The Journal of PHARMACOLOGY And Experimental Therapeutics A Publication of the American Society for Pharmacology and Experimental Therapeutics July 2007 Vol. 322, No. 1 Contents BEHAVIORAL PHARMACOLOGY Decrease in N-Methyl-D-aspartic Acid Receptor-NR2B Subunit Bichoy H. Gabra, Fay K. Kessler, 186 Levels by Intrathecal Short-Hairpin RNA Blocks Group I Joseph K. Ritter, William L. Dewey, and Metabotropic Glutamate Receptor-Mediated Hyperalgesia Forrest L. Smith Downloaded from Antibodies to Nerve Growth Factor Reverse Established Kenneth D. Wild, Di Bian, Dawn Zhu, 282 Tactile Allodynia in Rodent Models of Neuropathic Pain James Davis, Anthony W. Bannon, without Tolerance Tie J. Zhang, and Jean-Claude Louis Induction by Antipsychotics of “Win-Shift” in the Drug Francis Colpaert, Wouter Koek, 288 Discrimination Paradigm Mark Kleven, and Joel Besnard CARDIOVASCULAR jpet.aspetjournals.org Direct Effects of Nicotine on Contractility of the Uterine DaLiao Xiao, Xiaohui Huang, Shumei Yang, 180 Artery in Pregnancy and Lubo Zhang Chronic Treatment with Carvedilol Improves Ca2؉- K. Brixius, R. Lu, B. Boelck, S. Grafweg, 222 Dependent ATP Consumption in Triton X-Skinned Fiber F. Hoyer, C. Pott, U. Mehlhorn, W. Bloch, Preparations of Human Myocardium and R. H. G. Schwinger Modulation of Sympathetic Activity by Tissue Plasminogen Ulrich Schaefer, Sandra Vorlova, 265 at ASPET Journals on September 23, 2021 Activator Is Independent of Plasminogen and Urokinase Takuji Machida, Jerry P. Melchor, Sidney Strickland, and Roberto Levi An in Vitro Study with an Ussing Chamber Showing That Bita Moazed and Linda M. Hiebert 299 Unfractionated Heparin Crosses Rat Gastric Mucosa ␴ 2-Receptor Ligand-Mediated Inhibition of Inwardly Laurent Monassier, Boris Manoury, 341 ,Rectifying K؉ Channels in the Heart Chloe´Bellocq, Jacques Weissenburger Hugues Greney, Diane Zimmermann, Jean-Daniel Ehrhardt, Patrice Jaillon, Isabelle Baro´, and Pascal Bousquet Biomarker Optimization to Track the Antithrombotic and William A. Schumacher, 369 Hemostatic Effects of Clopidogrel in Rats Jeffrey S. Bostwick, Martin L. Ogletree, Anne B. Stewart, Thomas E. Steinbacher, Ji Hua, Laura A. Price, Pancras C. Wong, and Robert P. Rehfuss CELLULAR AND MOLECULAR Nicotine and Ethanol Activate Protein Kinase A Yuichiro Inoue, Lina Yao, 23 ␤␥ Synergistically via Gi Subunits in Nucleus F. Woodward Hopf, Peidong Fan, Accumbens/Ventral Tegmental Cocultures: The Role of Zhan Jiang, Antonello Bonci, and Dopamine D1/D2 and Adenosine A2A Receptors Ivan Diamond □S Neuroprotection by Small Molecule Activators of the Nerve Bo Lin, Michael C. Pirrung, Liu Deng, 59 Growth Factor Receptor Zhitao Li, Yufa Liu, and Nicholas J. G. Webster The Journal of Pharmacology and Experimental Therapeutics (ISSN Single copy: $85.00. GST Tax Number for Canadian subscribers: 0022-3565) is published monthly by the American Society for Phar- BN:13489 2330 RT. Indexed or abstracted by Biochemistry & Bio- macology and Experimental Therapeutics, 9650 Rockville Pike, physics Citation Index®, Biological Abstracts, BIOSIS Previews Data- Bethesda, MD 20814-3995; email: [email protected]; web site: base, BioSciences Information Services, Current Awareness in Bio- www.aspet.org. Periodicals postage paid at Bethesda, MD, and at ad- logical Sciences, Current Contents®/Life Sciences, EMBASE/ ditional mailing offices. POSTMASTER: Send address changes to The Excerpta Medica, Index Medicus, Medical Documentation Service®, Journal of Pharmacology and Experimental Therapeutics, 9650 Rock- PsycINFO, Reference Update®, Research Alert®, Science Citation ville Pike, Bethesda, MD 20814-3995. Subscription rates: U.S.: $850.00 Index®, SciSearch®, and SIIC Data Bases. Copyright © 2007 by the for institutions and $370.00 for non-ASPET members. Outside the American Society for Pharmacology and Experimental Therapeutics. U.S.: $999.00 for institutions and $519.00 for non-ASPET members. All rights reserved. Printed in the U.S.A. Beryllium Induces Premature Senescence in Human Shannon S. A. Coates, Bruce E. Lehnert, 70 Fibroblasts Sunil Sharma, Susan M. Kindell, and Ronald K. Gary □S Oxyntomodulin Differentially Affects Glucagon-Like Peptide-1 Rasmus Jorgensen, Valentina Kubale, 148 ␤ ␣ Receptor -Arrestin Recruitment and Signaling through G s Milka Vrecl, Thue W. Schwartz, and Christian E. Elling In Vitro Pharmacology of Clinically Used Central Nervous R. A. Bakker, M. W. Nicholas, T. T. Smith, 172 System-Active Drugs as Inverse H1 Receptor Agonists E. S. Burstein, U. Hacksell, H. Timmerman, R. Leurs, M. R. Brann, and D. M. Weiner Apomine Enhances the Antitumor Effects of Lovastatin on Anke J. Roelofs, Claire M. Edwards, 228 Myeloma Cells by Down-Regulating 3-Hydroxy-3- R. Graham G. Russell, F. Hal Ebetino, methylglutaryl-Coenzyme A Reductase Michael J. Rogers, and Philippa A. Hulley CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY Tumor Priming Enhances Delivery and Efficacy of Dan Lu, M. Guillaume Wientjes, Ze Lu, and 80 Nanomedicines Jessie L.-S. Au Combination Silencer RNA (siRNA) Targeting Bcl-2 Aleksandra A. Pandyra, Randal Berg, 123 Antagonizes siRNA against Thymidylate Synthase in Human Mark Vincent, and James Koropatnick Tumor Cell Lines ENDOCRINE AND DIABETES Downloaded from Nateglinide and Mitiglinide, but Not Sulfonylureas, Induce Makoto Shigeto, Masashi Katsura, 1 Insulin Secretion through a Mechanism Mediated by Calcium Masafumi Matsuda, Seitaro Ohkuma, and Release from Endoplasmic Reticulum Kohei Kaku Pharmacological Profile of the Thyroid Hormone Receptor Gary J. Grover, Celeste Dunn, 385 Antagonist NH3 in Rats Ngoc-Ha Nguyen, Jamie Boulet, Gao Dong, Jason Domogauer, Peter Barbounis, and jpet.aspetjournals.org Thomas S. Scanlan GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL Cisplatin-Induced Acute Renal Failure Is Associated with an Sarah Faubel, Eli C. Lewis, 8 Increase in the Cytokines Interleukin (IL)-1␤, IL-18, IL-6, Leonid Reznikov, Danica Ljubanovic, and Neutrophil Infiltration in the Kidney Thomas S. Hoke, Hilary Somerset, Dong-Jin Oh, Lawrence Lu, at ASPET Journals on September 23, 2021 Christina L. Klein, Charles A. Dinarello, and Charles L. Edelstein Conditional Deletion of Cytochrome P450 Oxidoreductase in Robert D. Finn, Aileen W. McLaren, 40 the Liver and Gastrointestinal Tract: A New Model for Dianne Carrie, Colin J. Henderson, and Studying the Functions of the P450 System C. Roland Wolf Role of Transforming Growth Factor ␤ in Rat Bladder Maurits M. Barendrecht, 117 Smooth Muscle Cell Proliferation Arthur C. M. Mulders, Henk van der Poel, Maurice J. B. van den Hoff, Martina Schmidt, and Martin C. Michel Centrally Administered Nociceptin/Orphanin FQ (N/OFQ) Melissa A. Burmeister and 324 Evokes Bradycardia, Hypotension, and Diuresis in Mice via Daniel R. Kapusta Activation of Central N/OFQ Peptide Receptors INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA Neuroinflammation and Behavioral Abnormalities after M. C. Zerrate, M. Pletnikov, S. L. Connors, 16 Neonatal Terbutaline Treatment in Rats: Implications for D. L. Vargas, F. J. Seidler, Autism A. W. Zimmerman, T. A. Slotkin, and C. A. Pardo Attenuation of Ozone-Induced Airway Inflammation and Alison S. Williams, Razao Issa, 351 Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Sum Yee Leung, Puneeta Nath, Inhibitor SP600125 Gregory D. Ferguson, Brydon L. Bennett, Ian M. Adcock, and Kian Fan Chung METABOLISM, TRANSPORT, AND PHARMACOGENOMICS □S Central Nervous System Drug Disposition: The Relationship Scott G. Summerfield, Kevin Read, 205 between in Situ Brain Permeability and Brain Free Fraction David J. Begley, Tanja Obradovic, Ismael J. Hidalgo, Sara Coggon, Ann V. Lewis, Rod A. Porter, and Phil Jeffrey Accelerated Urinary Excretion of Methylmercury following Michael S. Madejczyk, David A. Aremu, 378 Administration of Its Antidote N-Acetylcysteine Requires Tracey A. Simmons-Willis, Mrp2/Abcc2, the Apical Multidrug Resistance-Associated Thomas W. Clarkson, and Protein Nazzareno Ballatori Rifaximin Is a Gut-Specific Human Pregnane X Receptor Xiaochao Ma, Yatrik M. Shah, 391 Activator Grace L. Guo, Ting Wang, Kristopher W. Krausz, Jeffrey R. Idle, and Frank J. Gonzalez Doxorubicin Degradation in Cardiomyocytes Pierantonio Menna, Emanuela Salvatorelli, 408 and Giorgio Minotti NEUROPHARMACOLOGY Using Hapten Design to Discover Therapeutic Monoclonal Eric C. Peterson, Melinda Gunnell, 30 Antibodies for Treating Methamphetamine Abuse Yingni Che, Robyn L. Goforth, F. Ivy Carroll, Ralph Henry, Huimin Liu, and S. Michael Owens Competitive Antagonism between the Nicotinic Allosteric Cristiane Lopes, Edna F. R. Pereira, 48 Potentiating Ligand Galantamine and Kynurenic Acid at ␣7* Hui-Qiu Wu, Puranik Purushottamachar, Nicotinic Receptors Vincent Njar, Robert Schwarcz, and Edson X. Albuquerque In Vivo Effect of Venlafaxine on Locus Coeruleus Neurons: Esther Berrocoso and Juan Antonio Mico 101 ␣ Role of Opioid, 2-Adrenergic, and 5-Hydroxytryptamine1A Receptors Olanzapine Increases RGS7 Protein Expression via Rakesh K. Singh, Ju Shi, 133 Stimulation of the Janus Tyrosine Kinase-Signal Transducer Bozena W. Zemaitaitis, and Nancy A. Muma Downloaded from and Activator of Transcription Signaling Cascade Region-Specific Overexpression of P-glycoprotein at the E. A. van Vliet, R. van Schaik, 141 Blood-Brain Barrier Affects Brain Uptake of Phenytoin in P. M. Edelbroek, R. A. Voskuyl, S. Redeker, Epileptic Rats E. Aronica, W. J. Wadman, and J. A. Gorter Selectivity of ␦- and ␬-Opioid Ligands Depends on the Route Mary M. Lunzer and Philip S. Portoghese 166 of Central Administration in Mice jpet.aspetjournals.org