C6orf192 NM_052831 Chromosome 6 open reading frame 192 -0.15 0.46 C6orf35 NM_018452 Chromosome 6 open reading frame 35 -0.3 0.8 Calcium channel, voltage-dependent, alpha 2/delta subunit CACNA2D2 NM_001005505 > -0.02 0.76 2 CALR NM_004343 Calreticulin -0.07 0.34 √ CAMSAP1L1 NM_203459 Calmodulin regulated spectrin-associated protein 1-like 1 -0.18 0.34 CAMTA2 NM_001171166 Calmodulin binding transcription activator 2 -0.1 0.33 CAPRIN1 NM_203364 Cell cycle associated protein 1 -0.3 0.63 CARM1 NM_199141 Coactivator-associated arginine methyltransferase 1 -0.12 0.67 CASP10 NM_001206524 Caspase 10, apoptosis-related cysteine peptidase > -0.03 0.25 Core-binding factor, runt domain, alpha subunit 2; CBFA2T3 NM_005187 -0.24 0.6 √ translocated to, 3 Cas-Br-M (murine) ecotropic retroviral transforming CBLB NM_170662 -0.24 0.33 √ sequence b Cas-Br-M (murine) ecotropic retroviral transforming CBLL1 NM_024814 -0.19 0.51 sequence-like 1 CBX4 NM_003655 Chromobox homolog 4 -0.29 0.69 CBX5 NM_001127321 Chromobox homolog 5 > -0.03 0.7 CCDC117 NM_173510 Coiled-coil domain containing 117 > -0.03 0.56 CCDC141 NM_173648 Coiled-coil domain containing 141 > -0.02 0.48 CCDC17 NM_001114938 Coiled-coil domain containing 17 N/A 0.35 CCDC6 NM_005436 Coiled-coil domain containing 6 > -0.03 0.62 √ CCDC64 NM_207311 Coiled-coil domain containing 64 > -0.01 0.58 CCDC90A NM_001031713 Coiled-coil domain containing 90A > -0.03 < 0.1 CCL8 NM_005623 Chemokine (C-C motif) ligand 8 -0.23 <0.1 CCNG1 NM_004060 Cyclin G1 -0.17 <0.1 CCNJ NM_001134375 Cyclin J -0.16 0.69 CCNK NM_001099402 Cyclin K -0.23 0.72 CCNT2 NM_001241 Cyclin T2 -0.22 0.1 CD4 NM_000616 CD4 molecule -0.17 0.55 CD69 NM_001781 CD69 molecule -0.15 0.41 CDC27 NM_001114091 Cell division cycle 27 homolog (S. Cerevisiae) -0.04 0.34 Cell division cycle 73, Paf1/RNA polymerase II complex CDC73 NM_024529 -0.22 0.4 √ component, homolog (S. Cerevisiae ) CDH13 NM_001220488 Cadherin 13, H-cadherin (heart) -0.11 0.47 CDK8 NM_001260 Cyclin-dependent kinase 8 -0.07 0.34 CDKL2 NM_003948 Cyclin-dependent kinase-like 2 (CDC2-related kinase) -0.14 0.66 CDON NM_016952 Cdon homolog (mouse) -0.34 0.81 CDYL NM_001143970 Chromodomain protein, Y-like -0.24 0.32 CEBPA NM_004364 CCAAT/enhancer binding protein (C/EBP), alpha > -0.02 0.49 √ Cadherin, EGF LAG seven-pass G-type receptor 3 CELSR3 NM_001407 > -0.01 0.41 (flamingo homolog, Drosophila) CEP350 NM_014810 Centrosomal protein 350kda > -0.03 0.33 CHD1 NM_001270 Chromodomain helicase DNA binding protein 1 -0.05 0.34 CHD7 NM_017780 Chromodomain helicase DNA binding protein 7 -0.05 0.69 CHD9 NM_025134 Chromodomain helicase DNA binding protein 9 -0.11 0.54 CHIC1 NM_001039840 Cysteine-rich hydrophobic domain 1 -0.09 0.44 CHMP1B NM_020412 Chromatin modifying protein 1B -0.31 0.59 CLCC1 NM_001048210 Chloride channel CLIC-like 1 -0.1 0.41 CLIP1 NM_002956 CAP-GLY domain containing linker protein 1 -0.33 0.49 CLMN NM_024734 Calmin (calponin-like, transmembrane) -0.33 0.78 CLVS1 NM_173519 Clavesin 1 -0.43 0.59 CNKSR2 NM_001168647 Connector enhancer of kinase suppressor of Ras 2 -0.06 0.65 CNKSR3 NM_173515 CNKSR family member 3 -0.27 0.47 CNOT6L NM_144571 CCR4-NOT transcription complex, subunit 6-like > -0.05 0.44 CNR1 NM_001160226 Cannabinoid receptor 1 (brain) -0.08 0.53 CNTN4 NM_001206955 Contactin 4 -0.16 <0.1 CNTNAP2 NM_014141 Contactin associated protein-like 2 -0.16 0.81 COL5A1 NM_000093 Collagen, type V, alpha 1 > -0.02 0.37 COMMD6 NM_203495 COMM domain containing 6 -0.1 0.55 COP9 constitutive photomorphogenic homolog subunit 2 COPS2 NM_001143887 -0.13 0.83 (Arabidopsis) CPD NM_001199775 Carboxypeptidase D > -0.05 0.67 CPT1A NM_001876 Carnitine palmitoyltransferase 1A (liver) -0.23 0.29 CREBL2 NM_001310 Camp responsive element binding protein-like 2 > -0.04 0.49 √ Cysteine rich transmembrane BMP regulator 1 (chordin- CRIM1 NM_016441 > -0.03 0.6 like) CRISPLD1 NM_031461 Cysteine-rich secretory protein LCCL domain containing 1 -0.13 0.54 CSNK1G3 NM_001031812 Casein kinase 1, gamma 3 -0.1 0.58 CSRNP3 NM_001172173 Cysteine-serine-rich nuclear protein 3 > -0.03 0.54 CTD (carboxy-terminal domain, RNA polymerase II, CTDSPL NM_001008392 -0.37 0.95 polypeptide A) small phosphatase-like CTIF NM_001142397 CBP80/20-dependent translation initiation factor > -0.03 0.37 CTTNBP2NL NM_018704 CTTNBP2 N-terminal like -0.22 0.96 CUL3 NM_003590 Cullin 3 -0.06 0.89 CUL4A NM_001008895 Cullin 4A -0.04 0.25 CXADR NM_001207063 Coxsackie virus and adenovirus receptor > -0.04 0.7 CYLD NM_001042355 Cylindromatosis (turban tumor syndrome) -0.06 0.57 √ DCP1A NM_018403 DCP1 decapping enzyme homolog A (S. Cerevisiae) > -0.01 0.26 DCP2 NM_001242377 DCP2 decapping enzyme homolog (S. Cerevisiae) > -0.01 0.28 DDIT4 NM_019058 DNA-damage-inducible transcript 4 -0.18 0.62 DDX3X NM_001193416 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked -0.34 0.98 DDX3Y NM_001122665 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked -0.36 0.66 DEPTOR NM_022783 DEP domain containing MTOR-interacting protein -0.24 0.64 DERL1 NM_001134671 Der1-like domain family, member 1 -0.21 0.69 DGCR2 NM_001173533 Digeorge syndrome critical region gene 2 > -0.02 0.65 DIP2A NM_001146116 DIP2 disco-interacting protein 2 homolog A (Drosophila) > -0.01 0.31 DIP2B NM_173602 DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.16 0.73 DIP2C NM_014974 DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.1 0.61 DLG2 NM_001142699 Discs, large homolog 2 (Drosophila) -0.07 0.59 DLGAP2 NM_004745 Discs, large (Drosophila) homolog-associated protein 2 -0.12 0.93 DMXL2 NM_001174116 Dmx-like 2 -0.16 0.85 DNAJA4 NM_001130182 Dnaj (Hsp40) homolog, subfamily A, member 4 -0.26 0.47 DNAL1 NM_001201366